{"title":"New Essentials","description":"","products":[{"product_id":"magnesium-bisglycinate","title":"Magnesium Bisglycinate","description":"\u003cp\u003e\u003cb\u003eMagnesium\u003c\/b\u003e is an essential mineral required for hundreds of biochemical reactions that govern energy production, neuromuscular function, cardiovascular health, and metabolic balance. Yet inadequate magnesium intake remains common due to modern dietary patterns, environmental factors, and increased physiological demands from stress and physical activity. \u003cb\u003eMagnesium bisglycinate\u003c\/b\u003e—a chelated form of magnesium bound to the amino acid glycine—is widely recognized for its superior absorption, excellent gastrointestinal tolerance, and calming neuromuscular effects. This highly bioavailable form is designed to efficiently restore magnesium status while supporting relaxation, recovery, sleep quality, and overall systemic wellness.\u003c\/p\u003e\n\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eFULL SCIENCE\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eMagnesium\u003c\/b\u003e is an essential mineral involved in over 300 enzymatic reactions in the body, supporting energy production, neuromuscular coordination, cardiovascular function, and metabolic health. Despite its importance, inadequate intake is common due to modern diets, stress, and high physical demands.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eMagnesium bisglycinate\u003c\/b\u003e is a chelated form in which magnesium is bound to the amino acid \u003ci\u003eglycine\u003c\/i\u003e. This structure enhances absorption and improves gastrointestinal tolerance by utilizing amino acid transport pathways rather than relying solely on passive mineral absorption. As a result, it delivers consistent systemic magnesium levels with minimal laxative effects compared to poorly absorbed forms like magnesium oxide, making it ideal for daily or higher-dose supplementation.\u003c\/p\u003e\n\n\u003cp\u003eAt the cellular level, \u003cb\u003emagnesium\u003c\/b\u003e is required for biologically active ATP, directly supporting energy metabolism, muscular performance, and recovery. It also plays a role in insulin signaling and glucose regulation, contributing to metabolic stability. In muscle tissue, magnesium acts as a natural calcium antagonist, promoting proper contraction and relaxation and helping reduce cramps and tension.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eMagnesium\u003c\/b\u003e is equally important for nervous system balance, regulating NMDA receptors and supporting GABA activity to maintain healthy excitation–relaxation dynamics. The \u003ci\u003eglycine\u003c\/i\u003e component further supports calmness and sleep quality. Additionally, magnesium contributes to cardiovascular health by promoting vascular relaxation and healthy blood pressure.\u003c\/p\u003e\n\n\u003cp\u003eOverall, \u003cb\u003emagnesium bisglycinate\u003c\/b\u003e is a highly bioavailable, well-tolerated form that supports performance, recovery, metabolic function, sleep, and long-term wellness.\u003c\/p\u003e\n\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eNielsen FH. \u003ci\u003eMagnesium deficiency and increased inflammation: current perspectives.\u003c\/i\u003e Journal of Inflammation Research. 2018;11:25–34.\u003c\/p\u003e\n\n\u003cp\u003eVolpe SL. \u003ci\u003eMagnesium in disease prevention and overall health.\u003c\/i\u003e Advances in Nutrition. 2013;4(3):378S–383S.\u003c\/p\u003e\n\n\u003cp\u003eRosanoff A, Weaver CM, Rude RK. \u003ci\u003eSuboptimal magnesium status in the United States: are the health consequences underestimated?\u003c\/i\u003e Nutrition Reviews. 2012;70(3):153–164.\u003c\/p\u003e\n\n\u003cp\u003eCuciureanu MD, Vink R. \u003ci\u003eMagnesium and stress.\u003c\/i\u003e Magnesium Research. 2011;24(3):S37–S44.\u003c\/p\u003e\n\n\u003cp\u003eBoyle NB, Lawton C, Dye L. \u003ci\u003eThe effects of magnesium supplementation on subjective anxiety and stress—A systematic review.\u003c\/i\u003e Nutrients. 2017;9(5):429.\u003c\/p\u003e\n\n\u003cp\u003eUwitonze AM, Razzaque MS. \u003ci\u003eRole of magnesium in vitamin D activation and function.\u003c\/i\u003e Journal of the American Osteopathic Association. 2018;118(3):181–189.\u003c\/p\u003e\n\n\u003cp\u003eSchwalfenberg GK, Genuis SJ. \u003ci\u003eThe importance of magnesium in clinical healthcare.\u003c\/i\u003e Scientifica. 2017;2017:4179326.\u003c\/p\u003e\n\n\u003cp\u003eDiNicolantonio JJ, O’Keefe JH, Wilson W. \u003ci\u003eSubclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis.\u003c\/i\u003e Open Heart. 2018;5(1):e000668.\u003c\/p\u003e\n\n\u003cp\u003eZhang X, Li Y, Del Gobbo LC, et al. \u003ci\u003eEffects of magnesium supplementation on blood pressure: a meta-analysis of randomized controlled trials.\u003c\/i\u003e Hypertension. 2016;68(2):324–333.\u003c\/p\u003e\n\n\u003cp\u003eBarbagallo M, Dominguez LJ. \u003ci\u003eMagnesium and type 2 diabetes.\u003c\/i\u003e World Journal of Diabetes. 2015;6(10):1152–1157.\u003c\/p\u003e\n\n\u003cp\u003ede Baaij JHF, Hoenderop JGJ, Bindels RJM. \u003ci\u003eMagnesium in man: implications for health and disease.\u003c\/i\u003e Physiological Reviews. 2015;95(1):1–46.\u003c\/p\u003e\n\n\u003cp\u003eWalker AF, Marakis G, Christie S, Byng M. \u003ci\u003eMg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study.\u003c\/i\u003e Magnesium Research. 2003;16(3):183–191.\u003c\/p\u003e\n\n\u003cp\u003eRanade VV, Somberg JC. \u003ci\u003eBioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans.\u003c\/i\u003e American Journal of Therapeutics. 2001;8(5):345–357.\u003c\/p\u003e\n\n\u003cp\u003eAbbasi B, Kimiagar M, Sadeghniiat-Haghighi K, et al. \u003ci\u003eThe effect of magnesium supplementation on primary insomnia in elderly subjects.\u003c\/i\u003e Journal of Research in Medical Sciences. 2012;17(12):1161–1169.\u003c\/p\u003e\n\n\u003cp\u003eWienecke E, Nolden C. \u003ci\u003eGlycine and sleep quality—mechanistic considerations and clinical implications.\u003c\/i\u003e Sleep and Biological Rhythms. 2016;14(1):3–9.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45008591945904,"sku":"850080302668","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/MAG_BIS_FRONT_ffd6e6fd-6cd9-4928-921a-c505f2d00c17.png?v=1775484893"},{"product_id":"vitamin-d3-k2","title":"Vitamin D3+K2","description":"\u003cp\u003e\u003cb\u003eVitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e are fat-soluble nutrients that work together to regulate calcium metabolism and support overall skeletal and cardiovascular health. While \u003cb\u003evitamin D\u003c\/b\u003e enhances calcium absorption and stimulates the production of calcium-dependent proteins, \u003cb\u003evitamin K2\u003c\/b\u003e activates those proteins to ensure calcium is properly utilized in bone and not deposite\u003cimg\u003ed in soft tissues. When combined, these vitamins form a coordinated system that promotes optimal calcium balance, structural integrity, and long-term health.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFULL SCIENCE\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eVitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e are fat-soluble nutrients that work synergistically to regulate calcium metabolism, support skeletal integrity, and promote cardiovascular health. \u003cb\u003eVitamin D\u003c\/b\u003e, particularly in its D3 form (\u003ci\u003echolecalciferol\u003c\/i\u003e), is converted in the body to its active hormonal form, \u003ci\u003ecalcitriol\u003c\/i\u003e, which increases intestinal absorption of calcium and phosphorus and stimulates the production of calcium-binding proteins such as \u003ci\u003eosteocalcin\u003c\/i\u003e. This process raises circulating calcium levels and enhances the body’s capacity to mineralize bone. However, while \u003cb\u003evitamin D\u003c\/b\u003e increases calcium availability and upregulates the production of key calcium-dependent proteins, it does not determine where that calcium is ultimately deposited. That essential targeting function depends largely on \u003cb\u003evitamin K2\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eVitamin K2\u003c\/b\u003e, in the form of \u003ci\u003emenaquinones\u003c\/i\u003e such as \u003ci\u003eMK-4\u003c\/i\u003e and \u003ci\u003eMK-7\u003c\/i\u003e, acts as a cofactor for the enzyme \u003ci\u003egamma-glutamyl carboxylase\u003c\/i\u003e, which activates vitamin K–dependent proteins through a process called \u003ci\u003ecarboxylation\u003c\/i\u003e. Among the most important of these proteins are \u003ci\u003eosteocalcin\u003c\/i\u003e, which binds calcium into the bone matrix, and \u003ci\u003ematrix Gla protein (MGP)\u003c\/i\u003e, which inhibits inappropriate calcium deposition in blood vessels and soft tissues. Without adequate \u003cb\u003evitamin K2\u003c\/b\u003e, these proteins remain undercarboxylated and functionally inactive, reducing their ability to properly regulate calcium distribution. In this context, \u003cb\u003evitamin D\u003c\/b\u003e can increase the production of \u003ci\u003eosteocalcin\u003c\/i\u003e and \u003ci\u003eMGP\u003c\/i\u003e, but \u003cb\u003evitamin K2\u003c\/b\u003e is required to activate them so they can perform their physiological roles.\u003c\/p\u003e\n\u003cp\u003eTogether, \u003cb\u003evitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e form a coordinated system of calcium management: \u003cb\u003evitamin D\u003c\/b\u003e enhances calcium absorption and stimulates the synthesis of calcium-regulating proteins, while \u003cb\u003evitamin K2\u003c\/b\u003e activates those proteins to ensure calcium is directed into bones and away from arteries and soft tissues. This synergy supports bone mineral density by improving both calcium supply and incorporation into skeletal structure. At the same time, activation of \u003ci\u003eMGP\u003c\/i\u003e by \u003cb\u003evitamin K2\u003c\/b\u003e contributes to vascular health by helping prevent arterial calcification, a process associated with cardiovascular risk. Beyond bone and vascular effects, the combination may also influence muscle function and overall metabolic health, as \u003cb\u003evitamin D\u003c\/b\u003e supports neuromuscular performance and immune regulation, while \u003cb\u003evitamin K2\u003c\/b\u003e contributes to cellular signaling and tissue integrity. For these reasons, co-supplementation of \u003cb\u003evitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e is often considered a more physiologically comprehensive strategy than \u003cb\u003evitamin D\u003c\/b\u003e alone, particularly in individuals seeking to optimize bone strength, calcium utilization, and long-term cardiovascular support.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eHolick MF. \u003ci\u003eVitamin D deficiency.\u003c\/i\u003e New England Journal of Medicine. 2007;357(3):266–281.\u003c\/p\u003e\n\u003cp\u003eHeaney RP. \u003ci\u003eVitamin D in health and disease.\u003c\/i\u003e Clinical Journal of the American Society of Nephrology. 2008;3(5):1535–1541.\u003c\/p\u003e\n\u003cp\u003eBouillon R, et al. \u003ci\u003eVitamin D and human health: lessons from vitamin D receptor null mice.\u003c\/i\u003e Endocrine Reviews. 2008;29(6):726–776.\u003c\/p\u003e\n\u003cp\u003eSchurgers LJ, Vermeer C. \u003ci\u003eDifferential lipoprotein transport pathways of K-vitamins in healthy subjects.\u003c\/i\u003e Biochimica et Biophysica Acta. 2000;1486(2–3):200–210.\u003c\/p\u003e\n\u003cp\u003eGast GCM, et al. \u003ci\u003eA high menaquinone intake reduces the incidence of coronary heart disease.\u003c\/i\u003e Nutrition, Metabolism \u0026amp; Cardiovascular Diseases. 2009;19(7):504–510.\u003c\/p\u003e\n\u003cp\u003eVermeer C. \u003ci\u003eVitamin K2: the missing nutrient in bone and vascular health.\u003c\/i\u003e Netherlands Journal of Medicine. 2001;58(10):411–414.\u003c\/p\u003e\n\u003cp\u003eVermeer C, et al. \u003ci\u003eVitamin K–dependent proteins in bone and cardiovascular health.\u003c\/i\u003e Nutrients. 2018;10(10):1525.\u003c\/p\u003e\n\u003cp\u003eKnapen MHJ, et al. \u003ci\u003eMenaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women.\u003c\/i\u003e Thrombosis and Haemostasis. 2015;113(5):1135–1144.\u003c\/p\u003e\n\u003cp\u003eGundberg CM, et al. \u003ci\u003eVitamin K status and cardiovascular health: implications for bone and vascular calcium regulation.\u003c\/i\u003e Current Osteoporosis Reports. 2012;10(2):142–150.\u003c\/p\u003e\n\u003cp\u003eSaito Y, et al. \u003ci\u003eCombined vitamin K2 and vitamin D3 enhance calcium utilization in bone.\u003c\/i\u003e Clinical Calcium. 2010;20(2):219–225.\u003c\/p\u003e\n\u003cp\u003eKnapen MHJ, et al. \u003ci\u003eVitamin K2 supplementation improves hip bone geometry and bone strength indices.\u003c\/i\u003e Osteoporosis International. 2013;24(9):2499–2507.\u003c\/p\u003e\n\u003cp\u003eCheung AM, et al. \u003ci\u003eVitamin K supplementation and bone loss in older men and women.\u003c\/i\u003e Journal of Bone and Mineral Research. 2008;23(4):652–658.\u003c\/p\u003e\n\u003cp\u003eBeulens JWJ, et al. \u003ci\u003eHigh dietary menaquinone intake is associated with reduced coronary calcification.\u003c\/i\u003e Atherosclerosis. 2008;200(2):489–496.\u003c\/p\u003e\n\u003cp\u003eTheuwissen E, et al. \u003ci\u003eLow vitamin K status is associated with increased coronary calcification and mortality.\u003c\/i\u003e Nutrition, Metabolism \u0026amp; Cardiovascular Diseases. 2012;22(7):589–595.\u003c\/p\u003e\n\u003cp\u003eCannell JJ, et al. \u003ci\u003eVitamin D and the prevention of chronic diseases.\u003c\/i\u003e Journal of Steroid Biochemistry and Molecular Biology. 2008;103(3–5):373–378.\u003c\/p\u003e\n\u003cp\u003eWang TT, et al. \u003ci\u003eVitamin D receptor signaling is critical for muscle function.\u003c\/i\u003e Nature Medicine. 2010;16(10):1260–1265.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45008629104816,"sku":"850080302057","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/D3_K2_FRONT_062249e1-5dac-4a41-b10f-f56c6619e9fb.png?v=1775484889"},{"product_id":"bionmn","title":"NMN","description":"\u003cp\u003e\u003cb\u003eBioNMN®\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eINTRO\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAt the core of cellular energy, recovery, and longevity lies one critical molecule: \u003cb\u003eNAD+\u003c\/b\u003e. BioNMN® (Beta-Nicotinamide Mononucleotide) is a direct precursor to NAD+, the essential coenzyme required for ATP production—the fuel that powers nearly every biological process in the body. As NAD+ levels naturally decline with age, cellular efficiency, metabolic resilience, cognitive performance, and mitochondrial function can begin to deteriorate.\u003c\/p\u003e \u003cp\u003eBy supplying a highly bioavailable source of NMN, BioNMN® helps replenish NAD+ levels at the cellular level, supporting sustained energy production, mitochondrial integrity, and whole-body vitality. Designed for optimal absorption, this advanced form of NMN provides a foundational approach to performance, metabolic health, and healthy aging from the inside out.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFULL SCIENCE\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBioNMN® (Beta-Nicotinamide Mononucleotide)\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNicotinamide Mononucleotide (NMN) is a ribo-nucleotide, which is a simple structural unit of RNA. NMN is the direct precursor of nicotinamide adenine dinucleotide (NAD+) and is considered a vital component to cellular increases in NAD+ levels. NAD+ is an essential coenzyme required to produce ATP (adenosine triphosphate), the fuel used by almost all cells in the body. As we age, NAD+ levels naturally decline, which can lead to less-than-optimal functioning and contribute to conditions such as obesity, insulin resistance, and impaired cognitive function.\u003c\/p\u003e \u003cp\u003eWhile humans cannot absorb NAD directly, using NAD+ precursors like NMN can help maintain NAD+ levels. BioNMN® emphasizes enhanced bioavailability so the full benefits of this ingredient can be achieved.\u003c\/p\u003e \u003cp\u003eNMN supplementation offers a wide range of benefits that influence nearly all body systems, including brain and cardiovascular support, reduced age-related inflammation, neuroprotection, hormonal balance, improved mitochondrial function, enhanced muscle endurance and strength, and overall longevity. These benefits rely on NAD+ as a key coenzyme that drives these biological processes.\u003c\/p\u003e \u003cp\u003eIn terms of muscle performance, skeletal muscles require significant amounts of energy molecules to maintain strength and function. NAD+ is required to metabolize these molecules, meaning muscles benefit from a steady supply of NMN as a building block.\u003c\/p\u003e \u003cp\u003eMitochondria, known as the powerhouse of the cell, are essential for converting nutrients into usable energy. NAD+ plays a central role in this metabolic process. Without sufficient NAD+, mitochondria cannot function properly, leading to reduced energy production and potential cellular damage. Research suggests that NMN supplementation supports NAD+ production, helping protect mitochondria and maintain proper metabolic function.\u003c\/p\u003e \u003cp\u003eNMN also plays a role in longevity. As many bodily functions decline with age, maintaining NAD+ levels may help slow aspects of the aging process. Supporting NAD+ levels may help sustain optimal function across body systems over time, while low levels are linked to increased risk of dysfunction and disease.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eNomiyama T, Setoyama D, Yasukawa T, Kang D. Mitochondria Metabolomics Reveals a Role of β-Nicotinamide Mononucleotide Metabolism in Mitochondrial DNA Replication. J Biochem. 2021.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eKlimova N., Long A., Kristian T. (2019). Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eShade C. (2020). The Science Behind NMN—A Stable, Reliable NAD+ Activator and Anti-Aging Molecule.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYoshino J., Baur J.A., Imai S. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eImai S., Guarente L. (2014). NAD+ and sirtuins in aging and disease.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCanto C., Menzies K.J., Auwerx J. (2015). NAD+ Metabolism and the Control of Energy Homeostasis.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMills K.F., et al. (2016). Long-Term Administration of NMN Mitigates Age-Associated Physiological Decline in Mice.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eGomes A.P., et al. (2013). Declining NAD+ Disrupts Cellular Communication during Aging.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYoshino J., et al. (2021). NMN increases muscle insulin sensitivity in prediabetic women.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eVerdin E. (2015). NAD+ in aging, metabolism, and neurodegeneration.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eRajman L., Chwalek K., Sinclair D.A. (2018). Therapeutic Potential of NAD-Boosting Molecules.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eLiao B., et al. (2021). NMN supplementation enhances aerobic capacity in amateur runners.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eSource: :contentReference[oaicite:0]{index=0}\u003c\/i\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45034516021424,"sku":"850080302644","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/NMN_FRONT_674013b3-539b-45f5-b123-47fdd43e6720.png?v=1775484886"}],"url":"https:\/\/www.corenutritionals.com\/collections\/new-essentials.oembed","provider":"Core Nutritionals","version":"1.0","type":"link"}