{"title":"New Arrivals","description":"","products":[{"product_id":"core-mrp","title":"MRP","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein blend\u003c\/strong\u003e - \u003cspan data-mce-fragment=\"1\"\u003eSustained release for all day amino acid support \u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCarb blend\u003c\/strong\u003e - Low glycemic and grain-sourced carbohydrates\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMicronutrients\u003c\/strong\u003e - Full spectrum of vitamins and minerals\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eDiet is the most critical aspect for training success.\u003c\/p\u003e\n\u003cp\u003eCore MRP is designed with optimal results in mind. Our high quality, grain-sourced carbohydrates, multiple (and rich) protein sources, premium flavors, and a plethora of extras all come in a gourmet-tasting, instantized powder.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e2 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e20 servings per container.\u003c\/li\u003e\n\u003cli\u003eComprehensive meal formula.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePop quiz: what’s the absolute, without question, most critical component to achieving those roadmap veins and granite abs you have always wanted? How hard and how frequently you work your abs? The intensity of your cardio training, maybe; or the HIIT training you’ve been doing? If you said any of the above, you’re wrong – while exercise is a critical component of achieving your body composition goals, the diet remains king.\u003c\/p\u003e\n\u003cp\u003eWhile it remains the most important component in a healthy lifestyle, a finely-tuned diet is often a difficult and impractical thing to implement. The most dedicated among us – and probably you, too – pack our fridge with Tupperware so high that chicken and plastic starts bursting through the freezer. We’ve all had the, “I eat this because...” conversation while at work, lugged our preferred food items to school, work, the park, and everywhere in between, and cursed the fact we went anywhere ill-prepared that day. There needs to be an easier – but equally effective – way, doesn’t there?\u003c\/p\u003e\n\u003cp\u003eWell, at Core Nutritionals, we think we have found that better way: Core MRP. Core MRP is not only designed with optimal nutrients (macro and micro) in mind, but perhaps more importantly, it’s designed to fit in your life, not run it. Our high quality, grain-sourced carbohydrates, multiple (and rich) protein sources, premium flavors, and a plethora of extras all come in a gourmet-tasting, instantized powder – giving you the freedom to plan your favorite activities, and your diet, together.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCarbohydrate Blend:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBefore we dive in to understand the complexity of Core MRP, lets back up and first understand exactly what’s occurring when we consume carbohydrates on a daily basis – and in particular, when we consume around our workouts (peri-workout nutrition).\u003c\/p\u003e\n\u003cp\u003eThe consumption of carbohydrates, by its nature, results in an increase in the concentration of plasma glucose (or blood sugar) – and, in turn, insulin is released from the pancreas as a result. Insulin then initiates a number of signal transduction pathways related to both protein and glucose metabolism, with the upshot being increased glycolysis (breakdown of glucose to ATP), glucose oxidation in response to greater glucose availability in the cell, and glycogen synthesis (the stuff that essentially makes muscles, “pop”). In other words, an entire host of both necessary and amazing things!\u003c\/p\u003e\n\u003cp\u003eWith that said, insulin does induce some negative effects, as well. This powerful hormone is responsible for a range of lipogenic (fat-creating) effects, including both adipocyte differentiation (turning what are known as pre-adipocytes into mature adipocytes, or fat cells), and proliferation (the expansion of cells). Insulin controls these processes by tightly regulating numerous signal transduction pathways, and is in fact one of the key hormones responsible for controlling how adipocytes function.\u003c\/p\u003e\n\u003cp\u003eSo, you have a hormone that, on the one hand, does a range of absolutely crucial things related to muscle and muscle cell metabolism, and on the other, does similarly crucial things related to fat and fat cell metabolism. How do we separate the good from the bad, then?\u003c\/p\u003e\n\u003cp\u003eThe easiest, most reliable way to ensure that these processes continue to work in favor of your body composition goals, is to very carefully and strategically select your carbohydrates sources. For us at Core, and specifically for Core MRP, this means choosing only low glycemic carbohydrates for inclusion in our everyday meal supplement.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhole Grain Oats:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLow-glycemic carbohydrates are ones that elicit a smaller, “glycemic” or glucose-releasing response in the body; meaning they also induce less of an insulinemic response, as well. The result is that low glycemic carbohydrates, as research indicates, not only cause enhanced fat oxidation (the literal burning of fat) when compared to high GI carbs, but also spare muscle glycogen. This result is the best of both worlds: your metabolic engine stays engaged, and the substance that gives your muscles their fullness, glycogen, is spared.\u003c\/p\u003e\n\u003cp\u003eIt is for the reasons above that high-quality, low-glycemic carbohydrates are such a crucial component to an excellent meal supplement. Unfortunately, that is simply not the industry trend: even a cursory glance at most, “meal replacements” reveals a litany of high-glycemic, insulin-inducing carbohydrates that, while they have their place, are completely inappropriate to include in an all-day, everyday meal replacement.\u003c\/p\u003e\n\u003cp\u003eCore MRP is not like the rest. We are setting a new standard with the product that started it all. We have chosen only high-quality whole grain oat flour to include as your carbohydrate source. Oats offer a wide variety of benefits aside from just providing carbohydrates for the body. Some of these include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eOats contain considerable amounts of valuable nutrients such as proteins, starch, unsaturated fatty acids and dietary fiber as soluble and insoluble fractions.\u003c\/li\u003e\n\u003cli\u003eOats contain high amounts of beta glucan, a fiber that has been studied extensively for its benefits on aiding digestion and supporting the gut microbiome.\u003c\/li\u003e\n\u003cli\u003eOats also have been shown to aid in the controlling of certain heart related conditions, such as high cholesterol.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWe at Core have put a lot of time and effort into the formulation of our products, and Core MRP is not different. This allows you to remain confident that consuming Core MRP is not only allowing you to cost-effectively and conveniently meet your caloric goals for the day, but more importantly, that our product is not compromising your hard work or lifestyle.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtein Blend:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf you have been following us for quite some time, we likely don’t need to explain just how and why adequate protein intake is fundamental to achieving your goals. With that said, there may be some confusion as to what specific kinds of protein are going to benefit your goals and why.\u003c\/p\u003e\n\u003cp\u003eLike we did with carbohydrates above, let’s look into the specifics a little bit rather than just supplying a generic answer. We are anything but generic after all! The word “protein,” without any qualification, is perhaps the broadest term you can possibly use when speaking about biology – to the point where asking, “How much protein should I consume, and which kind?” renders itself useless. Considering proteins are more or less complex compositions of amino acids, and considering that amino acids have different functions, what we want to ask is something more specific like, “Which kinds of protein have the amino acid composition best suited to my goals, and when should I consume them?” A mouthful, but you get the point!\u003c\/p\u003e\n\u003cp\u003eSo, what does a, “good” amino acid composition for a protein supplement look like? Well, while biologists would never use the term, “good”, they describe more robust proteins – one with amino acid profiles that can best facilitate tissue growth – as, “complete proteins.” These proteins contain high amounts of essential amino acids, are rapidly digestible, and support the available amino acid profile over a long period of time.\u003c\/p\u003e\n\u003cp\u003eSimply put, and if we use the definition above, Core MRP has one of the most complete amino acid profiles available in any supplement. We have a included a blend of the most bioavailable and high quality proteins to create a blend specifically catered to fuel your body’s need throughout an entire day, not to mention we have full transparency on our label too, so you know exactly how much of each protein you are getting.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCold-processed undenatured whey protein concentrate:\u003c\/strong\u003e Whey protein concentrate is probably the most common form of whey protein you will find. However, how it is processed is where the benefit truly lies. This process of cold processed undenaturization preserves the molecular structure of the amino acid particles as well as the immune boosting benefits that it contains. This undenatured protein is also a rich source of amino acids, including those needed for the synthesis of glutathione, which is an important antioxidant that can be depleted by stress (exercise stress included). This makes it a great foundation for your post workout recovery nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCross-flow microfiltered whey protein isolate:\u003c\/strong\u003e whey protein isolate is an extremely “clean” form of whey protein. It yields a higher amount of amino acids, half of which are from the essential amino acids (cannot be made by the body). Microfiltration eliminates a large majority of the fat and lactose from the whey, which makes it easily digestible and quickly absorbed into the body. This cross-flow process uses a highly intricate method to isolate the protein. It is not subjected to chemicals and is thus left in its most natural state.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Protein Isolate:\u003c\/strong\u003e milk protein isolate is obtained through the partial removal of non-protein materials from skim milk (lactose and other minerals). What you are left with is a dry product that contains more than 90% protein by weight. This product contains both casein and whey proteins in their original proportions found in milk, without combining separately produced casein and whey proteins. It contains very little fat and lactose and also has a very high amino acid composition making it a perfect addition to this blend.\u003c\/p\u003e\n\u003cp\u003eTo both immediately increase the amino acid pool, and fuel your bodily processes (like protein synthesis) throughout the day, we’ve strategically included such a robust, multi-purpose blend using multiple forms of synergistic proteins that truly complement each other to positively impact your health and fitness.\u003c\/p\u003e\n\u003cp\u003eThe point of an excellent meal supplement is to cover all your bases, so you don’t have to. Core MRP in MJ with the ball with 5 seconds on the clock and The Bulls down by 1. Our multi-stage protein blend is ready to give you everything you need to maximize recovery, increase protein synthesis, and improve your health when you need it most. If your body needs it, Core MRP has it.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhole Food Based Vitamins and Minerals:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThere are a lot of great things about Core MRP already, but what really makes it stand out from other meal supplements on the market is the complete and well-roundedness of this product. Our sources of carbohydrates are more superior, our blend of protein is unmatched, and last but not least, our completely whole food-based blend of micronutrients is second to none.\u003c\/p\u003e\n\u003cp\u003eListing each of our micronutrients in succession, along with all the benefits they pose to the human body, would require us to write a book – literally. We have included everything from A to Zinc in dosages needed that will truly make a difference. We have also added a specific and blend of key foods, like broccoli, kale, sweet potato, chlorella, and shiitake mushroom to name a few. This is the most complete meal supplement on the market.\u003c\/p\u003e\n\u003cp\u003eIn addition to our vitamin and mineral matrix, we have also included the digestive enzyme blend, DigeSEB™, comprised by five of the most clinically-researched, critical function enzymes available. We have chosen this blend for its powerful synergistic properties and abilities to help aid in the breakdown of milk proteins and sugars, support healthy carbohydrate and fat metabolism and breakdown, and assist in the metabolism of carbohydrates and starch.\u003c\/p\u003e\n\u003cp\u003eFor a more in-depth look, take a look at our supplement facts table below!\u003c\/p\u003e\n\u003cp\u003eFor a more in-depth look, take a look at our supplement facts table below!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-MRP2020.jpg?v=1595228900\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_MRP_2023_BANANA_NUT_BREAD-FIN_1.pdf?v=1695644681\"\u003eBanana Nut Bread Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-BLUEBERRY_CRUMB_FIN-OL.pdf?v=1639495234\"\u003eBlueberry Crumb Cake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-DOUBLE_CHOCOLATE_FIN-OL_compressed_1.pdf?v=1639495571\"\u003eDouble Chocolate Oatmeal Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-PB_OATMEAL_COOKIE_FIN-OL_compressed.pdf?v=1639496009\"\u003ePeanut Butter Oatmeal Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-VANILLA_POUNDCAKE_FIN-OL_compressed.pdf?v=1639496196\"\u003eVanilla Poundcake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020_CHOCOLATE_CARAMEL_CANDY_BAR-FIN_compressed.pdf?v=1639556587\"\u003eCaramel Candy Bar Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020_PUMPKIN_PIE-FIN_compressed_1.pdf?v=1639495111\"\u003ePumpkin Pie Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2021-CARROT_CAKE-FIN_compressed.pdf?v=1639496458\"\u003eCarrot Cake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2021-SMORES-FIN_compressed_1_ba0fbab8-9a60-46f6-a060-a82d73cdfe7f.pdf?v=1639497007\"\u003eS'mores Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-BROWN_SUGAR_FIN-OL.pdf?v=1658906456\"\u003eBrown Sugar \u0026amp; Cinnamon Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-MRP-REFFERENCES.pdf?v=1595229378\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Banana Nut Bread","offer_id":42833452695728,"sku":"SHOP850051031252","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Blueberry Muffin","offer_id":31915088674931,"sku":"SHOP850757001849","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Peanut Butter Oatmeal Cookie","offer_id":31915088740467,"sku":"SHOP8507570018070","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Cookies n' Cream","offer_id":44921434407088,"sku":"SHOP850057789379","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Death By Chocolate","offer_id":44921434439856,"sku":"SHOP850057789874","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Vanilla Poundcake","offer_id":31915088773235,"sku":"SHOP672975315818","price":54.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/MRP_PBOC_FRONT_6176821a-da83-48f5-8d0c-5636bd093980.png?v=1772111616"},{"product_id":"core-pro-2lb","title":"Pro 2lb","description":"\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhey protein blend\u003c\/strong\u003e - Sustained release of recovery and growth agents\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eDigestive enzyme blend\u003c\/strong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e - Digestive enzyme blend supports healthy carbohydrate and fat breakdown\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eVersatility\u003c\/strong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e - Designed to maximize your protein needs any time of the day\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003ca href=\"https:\/\/www.corenutritionals.com\/products\/core-pro-5lb\"\u003e \u003cbutton style=\"width: 100%; height: 50px; font-size: 20px;\" class=\"btn black-carbon-btn\" type=\"submit\"\u003eGet Core PRO 5LB\u003c\/button\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSustained Release Protein Blend\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYou want to recover. You don’t want to gag while doing it.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThat’s why we built Core PRO: a protein powder that tastes incredible and works even better. Our carefully chosen protein blend offers a robust amino acid profile shown to support lean muscle growth—while our flavors make it feel like a cheat.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003e1 scoop per serving\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003e28 (2LB) \/ 70 (5LB) servings per container\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eProtein blend with gourmet taste\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhy Core PRO?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn today’s world, taste is everything—and Core PRO delivers. But this is Core Nutritionals, meaning function always matches flavor. Our mix of whey concentrate, whey isolate, and milk protein isolate creates a smooth texture, complete amino acid profile, and both fast- and slow-digesting proteins. The result is a marriage of taste and performance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCore PRO is a clinical-strength, sustained release formula designed to fuel growth and recovery over extended periods. By combining fast-uptake whey with casein-rich milk protein, this blend supports immediate recovery and long-term muscle repair. It is loaded with naturally occurring BCAAs, helping delay fatigue and speed up recovery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWe’ve gone further by adding digestive enzymes for absorption and MCTs (medium chain triglycerides) to help preserve lean mass while boosting metabolism. Core PRO works any time—day or night—keeping you fueled whenever you need it.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003esplit\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eScientific Breakdown\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eRecovery depends on positive net protein balance: slowing muscle protein breakdown while increasing synthesis. After training, protein supplements provide the amino acids your body needs to tip this balance in your favor.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBut not all proteins are equal. Many products are filled with low-quality blends and fillers. Core PRO is different. Our cold-processed whey concentrate, cross-flow micro filtered whey isolate, and milk protein isolate deliver:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eA complete amino acid profile\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eSuperior nitrogen retention\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eIncreased lean muscle impact\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eStrong satiety (feeling of fullness)\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAnd unlike most brands, we’re fully transparent. Our label discloses exact yields and the full amino acid profile. Each serving provides 2.6g of leucine, the proven dose to maximize muscle protein synthesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eThe Core PRO Protein Sources\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCold-Processed Whey Concentrate: Preserves amino acid structure and immune-boosting benefits while supplying antioxidants like glutathione. A strong base for recovery nutrition.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCross-Flow Whey Isolate: Extremely clean, with minimal fat and lactose, making it highly digestible and rapidly absorbed without harsh chemicals.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMilk Protein Isolate: Over 90% protein by weight, containing both casein and whey in their natural ratios. Low fat, low lactose, and high in amino acids for sustained recovery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis combination provides immediate recovery support and long-lasting amino acid delivery until your next meal.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eAdded Support Ingredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDigeSEB Digestive Enzyme Blend: Many brands overlook enzymes, but they are crucial for breaking down carbs, fats, and proteins. Core PRO includes amylases, proteases, lactases, and cellulases to ensure complete digestion and absorption. This makes your protein more effective both pre- and post-workout.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCoconut Oil Creamer (MCTs): MCTs bypass gastric uptake, go directly to the liver, and are rapidly used for energy. Research shows they increase resting energy expenditure by up to 65 percent while reducing fat storage, supporting both performance and body composition.\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cb\u003e\u003c\/b\u003e\u003cb id=\"docs-internal-guid-595b37a9-7fff-3ef7-e163-14316b189977\"\u003e\u003c\/b\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-PRO-2020.jpg?v=1585897600\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PRO-PeachCobbler-FINAL_Outlined.jpg?v=1738576863\"\u003ePeach Cobbler 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_PRO_2lb_CHOCOLATE_CARAMEL_BAR-FIN_compressed_1.pdf?v=1710751204\"\u003eChocolate Caramel Candy Bar 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_PEANUT_BUTTER_CUP_FIN-OL_compressed.pdf?v=1643989028\"\u003eChocolate Peanut Butter 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_FRENCH_TOAST_FIN-OL_compressed.pdf?v=1643988825\"\u003eCinnamon French Toast 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_COOKIES_N_CREAM_FIN-OL_compressed.pdf?v=1643988771\"\u003eCookies 'n Cream 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_CHOCOLATE_FIN-OL_compressed.pdf?v=1643988523\"\u003eDeath by Chocolate 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_VANILLA_CUPCAKE_FIN-OL_compressed.pdf?v=1643989086\"\u003eFrosted Vanilla Cupcake 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_FRUITY_CEREAL_FIN-OL_compressed.pdf?v=1643988885\"\u003eFruity Cereal 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_CHOCOLATE_MOCHA-FIN-OL_compressed.pdf?v=1643988590\"\u003eChocolate Mocha 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_BLUBERRY_MUFFIN_FIN-OL_compressed.pdf?v=1643988446\"\u003eBlueberry Muffin 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_GAINTIME_FIN-OL_compressed.pdf?v=1643988930\"\u003eVanilla Toffee Gaintime 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_COCONUT_CREAM_PIE_FIN-OL_compressed.pdf?v=1643988640\"\u003eCoconut Cream Pie 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_PISTACHIO_ICE_CREAM-FIN.pdf?v=1656589730\"\u003ePistachio Ice Cream 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES_-_Core_PRO.pdf?v=1586182614\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Banana Cream Pie","offer_id":45211912634544,"sku":"SHOP850080302767","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Airplane Cookies \u0026 Cream","offer_id":45113118064816,"sku":"SHOP850080302286","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Peanut Butter","offer_id":45031036813488,"sku":"SHOP850057789850","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Shamripped Shake","offer_id":45003451924656,"sku":"SHOP850080302293","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Frosted Vanilla Cupcake","offer_id":39799461314736,"sku":"SHOP850080302163","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Strawberries n' Cream","offer_id":44949988081840,"sku":"SHOP850057789867","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Cinnamon French Toast","offer_id":44915285328048,"sku":"SHOP850080302132","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Cookies n' Cream","offer_id":44915285360816,"sku":"SHOP850080302149","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Blueberry Muffin","offer_id":39799460987056,"sku":"SHOP850080302118","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Chocolate Peanut Butter Cup","offer_id":44878107148464,"sku":"SHOP850080302125","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Death by Chocolate","offer_id":39799461249200,"sku":"SHOP850080302156","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Holiday Sugar Cookie","offer_id":44848261267632,"sku":"SHOP850057790009","price":54.99,"currency_code":"USD","in_stock":false},{"title":"Chocolate Caramel Candy Bar","offer_id":43271681966256,"sku":"SHOP850051031801","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Milk Chocolate Cookies 'n Cream","offer_id":44931010855088,"sku":"SHOP850057789645","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Mixed Berry Cheesecake","offer_id":44931010887856,"sku":"SHOP850057789447","price":54.99,"currency_code":"USD","in_stock":true},{"title":"PB Cookies 'N Cream","offer_id":44931010920624,"sku":"SHOP850057789461","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Vanilla Honey Graham","offer_id":44931010953392,"sku":"SHOP850057789454","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PRO_BCP_FRONT_b4cf66bb-0c19-4287-92db-7aa9fad44712.png?v=1781519795"},{"product_id":"burn-thermogenic-sale","title":"Burn","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eZum XR®\u003c\/strong\u003e - Delayed release caffeine for sustained energy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Reduction in cortisol levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSaffSerrene\u003cspan data-mce-fragment=\"1\"\u003e™\u003c\/span\u003e\u003c\/strong\u003e - Supports mental health and mood balance, suppresses appetite\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eCore BURN is a comprehensive weight management supplement and appetite suppressants\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e1 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e50 servings per container.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBURN is the next innovation in thermogenics. A modern weight loss solution using trademarked and patented ingredients, BURN addresses every major metabolic pathway of adipose creation and deposition. Whereas many thermogenics focus exclusively on stimulation, BURN contains ingredients with specific, high-quality evidence demonstrating their efficacy. SaffSerene™, for example, has been demonstrated to significantly reduce subjective feelings of hunger – one of the only dietary ingredients on the market that the FDA allows to make such a claim. KSM-66®, a patented extract of Ashwagandha, has been shown to significantly reduce corstiol – the body’s key stress hormone – in clinical trials. Together with the other premium ingredients in BURN, these two ingredients create an unparalleled weight management product.\u003c\/p\u003e\n\u003cp\u003eA complete formula, BURN is simply the modern evolution in weight loss supplements. With every facet of weight loss covered, BURN is the perfect companion to your diet and exercise regimen.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcetyl-l-Carnitine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions.\u003c\/p\u003e\n\u003cp\u003eUnfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eWithania somnifera Dunal\u003c\/i\u003e, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003ci\u003eWithania somnifera\u003c\/i\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).\u003c\/p\u003e\n\u003cp\u003eTo put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGarcinia cambogia fruit extract (50% hydroxycitric acid):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGarcinia cambogia, more commonly known under a variety of names, including the tamarind, is a small tropical fruit endemic to Indonesia. This plant has come under increased media attention over the past few years, due largely to the purported effects of its principal constituent, hyrdoxycitric acid, or HCA.\u003c\/p\u003e\n\u003cp\u003eHCA itself is a derivative of citric acid, and competitively inhibits the enzyme adenosine triphosphatase-citrate-lyase. This enzyme is an extra-mitochondrial enzyme (meaning it sits outside the mitochondria) chiefly responsible for a process known as de novo lipogenesis – or the production of fatty acids from glucose.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGreen coffee extract (50% chlorogenic acid): \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChlorogenic acids are phenolic compounds created during the metabolism of various isoquinic acids found in the leaves of both coffee and tea. In addition to the well-established sympathomimetic effects of coffee and tea’s constituents, recent research has demonstrated a range of other potential benefits for compounds such as chlorogenic acids.\u003c\/p\u003e\n\u003cp\u003eRecent literature suggests that the consumption of both green coffee, as well as standardized extracts of CGAs, relax the vasculature and improve vasoreactivity, impose an inhibitory effect on lipid accumulation and body weight in both mice and humans, and modulate glucose metabolism via the glucose-6-phosphate pathway.\u003c\/p\u003e\n\u003cp\u003eTrials in both humans and mice using 1% extracts of green coffee bean revealed significant bodyweight reductions over periods of two and eight weeks. Researchers hypothesized that the bodyweight reductions associated with oral CGA administration was associated with the product’s numerous mechanisms of action, rather than a single, isolated cause.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eYerba Mate Extract 4:1 (Ilex paraguariensis)(leaf)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYerba Mate, otherwise known by its scientific name Ilex Paraguariensis, is a flowering tree with leaves rich in polyphenols, saponins and xanthines. The metabolic effectiveness of Yerba Mate has been studies on both fatty acid oxidation (FAO) as well as energy expenditure derived FAO (EEFAO). A recent study showed that supplementing Yerba Mate paired with sub-maximal exercise increased fat utilization by 23%. Another study concluded that Yerba Mate increase FAO and EEFAO by 24% in exercise intensities below 70% and even more profound FAO when exercising below 50% of exercise intensity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCaffeine (1,3,7-trimethylxanthine) and Theobromine (3,7-dimethyl-1H-purine-2,6-dione):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCaffeine is the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities. Caffeine is also the most well-known in the methylxanthine compound class, the constituents of which inter-metabolize into one another in the human body and largely share similar effects.\u003c\/p\u003e\n\u003cp\u003eVarious clinical trials have demonstrated that xanthines – including caffeine and theobromine – exert potent lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning’ of fat) actions as sympathomimetic amines. In less scientifically-complex parlance, this means caffeine is forcing your body to preferentially use fat tissue as a fuel source for the oxidative provision of ATP (your body’s energy currency).\u003c\/p\u003e\n\u003cp\u003eEvidence for caffeine’s capacity as a lipolytic is widely available. In a clinical study featuring four separate trials in both normal and obese subjects, for example, caffeine was found to significantly increase fatty acid metabolism (as measured by serum fatty acid concentration), resting metabolic rate, and total fat oxidation – suggesting the preferential substrate selection spoken about above occurs in both normal and obese individuals. Other trials have demonstrated the effects of methylxanthines on total fat mass (reduction), lean body mass (increases), stamina and endurance, as well as cardiovascular capacity.\u003c\/p\u003e\n\u003cp\u003eAdditionally, as selective cAMP potentiators, through the beta-adrenergic pathway, caffeine and theobromine have been hypothesized to exert a synergistic effect on lipolysis when combined with forskolin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBacopa monnieri (50% bacosides):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBacopa monnieri, also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6th century A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.\u003c\/p\u003e\n\u003cp\u003eMore recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy humans have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.\u003c\/p\u003e\n\u003cp\u003eBeyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core BURN Ultra formula may help to smooth the effect curve of the product’s stimulants, reducing jitteriness or, “crash.”\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZüm-XR ® XR Caffeine (provides 50mg caffeine):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eZüm-XR is a patented coating technology that allows the dissolution profile of certain ingredients, primarily caffeine, to have a longer lasting affect in blood serum levels. The release of those ingredients is initiated by an abrasion in the stomach and pH levels between the stomach and the upper gastrointestinal tract. The coating of the microbead technology is a patented timing system with pharmaceutical grade safe polymers. Comparatively speaking, the dissolution profile of Züm-XR caffeine to your typical immediate release caffeine showed that Züm-XR took a far greater amount of time, well over 120 minutes to complete the process of dissolution.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSaffron Extract (stigma) (Crocus sativus L.) (SaffSerene ™):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSaffSerene ™ patented Saffron is a deviate from non-GMO saffron flowers source from Turkey and Morocco. This particular Saffron extract contains 2% safronal, crocin, and pirocrocin as primary active constituents. Saffron has been used in ancient folk medicine as a sedative, antidepressant, etc. A randomized double-blind placebo controlled trial conducted in 2005 between 30 female and male testers suggested that a moderate and consistent dose of saffron significantly benefited mood after 6 weeks. Furthermore, a pilot trial conducted in 2004 evaluated the effectiveness of Saffron comparatively to Fluoxetine. In a minimal dose of 15mg daily, the consistency of saffron compared to fluoxetine was overwhelmingly positive in regards to alleviating acute depression and anxiety. In addition it has been suggested that crocin and safranal inhibit repute of dopamine, norepinephrine and serotonin levels.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-BURN-2023.jpg?v=1686640225\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_BURN_2023_AUS_RASPBERRY_CHEWS-FIN-REV.pdf?v=1694441127\" target=\"_blank\"\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-BURN-Product-References.pdf?17308039998631632076\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Australian Gummy Snakes","offer_id":44058682884272,"sku":"SHOP658580071493","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Watermelon Grape","offer_id":44058682949808,"sku":"SHOP658580071523","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Apple Guava","offer_id":44058682917040,"sku":"SHOP658580071486","price":49.99,"currency_code":"USD","in_stock":false},{"title":"Sour Candy","offer_id":44058682982576,"sku":"SHOP658580071516","price":49.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/BURN_AGS_FRONT.png?v=1760385546"},{"product_id":"collagen-indulgence","title":"Collagen Indulgence","description":"\u003ch2 class=\"slogan\"\u003e\u003cstrong\u003eJOINTS\/HAIR, SKIN, NAILS\/BONES\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eMedium Chain Triglycerides\u003c\/p\u003e\n\u003cp\u003eCoconut oil made of 100% Medium chain triglycerides has been shown to have the greatest health benefits. MCTs are made up of a chemical structure that allows them to quickly and effectively bypass gastric uptake for transport directly to the liver for oxidation and then used for energy. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003eThey also allow for a rich and smooth mouthfeel, which in the context of a collagen creamer, this will add a velvety addition to your favorite beverage.\u003c\/p\u003e\n\u003cp\u003eCollagen is by far the most plentiful protein found in the human body. It makes up the body’s skeletal framework, as well as provides integrity to ligaments, tendons, and other connective tissues found inside the body. It is also a primary component of healthy hair, skin, nails, as well as other important structures of the body. Collagen supplements have become increasingly popular as of late, but most people do not know that the type of collagen matters just as much as the quality of the source. Core has combined Collagen Types I and III from high quality bovine hide that works to provide strength for structures such as skin, tendons, bones, connective tissues, teeth, muscles, organs, and arteries.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eCollagen and its many types are by far the most plentiful protein found in the human body. It makes up the body’s skeletal framework as well as provides integrity to ligaments, tendons, and other connective tissues found inside the body. It is also a primary component of healthy hair, skin, nails, as well as other important structures of the body. Collagen supplementation has become increasingly popular, especially for its cosmetic benefits. When it comes to your skin, as the largest organ in the body, it relies very heavily on the presence of collagen (skin is roughly 70% collagen protein). As we age, natural collagen production begins to slow, and we have to rely on dietary sources to keep collagen levels up. Foods like chicken, bone broth, fish, citrus fruits, berries, garlic, and leafy greens contain nutrients that can stimulate natural collagen formation, but supplementing with collagen protein (and its specific types) can also be crucially beneficial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eType I\u003c\/strong\u003e specifically benefits your skin health. One randomized, placebo-controlled clinical trial confirmed that skin aging can be addressed using nutrients, such as collagen, that are able to promote skin health. Results showed that after three months of oral intake, skin hydration, elasticity, roughness, and density all showed significant improvements. Also, since the nutrients were taken orally, a deeper dermatological activation was achieved, which can equate to a longer lasting regeneration of skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eType III\u003c\/strong\u003e collagen on the other hand is found in the walls of arteries and organs such as the esophagus, spleen, pancreas, and gallbladder. It can also be found in some muscle fibers. As with the skin, as we age, the structural integrity of tissues can begin to degenerate. Supplementation can provide an extra backbone of support when adequate nutrients are not being taken in to aid in supporting an optimally functioning digestive system.\u003c\/p\u003e\n\u003cp\u003eCollagen protein can also be a great protein type for those who do not digest other protein powders very well. It is well tolerated by most consumers and offers another high-quality source of protein that can ultimately increase the function of digestive organs that work to break down and absorb other whole food sources and proteins. As a result, collagen protein can arguably be seen as one of the most beneficial types of protein one can consume.\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Collagen_CHOCOLATE-FIN.pdf?v=1654069447\"\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Death By Chocolate","offer_id":44895981895856,"sku":"SHOP850080302026","price":44.99,"currency_code":"USD","in_stock":true},{"title":"Vanilla Ice Cream","offer_id":44895981928624,"sku":"SHOP850057789881","price":44.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/COLL_CH_FRONT_39f28997-b2ee-4519-80b6-b3d5e33e36c3.png?v=1767388327"},{"product_id":"creatine-chews","title":"Creatine Chews","description":"\u003cp\u003eCORE Nutritionals® Creatine Chews are an anabolic candy you’ll look forward to! Each serving delivers 5 grams of creatine monohydrate, enhanced with sea salt to support hydration and performance.\u003c\/p\u003e\n\u003cp\u003eWith only 2 grams of sugar and just 10 calories, Creatine Chews make taking creatine simple, delicious, and convenient. Enjoy 30 servings per bottle—perfect for the gym, travel, or on-the-go performance.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Tropical Mango Pineapple","offer_id":44932000350384,"sku":"SHOP850080302316","price":24.99,"currency_code":"USD","in_stock":true},{"title":"Strawberry Lemonade","offer_id":44932000383152,"sku":"SHOP850757001047","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/CHEWS_TMP_FRONT.png?v=1769111773"},{"product_id":"pump-black","title":"Pump Black","description":"\u003cp\u003eBuilt for athletes who refuse to compromise intensity—even without stimulants—PUMP BLACK is a fully loaded, precision-engineered pre-workout designed to drive extreme blood flow, relentless endurance, cellular hydration, and razor-sharp focus from the first rep to the final set. Anchored by dual-pathway nitric oxide support, clinically relevant performance dosing, and synergistic ingredients that enhance perfusion, buffering capacity, and mental drive, this formula is constructed to elevate total training output while maintaining a clean, controlled experience. The result is deeper, longer-lasting pumps, sustained work capacity, and a locked-in mind-muscle connection—delivering the dark, uncompromising performance edge worthy of the name PUMP BLACK.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eSodium (as sodium citrate) - 200 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eSodium, one of the most essential electrolytes for our body to utilize, is vital for not just overall daily bodily function but also adequate and high physical performance. Sodium helps to keep the water (mainly amount of fluid outside of the body’s cells) and electrolyte balance of the body, while also aiding in the contraction and relaxation of muscles as well as conducting nerve impulses. While only 500mg of sodium is needed per day for these functions to occur, we as active individuals need far more sodium to maintain these functions. We mostly lose sodium through sweat and urine, so the more active we are\/the more we sweat and the more we urinate, the more sodium is lost. Acquiring enough sodium through food and drink is crucial to establishing equilibrium again to maintain proper functioning and electrolyte balance within the body.  Citrate salts (like sodium citrate) also function as an extracellular buffering agent: citrate is metabolized to bicarbonate, increasing blood alkalinity and potentially improving high-intensity performance when acidosis is limiting. Research in endurance and high-intensity settings shows sodium citrate can induce alkalosis and, in some protocols, improve performance, though effects are variable and higher “ergogenic” doses used in studies are much larger than typical electrolyte-only inclusions and can raise GI-tolerance considerations.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003ePotassium (as potassium citrate) - 300 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003ePotassium citrate is a highly effective electrolyte for supporting exercise performance by helping maintain proper muscle contraction, nerve signaling, and cellular hydration. The potassium component replenishes what’s lost through sweat and intense training, promoting consistent strength, endurance, and reduced cramping risk, while the citrate portion contributes to acid–base balance by supporting the body’s natural buffering of exercise-induced acidity. Together, these effects help delay fatigue, improve fluid balance, and create a more stable internal environment for sustained training output and recovery, making potassium citrate a smart foundational ingredient in performance and hydration formulas.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eL-Citrulline (fermented) — 10,000 mg (with 9,270 mg straight L-citrulline + nitrate-bound yield)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eL-citrulline is a non-essential amino acid that increases arginine bioavailability (citrulline → arginine) and can support nitric oxide (NO) production via the NOS-dependent pathway, contributing to vasodilation and potentially improved blood flow during exercise. Reviews of citrulline\/citrulline-malate discuss this NO-related rationale and the practical performance claims (pump, fatigue resistance), while also noting that results depend heavily on dose, timing, training status, and the specific outcome measured. While the clinical dose of L-Citrulline falls somewhere around the 3g mark, effective benefits have also been seen as high as 12g.\u003c\/p\u003e\n\u003cp\u003eFrom an evidence standpoint, meta-analyses and systematic reviews show mixed performance outcomes: some protocols show modest benefits (often in muscular endurance\/repetition performance), while others show null findings for strength or aerobic metrics. Practically, citrulline tends to be more consistent for “hemodynamics\/pump” outcomes than for guaranteed PR-level performance changes—especially in already well-trained lifters.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eCitrulline nitrate (as NO3-T®) - 1,000 mg (yielding ~730 mg citrulline)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCitrulline nitrate enhances exercise performance through two complementary nitric-oxide–producing pathways that improve blood flow, oxygen delivery, and muscular endurance. L-citrulline is converted in the kidneys to arginine, which then fuels endothelial nitric oxide synthase (eNOS) to raise nitric oxide levels, supporting vasodilation, nutrient delivery, and reduced accumulation of fatigue-related metabolites like ammonia. At the same time, the nitrate portion follows the nitrate → nitrite → nitric oxide pathway, which becomes especially active under low-oxygen and acidic conditions typical of intense training, helping sustain blood flow and improve exercise efficiency and time to exhaustion. This dual-pathway mechanism not only amplifies muscle pumps and vascularity but also supports mitochondrial efficiency, reduced oxygen cost of exercise, and improved high-intensity performance, making citrulline nitrate a scientifically robust ingredient for strength, endurance, and recovery support.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBeta-alanine — 3,200 mg (with 2,600 mg straight + nitrate-bound yield)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBeta-alanine’s primary performance mechanism is increasing intramuscular carnosine, a dipeptide that buffers hydrogen ions (H⁺) during high-intensity work. This buffering can delay fatigue in efforts where acidosis meaningfully contributes—classically repeated high-intensity bouts and sustained hard efforts in the ~1–4 minute range (with some crossover into hard sets and density work). The ISSN position stand and large meta-analyses support beta-alanine’s role in improving exercise capacity\/performance in these domains, though not necessarily in very short efforts where acidosis is less limiting.\u003c\/p\u003e\n\u003cp\u003eBeta-alanine commonly causes paresthesia (tingling) at larger single doses; splitting doses or using sustained-release formats improves tolerability. The key practical point: beta-alanine is a loading ingredient—benefits accrue over weeks as carnosine rises, not “instant.”\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBeta-alanine nitrate (as NO3-T®) — 1,000 mg (yielding ~600 mg beta-alanine)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBeta-alanine nitrate combines beta-alanine’s role in raising intramuscular carnosine with the nitric-oxide–supporting effects of dietary nitrate, creating a dual mechanism that supports both muscular endurance and blood flow during high-intensity exercise. Beta-alanine increases carnosine concentrations inside muscle cells, which helps buffer hydrogen ions produced during intense training and delays the drop in pH that contributes to fatigue, allowing athletes to sustain effort for more repetitions and greater total workload. The nitrate portion simultaneously follows the nitrate → nitrite → nitric oxide pathway, promoting vasodilation, improved oxygen and nutrient delivery, and enhanced exercise efficiency—particularly under hypoxic, high-stress conditions. Together, these complementary mechanisms support longer time to exhaustion, stronger performance output, improved pumps, and more productive training sessions, making beta-alanine nitrate a scientifically synergistic ingredient for strength and endurance-focused performance formulas.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBetaine — 2,500 mg (with 1,850 mg anhydrous + nitrate-bound yield)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBetaine (trimethylglycine) acts as an osmolyte (cell hydration) and as a methyl donor (one-carbon metabolism; homocysteine remethylation), which can influence cellular stress tolerance and potentially training adaptations. In sports performance research, betaine has been studied most often around ~2.5 g\/day. Recent systematic review\/meta-analysis work suggests betaine may provide small improvements in certain performance outcomes, though results vary by test type, training status, and study design.\u003c\/p\u003e\n\u003cp\u003eBetaine tends to be positioned as a useful ergogenic aid for power-output support, training volume tolerance, and body-composition adjacent outcomes in some athletes.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBetaine nitrate (as NO3-T®) - 1,000 mg (yielding ~650 mg betaine)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBetaine nitrate delivers a dual-performance mechanism by combining betaine’s well-studied effects on cellular hydration, methylation, and power output with nitrate’s ability to enhance nitric-oxide–mediated blood flow and exercise efficiency. Betaine functions as an osmolyte that helps maintain cell volume and fluid balance during intense training, which is linked to improved strength, muscular endurance, and favorable body-composition outcomes in clinical research, while also supporting methylation pathways involved in creatine synthesis and overall metabolic performance. The nitrate component follows the nitrate → nitrite → nitric oxide pathway, particularly active in low-oxygen, high-acidity conditions, promoting vasodilation, oxygen delivery, and reduced oxygen cost of exercise. Together, these mechanisms can support greater training volume, improved power production, enhanced muscle pumps, and delayed fatigue, making betaine nitrate a scientifically synergistic ingredient for comprehensive strength and performance formulas.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eL-Tyrosine - 2,000 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eL-tyrosine is a precursor to catecholamines (dopamine, norepinephrine, epinephrine) and thyroid hormones. Supplementation is best supported in situations where stressors (cold, sleep deprivation, multitasking, demanding cognitive work) may transiently tax catecholamine signaling; in those cases, tyrosine has been reported to help maintain aspects of cognitive performance rather than necessarily boost cognition in an unstressed baseline state. Reviews in humans conclude benefits are most plausible under acute stress and high cognitive demand.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eTaurine - 1,000 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eTaurine is a conditionally essential amino sulfonic acid involved in cell volume regulation, calcium handling, membrane stabilization, and antioxidant\/anti-inflammatory signaling. In exercise research, taurine has been studied for acute performance (endurance and some high-intensity contexts) and for recovery-related endpoints (markers of muscle damage\/soreness). Meta-analyses suggest taurine can improve certain performance outcomes in some protocols, but results vary by dose, timing, and modality.\u003c\/p\u003e\n\u003cp\u003eMechanistically, taurine’s proposed benefits include improved excitation–contraction coupling and reduced oxidative stress during demanding efforts; practically, athletes often report smoother muscular output, better hydration, and more stable endurance when it is included in a fully non-stimulant performance formula. The evidence base is active and evolving, and the most consistent effects tend to appear when taurine is dosed appropriately relative to the exercise bout and population studied.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003ePine bark extract (Pinus pinaster, ~95% proanthocyanidins) - 250 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eMaritime pine bark extracts are rich in proanthocyanidins and related polyphenols with antioxidant and vascular-function relevance. Human trials and systematic reviews in cardiometabolic contexts evaluate outcomes like blood pressure, endothelial function, and oxidative stress markers; recent meta-analytic work suggests potential improvements in certain cardiometabolic risk factors, though findings across conditions are not uniformly consistent and study quality varies.\u003c\/p\u003e\n\u003cp\u003eIn a pump and performance formula, the defensible rationale is support for endothelial function and NO signaling environment (plus oxidative-stress modulation), which may complement direct NO precursors (citrulline\/nitrate).\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eCognizin® (citicoline \/ CDP-choline) - 250 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCiticoline (CDP-choline) is a choline donor and a precursor for phosphatidylcholine synthesis, supporting neuronal membrane turnover and cholinergic neurotransmission. Human RCT data in healthy adults and older adults suggests supplementation can improve aspects of memory and attention over weeks, aligning with its role in supporting brain bioenergetics and membrane phospholipid metabolism.\u003c\/p\u003e\n\u003cp\u003eCognizin® is a branded form of citicoline used in supplement trials focused on attention and cognitive performance; branded pages summarize clinical study outcomes, while independent sources also review citicoline’s cognitive evidence and safety. In practice, citicoline is often experienced as \u003ci\u003e“clean focus”\u003c\/i\u003e (less jitter, more mental clarity), making it a logical nootropic pairing with stimulants and\/or other performance ingredients.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003ePeptiPump® — 200 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003ePeptiPump® is a patented bioactive lentil (Lens culinaris) peptide hydrolysate standardized to provide small signaling peptides that influence vascular function and exercise-related blood flow. Unlike nitric-oxide precursors that work upstream through arginine or nitrate metabolism, lentil-derived bioactive peptides are proposed to act more directly at the endothelial and smooth-muscle level, supporting vasodilation, microcirculatory perfusion, and contractile efficiency. Research on pulse-derived protein hydrolysates demonstrates potential effects on angiotensin-converting enzyme (ACE) modulation, endothelial nitric-oxide signaling, and vascular tone regulation, mechanisms that collectively support improved muscle oxygenation and nutrient delivery during exercise.\u003c\/p\u003e\n\u003cp\u003eWithin a performance formula like PUMP BLACK, PeptiPump® should be interpreted as a hemodynamic (movement and pressure of blood through the CV system) and perfusion-support (delivery of blood, oxygen, and nutrients to tissues) ingredient rather than a primary ergogenic stimulant or buffer. Its role is to complement upstream nitric-oxide pathways (citrulline and nitrate) by improving the vascular responsiveness and tissue-level blood distribution once nitric oxide is produced. Early human and preclinical data on lentil-derived peptides suggest benefits for blood pressure regulation, endothelial health, and circulation, which provide the mechanistic rationale for enhanced exercise “pump,” muscular endurance support, and recovery signaling. However, as with many novel peptide ingredients, large independent exercise-performance trials remain limited, so the strongest scientific position is that PeptiPump® contributes complementary vascular bioactivity within a multi-pathway pump system rather than acting as a standalone performance driver.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eAstraGin® - 50 mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAstraGin® is a standardized blend of Panax notoginseng and Astragalus membranaceus extracts developed to enhance intestinal absorption of amino acids, vitamins, and other nutrients. Mechanistic research in cell and animal models shows AstraGin® can upregulate expression of key intestinal transporters (including amino-acid transport proteins and glucose transporters) and influence tight-junction integrity, suggesting improved trans-epithelial nutrient movement and gut barrier support. These transporter-modulating effects form the biological basis for its positioning as a bioavailability enhancer in sports-nutrition formulations.\u003c\/p\u003e\n\u003cp\u003eHuman data on AstraGin® specifically are still emerging, but studies on its constituent botanicals—particularly astragalus polysaccharides and ginsenosides—demonstrate immunomodulatory, anti-inflammatory, and gut-supportive properties that may indirectly support training recovery and nutrient utilization. In applied formulation strategy, AstraGin® is not intended to provide an acute perceptible effect; instead, it functions as a systems-level absorption amplifier, theoretically improving the efficiency of amino acids (like citrulline and taurine), osmolytes (betaine), and nootropics (tyrosine, citicoline) delivered in the same serving. Due to the fact that large-scale human pharmacokinetic trials remain limited, AstraGin® is best interpreted as a supportive bioavailability technology with strong mechanistic plausibility and growing—but not yet definitive—clinical validation.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Pink Venom (Pink Lemonade)","offer_id":44978439028912,"sku":"SHOP850080302255","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Red Alert (Tropical Punch)","offer_id":44978439061680,"sku":"SHOP850080302279","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Texas Peach (Peach Candy)","offer_id":44978439094448,"sku":"SHOP850080302651","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Tsunami (Strawberry Watermelon)","offer_id":44978439127216,"sku":"SHOP850080302262","price":49.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PUMP_TSU_FRONT.png?v=1771868161"},{"product_id":"magnesium-bisglycinate","title":"Magnesium Bisglycinate","description":"\u003cp\u003e\u003cb\u003eMagnesium\u003c\/b\u003e is an essential mineral required for hundreds of biochemical reactions that govern energy production, neuromuscular function, cardiovascular health, and metabolic balance. Yet inadequate magnesium intake remains common due to modern dietary patterns, environmental factors, and increased physiological demands from stress and physical activity. \u003cb\u003eMagnesium bisglycinate\u003c\/b\u003e—a chelated form of magnesium bound to the amino acid glycine—is widely recognized for its superior absorption, excellent gastrointestinal tolerance, and calming neuromuscular effects. This highly bioavailable form is designed to efficiently restore magnesium status while supporting relaxation, recovery, sleep quality, and overall systemic wellness.\u003c\/p\u003e\n\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eFULL SCIENCE\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eMagnesium\u003c\/b\u003e is an essential mineral involved in over 300 enzymatic reactions in the body, supporting energy production, neuromuscular coordination, cardiovascular function, and metabolic health. Despite its importance, inadequate intake is common due to modern diets, stress, and high physical demands.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eMagnesium bisglycinate\u003c\/b\u003e is a chelated form in which magnesium is bound to the amino acid \u003ci\u003eglycine\u003c\/i\u003e. This structure enhances absorption and improves gastrointestinal tolerance by utilizing amino acid transport pathways rather than relying solely on passive mineral absorption. As a result, it delivers consistent systemic magnesium levels with minimal laxative effects compared to poorly absorbed forms like magnesium oxide, making it ideal for daily or higher-dose supplementation.\u003c\/p\u003e\n\n\u003cp\u003eAt the cellular level, \u003cb\u003emagnesium\u003c\/b\u003e is required for biologically active ATP, directly supporting energy metabolism, muscular performance, and recovery. It also plays a role in insulin signaling and glucose regulation, contributing to metabolic stability. In muscle tissue, magnesium acts as a natural calcium antagonist, promoting proper contraction and relaxation and helping reduce cramps and tension.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eMagnesium\u003c\/b\u003e is equally important for nervous system balance, regulating NMDA receptors and supporting GABA activity to maintain healthy excitation–relaxation dynamics. The \u003ci\u003eglycine\u003c\/i\u003e component further supports calmness and sleep quality. Additionally, magnesium contributes to cardiovascular health by promoting vascular relaxation and healthy blood pressure.\u003c\/p\u003e\n\n\u003cp\u003eOverall, \u003cb\u003emagnesium bisglycinate\u003c\/b\u003e is a highly bioavailable, well-tolerated form that supports performance, recovery, metabolic function, sleep, and long-term wellness.\u003c\/p\u003e\n\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eNielsen FH. \u003ci\u003eMagnesium deficiency and increased inflammation: current perspectives.\u003c\/i\u003e Journal of Inflammation Research. 2018;11:25–34.\u003c\/p\u003e\n\n\u003cp\u003eVolpe SL. \u003ci\u003eMagnesium in disease prevention and overall health.\u003c\/i\u003e Advances in Nutrition. 2013;4(3):378S–383S.\u003c\/p\u003e\n\n\u003cp\u003eRosanoff A, Weaver CM, Rude RK. \u003ci\u003eSuboptimal magnesium status in the United States: are the health consequences underestimated?\u003c\/i\u003e Nutrition Reviews. 2012;70(3):153–164.\u003c\/p\u003e\n\n\u003cp\u003eCuciureanu MD, Vink R. \u003ci\u003eMagnesium and stress.\u003c\/i\u003e Magnesium Research. 2011;24(3):S37–S44.\u003c\/p\u003e\n\n\u003cp\u003eBoyle NB, Lawton C, Dye L. \u003ci\u003eThe effects of magnesium supplementation on subjective anxiety and stress—A systematic review.\u003c\/i\u003e Nutrients. 2017;9(5):429.\u003c\/p\u003e\n\n\u003cp\u003eUwitonze AM, Razzaque MS. \u003ci\u003eRole of magnesium in vitamin D activation and function.\u003c\/i\u003e Journal of the American Osteopathic Association. 2018;118(3):181–189.\u003c\/p\u003e\n\n\u003cp\u003eSchwalfenberg GK, Genuis SJ. \u003ci\u003eThe importance of magnesium in clinical healthcare.\u003c\/i\u003e Scientifica. 2017;2017:4179326.\u003c\/p\u003e\n\n\u003cp\u003eDiNicolantonio JJ, O’Keefe JH, Wilson W. \u003ci\u003eSubclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis.\u003c\/i\u003e Open Heart. 2018;5(1):e000668.\u003c\/p\u003e\n\n\u003cp\u003eZhang X, Li Y, Del Gobbo LC, et al. \u003ci\u003eEffects of magnesium supplementation on blood pressure: a meta-analysis of randomized controlled trials.\u003c\/i\u003e Hypertension. 2016;68(2):324–333.\u003c\/p\u003e\n\n\u003cp\u003eBarbagallo M, Dominguez LJ. \u003ci\u003eMagnesium and type 2 diabetes.\u003c\/i\u003e World Journal of Diabetes. 2015;6(10):1152–1157.\u003c\/p\u003e\n\n\u003cp\u003ede Baaij JHF, Hoenderop JGJ, Bindels RJM. \u003ci\u003eMagnesium in man: implications for health and disease.\u003c\/i\u003e Physiological Reviews. 2015;95(1):1–46.\u003c\/p\u003e\n\n\u003cp\u003eWalker AF, Marakis G, Christie S, Byng M. \u003ci\u003eMg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study.\u003c\/i\u003e Magnesium Research. 2003;16(3):183–191.\u003c\/p\u003e\n\n\u003cp\u003eRanade VV, Somberg JC. \u003ci\u003eBioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans.\u003c\/i\u003e American Journal of Therapeutics. 2001;8(5):345–357.\u003c\/p\u003e\n\n\u003cp\u003eAbbasi B, Kimiagar M, Sadeghniiat-Haghighi K, et al. \u003ci\u003eThe effect of magnesium supplementation on primary insomnia in elderly subjects.\u003c\/i\u003e Journal of Research in Medical Sciences. 2012;17(12):1161–1169.\u003c\/p\u003e\n\n\u003cp\u003eWienecke E, Nolden C. \u003ci\u003eGlycine and sleep quality—mechanistic considerations and clinical implications.\u003c\/i\u003e Sleep and Biological Rhythms. 2016;14(1):3–9.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45008591945904,"sku":"SHOP850080302668","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/MAG_BIS_FRONT.png?v=1775484893"},{"product_id":"vitamin-d3-k2","title":"Vitamin D3+K2","description":"\u003cp\u003e\u003cb\u003eVitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e are fat-soluble nutrients that work together to regulate calcium metabolism and support overall skeletal and cardiovascular health. While \u003cb\u003evitamin D\u003c\/b\u003e enhances calcium absorption and stimulates the production of calcium-dependent proteins, \u003cb\u003evitamin K2\u003c\/b\u003e activates those proteins to ensure calcium is properly utilized in bone and not deposite\u003cimg\u003ed in soft tissues. When combined, these vitamins form a coordinated system that promotes optimal calcium balance, structural integrity, and long-term health.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFULL SCIENCE\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eVitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e are fat-soluble nutrients that work synergistically to regulate calcium metabolism, support skeletal integrity, and promote cardiovascular health. \u003cb\u003eVitamin D\u003c\/b\u003e, particularly in its D3 form (\u003ci\u003echolecalciferol\u003c\/i\u003e), is converted in the body to its active hormonal form, \u003ci\u003ecalcitriol\u003c\/i\u003e, which increases intestinal absorption of calcium and phosphorus and stimulates the production of calcium-binding proteins such as \u003ci\u003eosteocalcin\u003c\/i\u003e. This process raises circulating calcium levels and enhances the body’s capacity to mineralize bone. However, while \u003cb\u003evitamin D\u003c\/b\u003e increases calcium availability and upregulates the production of key calcium-dependent proteins, it does not determine where that calcium is ultimately deposited. That essential targeting function depends largely on \u003cb\u003evitamin K2\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eVitamin K2\u003c\/b\u003e, in the form of \u003ci\u003emenaquinones\u003c\/i\u003e such as \u003ci\u003eMK-4\u003c\/i\u003e and \u003ci\u003eMK-7\u003c\/i\u003e, acts as a cofactor for the enzyme \u003ci\u003egamma-glutamyl carboxylase\u003c\/i\u003e, which activates vitamin K–dependent proteins through a process called \u003ci\u003ecarboxylation\u003c\/i\u003e. Among the most important of these proteins are \u003ci\u003eosteocalcin\u003c\/i\u003e, which binds calcium into the bone matrix, and \u003ci\u003ematrix Gla protein (MGP)\u003c\/i\u003e, which inhibits inappropriate calcium deposition in blood vessels and soft tissues. Without adequate \u003cb\u003evitamin K2\u003c\/b\u003e, these proteins remain undercarboxylated and functionally inactive, reducing their ability to properly regulate calcium distribution. In this context, \u003cb\u003evitamin D\u003c\/b\u003e can increase the production of \u003ci\u003eosteocalcin\u003c\/i\u003e and \u003ci\u003eMGP\u003c\/i\u003e, but \u003cb\u003evitamin K2\u003c\/b\u003e is required to activate them so they can perform their physiological roles.\u003c\/p\u003e\n\u003cp\u003eTogether, \u003cb\u003evitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e form a coordinated system of calcium management: \u003cb\u003evitamin D\u003c\/b\u003e enhances calcium absorption and stimulates the synthesis of calcium-regulating proteins, while \u003cb\u003evitamin K2\u003c\/b\u003e activates those proteins to ensure calcium is directed into bones and away from arteries and soft tissues. This synergy supports bone mineral density by improving both calcium supply and incorporation into skeletal structure. At the same time, activation of \u003ci\u003eMGP\u003c\/i\u003e by \u003cb\u003evitamin K2\u003c\/b\u003e contributes to vascular health by helping prevent arterial calcification, a process associated with cardiovascular risk. Beyond bone and vascular effects, the combination may also influence muscle function and overall metabolic health, as \u003cb\u003evitamin D\u003c\/b\u003e supports neuromuscular performance and immune regulation, while \u003cb\u003evitamin K2\u003c\/b\u003e contributes to cellular signaling and tissue integrity. For these reasons, co-supplementation of \u003cb\u003evitamin D\u003c\/b\u003e and \u003cb\u003evitamin K2\u003c\/b\u003e is often considered a more physiologically comprehensive strategy than \u003cb\u003evitamin D\u003c\/b\u003e alone, particularly in individuals seeking to optimize bone strength, calcium utilization, and long-term cardiovascular support.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eHolick MF. \u003ci\u003eVitamin D deficiency.\u003c\/i\u003e New England Journal of Medicine. 2007;357(3):266–281.\u003c\/p\u003e\n\u003cp\u003eHeaney RP. \u003ci\u003eVitamin D in health and disease.\u003c\/i\u003e Clinical Journal of the American Society of Nephrology. 2008;3(5):1535–1541.\u003c\/p\u003e\n\u003cp\u003eBouillon R, et al. \u003ci\u003eVitamin D and human health: lessons from vitamin D receptor null mice.\u003c\/i\u003e Endocrine Reviews. 2008;29(6):726–776.\u003c\/p\u003e\n\u003cp\u003eSchurgers LJ, Vermeer C. \u003ci\u003eDifferential lipoprotein transport pathways of K-vitamins in healthy subjects.\u003c\/i\u003e Biochimica et Biophysica Acta. 2000;1486(2–3):200–210.\u003c\/p\u003e\n\u003cp\u003eGast GCM, et al. \u003ci\u003eA high menaquinone intake reduces the incidence of coronary heart disease.\u003c\/i\u003e Nutrition, Metabolism \u0026amp; Cardiovascular Diseases. 2009;19(7):504–510.\u003c\/p\u003e\n\u003cp\u003eVermeer C. \u003ci\u003eVitamin K2: the missing nutrient in bone and vascular health.\u003c\/i\u003e Netherlands Journal of Medicine. 2001;58(10):411–414.\u003c\/p\u003e\n\u003cp\u003eVermeer C, et al. \u003ci\u003eVitamin K–dependent proteins in bone and cardiovascular health.\u003c\/i\u003e Nutrients. 2018;10(10):1525.\u003c\/p\u003e\n\u003cp\u003eKnapen MHJ, et al. \u003ci\u003eMenaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women.\u003c\/i\u003e Thrombosis and Haemostasis. 2015;113(5):1135–1144.\u003c\/p\u003e\n\u003cp\u003eGundberg CM, et al. \u003ci\u003eVitamin K status and cardiovascular health: implications for bone and vascular calcium regulation.\u003c\/i\u003e Current Osteoporosis Reports. 2012;10(2):142–150.\u003c\/p\u003e\n\u003cp\u003eSaito Y, et al. \u003ci\u003eCombined vitamin K2 and vitamin D3 enhance calcium utilization in bone.\u003c\/i\u003e Clinical Calcium. 2010;20(2):219–225.\u003c\/p\u003e\n\u003cp\u003eKnapen MHJ, et al. \u003ci\u003eVitamin K2 supplementation improves hip bone geometry and bone strength indices.\u003c\/i\u003e Osteoporosis International. 2013;24(9):2499–2507.\u003c\/p\u003e\n\u003cp\u003eCheung AM, et al. \u003ci\u003eVitamin K supplementation and bone loss in older men and women.\u003c\/i\u003e Journal of Bone and Mineral Research. 2008;23(4):652–658.\u003c\/p\u003e\n\u003cp\u003eBeulens JWJ, et al. \u003ci\u003eHigh dietary menaquinone intake is associated with reduced coronary calcification.\u003c\/i\u003e Atherosclerosis. 2008;200(2):489–496.\u003c\/p\u003e\n\u003cp\u003eTheuwissen E, et al. \u003ci\u003eLow vitamin K status is associated with increased coronary calcification and mortality.\u003c\/i\u003e Nutrition, Metabolism \u0026amp; Cardiovascular Diseases. 2012;22(7):589–595.\u003c\/p\u003e\n\u003cp\u003eCannell JJ, et al. \u003ci\u003eVitamin D and the prevention of chronic diseases.\u003c\/i\u003e Journal of Steroid Biochemistry and Molecular Biology. 2008;103(3–5):373–378.\u003c\/p\u003e\n\u003cp\u003eWang TT, et al. \u003ci\u003eVitamin D receptor signaling is critical for muscle function.\u003c\/i\u003e Nature Medicine. 2010;16(10):1260–1265.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45008629104816,"sku":"SHOP850080302057","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/D3_K2_FRONT.png?v=1775484889"},{"product_id":"core-nutritionals®-performance-pill-organizer","title":"Core Nutritionals® Performance Pill Organizer","description":"\u003cp\u003eWhen you’re serious about results, consistency is everything. The \u003cb\u003eCORE Nutritionals® Performance Pill Organizer\u003c\/b\u003e is designed to keep your supplement protocol locked in, dialed in, and never missed. This isn’t your average flimsy pill box. It’s built for athletes, high performers, and anyone running a serious stack.\u003cspan class=\"ͼv\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\n\n\n\u003cp\u003e\u003cb\u003eFULL WEEKLY SYSTEM\u003c\/b\u003e\u003cbr\u003e\nSeven full days of organization so your entire week is ready to go.\u003c\/p\u003e\n\n\n\n\n\u003cp\u003e\u003cb\u003eFOUR DAILY COMPARTMENTS\u003c\/b\u003e\u003cbr\u003e\nEach day is divided into \u003ci\u003eMorning, Noon, Night, and Backup\u003c\/i\u003e, making it easy to separate your essential supplements from extras or emergency doses.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eREMOVABLE DAILY PODS\u003c\/b\u003e\u003cbr\u003e\nEvery day pops out individually so you can grab exactly what you need and take it with you — perfect for the gym, work, or travel.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eLARGE CAPACITY COMPARTMENTS\u003c\/b\u003e\u003cbr\u003e\nBuilt to hold full performance stacks, not just a couple vitamins. Whether you’re running \u003cb\u003eCORE Nutritionals®\u003c\/b\u003e health products, performance formulas, or both, there’s room for it.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eLOCKED-IN ORGANIZATION\u003c\/b\u003e\u003cbr\u003e\nThe secure case keeps all pods together and protected so your supplements stay organized wherever your day takes you.\u003c\/p\u003e\n\n\u003cp\u003eIf you’re running a serious supplement protocol, the \u003cb\u003eCORE Nutritionals® Performance Pill Organizer\u003c\/b\u003e keeps your routine tight, efficient, and consistent — exactly how it should be.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003ePLAN YOUR STACK. STAY CONSISTENT. CRUSH IT.\u003c\/b\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45026740043952,"sku":"Core-PillBox","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Frame39.jpg?v=1774530110"},{"product_id":"bionmn","title":"NMN","description":"\u003cp\u003e\u003cb\u003eBioNMN®\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eINTRO\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAt the core of cellular energy, recovery, and longevity lies one critical molecule: \u003cb\u003eNAD+\u003c\/b\u003e. BioNMN® (Beta-Nicotinamide Mononucleotide) is a direct precursor to NAD+, the essential coenzyme required for ATP production—the fuel that powers nearly every biological process in the body. As NAD+ levels naturally decline with age, cellular efficiency, metabolic resilience, cognitive performance, and mitochondrial function can begin to deteriorate.\u003c\/p\u003e \u003cp\u003eBy supplying a highly bioavailable source of NMN, BioNMN® helps replenish NAD+ levels at the cellular level, supporting sustained energy production, mitochondrial integrity, and whole-body vitality. Designed for optimal absorption, this advanced form of NMN provides a foundational approach to performance, metabolic health, and healthy aging from the inside out.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFULL SCIENCE\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBioNMN® (Beta-Nicotinamide Mononucleotide)\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNicotinamide Mononucleotide (NMN) is a ribo-nucleotide, which is a simple structural unit of RNA. NMN is the direct precursor of nicotinamide adenine dinucleotide (NAD+) and is considered a vital component to cellular increases in NAD+ levels. NAD+ is an essential coenzyme required to produce ATP (adenosine triphosphate), the fuel used by almost all cells in the body. As we age, NAD+ levels naturally decline, which can lead to less-than-optimal functioning and contribute to conditions such as obesity, insulin resistance, and impaired cognitive function.\u003c\/p\u003e \u003cp\u003eWhile humans cannot absorb NAD directly, using NAD+ precursors like NMN can help maintain NAD+ levels. BioNMN® emphasizes enhanced bioavailability so the full benefits of this ingredient can be achieved.\u003c\/p\u003e \u003cp\u003eNMN supplementation offers a wide range of benefits that influence nearly all body systems, including brain and cardiovascular support, reduced age-related inflammation, neuroprotection, hormonal balance, improved mitochondrial function, enhanced muscle endurance and strength, and overall longevity. These benefits rely on NAD+ as a key coenzyme that drives these biological processes.\u003c\/p\u003e \u003cp\u003eIn terms of muscle performance, skeletal muscles require significant amounts of energy molecules to maintain strength and function. NAD+ is required to metabolize these molecules, meaning muscles benefit from a steady supply of NMN as a building block.\u003c\/p\u003e \u003cp\u003eMitochondria, known as the powerhouse of the cell, are essential for converting nutrients into usable energy. NAD+ plays a central role in this metabolic process. Without sufficient NAD+, mitochondria cannot function properly, leading to reduced energy production and potential cellular damage. Research suggests that NMN supplementation supports NAD+ production, helping protect mitochondria and maintain proper metabolic function.\u003c\/p\u003e \u003cp\u003eNMN also plays a role in longevity. As many bodily functions decline with age, maintaining NAD+ levels may help slow aspects of the aging process. Supporting NAD+ levels may help sustain optimal function across body systems over time, while low levels are linked to increased risk of dysfunction and disease.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eNomiyama T, Setoyama D, Yasukawa T, Kang D. Mitochondria Metabolomics Reveals a Role of β-Nicotinamide Mononucleotide Metabolism in Mitochondrial DNA Replication. J Biochem. 2021.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eKlimova N., Long A., Kristian T. (2019). Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eShade C. (2020). The Science Behind NMN—A Stable, Reliable NAD+ Activator and Anti-Aging Molecule.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYoshino J., Baur J.A., Imai S. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eImai S., Guarente L. (2014). NAD+ and sirtuins in aging and disease.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCanto C., Menzies K.J., Auwerx J. (2015). NAD+ Metabolism and the Control of Energy Homeostasis.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMills K.F., et al. (2016). Long-Term Administration of NMN Mitigates Age-Associated Physiological Decline in Mice.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eGomes A.P., et al. (2013). Declining NAD+ Disrupts Cellular Communication during Aging.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYoshino J., et al. (2021). NMN increases muscle insulin sensitivity in prediabetic women.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eVerdin E. (2015). NAD+ in aging, metabolism, and neurodegeneration.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eRajman L., Chwalek K., Sinclair D.A. (2018). Therapeutic Potential of NAD-Boosting Molecules.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eLiao B., et al. (2021). NMN supplementation enhances aerobic capacity in amateur runners.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eSource: :contentReference[oaicite:0]{index=0}\u003c\/i\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45034516021424,"sku":"SHOP850080302644","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/NMN_FRONT.png?v=1775484886"},{"product_id":"fury-black","title":"Fury Black","description":"\u003cp\u003e\u003cstrong\u003eFURY BLACK\u003c\/strong\u003e is the next evolution of our flagship pre—built from years of real performance, athlete feedback, and relentless upgrades.\u003c\/p\u003e\n\u003cp\u003eDesigned for lifters who demand more than energy.\u003c\/p\u003e\n\u003cp\u003eExtreme pumps. Endurance. Locked-in focus. Electrolyte balance. Sustained output.\u003c\/p\u003e\n\u003cp\u003eNo trends. No underdosing.\u003c\/p\u003e\n\u003cp\u003eResearch-backed ingredients at performance levels, driving nitric oxide, hydration, and neural output.\u003c\/p\u003e\n\u003cp\u003eOne system.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAll-out pure strength, power, precision.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eL-Citrulline\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eCitrulline is a non-essential, non-protein amino acid that forms during the urea cycle and forms ornithine when combined with carbon dioxide. Citrulline is also a critical source of endogenous (natural) arginine, as it is rapidly and efficiently converted to arginine in the vascular endothelium and other tissues.\u003c\/p\u003e\n\n\u003cp\u003eCitrulline’s benefits have been shown to be greater than its parent compound. While arginine undergoes direct hepatic (liver) metabolism through the enzyme arginase, citrulline bypasses hepatic metabolism entirely and it is delivered straight to the bloodstream. The result is that gut absorption and plasma (blood) bioavailability studies comparing citrulline and arginine have shown two things. First, citrulline is less readily destroyed and has greater absorption than arginine. Second, citrulline supplementation increases arginine levels more effectively than arginine supplementation itself.\u003c\/p\u003e\n\n\u003cp\u003eThis translates to promising results. For example, animal studies show a significant increase in anaerobic performance at a 250mg\/kg\/day serving of citrulline, while studies in humans implicate citrulline in both aerobic and anaerobic performance increases. As a critical part of the urea cycle, citrulline’s performance benefits are thought to be a result of its role in ammonia clearance. Citrulline is implicated in reducing the oxygen cost of muscle processes, along with increasing the rate of post-exercise ATP and phosphocreatine replenishment. As ATP and phosphocreatine are the body’s ‘exercise fuel,’ this may result in citrulline delaying time to exhaustion in aerobic and anaerobic exercise.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBetaine Anhydrous\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eBetaine, also known as trimethyl glycine, is a naturally occurring compound found in various living organisms. It serves as a protective agent in non-mammalian animals during osmotic stress and functions as an osmolyte in mammalian tissues, including those of humans. In mammalian cells, betaine is produced through the oxidation of choline and can be acquired from dietary sources such as spinach and beets. Although research on betaine is relatively limited and recent, available literature suggests its potential effects in several areas. Studies investigating betaine supplementation at doses ranging from 1.25g\/day to 5g\/day for up to 14 days have demonstrated promising results. For instance, one study found that a daily serving of 2.5g enhanced endurance and total repetition volume during exercises like the squat, bench press, and jump squat in healthy, exercise-trained adults. Another study reported increased peak power, maximum peak power, force, and the maintenance of force and power in similar subjects with the same dosage of betaine. Moreover, research exploring betaine's impact on the endocrine system has shown potential effects on various endocrine processes. These findings have led researchers to hypothesize that longer-term betaine supplementation may enhance the hypertrophic response to resistance training, indicating its potential as a performance-enhancing supplement in the realm of exercise physiology.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBeta Alanine\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eCarnosine is a bit of an odd duck: we know that it is crucial for muscle function, and that dietary sources of carnosine are essential, but we don’t know precisely how it’s working. Moreover, for decades, we had no idea how to increase intramuscular concentrations, as exogenous carnosine sources degraded in the body so fast as to be effectively useless.\u003c\/p\u003e\n\n\u003cp\u003eEnter beta-alanine. Simply a different iteration of one of the amino acids that comprises carnosine itself (alanine), beta-alanine has proven to be the most effective means of significantly increasing intramuscular concentrations of carnosine – and therefore of promoting all of carnosine’s various beneficial effects on muscle performance. If that weren’t enough, beta-alanine has also demonstrated beneficial physiological effects independent of its parent compound. To understand why, though, we need to first understand some of the basics behind carnosine itself.\u003c\/p\u003e\n\n\u003cp\u003eCarnosine, a cytoplasmic dipeptide synthesized from the precursors L-histidine and l-alanine, is present in high concentrations in skeletal muscle and plays a pivotal role as a, “chemical buffer” in myocytes (muscle cells). It has long been known that carnosine concentrations are highest in glycolytic, rather than oxidative muscle fibers (roughly speaking, explosive vs., endurance muscle fibers, respectively), and thus long hypothesized that this amino acid is required for sustained performance during supramaximal exercise. Recent research demonstrates that carnosine exerts its physiological effects in long hypoxic (low oxygen) drives by functioning as a high-capacity pH buffer in skeletal muscle, preventing the pH ratio of plasma from dropping too low – and therefore preventing crucial pH-dependent processes such as protein synthesis from being inhibited by acidosis.\u003c\/p\u003e\n\n\u003cp\u003eDespite its critical role in skeletal muscle anaerobic performance, intramyocellular synthesis of carnosine is rate-limited by the availability of l-alanine. Unfortunately, the majority of literature demonstrates that attempting to increase intramuscular levels of carnosine via either direct carnosine or alanine supplementation is largely ineffective due to carnosine\/alanine pharmacokinetics. Enter beta-alanine. Research with beta-alanine demonstrates consistent and dose-dependent increases to intramuscular carnosine concentrations with beta-alanine supplementation, with certain studies showing an increase of 40-60% with chronic administration. These same literatures reveal a synergistic effect of exercise on beta-alanine supplementation, whereby the muscle adaptive changes associated with resistance training promote further intramuscular carnosine production in response to beta-alanine supplementation.\u003c\/p\u003e\n\n\u003cp\u003eIn simpler language, this essentially means that beta-alanine is a dietary supplement that promotes its own effects in combination with exercise. As you exercise, you simultaneously intensify beta-alanine’s physiological actions – both directly, as well as in the production of intramuscular carnosine. Once ingested, beta-alanine’s exercise-specific beneficial activity is well-established. Elevation of intramuscular carnosine content via beta-alanine supplementation has been shown to improve performance in the following ways.\u003c\/p\u003e\n\n\u003cul\u003e\n  \u003cli\u003eBoth acute and chronic increases in total work capacity, measured by total volume during exercise sessions.\u003c\/li\u003e\n  \u003cli\u003eHighly significant increases to TTE (total time to exhaustion), one of the most accurate and comprehensive measures of endurance. In various trials, beta-alanine supplementation has been shown to increase TTE by upwards of 20%.\u003c\/li\u003e\n  \u003cli\u003eIncreases to total muscle power output in both acute and chronic trials, suggesting that beta-alanine’s most significant benefit is to those engaging in power-dependent resistance training.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eIn total, a significant body of research exists to suggest that beta-alanine may significantly increase muscle power output, strength, training volume and output, overall performance in hypoxic (oxygen-deprived) conditions and peak VO2 max (oxygen holding capacity).\u003c\/p\u003e\n\n\u003cp\u003eThese myriad benefits make beta-alanine both one of the most-studied, and most well-rounded dietary supplements. Beta-alanine not only has direct, actionable physiological effects, but also promotes critical muscle physiologic adaptations that promote its own effects.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eL-Tyrosine\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eTyrosine is amongst a class of amino acids known as ‘non-essential’ amino acids, so called because the body can produce them endogenously, and it is therefore not essential to consume dietary tyrosine. That said, tyrosine is also what is known as a conditionally-essential amino acid; conditionally-essential because, along with glucose and ammonia, the synthesis of tyrosine additionally requires adequate levels of phenylalanine. Once synthesized, tyrosine is one of the most critical amino acids, given its prominent role as a substrate in the synthesis of the catecholamines dopamine, norepinephrine, and epinephrine, in addition to both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones.\u003c\/p\u003e\n\n\u003cp\u003eIn studies on stress modulation, tyrosine has been demonstrated to reverse stress-induced norepinephrine depletion and the depressant-behavioral effects normally associated with it. In simpler terms, tyrosine may, in certain conditions, dampen the extent to which norepinephrine is removed from the bloodstream during a stress event. In simpler terms still, tyrosine may help to mitigate the sense of depletion and fatigue felt at the end of a workout.\u003c\/p\u003e\n\n\u003cp\u003eTyrosine may also play important metabolic functions, mostly related to its role in synthesizing compounds which stimulate the nervous system. While not traditionally considered a sympathomimetic amine, studies which have coadministered tyrosine and stimulants demonstrate a synergistic effect. These studies suggest that tyrosine may potentiate the effects of both endogenous and supplemental norepinephrine and its mimetics (in the case of exogenous use) with respect to lipolysis, thermogenesis, and energy expenditure. This means that tyrosine may play a role in assisting norepinephrine to break up triglycerides and increase body heat transiently.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eTaurine\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eThough traditionally referred to as an amino acid due to its chemical structure, taurine is not an amino acid in the sense that leucine, alanine, or glutamine are. Its chemical status aside, taurine is considered one of the body’s most essential chemical compounds, as cardiovascular function, muscle development and function, along with optical and nervous systems in the body depend on its abundance. While data on taurine typically occurs with taurine in supplement combinations (with caffeine and other amino acids), these data nevertheless suggest that dietary supplementation with taurine may have beneficial effects on mental focus and alertness and may assist during times of increased physical exertion.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eCaffeine Anhydrous\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eCaffeine is one of the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities.\u003c\/p\u003e\n\n\u003cp\u003eMost importantly to FURY BLACK, caffeine has been shown to have significant effects on exercise performance, even with ingestion in servings as small 3 to 9mg\/kg\/bw\/day (the equivalent of 2 cups of standard coffee, for a 170lb male). In endurance training, possible explanations for caffeine’s performance-enhancing effects lie in its metabolic effects on both lean and fat tissue. It is suggested that caffeine’s potent lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning’ of fat) action allow the body to utilize these sources during prolonged submaximal exercise. Consequently, muscle glycogen is spared and available for use later in the training session. Practically speaking, this means caffeine is forcing your body to preferentially use fat tissue as a fuel source, while sparing the glycogen which gives you the full-bodied look!\u003c\/p\u003e\n\n\u003cp\u003eIn short-term exercise, caffeine’s demonstrated role in the inhibition of cyclic AMP- phosphodiesterase’s (PDE), adenosine receptor antagonism, and adrenoreceptor agonism come into play. These three pathways stimulate lipolytic activity, boost fat metabolism, increase metabolic rate and energy expenditure, and regulate the body’s thermogenic activity. The practical results of activating these pathways are increases to the contractile force of both cardiac and skeletal muscle (harder flexion), an increase in energy expenditure (freeing up more caloric energy to be used in contraction), dilation of vasculature (better blood flow), and improvements to both nitrogen retention and skeletal muscle protein synthesis (key components to muscle building).\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eVasoDrive-AP® (Isoleucyl-prolyl-proline (IPP) and Valyl-prolyl-proline (VPP) (from hydrolyzed milk casein)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eVasodrive-AP® is a patented dietary supplement ingredient composed of a precise blend of naturally derived peptides, primarily derived from casein hydrolysate. This ingredient has garnered attention for its potential benefits in enhancing exercise performance through its vasodilatory properties. Vasodrive-AP® works by promoting the release of nitric oxide (NO), a key signaling molecule involved in vasodilation, which leads to the relaxation of blood vessels and increased blood flow to exercising muscles. It does this through several mechanisms of action. First, the increase in the production of endothelial nitric oxide synthase (eNOS) improve arterial flexibility leading to enhanced blood flow. Second, Vasodrive-AP® can also inhibit the enzyme that leads to the constriction of blood vessels. By improving blood flow and oxygen delivery to working muscles, Vasodrive-AP® may enhance exercise capacity, delay the onset of fatigue, and improve overall performance during both endurance and resistance training activities. Additionally, the improved nutrient and oxygen delivery facilitated by Vasodrive-AP® may aid in muscle recovery post-exercise, potentially reducing muscle soreness and accelerating the repair process. While further research is needed to fully elucidate its mechanisms and optimal dosages, Vasodrive-AP® shows promise as a natural ergogenic aid for individuals seeking to maximize their exercise performance and recovery.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eCognizin® Citicoline\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eCholine is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for several functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003c\/p\u003e\n\n\u003cp\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.\u003c\/p\u003e\n\n\u003cp\u003eCiticoline (Cytidine 5’-diphosphocoline), also known as CDP-choline, is a potentially superior form of choline due to its ability to cross the blood brain barrier. In fact, most studies with neurological or nootropic effects used this form. In that regard, studies in otherwise healthy, normal adults demonstrated meaningful and statistically significant impacts on working memory, recall, and attention. We have chosen to use the clinically tested, Cognizin®, in this premium formula as our primary choline source. Unlike other synthetic stimulants that can cause a rapid decline in effectiveness after an initial burst of energy, Cognizin® can offer critical nutritional support for the brain that can help support needed focus and attention.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eMethylliberine (as 40% Dynamine™ yielding 60mg)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eDynamine™ (methylliberine) is a naturally occurring alkaloid structurally similar to the stimulant’s caffeine and theacrine. It is most widely known and utilized for its rapid onset of action, non-habit-forming properties, and ability to enhance energy, cognition, and mood without significant cardiovascular stimulation. Due to these characteristics, Dynamine™ has gained attention as a reliable and potential ergogenic aid in sports and exercise performance.\u003c\/p\u003e\n\n\u003cp\u003eDynamine™ works primarily through the mechanism of action of modulating adenosine receptors. This action is similar to caffeine but with a shorter half-life and reduced tolerance build-up. It also influences dopamine and noradrenaline levels, leading to enhanced mood and motivation. Unlike caffeine, Dynamine™ has been shown to provide a rapid onset of energy without the associated increase in blood pressure or heart rate, making it a safer alternative for individuals sensitive to stimulants.\u003c\/p\u003e\n\n\u003cp\u003eWhen combined like in F Tyranny, Dynamine™ and caffeine can create a synergistic effect that enhances focus, energy, and mood. Dynamine™ can extends caffeine’s stimulatory benefits by inhibiting adenosine receptors while also influencing dopamine pathways, leading to heightened alertness and motivation. Additionally, Dynamine’s™ shorter half-life than caffeine, means it kicks in quickly and enhances the initial energy surge without significantly increasing heart rate or blood pressure rapidly.\u003c\/p\u003e\n\n\u003cp\u003eTo summarize Dynamine’s™ benefits for exercise performance:\u003c\/p\u003e\n\n\u003cul\u003e\n  \u003cli\u003e\n\u003cb\u003eEnhanced Energy and Alertness\u003c\/b\u003e\u003cbr\u003eDynamine™ provides a rapid boost in energy by inhibiting adenosine, a neurotransmitter responsible for inducing fatigue. This allows athletes to experience heightened alertness and prolonged endurance during workouts.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cb\u003eIncreased Motivation and Mood\u003c\/b\u003e\u003cbr\u003eBy influencing dopamine levels, Dynamine™ can improve motivation and mood, leading to better mental engagement and workout consistency. This effect is particularly beneficial for individuals experiencing mental fatigue or lack of drive.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cb\u003eReduced Perceived Effort and Fatigue\u003c\/b\u003e\u003cbr\u003eStudies suggest that Dynamine™ can reduce the perception of effort during physical activity, allowing users to train harder and longer, which is crucial for endurance sports and high-intensity training sessions.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cb\u003eSynergistic Effects with Caffeine and Theacrine\u003c\/b\u003e\u003cbr\u003eWhen combined with caffeine or theacrine, Dynamine™ enhances the stimulatory effects without increasing jitters or crashes. This combination provides sustained energy levels, improved reaction times, and enhanced cognitive function during events.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cb\u003eMinimal Cardiovascular Impact\u003c\/b\u003e\u003cbr\u003eUnlike traditional stimulants, Dynamine™ does not significantly increase heart rate or blood pressure, making it a safer option for athletes looking for an energy boost without excessive strain on the cardiovascular system.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cb\u003eZümXR® Extended Release Caffeine (yields 70% caffeine)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eZüm-XR is a patented coating technology that allows the dissolution profile of certain ingredients, primarily caffeine, to have a longer lasting effect in blood serum levels. The release of those ingredients is initiated by an abrasion in the stomach and pH levels between the stomach and the upper gastrointestinal tract. The coating of the microbead technology is a patented timing system with pharmaceutical grade safe polymers. Comparatively speaking, the dissolution profile of Züm-XR caffeine to your typical immediate release caffeine showed that Züm-XR took a far greater amount of time, well over 120 minutes to complete the process of dissolution.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eIoniplex® Trace Mineral Complex\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eOur bodies are high-functioning machines and require a lot of support to continue to perform at a high-level day in and day out. A lot of these needs are difficult to acquire by dieting alone, so supplementation is critical. Minerals are included in these daily needs and are vital to the bodies’ many processes.\u003c\/p\u003e\n\n\u003cp\u003eIoniplex® is a patented and clinically tested high-quality trace mineral complex providing a comprehensive blend of nutrients that are often hard to acquire from diet alone. Containing 65+ ionic trace minerals, its high bioavailability allows each mineral to penetrate cellular membranes easily to allow for the transport of nutrients directly to the cell structures for maximal absorption. Ioniplex® also actas as a natural chelator, meaning it can bind up toxic compounds, heavy metals, and other foreign substances to transport out of the cells so your essential body cells can continue to thrive.\u003c\/p\u003e\n\n\u003cp\u003eMinerals contained in Ioniplex® are catalysts for all of the vitamins and other nutrients our body requires to function at an optimal level and maintain health. Some of these functions include electrolyte replacement, maintaining pH balance in the body, nourishing hair and skin, strengthening bones and joints, regulating the digestive system, and improving athletic performance.\u003c\/p\u003e\n\n\u003cp\u003eClinical studies have shown that Ioniplex® has been a contributing factor to:\u003c\/p\u003e\n\n\u003cul\u003e\n  \u003cli\u003estimulating mitochondrial activity by nearly 35%\u003c\/li\u003e\n  \u003cli\u003eStimulating key gene expression involved in mitochondria metabolism including energy production 200%-370%\u003c\/li\u003e\n  \u003cli\u003eIncreasing production of type I collagen over 40%\u003c\/li\u003e\n  \u003cli\u003eIncreasing production of beneficial bacteria while inhibiting pathogenic bacteria\u003c\/li\u003e\n  \u003cli\u003eReduce excess glucose in the bloodstream by up to 75%\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eWe demand a lot from our bodies and expect high performance on the outside, why not expect the same of our bodies on the inside.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBitter Orange Extract (Citrus aurantium) (Fruit) (30% synephrine)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eBitter orange extract, derived from the fruit of Citrus aurantium, contains a diverse array of bioactive compounds, notably including synephrine, flavonoids, and essential oils. Synephrine, the principal alkaloid in bitter orange extract, exhibits sympathomimetic properties, stimulating the sympathetic nervous system and potentially increasing heart rate, blood pressure, and metabolic rate. These effects have led to interest in bitter orange extract as a potential aid for weight management, with studies suggesting its ability to enhance thermogenesis, suppress appetite, and stimulate lipolysis.\u003c\/p\u003e\n\n\u003cp\u003eThe flavonoids present in bitter orange extract contribute antioxidant activity, which may offer additional health benefits by protecting cells from oxidative damage. Additionally, the combination of caffeine and synephrine appears to potentiate each ingredient’s effects – with rates of fatty acid liberation, heart rate, metabolic rate, and fatty acid oxidation increased in clinical trials featuring the combination. In several studies utilizing other forms of synephrine, it was found that the combination of synephrine and caffeine led to a small but significant reduction in fat mass of 3lbs, and a reduction in bodyfat of 2.9%.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eRauwolscine (std. to 90% alpha yohimbine) (Root)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eAlpha Yohimbine, also known as rauwolscine, offers several potential benefits, particularly in the realm of sports performance as well as weight management. As a dietary supplement, it is often touted for its ability to enhance fat loss and promote energy expenditure, making it popular amongst many athletes.\u003c\/p\u003e\n\n\u003cp\u003eAlpha Yohimbine exhibits a mechanism of action that works to antagonize alpha-2 adrenergic receptors, which can lead to increased lipolysis, which is the breakdown of stored fatty acids that can then be used as a fuel source for the body. This utilization of fatty acids for energy can support weight loss and management, thus improving overall body composition.\u003c\/p\u003e\n\n\u003cp\u003eIt’s essential to note that while Alpha Yohimbine shows promise, more research is needed to fully understand its effects.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cul\u003e\n  \u003cli\u003eShurtleff D, Thomas JR, Shlers ST, et al. \u003ci\u003eTyrosine ameliorates a coldinduced delayed matching to sample performance decrements in rats.\u003c\/i\u003e Psychopharmacology 1993; 112:228-232.\u003c\/li\u003e\n  \u003cli\u003eOwasoyo JO, Neri DF, Lamberth JG. \u003ci\u003eTyrosine and its potential use as a countermeasure to performance decrement in military sustained operations.\u003c\/i\u003e Aviation Space and Enviromental Medicine 1992; 63:364369.\u003c\/li\u003e\n  \u003cli\u003eLehnert H, Reinstein DK, Strowbridge BW et al. \u003ci\u003eNeurochemical and behavioral consequences of acute, uncontrollable stress: effects of dietary tyrosine.\u003c\/i\u003e Brain Res 1984 Jun 15;303(2):215-23.\u003c\/li\u003e\n  \u003cli\u003eShurtleff D, Thomas JR, Schrot J, et al. \u003ci\u003eTyrosine reverses a coldinduced working memory deficit in humans.\u003c\/i\u003e Pharmacol Biochem Behav 1994 Apr;47(4):935-41.\u003c\/li\u003e\n  \u003cli\u003eUeland PM. \u003ci\u003eCholine and betaine in health and disease.\u003c\/i\u003e J Inherit Metab Dis. 2011;34:3–15.\u003c\/li\u003e\n  \u003cli\u003eZeisel SH, Niculescu MD. \u003ci\u003ePerinatal choline influences brain structure and function.\u003c\/i\u003e Nutr Rev 2006;64:197–203.\u003c\/li\u003e\n  \u003cli\u003eZeisel SH. \u003ci\u003eThe fetal origins of memory: the role of dietary choline in optimal brain development.\u003c\/i\u003e J Pediatr 2006;149(suppl):S131–6.\u003c\/li\u003e\n  \u003cli\u003eMichel V, Yuan Z, Ramsubir S, Bakovic M. \u003ci\u003eCholine transport for phospholipid synthesis.\u003c\/i\u003e Exp Biol Med (Maywood) 2006;231:490–504.\u003c\/li\u003e\n  \u003cli\u003eFitts RH, Balog EM. \u003ci\u003eEffect of intracellular and extracellular ion changes on E-C coupling and skeletal muscle fatigue.\u003c\/i\u003e Acta Physiol Scand. (1996)\u003c\/li\u003e\n  \u003cli\u003eGil-Agustí M1, Esteve-Romero J, Carda-Broch S. \u003ci\u003eAnserine and carnosine determination in meat samples by pure micellar liquid chromatography.\u003c\/i\u003e J Chromatogr A. (2008)\u003c\/li\u003e\n  \u003cli\u003eAbe H, et al. \u003ci\u003eRole of histidine-related compounds to intracellular buffering in fish skeletal muscle.\u003c\/i\u003e Am J Physiol. (1985)\u003c\/li\u003e\n  \u003cli\u003eDrozak J, et al. \u003ci\u003eMolecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1).\u003c\/i\u003e J Biol Chem. (2010)\u003c\/li\u003e\n  \u003cli\u003eMiyaji T, et al. \u003ci\u003eExpression profiles of carnosine synthesis-related genes in mice after ingestion of carnosine or ß-alanine.\u003c\/i\u003e J Int Soc Sports Nutr. (2012)\u003c\/li\u003e\n  \u003cli\u003eChez MG, et al. \u003ci\u003eDouble-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders.\u003c\/i\u003e J Child Neurol. (2002)\u003c\/li\u003e\n  \u003cli\u003eHipkiss AR. \u003ci\u003eOn the enigma of carnosine’s anti-ageing actions.\u003c\/i\u003e Exp Gerontol. (2009)\u003c\/li\u003e\n  \u003cli\u003eBoldyrev AA. \u003ci\u003eDoes carnosine possess direct antioxidant activity.\u003c\/i\u003e Int J Biochem. (1993)\u003c\/li\u003e\n  \u003cli\u003eHipkiss AR, Michaelis J, Syrris P. \u003ci\u003eNon-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent.\u003c\/i\u003e FEBS Lett. (1995)\u003c\/li\u003e\n  \u003cli\u003eDutka TL, Lamb GD. \u003ci\u003eEffect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscle.\u003c\/i\u003e J Muscle Res Cell Motil. (2004)\u003c\/li\u003e\n  \u003cli\u003eBauer K, Schulz M. \u003ci\u003eBiosynthesis of carnosine and related peptides by skeletal muscle cells in primary culture.\u003c\/i\u003e Eur J Biochem. (1994)\u003c\/li\u003e\n  \u003cli\u003eDunnett M, Harris RC. \u003ci\u003eInfluence of oral beta-alanine and histidine supplementation on the carnosine content of the gluteus medius.\u003c\/i\u003e Equine Vet J Suppl. (1999)\u003c\/li\u003e\n  \u003cli\u003eZeisel SH. \u003ci\u003eNutritional importance of choline for brain development.\u003c\/i\u003e J Am Coll Nutr 2004;23(suppl):621S–6S.\u003c\/li\u003e\n  \u003cli\u003eBlusztajn JK. \u003ci\u003eCholine, a vital amine.\u003c\/i\u003e Science 1998;281:794–5.\u003c\/li\u003e\n  \u003cli\u003eda Costa KA, Gaffney CE, Fischer LM, Zeisel SH. \u003ci\u003eCholine deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load.\u003c\/i\u003e Am J Clin Nutr 2005;81:440–4.\u003c\/li\u003e\n  \u003cli\u003eZeisel SH. \u003ci\u003eGene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.\u003c\/i\u003e IUBMB Life 2007;59:380–7.\u003c\/li\u003e\n  \u003cli\u003eZeisel SH. \u003ci\u003eCholine: an essential nutrient for humans.\u003c\/i\u003e Nutrition 2000;16:669–71.\u003c\/li\u003e\n  \u003cli\u003eTuszynski M. H., Sang H., Yoshida K., Gage F. H. \u003ci\u003eRecombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain.\u003c\/i\u003e Ann. Neurol. 30, 625–63610. (1991)\u003c\/li\u003e\n  \u003cli\u003eBracco D, Ferrarra J-M, Arnaud MJ, Jéquier E, Schutz Y. \u003ci\u003eEffects of caffeine on energy metabolism, heart rate and methylxanthine metabolism in lean and obese women.\u003c\/i\u003e Am J Physiol 1995;269:E671–8.\u003c\/li\u003e\n  \u003cli\u003eBellet S, Kershbaum A, Finck EM. \u003ci\u003eResponse of free fatty acids to coffee and caffeine.\u003c\/i\u003e Metabolism 1968;17:702–7.\u003c\/li\u003e\n  \u003cli\u003eBellet S, Roman L, de Castro O, Kim KE, Kershbaum A. \u003ci\u003eEffect of coffee ingestion on catecholamine release.\u003c\/i\u003e Metabolism 1969;18:288–91.\u003c\/li\u003e\n  \u003cli\u003eAllerton, T. D., Proctor, D. N., Stephens, J. M., Dugas, T. R., Spielmann, G., \u0026amp; Irving, B. A. (2018). \u003ci\u003el-Citrulline Supplementation: Impact on Cardiometabolic Health.\u003c\/i\u003e Nutrients, 10(7), 921. https:\/\/doi.org\/10.3390\/nu10070921\u003c\/li\u003e\n  \u003cli\u003eFigueroa, A., Wong, A., Jaime, S. J., \u0026amp; Gonzales, J. U. (2017). \u003ci\u003eInfluence of L-citrulline and watermelon supplementation on vascular function and exercise performance.\u003c\/i\u003e Current Opinion in Clinical Nutrition and Metabolic Care, 20(1), 92–98. https:\/\/doi.org\/10.1097\/MCO.0000000000000340\u003c\/li\u003e\n  \u003cli\u003eKim, I. Y., Schutzler, S. E., Schrader, A., Spencer, H. J., Azhar, G., Deutz, N. E., \u0026amp; Wolfe, R. R. (2015). \u003ci\u003eAcute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure.\u003c\/i\u003e American Journal of Physiology. Endocrinology and Metabolism, 309(11), E915–E924. https:\/\/doi.org\/10.1152\/ajpendo.00339.2015\u003c\/li\u003e\n  \u003cli\u003eFlores-Ramírez, A. G., Tovar-Villegas, V. I., Maharaj, A., Garay-Sevilla, M. E., \u0026amp; Figueroa, A. (2021). \u003ci\u003eEffects of L-Citrulline Supplementation and Aerobic Training on Vascular Function in Individuals with Obesity across the Lifespan.\u003c\/i\u003e Nutrients, 13(9), 2991. https:\/\/doi.org\/10.3390\/nu13092991\u003c\/li\u003e\n  \u003cli\u003eJabir, N. R., Firoz, C. K., Zughaibi, T. A., Alsaadi, M. A., Abuzenadah, A. M., Al-Asmari, A. I., Alsaieedi, A., Ahmed, B. A., Ramu, A. K., \u0026amp; Tabrez, S. (2022). \u003ci\u003eA literature perspective on the pharmacological applications of yohimbine.\u003c\/i\u003e Annals of Medicine, 54(1), 2861–2875. https:\/\/doi.org\/10.1080\/07853890.2022.2131330\u003c\/li\u003e\n  \u003cli\u003eOstojic S. M. (2006). \u003ci\u003eYohimbine: the effects on body composition and exercise performance in soccer players.\u003c\/i\u003e Research in Sports Medicine (Print), 14(4), 289–299. https:\/\/doi.org\/10.1080\/15438620600987106\u003c\/li\u003e\n  \u003cli\u003eBarnes, M. E., Cowan, C. R., Boag, L. E., Hill, J. G., Jones, M. L., Nixon, K. M., Parker, M. G., Parker, S. K., Raymond, M. V., Sternenberg, L. H., Tidwell, S. L., Yount, T. M., Williams, T. D., Rogers, R. R., \u0026amp; Ballmann, C. G. (2022). \u003ci\u003eEffects of Acute Yohimbine Hydrochloride Supplementation on Repeated Supramaximal Sprint Performance.\u003c\/i\u003e International Journal of Environmental Research and Public Health, 19(3), 1316. https:\/\/doi.org\/10.3390\/ijerph19031316\u003c\/li\u003e\n  \u003cli\u003e\n\u003ci\u003eIoniplex® \u0026amp; Bioavailability.\u003c\/i\u003e Mineral BioSciences. (2017, April 27). Retrieved March 31, 2023, from https:\/\/www.mineralbiosciences.com\/ioniplex-bioavailability\/\u003c\/li\u003e\n  \u003cli\u003eHirota, T., Ohki, K., Kawagishi, R., Kajimoto, Y., Mizuno, S., Nakamura, Y., \u0026amp; Kitakaze, M. (2007). \u003ci\u003eCasein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme.\u003c\/i\u003e Hypertension Research, 30(6), 489–496. https:\/\/doi.org\/10.1291\/hypres.30.489\u003c\/li\u003e\n  \u003cli\u003eFekete, Á. A., Givens, D. I., \u0026amp; Lovegrove, J. A. (2015). \u003ci\u003eCasein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials.\u003c\/i\u003e Nutrients, 7(1), 659–681. https:\/\/doi.org\/10.3390\/nu7010659\u003c\/li\u003e\n  \u003cli\u003eFekete, Á. A., Givens, D. I., \u0026amp; Lovegrove, J. A. (2015). \u003ci\u003eCasein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials.\u003c\/i\u003e Nutrients, 7(1), 659–681. https:\/\/doi.org\/10.3390\/nu7010659\u003c\/li\u003e\n  \u003cli\u003eArumugam, M. K., Paal, M. C., Donohue, T. M., Jr, Ganesan, M., Osna, N. A., \u0026amp; Kharbanda, K. K. (2021). \u003ci\u003eBeneficial Effects of Betaine: A Comprehensive Review.\u003c\/i\u003e Biology, 10(6), 456. https:\/\/doi.org\/10.3390\/biology10060456\u003c\/li\u003e\n  \u003cli\u003eCholewa, J. M., Wyszczelska-Rokiel, M., Glowacki, R., Jakubowski, H., Matthews, T., Wood, R., Craig, S. A., \u0026amp; Paolone, V. (2013). \u003ci\u003eEffects of betaine on body composition, performance, and homocysteine thiolactone.\u003c\/i\u003e Journal of the International Society of Sports Nutrition, 10(1), 39. https:\/\/doi.org\/10.1186\/1550-2783-10-39\u003c\/li\u003e\n  \u003cli\u003eIsmaeel A. (2017). \u003ci\u003eEffects of Betaine Supplementation on Muscle Strength and Power: A Systematic Review.\u003c\/i\u003e Journal of Strength and Conditioning Research, 31(8), 2338–2346. https:\/\/doi.org\/10.1519\/JSC.0000000000001959\u003c\/li\u003e\n  \u003cli\u003eArazi, H., Aboutalebi, S., Taati, B., Cholewa, J. M., \u0026amp; Candow, D. G. (2022). \u003ci\u003eEffects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes.\u003c\/i\u003e Journal of the International Society of Sports Nutrition, 19(1), 1–16. https:\/\/doi.org\/10.1080\/15502783.2022.2041988\u003c\/li\u003e\n  \u003cli\u003eTartar, J. L., Banks, J. B., Marang, M., Pizzo, F., \u0026amp; Antonio, J. (2021). \u003ci\u003eA Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers.\u003c\/i\u003e Cureus, 13(12), e20534. https:\/\/doi.org\/10.7759\/cureus.20534\u003c\/li\u003e\n  \u003cli\u003eVanDusseldorp, T. A., Stratton, M. T., Bailly, A. R., Holmes, A. J., Alesi, M. G., Feito, Y., Mangine, G. T., Hester, G. M., Esmat, T. A., Barcala, M., Tuggle, K. R., Snyder, M., \u0026amp; Modjeski, A. S. (2020). \u003ci\u003eSafety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults.\u003c\/i\u003e Nutrients, 12(3), 654. https:\/\/doi.org\/10.3390\/nu12030654\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Acid Rain (Lemon Italian Ice)","offer_id":45042425594032,"sku":"SHOP850080302330","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Red Alert (Tropical Punch)","offer_id":45042425626800,"sku":"SHOP850080302354","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Tropical Storm (Strawberry Mango)","offer_id":45042425659568,"sku":"SHOP850080302347","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/FURY_AR_FRONT.png?v=1775672233"},{"product_id":"gda","title":"GDA","description":"\u003cp\u003eCore Nutritionals® Lifeline GDA has redefined what a true glucose disposal agent should be. While most GDAs on the market rely on single-pathway, underdosed formulas, Core Life Line GDA targets multiple critical pathways through clinical or near-clinical serving sizes. More importantly, it utilizes non-redundant ingredients that precisely target both glycogenic (glycogen-creating) and lipolytic (fat-mitigating) processes.\u003c\/p\u003e\n\u003cp\u003eThe effectiveness of Core Life Line GDA lies in its ability to influence key pathways of glycogen storage and lipid metabolism. This includes increasing GLUT4 translocation to enhance glucose uptake into muscle cells, improving insulin sensitivity, and modulating the body’s response to carbohydrate intake at both the digestive and cellular level.\u003c\/p\u003e\n\u003cp\u003eWhile other GDAs may attempt to target similar pathways, Core Life Line GDA does so through multiple distinct mechanisms. Rather than relying on a single ingredient approach, it maximizes glycogen storage while minimizing the likelihood of excess glucose being stored as body fat.\u003c\/p\u003e\n\u003cp\u003eWhen you consume carbohydrates, they are broken down into glucose and released into the bloodstream. From there, glucose is either directed toward muscle tissue—where it can be stored as glycogen and used for performance—or toward adipose tissue for storage as fat.\u003c\/p\u003e\n\u003cp\u003eBy enhancing glycogen storage, Core Life Line GDA helps fuel performance, recovery, and muscle fullness, while acting as a safeguard against fat storage. At the same time, it works to stabilize blood glucose levels and reduce pathways associated with fat accumulation.\u003c\/p\u003e\n\u003cp\u003eThe result is a comprehensive, multi-pathway system designed to optimize nutrient utilization, support performance, and promote a leaner physique.\u003c\/p\u003e\n\u003cp\u003eCore Life Line GDA sets a new standard for GDAs.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eScientific Write-Up: Chromium (as Chromium Picolinate) (Chromax®)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eChromium, a naturally occurring trace element in many foods, has been linked to benefits including weight management, body composition, cognitive health, glucose metabolism, appetite control, and energy support.\u003c\/p\u003e\n\u003cp\u003eChromax® Chromium Picolinate is a highly bioavailable form of chromium that has been extensively studied for its benefits listed above.\u003c\/p\u003e\n\u003cp\u003ePerhaps chromium picolinates’ most important function that leads to these benefits is in its ability to regulate insulin through carbohydrate, lipid, and protein metabolism.\u003c\/p\u003e\n\u003cp\u003eThe proposed mechanism of action is through its ability to regulate glucose utilization and increase sensitivity of insulin receptors by prolonging kinase activity through stimulating the tyrosine kinase pathway, thus leading to improved glucose absorption.\u003c\/p\u003e\n\u003cp\u003eThis further then leads to more stable blood sugar, which can reduce cravings, overall caloric intake, and reduce cravings, thus leading to improved body composition.\u003c\/p\u003e\n\u003cp\u003eChromax® Chromium Picolinate is particularly formulated to be up to 15x more absorbable than other traditional forms of chromium, leading to more efficient and consistent benefits.\u003c\/p\u003e\n\u003cp\u003eWhen the body can more efficiently break down food particles and shuttle their molecules to their targets for usage, the body has a much higher chance of performing optimally.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGreen Coffee Extract (Coffea robusta) (bean) (50% Chlorogenic acid)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCoffee is widely recognized as not only the most consumed psychoactive compound on earth, but perhaps also the most consumed plant material in general.\u003c\/p\u003e\n\u003cp\u003eDue to the extent of coffee consumption by humans, several species of coffee beans, along with their bioactive constituents, have been research targets for a number of therapeutic pathways.\u003c\/p\u003e\n\u003cp\u003eThe most abundant polyphenol in coffee is Chlorogenic acid (CGA).\u003c\/p\u003e\n\u003cp\u003eAn abundance of data suggests that CGA has numerous physiological properties, and that its most potent physiological effects are hypoglycemic (blood sugar-lowering) and lipolytic\/anti-lipogenic in nature.\u003c\/p\u003e\n\u003cp\u003eRecent evidence demonstrates that CGA is a powerful and novel glucose modulator, in vivo, in both healthy and diseased populations.\u003c\/p\u003e\n\u003cp\u003eResearch shows that one of CGA’s potential hypoglycemic mechanisms is insulin sensitization – in other words, making existing cells more sensitive to the glucose shuttling effects of insulin.\u003c\/p\u003e\n\u003cp\u003eIn a trial on streptozotocin (STZ) (45 mg\/kgbw) nicotinamide-induced diabetic rats, a 5mg\/kgbw dose of CGA significantly mitigated the diabetic effects of STZ and caused an increase to glucose uptake.\u003c\/p\u003e\n\u003cp\u003eOf note, the 5mg\/kgbw dose of CGA used in the animal trial is significantly less than the mg\/kgbw serving size of CGA included in Core LOAD. (Assuming an average Core LOAD consumer bodyweight of 75kg.)\u003c\/p\u003e\n\u003cp\u003eAn additional trial in obese Zucker rats demonstrated that CGA is capable of improving glucose tolerance and insulin resistance.\u003c\/p\u003e\n\u003cp\u003eThe trial found that the CGA group had better glucose tolerance, higher insulin sensitivity index (ISI), and lower HOMA-IR (insulin resistance) index.\u003c\/p\u003e\n\u003cp\u003eA trial in healthy humans showed similar promise.\u003c\/p\u003e\n\u003cp\u003eHealthy, human subjects were challenged with an acute serving of CGA and then assessed for hepatic glucose output, blood glucose levels, and glucose tolerance.\u003c\/p\u003e\n\u003cp\u003eCGA induced a significant reduction in peak plasma glucose levels – an important fact, as glucose fluctuations and\/or chronically excessive blood glucose levels are associated with fat cell proliferation.\u003c\/p\u003e\n\u003cp\u003eUnlike the animal trial, however, the human trial hypothesized that CGA worked through a different, more novel mechanism: attenuating glucose absorption in the gastric uptake phase.\u003c\/p\u003e\n\u003cp\u003eIn this trial, CGA effectively CGA functioned as both an insulin sensitizing agent and a glycemic index lowering agent.\u003c\/p\u003e\n\u003cp\u003eIn addition to both the above mechanisms, CGA was shown to inhibit the activities of α-amylase and α-glucosidase – two enzymes responsible for metabolizing carbohydrates into saccharides.\u003c\/p\u003e\n\u003cp\u003eAs a result, CGA again reduced postprandial (post-meal) blood glucose concentration.\u003c\/p\u003e\n\u003cp\u003eThe potentially novel glycemic index-lowering and carbohydrate metabolism effects of CGA were confirmed in two further trials: one in which CGA intake significantly reduced fasting glucose and insulin levels in obese men, and another in which CGA lowered the glycemic impact (how quickly and to what degree plasma glucose was increased) and lowered blood glucose levels.\u003c\/p\u003e\n\u003cp\u003eCGA is an interesting compound due not only to its potent insulin-sensitizing and glycemic effects, but also its novel action on lipid metabolism.\u003c\/p\u003e\n\u003cp\u003eA 2006 trial found that CGA – in addition to caffeine and other polyphenols found in green coffee bean extract – suppressed body weight gain and the accumulation of visceral fat in mice.\u003c\/p\u003e\n\u003cp\u003eAgain, the mechanism of action was quite unique: CGA was found to inhibit and delay the absorption of fat at the gastric uptake phase and reduce lipid metabolism in the liver.\u003c\/p\u003e\n\u003cp\u003eIn a separate trial on obese rates, CGA significantly reduced body weight, visceral fat mass (adipose tissue surrounding the internal organs), and plasma insulin concentrations.\u003c\/p\u003e\n\u003cp\u003eThe authors of this trial hypothesize that, in addition to the profound effects on glucose metabolism noted above, CGA reduced body weight and fat mass due to increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver.\u003c\/p\u003e\n\u003cp\u003eIn sum, CGA is the perfect confluence of glycogenic, glycemic-impact lowering, insulin sensitizing, and anti-lipogenic factors.\u003c\/p\u003e\n\u003cp\u003eIts inclusion as a key ingredient in Core GDA, at well above clinical serving sizes, functions to promote healthy blood glucose levels, healthy bodyweight, and healthy insulin release.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eGS4 Plus® Gymnema sylvestre Extract (leaves) (25% gymnemic acids)\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eGymnema sylvestre is a plant endemic to the tropical and sub-tropical regions of Southeast Asa, including India and China. In these countries, G. sylvestre functions as a treatment for many pathological conditions, including diabetes and hypercholesterolemia – in fact, the Ayurvedic name for G. sylevestre is “Gurmar,” or “destroyer of sugars.” The principle bioactives in G. sylvestre, gymnemic acids, are concentrated highly in the leaves and have been isolated and observed for their glucose shuttling properties.\u003c\/p\u003e\n\u003cp\u003eIn a clinical trial in humans using a G. sylestre extract dietary supplement, 65 participants were administered G. sylvestre for 90 days. After the 90 day treatment, the participants were assessed for a number of biometrics, including prenadial (pre-eating) plasma glucose concentrations and HbA1c (haemoglobin A1c, a key marker for diabetes) levels. The researchers found that 90 days of supplementation with G. sylvestre lowered prenadial blood glucose by 11%, postpranadial glucose by 13%, and Hb1Ac by .8% (a seemingly small figure, but in fact statistically significant).\u003c\/p\u003e\n\u003cp\u003eIn another, small clinical study, fasting blood glucose levels significantly improved in a group of type II diabetes mellitus patients after receiving a 200mg extract of G. sylevestre (standardized for gymnemic acid) for 20 months.\u003c\/p\u003e\n\u003cp\u003eUnlike CGA, the mechanism(s) of action for G. sylevestre and gymnemic acid have not been precisely identified. Several trials in rats suggest that gymnemic acid’s structural similarity to glucose may have a role in its hypoglycemic effects; while still other trials suggest that, like CGA, gymemic acid may exert glucose uptake inhibitory effects at the intestinal level.\u003c\/p\u003e\n\u003cp\u003eWhatever the mechanism of action, however, the plant has demonstrated the ability to promote healthy blood glucose levels and assist in the management of a healthy body mass.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCeylon Cinnamon Bark Powder (Cinnamomum verum)\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCeylon cinnamon, often referred to as “true cinnamon,” is a well-studied botanical known for its powerful effects on glucose metabolism and insulin function. Unlike cassia cinnamon, Ceylon cinnamon contains significantly lower levels of coumarin, making it a safer option for consistent daily use. Its primary bioactives—cinnamaldehyde and polyphenols—have been shown to enhance insulin sensitivity by improving insulin receptor signaling.\u003c\/p\u003e\n\u003cp\u003eThis allows cells to more efficiently uptake glucose, helping to reduce circulating blood sugar levels and improve overall nutrient utilization.\u003c\/p\u003e\n\u003cp\u003eCeylon cinnamon also plays a role in slowing carbohydrate digestion by inhibiting key enzymes like α-amylase and α-glucosidase. This helps blunt post-meal blood sugar spikes, supporting more stable energy levels and reducing the likelihood of excess glucose being stored as body fat.\u003c\/p\u003e\n\u003cp\u003eClinical research supports cinnamon’s ability to lower fasting blood glucose, improve insulin sensitivity, and support long-term glycemic control.\u003c\/p\u003e\n\u003cp\u003eIn the context of Life Line GDA, Ceylon cinnamon acts as a foundational ingredient to promote efficient glucose disposal and metabolic health.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eGlucovantage® (Dihydroberberine)\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eGlucovantage® is a sustained release dihydroberberine, which is a highly bioavailable derivative of berberine. Once absorbed in the intestines, dihydroberberine rapidly converts to berberine in the blood and has been shown to be up to 5x more bioavailable than standard berberine.\u003c\/p\u003e\n\u003cp\u003eThe benefits of berberine have been extensively studied for its positive effects on glucose balance, lipid metabolism, and overall blood vessel health. In fact, berberine is one of the leading compounds that is used to increase insulin sensitivity, or how well your body responds to insulin.\u003c\/p\u003e\n\u003cp\u003eGlucose uptake to tissues is influenced by berberines ability to activate the adenosine monophosphate kinase (AMPK) pathway, which plays an important role in energy balance regulation.\u003c\/p\u003e\n\u003cp\u003eResults from pre-clinical studies indicate berberine promotes healthy cholesterol metabolism by a variety of actions. It has the ability to upregulate LDL-receptors on liver cells that shuttle cholesterol out of the blood and into the necessary cells. Berberine inhibits intestinal cholesterol absorption and increases excretion as well as provides antioxidant defense.\u003c\/p\u003e\n\u003cp\u003eBy activating AMP-K, for the purposes of glucose balance, it also increases fatty acid oxidation (burning) and decreases fatty acid synthesis.\u003c\/p\u003e\n\u003cp\u003eAs a highly bioavailable form of berberine, Glucovantage® dihydroberberine may help maintain healthy blood glucose and lipid levels in the normal range while supporting vascular health.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eBanaba Extract (Lagerstroemia speciose)(leaf)(20% corosolic acids)\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eLagerstroemia speciosa is a flowering tree of the Lagerstroemia genus that is native to large portions of south east Asia, India and the Phillipines, and its bark and leaves have a historical tradition in folk medicine for the treatment of diabetes mellitus. Banaba (L. speciosa’s common name) has been used as a folk medicine to treat diabetes in various parts of the world, primarily southeast Asia.\u003c\/p\u003e\n\u003cp\u003eThe hypoglycemic effect of aqueous (hot water) and methanol extracts have been demonstrated in many human studies. Most studies have focused on corosolic acid, the primary bioactive constituent of L. speciosa – and the compound for which Core LOAD’s banaba is standardized.\u003c\/p\u003e\n\u003cp\u003eA 12-week lifestyle intervention study, involving 56 subjects consuming a dietary supplement containing banaba, taken prior to each meal, measured body mass at the conclusion of the trial. At the end of 12 weeks, the subjects had lost an average of 6.29 kg (13.8 lb) including 3.72 kg (8.2 lb) body fat as determined by a bioelectric impedance body fat analyser.\u003c\/p\u003e\n\u003cp\u003eIn a separate, smaller study, 12 nondiabetic subjects with a baseline blood glucose level of 104 mg\/dL were given a soft gel capsule daily for 2 weeks containing 10 mg corosolic acid as a Banaba extract standardized to 18% corosolic acid. A 12% decrease in fasting glucose levels, as well as 60 min postprandial blood glucose levels, was observed after 2 weeks of administering the product. The authors also reported an average three-pound weight loss after the two weeks.\u003c\/p\u003e\n\u003cp\u003eIn an unpublished study using the same soft gel product containing 10 mg corosolic acid, 100 subjects with prediabetes or type 2 diabetes were enrolled. Half the subjects were given one soft gel containing the corosolic acid-standardized Banaba extract and the other half received a placebo for 30 days. Both fasting and 2 h postprandial blood glucose levels in the treated group decreased by 10% relative to the control (placebo) group. Also reported was an improvement in diabetic symptoms including a decrease in thirst, drowsiness, and hunger. Furthermore, no adverse effects were observed, with no changes in blood pressure, liver or kidney function, blood cell count, or hemoglobin.\u003c\/p\u003e\n\u003cp\u003eLastly, a study involving 31 subjects in a double-blind cross-over design were given a capsule containing 10 mg corosolic acid or a placebo 5 min before a 75g oral glucose tolerance test. Blood glucose levels were measured at 30 min intervals for 2h. The authors reported that corosolic acid treatment resulted in lower blood glucose levels from 60 to 120 min compared with controls, the difference being statistically significant (P \u0026lt; 0.05) at the 90 min time point. According to the authors, the corosolic acid that was used was 99% pure, thus indicating that the blood sugar lowering effect was specifically due to the corosolic acid.\u003c\/p\u003e\n\u003cp\u003eIn the context of Core GDA, the AUC (area under curve) demonstrated in this trial is important – as it demonstrates that corosolic acid exerts glucose stabilizing effects over a long time period (such as immediately before-to-after an intense workout).\u003c\/p\u003e\n\u003cp\u003eThe above clinical studies demonstrate that Banaba extract, Banaba extract standardized to corosolic acid, and corosolic acid itself, decrease fasting as well as postprandial blood glucose levels in humans. A decrease in blood glucose levels has been observed within 2 h of dosing, and the decrease is typically in the range of 10–15%, although a decrease of 30% has been reported.\u003c\/p\u003e\n\u003cp\u003eThe ability to corsolic acid to positively regulate healthy plasma glucose levels makes it a key addition to Core GDA’s glucose disposal agent lineup.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBanaba Leaf Research Update\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003eEffects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. \u003ci\u003eLife Sci.\u003c\/i\u003e 2005 Nov 12;77( 26):3344-54. 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(Jpn).\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eIkeda Y, Noguchi M, Kishi S, et al. \u003ci\u003eBlood glucose controlling effects and safety of single and long-term administration on the extract of banaba leaves.\u003c\/i\u003e Journal of Nutrition \u0026amp; Food. 2002;5:41–53. (Jpn).\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eJudy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YMA, Passwater R. \u003ci\u003eAntidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics: a dose-dependence study.\u003c\/i\u003e Journal of Ethnopharmacology. 2003;87(1):115–117. 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[PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eZheng JQ, Zheng CM, Lu KC. \u003ci\u003eCorosolic acid-induced acute kidney injury and lactic acidosis in a patient with impaired kidney function.\u003c\/i\u003e American Journal of Kidney Disease. 2010;56(2):419–420. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eGarcia F. \u003ci\u003eOn the hypoglycemic effect of a decoction of Lagerstroemia speciosa leaves (banaba) administered orally.\u003c\/i\u003e Philippine Medical Association. 1940;20:193–201.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eGarcia F. \u003ci\u003eDistribution and deterioration of insulin-like principle in Lagerstroemia speciosa (banaba).\u003c\/i\u003e Acta Medica Philippina. 1941;3:99–104.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eKakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. \u003ci\u003eHypoglycemic effect of extracts from Lagerstroemia speciosa L. Leaves in genetically diabetic KK-AY mice.\u003c\/i\u003e Bioscience, Biotechnology and Biochemistry. 1996;60(2):204–208. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSuzuki Y, Hayashi K, Sukabe I, Kakuda T. \u003ci\u003eEffects and mode of action of banaba (Lagerstroemia speciosa L.) leaf extracts on postprandial blood glucose in rats.\u003c\/i\u003e Japan Society of Nutrition and Food Science. 2001;54:131–137.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eYamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. \u003ci\u003eCorosolic acid prevents oxidative stress, inflammation and hypertension in SHR\/NDmcr-cp rats, a model of metabolic syndrome.\u003c\/i\u003e Life Sciences. 2006;79(26):2474–2479. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eMatsuura T, Yoshikawa Y, Masui H, Sano M. \u003ci\u003eSuppression of glucose absorption by various health teas in rats.\u003c\/i\u003e Yakugaku Zasshi. 2004;124(4):217–223. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHong H, Won JM. \u003ci\u003eEffects of malted barley extract and banaba extract on blood glucose levels in genetically diabetic mice.\u003c\/i\u003e Journal of Medicinal Food. 2004;7(4):487–490. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eYamada K, Hogokowa M, Fujimoto S. \u003ci\u003eEffect of corosolic acid on gluconeogenesis in rat liver.\u003c\/i\u003e Diabetes Research and Clinical Practice. 2008;80:48–55. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eYamada K, Hosokawa M, Yamada C, et al. \u003ci\u003eDietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.\u003c\/i\u003e Biological and Pharmaceutical Bulletin. 2008;31(4):651–655. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eDeocaris CC, Aguinaldo RR, dela Ysla JL, Asencion AS, Mojica E ERE. \u003ci\u003eHypoglycemic activity of irradiated banaba (Lagerstroemia speciosa L.) leaves.\u003c\/i\u003e Journal of Applied Sciences Research. 2005;1:95–98.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003ePark MY, Lee KS, Sung MK. \u003ci\u003eEffects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-α, PPAR-γ, and LPL mRNA expressions.\u003c\/i\u003e Life Sciences. 2005;77(26):3344–3354. [PubMed]\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eTian, H., Guo, X., Wang, X., He, Z., Sun, R., Ge, S., \u0026amp; Zhang, Z. (2013). \u003ci\u003eChromium picolinate supplementation for overweight or obese adults.\u003c\/i\u003e The Cochrane Database of Systematic Reviews, 2013(11), CD010063. https:\/\/doi.org\/10.1002\/14651858.CD010063.pub2\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eMoon, J. M., Ratliff, K. M., Hagele, A. M., Stecker, R. A., Mumford, P. W., \u0026amp; Kerksick, C. M. (2021). \u003ci\u003eAbsorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial.\u003c\/i\u003e Nutrients, 14(1), 124. https:\/\/doi.org\/10.3390\/nu14010124\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eChang, C., Roh, Y. S., Du, M., Kuo, Y. C., Zhang, Y., Hardy, M., Gahler, R., \u0026amp; Solnier, J. (2024). \u003ci\u003eDifferences in Metabolite Profiles of Dihydroberberine and Micellar Berberine in Caco-2 Cells and Humans-A Pilot Study.\u003c\/i\u003e International Journal of Molecular Sciences, 25(11), 5625. https:\/\/doi.org\/10.3390\/ijms25115625\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRanasinghe, P., Perera, S., Gunatilake, M., Abeywardene, E., Gunapala, N., Premakumara, S., Perera, K., Lokuhetty, D., \u0026amp; Katulanda, P. (2012). \u003ci\u003eEffects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model.\u003c\/i\u003e Pharmacognosy Research, 4(2), 73–79. https:\/\/doi.org\/10.4103\/0974-8490.94719\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRanasinghe, P., Galappaththy, P., Constantine, G. R., Jayawardena, R., Weeratunga, H. D., Premakumara, S., \u0026amp; Katulanda, P. (2017). \u003ci\u003eCinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial.\u003c\/i\u003e Trials, 18(1), 446. https:\/\/doi.org\/10.1186\/s13063-017-2192-0\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRanasinghe, P., Jayawardena, R., Pigera, S., Wathurapatha, W. S., Weeratunga, H. D., Premakumara, G. A. S., Katulanda, P., Constantine, G. R., \u0026amp; Galappaththy, P. (2017). \u003ci\u003eEvaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial.\u003c\/i\u003e BMC Complementary and Alternative Medicine, 17(1), 550. https:\/\/doi.org\/10.1186\/s12906-017-2067-7\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45110894166192,"sku":"SHOP850080302682","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/GDA_FRONT.png?v=1778678689"},{"product_id":"transformers®-bumblebee-stack","title":"Transformers® Bumblebee Stack","description":"\u003cp\u003eInspired by Bumblebee’s speed, energy, and relentless drive, the Transformers stack is designed to support every stage of your fitness journey. Energon delivers smooth energy, focus, endurance, and muscle pumps with ingredients like Enfinity® Paraxanthine, L-Citrulline, beta-alanine, Cognizin®, and Senactiv®, helping you train harder and stay locked in.\u003cbr\u003e\u003cbr\u003eFuel your training with the \u003cb\u003eEnergon – Pre-Workout\u003c\/b\u003e formula: delivering smooth, crash-free energy via \u003ci\u003eEnfinity® paraxanthine\u003c\/i\u003e, while \u003ci\u003eSenactiv®\u003c\/i\u003e, \u003ci\u003eVasoDrive-AP®\u003c\/i\u003e, and a strong citrulline + betaine matrix boost endurance, pumps, and muscle cell recovery.\u003c\/p\u003e\n\u003cp\u003eFollow with \u003cb\u003eAllspark – Hydration + EAA\u003c\/b\u003e, which replenishes essential electrolytes and supplies a full spectrum of fermented EAAs to support hydration, protein synthesis, and recovery during your workout.\u003c\/p\u003e\n\u003cp\u003eFinally, \u003cb\u003eProtron – Protein Blend\u003c\/b\u003e completes the stack: a premium whey + casein formula enhanced with MCTs and digestive enzymes for optimal absorption, recovery, and sustained amino acid delivery.\u003c\/p\u003e\n\u003cp\u003eTogether, these three deliver energy, hydration, and muscle support in one system.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"A","offer_id":45142602907824,"sku":null,"price":125.0,"currency_code":"USD","in_stock":true},{"title":"B","offer_id":45453669728432,"sku":null,"price":125.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Frame4_31188379-03b9-45f9-98c6-0fe93f5644ac.png?v=1784061670"},{"product_id":"liberty-ballz","title":"'Merica Labz Liberty Ballz","description":"\u003cp\u003e\u003cb\u003eOperation Hormone Freedom\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cul\u003e\n  \u003cli\u003eBoost Vitality\u003c\/li\u003e\n  \u003cli\u003eIncrease Strength\u003c\/li\u003e\n  \u003cli\u003eEnhance Performance\u003c\/li\u003e\n  \u003cli\u003eImprove Stamina\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cb\u003eAnacyclus pyrethrum Extract (Root) (5:1)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAnacyclus pyrethrum extract, standardized to a 5:1 ratio, is a potent herbal extract traditionally used in Ayurvedic and Unani medicine for its adaptogenic and aphrodisiac properties. This root extract contains bioactive compounds such as alkylamides and saponins, which have been shown to stimulate the hypothalamic-pituitary-gonadal (HPG) axis, leading to increased testosterone production. Elevated testosterone levels are associated with enhanced libido, improved physical performance, and greater muscle strength. Additionally, Anacyclus pyrethrum extract exhibits neuroprotective and antioxidant properties, supporting cognitive function and reducing oxidative stress. Research also highlights its potential to modulate energy metabolism and improve endurance, making it a valuable ingredient for vitality and physical resilience. A study by \u003ci\u003eSharma et al. (2011)\u003c\/i\u003e demonstrated that Anacyclus pyrethrum root extract significantly increased serum testosterone levels in male rats, alongside improvements in sexual behavior and spermatogenesis. The study attributed these effects to the extract’s alkylamide content, which stimulates luteinizing hormone (LH) secretion, thereby enhancing testicular testosterone synthesis. With its multifaceted benefits, Anacyclus pyrethrum extract (5:1) is gaining recognition as a natural solution for boosting hormonal health, physical performance, and overall well-being.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eFenugreek Extract (Trigonella foenum-graecum) (Seed) (50% Saponins)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eFenugreek extract (Trigonella foenum-graecum) is a fragrant herb commonly found in southern Europe, the Mediterranean, and Western Asia. Commonly used as a spice, it offers benefits such as blood sugar lowering, cholesterol support, and improvements in sexual health. Standardized to 50% saponins, these compounds support endocrine and metabolic pathways. Clinical studies show it supports testosterone by stimulating luteinizing hormone (LH) and reducing testosterone conversion to DHT. Benefits include improved strength, muscle mass, libido, and vitality. It also supports glucose metabolism and cardiovascular health through antioxidant and anti-inflammatory effects.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eSpilanthes acmella (Flower) Extract (3.5% Spilanthols)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eSpilanthes acmella is a botanical extract known for antioxidant and joint support, mood enhancement, and testosterone support. Scientific studies show it boosts testosterone by stimulating the pituitary gland to release LH. This suggests a potential for enhancing natural testosterone production in humans.\u003c\/p\u003e\n\n\u003cp\u003eOne notable study published in the \u003ci\u003eJournal of Ethnopharmacology\u003c\/i\u003e found that Spilanthes acmella significantly increased testosterone levels in male rats through LH stimulation, suggesting similar effects in humans.\u003c\/p\u003e\n\n\u003cp\u003eSpilanthes also has adaptogenic properties that help manage stress, protecting against cortisol-related testosterone suppression. Its antioxidant activity protects Leydig cells in the testes, which are vital for testosterone production, especially as men age.\u003c\/p\u003e\n\n\u003cp\u003eSpilanthes can offer a clinically validated approach to naturally boosting testosterone levels and enhancing male vitality. Whether you’re looking to improve your physical performance, support reproductive health, or maintain hormonal balance, Spilanthes can provide a powerful, research-backed solution for men seeking to optimize their well-being.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003e3,3’-Diindolylmethane (DIM)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to identify a specific estrogen.\u003c\/p\u003e\n\n\u003cp\u003eThese specific estrogens, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an estrogen antagonist. \u003ci\u003eYes, that is correct: there is an anti-estrogen, estrogen.\u003c\/i\u003e\u003c\/p\u003e\n\n\u003cp\u003eIn recent years, so-called “phytonutrients” have become the focus of clinical research, as these natural compounds have shown the ability to increase the ratio of good, estrogen decreasing estrogens, such as 2-OHE, to bad, estrogen increasing estrogens, such as 16-OHE1. One of these phytonutrients, a dietary indole known as indole-3-carbinol (I3C), is the bioactive phytochemical and a presumed modulator of reduced cancer risk in areas with high cruciferous vegetable consumption. Unfortunately, despite its potent antiestrogenic activity, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\n\u003cp\u003eLuckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound with respect to antiestrogenic action – promoting the metabolism of beneficial estrogens that themselves reduce estrogenic activity.\u003c\/p\u003e\n\n\u003cp\u003eAside from its healthy estrogen promoting abilities, DIM also exerts its own direct physiological effects, including:\u003c\/p\u003e\n\n\u003cul\u003e\n  \u003cli\u003ePromoting pathways of internal estrogen metabolism that favor the production of anti-estrogen estrogens.\u003c\/li\u003e\n  \u003cli\u003eAdjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.\u003c\/li\u003e\n  \u003cli\u003eLimiting the cell division and growth of certain estrogens.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eDespite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lies in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eEurycoma longifolia Extract (Root) (100:1)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eEurycoma longifolia extract, also known as Tongkat Ali, Malaysian Ginseng, and Longjack, has been used for centuries as an aphrodisiac in medicinal systems local to those regions. Standardized to a 100:1 ratio, this potent botanical known for its adaptogenic and androgen-supporting properties has been widely utilized for enhancing male vitality, physical performance, and overall health. Tongkat Ali works by modulating the hypothalamic-pituitary-gonadal (HPG) axis, which increases luteinizing hormone (LH) levels, stimulating the production of testosterone. Research has shown that Eurycoma longifolia can help optimize free testosterone by reducing the binding activity of sex hormone-binding globulin (SHBG), making more testosterone biologically available. Studies also suggest benefits for stress reduction by lowering cortisol levels, creating a favorable hormonal balance for improved energy, muscle strength, libido, and endurance. Furthermore, its antioxidant properties protect cells from oxidative damage, supporting reproductive health and mitigating age-related declines in testosterone. Eurycoma longifolia extract (100:1) is a clinically supported natural solution for promoting hormonal balance, enhancing physical performance, and improving overall vitality.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eWankhede, S., Mohan, V., \u0026amp; Thakurdesai, P. (2016). Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study. Journal of sport and health science, 5(2), 176–182. https:\/\/doi.org\/10.1016\/j.jshs.2014.09.005\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eMansoori, A., Hosseini, S., Zilaee, M., Hormoznejad, R., \u0026amp; Fathi, M. (2020). Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials. Phytotherapy research : PTR, 34(7), 1550–1555. https:\/\/doi.org\/10.1002\/ptr.6627\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSmith, S. J., Lopresti, A. L., Teo, S. Y. M., \u0026amp; Fairchild, T. J. (2021). Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review. Advances in nutrition (Bethesda, Md.), 12(3), 744–765. https:\/\/doi.org\/10.1093\/advances\/nmaa134\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChauhan, N. S., Sharma, V., Dixit, V. K., \u0026amp; Thakur, M. (2014). A review on plants used for improvement of sexual performance and virility. BioMed research international, 2014, 868062. https:\/\/doi.org\/10.1155\/2014\/868062\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eZhang, W. W., Feng, Z., \u0026amp; Narod, S. A. (2014). Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia. Journal of biomedical research, 28(5), 339–348. https:\/\/doi.org\/10.7555\/JBR.28.20140008\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ePlant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells * Le, Hien T. et al. Journal of Biological Chemistry, Volume 278, Issue 23, 21136 – 21145\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSepkovic DW. Bradlow HL. Bell M. Quantitative determination of 3,3′-diindolylmethane in the urine of individuals receiving indole-3-carbinol. Nutr Cancer. 2002;41:57–63.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eLi Y. Wang Z. Kong D. Murthy S. Dou QP. Sheng S. Reddy GP. Sarkar FH. Regulation of FOXO3a\/βcatenin\/GSK-3β signaling by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem. 2007;282:21542 21550.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eRahman KM. Ali S. Aboukameel A. Sarkar SH. Wang Z. Philip PA. Sakr WA. Raz A. Inactivation of NF-κB by 3,3′-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. Mol Cancer Ther. 2007;6:2757–2765.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eModi KP, Patel NM, Goyal RK. Estimation of L-dopa from Mucuna pruriens LINN and formulations containing M. pruriens by HPTLC method. Chem Pharm Bull (Tokyo). 2008 Mar;56(3):357-9.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChauhan, N. S., Sharma, V., Dixit, V. K., \u0026amp; Thakur, M. (2014). A review on plants used for improvement of sexual performance and virility. BioMed research international, 2014, 868062. https:\/\/doi.org\/10.1155\/2014\/868062\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eShukla, K. K., Mahdi, A. A., Ahmad, M. K., Jaiswar, S. P., Shankwar, S. N., \u0026amp; Tiwari, S. C. (2010). Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men. Evidence-based complementary and alternative medicine : eCAM, 7(1), 137–144. https:\/\/doi.org\/10.1093\/ecam\/nem171\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eShukla, K. K., Mahdi, A. A., Ahmad, M. K., Shankhwar, S. N., Rajender, S., \u0026amp; Jaiswar, S. P. (2010). Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertility and Sterility, 93(3), 649–660.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSharma, V., Thakur, M., Chauhan, N. S., \u0026amp; Dixit, V. K. (2011). Effect of Anacyclus pyrethrum DC. on sexual behavior and spermatogenesis in male rats. Journal of Ethnopharmacology, 133(3), 901–906.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSharma, V., Boonen, J., Spiegeleer, B. D., \u0026amp; Dixit, V. K. (2013). Androgenic and spermatogenic activity of alkylamide-rich ethanol solution extract of Anacyclus pyrethrum DC. Phytotherapy research : PTR, 27(1), 99–106. https:\/\/doi.org\/10.1002\/ptr.4697\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ePradhan, N. R., Mishra, K. G., Patnaik, N., \u0026amp; Nayak, R. (2021). Evaluation of effects of Spilanthes acmella extract on muscle mass and sexual potency in males: A population-based study. Journal of family medicine and primary care, 10(11), 4242–4246. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_746_21\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eLeisegang, K., Finelli, R., Sikka, S. C., \u0026amp; Panner Selvam, M. K. (2022). Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina (Kaunas, Lithuania), 58(8), 1047. https:\/\/doi.org\/10.3390\/medicina58081047\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eLeitão, A. E., Vieira, M. C. S., Pelegrini, A., da Silva, E. L., \u0026amp; Guimarães, A. C. A. (2021). A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM). Maturitas, 145, 78–85. https:\/\/doi.org\/10.1016\/j.maturitas.2020.12.002\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChan, K. Q., Stewart, C., Chester, N., Hamzah, S. H., \u0026amp; Yusof, A. (2021). The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males. Andrologia, 53(4), e14001. https:\/\/doi.org\/10.1111\/and.14001\u003c\/i\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45146031784112,"sku":"ML850057789508","price":49.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Picture1.png?v=1780773656"},{"product_id":"stars-pipes","title":"'Merica Labz Stars \u0026 Pipes","description":"\u003cul\u003e\n\u003cli\u003eEnhanced Blood Flow†\u003c\/li\u003e\n\u003cli\u003eIncreased Muscle Power Output†\u003c\/li\u003e\n\u003cli\u003eIncreased Muscular Endurance†\u003c\/li\u003e\n\u003cli\u003e100% 'Merican!†\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cb\u003eL-Citrulline\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eCitrulline is a non-essential, non-protein amino acid that forms during the urea cycle and forms ornithine when combined with carbon dioxide. Citrulline is also a critical source of endogenous (natural) arginine, as it is rapidly and efficiently converted to arginine in the vascular endothelium and other tissues.\u003c\/p\u003e\n\n\u003cp\u003eCitrulline’s benefits have been shown to be greater than its parent compound. While arginine undergoes direct hepatic (liver) metabolism through the enzyme arginase, citrulline bypasses hepatic metabolism entirely and it is delivered straight to the bloodstream. The result is that gut absorption and plasma (blood) bioavailability studies comparing citrulline and arginine have shown two things. First, citrulline is less readily destroyed and has greater absorption than arginine. Second, citrulline supplementation increases arginine levels more effectively than arginine supplementation itself.\u003c\/p\u003e\n\n\u003cp\u003eThis translates to promising results. For example, animal studies show a significant increase in anaerobic performance at a 250mg\/kg\/day serving of citrulline, while studies in humans implicate citrulline in both aerobic and anaerobic performance increases. As a critical part of the urea cycle, citrulline’s performance benefits are thought to be a result of its role in ammonia clearance. Citrulline is implicated in reducing the oxygen cost of muscle processes, along with increasing the rate of post-exercise ATP and phosphocreatine replenishment. As ATP and phosphocreatine are the body’s ‘exercise fuel, this may result in citrulline delaying time to exhaustion in aerobic and anaerobic exercise.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eHydroPrime® (65% Glycerol Powder)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eGlycerol is a fascinating and highly useful compound that has achieved a somewhat cult status in the fitness community – while both peer-reviewed research and anecdotal reports centered on the endurance functions of glycerol are plentiful, its bodybuilding applications are not as widely lauded. Those who do use glycerol, however, are persistent in their belief that it provides some of the most noticeable, and effective, engorging (“pump”) effects possible.\u003c\/p\u003e\n\n\u003cp\u003eGlycerol has been well-established as a so-called, “hyperhydrating agent” because of its ability to affect plasma (blood) osmolality potently and positively. As an incredibly powerful osmotic agent, and when combined with large quantities of water, glycerol induces the intracellular retention of fluid (not the extracellular kind, you do not want) that would otherwise be renally excreted. Various research has shown that glycerol’s capacity to positively affect osmolality and expand fluid volume (an increase in total body water) has beneficial effects on performance and physiological function.\u003c\/p\u003e\n\n\u003cp\u003eStudies that administered glycerol before both moderate and high endurance fitness tests found that glycerol reduced increases to core temperature, caused athletes to exercise significantly longer before fatigue, reduced urinary elimination of water and increased total body water content, and, in several studies, significantly improved intramuscular water expansion. In less complex terms, this means glycerol has been demonstrated to keep your muscles hydrated, significantly increase the ever desired, “pump effect” of muscle engorgement, and, maybe most importantly when it comes to a supplement formulation, deliver and keep more nutrients where they are needed (inside the muscle).\u003c\/p\u003e\n\n\u003cp\u003eUntil recently, however, most of these studies noted a significant drawback: the low glycerol concentration of market-available glycerol products forced researchers to test glycerol loads that were significantly higher than average use cases. STARS \u0026amp; PIPES uses HydroPrime® to overcome precisely this problem.\u003c\/p\u003e\n\n\u003cp\u003eHydroPrime®, from NNB Nutrition, is a highly concentrated (65%) form of glycerol that offers greater water stability, and therefore potency, as compared to standard GMS (glycerol monostearate). Of particular interest to bodybuilders, HydroPrime®’s greater potency translates to even greater levels of intramuscular water retention – keyword, intramuscular, and therefore no bloat – over GMS.\u003c\/p\u003e\n\n\u003cp\u003eOverall, supplementation with HydroPrime® has been shown to:\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003eKeep athletes hyperhydrated for extended periods of time.\u003c\/li\u003e\n\u003cli\u003eReduce post-workout urine volume (more efficient fluid use).\u003c\/li\u003e\n\u003cli\u003eLower heart rate and improve endurance time.\u003c\/li\u003e\n\u003cli\u003eEnhance plasma and intramuscular volume expansion.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cb\u003ePeakATP® (Adenosine 5’Triphosphate Disodium)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eAdenosine 5’-triphosphate (ATP) is the single most important molecule for our body’s cells. Every single cell in the human uses ATP as its primary source of energy for processes such as ion transport, muscle contraction, nerve impulse propagation, DNA\/RNA synthesis, and chemical reactions withing the body. Our body stores ATP and can produce ATP through the presence of oxygen from cellular respiration, the breakdown of foods ingested, as well as under certain anerobic conditions. Maintaining high levels of ATP is essential to continuously perform at optimal levels both in a physical and physiological way. This is important because it’s not just about ATP availability, but the timing and localization of ATP can be essential for the success of multiple physiological and metabolic actions. Knowing this, ingesting forms of ATP have been on the rise recently in the nutraceutical industry. Peak ATP® is a revolutionary innovation as a clinically validated and patented form of adenosine 5’-triphosphate disodium, which is the only nutritional ingredient that has an identical structure to the same ATP produced and utilized by the human body. Now for the common individual, ATP supplementation may not pose much of a benefit as their typical daily life and nutrition is likely sufficient, but for the individual engaged in heavy and intense physical activity and exercise the demand for ATP and useable energy at the ready is essential to performance and continuing to perform at a high level as well as recovering optimally. The demand for ATP in these cases can be increased up to 1000-fold during exercise and the rate at which ATP is broken down can limit performance.\u003c\/p\u003e\n\n\u003cp\u003ePeak ATP® helps to provide this readily available form of ATP as a highly bioavailable form of useable energy that potentiates the role of ATP in the human body. In relation to exercise, this equates to allowing for the potential of athletes to do more and achieve more, with much less fatigue. Peak ATP® also has been shown to benefit athletic performance through enhancements in:\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003eVasodilation and increasing blood flow by up to 54%.\u003c\/li\u003e\n\u003cli\u003eCalcium metabolism in muscle, which is essential for muscle contractions\u003c\/li\u003e\n\u003cli\u003eERK-mTOR pathway, which is the pathway that promotes protein synthesis and muscle hypertrophy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eIt’s a known subject that ATP is essential to the human body and its processes and maintaining high levels is of the utmost importance for optimal functioning. During increased energy needs these ATP pools naturally in the body can be depleted rather quickly, leading to less-than-optimal functioning and overall resulting factors. Peak ATP® has been shown to stimulate greater ATP production, decrease declines in ATP pools, and allow for greater energy usage potential. Peak ATP® can allow anyone to get more out of their body by providing the needed energy to perform at a high level.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eAstraGin® (\u003ci\u003eAstragalus membranaceous\u003c\/i\u003e and \u003ci\u003ePanax notoginseng\u003c\/i\u003e) Root Extracts\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eAstraGin® is a trademarked combination of \u003ci\u003eAstragalus membranaceous\u003c\/i\u003e and \u003ci\u003ePanax notoginseng\u003c\/i\u003e that has been widely used in the supplement manufacturing industry due to its clinically studied benefits for improving absorption of nutrients, peptides, and amino acids. Some statistics include increased absorption of creatine, leucine, citrulline, and other peptides by up to 67%, increased curcumin absorption by 92%, increases polyunsaturated fatty acids (from flax and fish oil) by 58% and 100% respectively, as well as can increase ATP production in the liver by 18%. AstraGin® has been shown capable of increasing muscle protein synthesis and increased mTOR through enhanced leucine absorption, which has an influence on improved glucose metabolism and mitochondrial functions. In addition to this benefit, AstraGin’s® ability to enhance polyunsaturated fatty acid absorption while also inhibiting saturated fatty acid absorption, thus reducing the risk of impaired glucose metabolism and mitochondrial function, can enhance ATP synthesis through mitochondrial respiration, and increase oxidative phosphorylation.\u003c\/p\u003e\n\n\u003cp\u003eIt has been further studied how \u003ci\u003eAstragalus\u003c\/i\u003e and \u003ci\u003ePanax notoginseng\u003c\/i\u003e specifically can protect mitochondria and enhance their function towards anti-aging. The proposed mechanism leads to \u003ci\u003eAstragalus\u003c\/i\u003e acting as a free radical scavenger, which can inhibit mitochondrial permeability transition and increase the activity of antioxidants against the peroxidation of membrane lipids. \u003ci\u003ePanax notoginseng\u003c\/i\u003e also works in a similar fashion through decreased free radical production. This lipid peroxidation has been shown to be a major cause of decreases in mitochondrial function. In addition to this, ensuring a highly permeable environment around the mitochondrial membrane is crucial for maintaining mitochondrial functions. This permeability allows for the passage of key electro chemicals to cross the gradient allowing for the process of energy development for the cells.\u003c\/p\u003e\n\n\u003cp\u003e\u003ci\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnore, treat, cure, or prevent any diseases.\u003c\/i\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"New Found Freedom  (Fruity Popsicle)","offer_id":45146116751536,"sku":"ML850057789133","price":39.99,"currency_code":"USD","in_stock":true},{"title":"Cherry Bootlegger","offer_id":45146116784304,"sku":"ML850057789126","price":39.99,"currency_code":"USD","in_stock":true},{"title":"Sour Apple Rebellion","offer_id":45146116817072,"sku":"ML850057789157","price":39.99,"currency_code":"USD","in_stock":true},{"title":"Teddy's Grape Melons","offer_id":45146116849840,"sku":"ML850057789164","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/STARS_PIPES_Teddy_s_Grape_Melons_FRONT.png?v=1780774181"},{"product_id":"f-tyranny","title":"'Merica Labz F-Tyranny","description":"\u003cul\u003e\n\u003cli\u003eBig D Energy†\u003c\/li\u003e\n\u003cli\u003eFuel The Rebellion†\u003c\/li\u003e\n\u003cli\u003eExplosive Pumps†\u003c\/li\u003e\n\u003cli\u003ePatriotic Power†\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eF Tyranny – Zero F#CK$ Given Pre-workout delivers a clinically charged blend of high-performance ingredients to help you conquer workouts with zero compromise. This pre-workout starts strong with L-Citrulline and Beta-Alanine, both powerful titans for endurance and performance. Citrulline can boost blood flow and ATP regeneration while flushing out fatigue-inducing ammonia, while beta-Alanine fuels carnosine synthesis, buffering lactic acid buildup in muscles to extend endurance and delay exhaustion—perfect for high-intensity, muscle-taxing sessions.\u003c\/p\u003e\n\n\u003cp\u003eTo sharpen your mental edge and amplify motivation, the tyranny fighting formula includes L-Tyrosine, Alpha-GPC, and Huperzine A, a synergistic trio for focus, neurotransmitter support, and memory enhancement. For relentless energy, Caffeine Anhydrous, Caffeine Citrate, and Dynamine™ team up for a fast-acting, sustained stimulant experience without the crash. Dynamine™ in particular adds a rapid mood and motivation boost with minimal cardiovascular strain.\u003c\/p\u003e\n\n\u003cp\u003e\u003ci\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnosis, treat, cure, or prevent any diseases.\u003c\/i\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Lychee Peach","offer_id":45146209222832,"sku":"ML850057789683","price":39.99,"currency_code":"USD","in_stock":true},{"title":"Strawberry Lemonade","offer_id":45146209255600,"sku":"ML850057789690","price":39.99,"currency_code":"USD","in_stock":true},{"title":"Dragonfruit Blueberry","offer_id":45146209288368,"sku":"ML850057789676","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/FTYRANNYFRONT.png?v=1780774747"},{"product_id":"red-white-boom","title":"'Merica Labz Red, White, \u0026 Boom","description":"\u003cul\u003e\n\u003cli\u003eIncreased muscle pumps and exercise performance.†\u003c\/li\u003e\n\u003cli\u003eIntense focus throughout your workout.†\u003c\/li\u003e\n\u003cli\u003eConsistent and sustained energy.†\u003c\/li\u003e\n\u003cli\u003e100% 'Merican!†\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cb\u003e3DPUMP Breakthrough® [L-Citrulline (Vegan Fermented) (3000mg), Glycerol, Amla (Phyllanthus emblica) Fruit Extract]\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003e3DPUMP Breakthrough® is a revolutionary new ingredient that is a patented combination of Fermented L-Citrulline, Glycerol (high yield), and a standardized extract of Amla Fruit. This ingredient supports increase vasodilation to the target muscle as well as improved endurance during training by utilizing complimentary pathways of action. If we break down each of these ingredients individually, we can begin to understand what makes this unique combination so beneficial.\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003eL-Citrulline - amino acid that converts to arginine and supports nitric oxide production, which aids blood flow and increase muscle pumps. Citrulline has also been shown to enhance exercise performance (particularly in resistance training protocols), boost power, reduce the onset of fatigue, and aid recovery.\u003c\/li\u003e\n\n\u003cli\u003eGlycerol - another common inclusion in pre workout supplements that serves as an osmolyte, which means it encourages muscle cells to attract and absorb more water. This increases cell volumization and cellular swelling, which not only enhances the pump but gives a full look to your muscles.\u003c\/li\u003e\n\n\u003cli\u003eAmla - has a long history of use in Indian medicine as a cardiotonic. It’s high in polyphenols and flavonoids (including pedunculagin, puniglucanin, emblicanin A, and emblicanin B) that are known to possess antioxidant activity and support cardiovascular health.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eIt’s common to find L-Citrulline and Glycerol amongst other nitric oxide and pump inducing ingredients with a track record of efficacy but the real question is if the addition of Amla enhances the experience. Studies have shown that this answer is undoubtedly yes! One study measured cell volumization and muscle swelling because of performing lower body exercises using multiple interventions, which included placebo, 1500mg glycerol, 150mg Amla, and 1350mg glycerol + 150mg Amla. The results showed that all interventions, including placebo, produced positive results on leg size and lean body mass, however, the glycerol + Amla produced significantly better results than the other interventions. The glycerol + Amla group increased their thigh circumference by 2.21 cm on average and had an increase of 693.1 grams in total body mass. These results make the combination of adding Amla to the already classic benefits of L-Citrulline and Glycerol extremely promising when it comes to making positive improves in your goals when it comes to sport performance products.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eCreatine Monohydrate\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eSometimes called the “grandfather” of dietary supplements, creatine is, along with caffeine, one of the most extensively studied dietary compounds. Certainly, it is the most well-studied ergogenic aid. Generally speaking, the extensive amount of data on creatine demonstrates that it positively contributes to dilation of the vasculature, plasma-nutrient mobilization, post-workout nitrogen retention and protein synthesis, along with dose-dependently increasing contractile force through ATP (adenosine triphosphate) provision (i.e., it helps support increased strength).\u003c\/p\u003e\n\n\u003cp\u003eIf the human body could be considered a bank account, then ATP would be the currency, and every cellular process would be like spending a little money from that account. Without making a deposit, the account runs dry (fatigue). Unfortunately, making a direct deposit to that account in the form of exogenous adenosine triphosphate is impossible, given that ATP itself is incredibly unstable. The use of supplemental creatine, however, is analogous to making a deposit in the body’s energy bank, given that creatine is eventually metabolized to ATP via several steps. In skeletal muscle, creatine is first phosphorylated into its primary derivative, known as phosphocreatine (PCr), by the muscle-specific creatine kinase, creatine kinase-MB (muscle-brain). Following the phosphorylation of creatine, phosphocreatine may then anaerobically donate a phosphate molecule to adenosine diphosphate (ADP) to form the ATP required during the initial stages of intense muscular contraction. The result is not only an increase in contractile force, but also an increase in potential type IIx (‘fast-twitch’) muscle recruitment – the type of muscle fibers which are not only traditionally associated with speed, strength, and impressive physiques, but which are also unsurprisingly the most energy-demanding fiber types. Literally speaking, creatine contributes to the building of muscle.\u003c\/p\u003e\n\n\u003cp\u003eBoth through the ATP provision just described, as well as effects on nutrient mobilization, protein-sparing, and fluid dynamics, creatine has been consistently demonstrated to increase both lean mass and muscle mass in clinical data. In the short-term, these effects are most likely the result of extra-cellular fluid retention normally associated with exogenous creatine use. In the long term, these effects are likely attributable to creatine’s collective effect on muscle metabolism. The most recent research on creatine suggests it exerts direct effects on muscle metabolism, including altering the expression of genes responsible for ribosomal assembly, attenuating the breakdown of leucine, and most famously, by expanding cell volume. Cutting through the jargon, let us just say that the amount of creatine monohydrate contained in Red, White, and Boom simply works: these servings have been shown time and again to significantly increase lean body mass and muscle volume, lower fatigue, and improve performance (measured in several ways).\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eBeta Alanine\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eCarnosine is a bit of an odd duck: we know that it is crucial for muscle function, and that dietary sources of caronsine are essential, but we don’t know precisely how it’s working. Moreover, for decades, we had no idea how to increase intramuscular concentrations, as exogenous carnosine sources degraded in the body so fast as to be effectively useless.\u003c\/p\u003e\n\n\u003cp\u003eEnter beta-alanine. Simply a different iteration of one of the amino acids that comprises carnosine itself (alanine), beta-alanine has proven to be the most effective means of significantly increasing intramuscular concentrations of carnosine – and therefore of promoting all of carnosine’s various beneficial effects on muscle performance. If that weren’t enough, beta-alanine has also demonstrated beneficial physiological effects independent of its parent compound. In order to understand why, though, we need to first understand some of the basics behind carnosine itself.\u003c\/p\u003e\n\n\u003cp\u003eCarnosine, a cytoplasmic dipeptide synthesized from the precursors L-histidine and l-alanine, is present in high concentrations in skeletal muscle and plays a pivotal role as a, “chemical buffer” in myocytes (muscle cells). It has long been known that carnosine concentrations are highest in glycolytic, rather than oxidative muscle fibers (roughly speaking, explosive vs., endurance muscle fibers, respectively), and thus long hypothesized that this amino acid is required for sustained performance during supramaximal exercise. Recent research demonstrates that carnosine exerts its physiological effects in long hypoxic (low oxygen) drives by functioning as a high-capacity pH buffer in skeletal muscle, preventing the pH ratio of plasma from dropping too low – and therefore preventing crucial pH-dependent processes such as protein synthesis from being inhibited by acidosis.\u003c\/p\u003e\n\n\u003cp\u003eDespite its critical role in skeletal muscle anaerobic performance, intramyocellular synthesis of carnosine is rate-limited by the availability of l-alanine. Unfortunately, the majority of literature demonstrates that attempting to increase intramuscular levels of carnosine via either direct carnosine or alanine supplementation is largely ineffective due to carnosine\/alanine pharmacokinetics. Enter beta-alanine. Research with beta-alanine demonstrates consistent and dose-dependent increases to intramuscular carnosine concentrations with beta-alanine supplementation, with certain studies showing an increase of 40-60% with chronic administration. These same literature reveal a synergistic effect of exercise on beta-alanine supplementation, whereby the muscle adaptive changes associated with resistance training promote further intramuscular carnosine production in response to beta-alanine supplementation.\u003c\/p\u003e\n\n\u003cp\u003eIn simpler language, this essentially means that beta-alanine is a dietary supplement that promotes its own effects in combination with exercise. As you exercise, you simultaneously intensify beta-alanine’s physiological actions – both directly, as well as in the production of intramuscular carnosine. Once ingested, beta-alanine’s exercise-specific beneficial activity is well-established. Elevation of intramuscular caronsine content via beta-alanine supplementation has been shown to improve performance in the following ways.\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003eBoth acute and chronic increases in total work capacity, measured by total volume during exercise sessions.\u003c\/li\u003e\n\n\u003cli\u003eHighly significant increases to TTE (total time to exhaustion), one of the most accurate and comprehensive measures of endurance. In various trials, beta-alanine supplementation has been shown to increase TTE by upwards of 20%.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eIncreases to total muscle power output in both acute and chronic trials, suggesting that beta-alanine’s most significant benefit is to those engaging in power-dependent resistance training.\u003c\/p\u003e\n\n\u003cp\u003eIn total, a significant body of research exists to suggest that beta-alanine may significantly increase muscle power output, strength, training volume and output, overall performance in hypoxic (oxygen-deprived) conditions and peak VO2 max (oxygen holding capacity).\u003c\/p\u003e\n\n\u003cp\u003eThese myriad benefits make beta-alanine both one of the most-studied, and most well-rounded dietary supplements. Beta-alanine not only has direct, actionable physiological effects, but also promotes critical muscle physiologic adaptations that promote its own effects.\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eArginine Nitrate (as NO3-T®)\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eNitric oxide (NO) is involved in many vascular and cellular functions as a signaling molecule for cellular respiration, vasodilation, and angiogenesis. NO is produced through both endogenous and exogenous pathways through dietary nitrate ingestion. Nitrates are converted to nitrite, which is then converted to nitric oxide. Found naturally in many foods such as leafy greens and beets, NO has a long history of scientific literature to back its potential effects as an ergogenic aid and other health-promoting effects. In terms of athletic performance, NO typically will make an impact through a few different mechanisms, such as:\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003eDelayed onset of fatigue\u003c\/li\u003e\n\u003cli\u003eIncreased nutrient and oxygen delivery to working muscles via increased vasodilation\u003c\/li\u003e\n\u003cli\u003eIncreased loss of metabolic by-products because of high intense exercise\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eHowever, when it comes to exercise and utilizing NO for its benefits in athletic performance, consuming whole foods is not always the most optimal form, so dietary supplemental forms of nitrates are often used to help provide this benefit.\u003c\/p\u003e\n\n\u003cp\u003e\u003ci\u003eContent continues unchanged through the remainder of the document.\u003c\/i\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003ci\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnore, treat, cure, or prevent any diseases.\u003c\/i\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Cherry Bootlegger","offer_id":45146237141168,"sku":"ML850051031924","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Newfound Freedom (Fruity Popsicle)","offer_id":45146237173936,"sku":"ML850051031931","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Teddy's Grape Melons","offer_id":45146237206704,"sku":"ML850051031962","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Make America Grape Again","offer_id":45146237239472,"sku":"ML850051031979","price":49.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/RED_WHITE_BOOM_Cherry_Bootlegger_FRONT.png?v=1780775092"},{"product_id":"organ-defender","title":"'Merica Labz Organ Defender","description":"\u003cul\u003e\n\u003cli\u003eTotal Organ Defense𐠒\u003c\/li\u003e\n\u003cli\u003eComplete Antioxidant Support†\u003c\/li\u003e\n\u003cli\u003eGut-Driven Immunity†\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eYour liver, heart, kidneys, and gut work hard every single day—so it’s time to give them the defense treatment that’s as strong as RFK’s grit and resilience. Organ Defender teams ingredients like NAC, milk thistle, CoQ10, and probiotics up to fight toxins, stress, and last night’s bad decisions. One scoop and your liver detoxes like it’s exposing corruption, your heart pumps with patriotic pride, your kidneys filter like a government cover-up, and your gut stays balanced enough to negotiate world peace. Your organs deserve a product with no fillers and no nonsense—so armor up and prepare to defend them! #MAHA\u003c\/p\u003e\n\u003cp\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eVitamin C (as Ascorbic Acid)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain. In contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in \u003ci\u003ein vitro\u003c\/i\u003e trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eIodine (as Kelp (Ascophyllum Nodosum))\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for proper cognitive development in the child. As implied, however, the most important of iodine’s functions is assisting the body’s production and maintenance of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine\/epinephrine, largely determine the body’s metabolic rate.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences\u003c\/b\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45146238353584,"sku":"ML850057789669","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Organ_Defender_FRONT.png?v=1780775454"},{"product_id":"first-blood-mango-mayhem","title":"'Merica Labz First Blood Mango Mayhem","description":"\u003cp\u003eFirst Blood: Mango Mayhem is the savage lovechild of ‘Merica and Panda Supps—two industry titans that don’t skip leg day or play by the rules. This limited-edition pre-workout kicks in like a mango-scented napalm strike, delivering explosive energy, skin-splitting pumps, and laser-like focus. The flavor? A juicy, ruthless fusion of peaches and mango that tastes like tropical warfare fighting on your tastebuds. If your current pre is soft and bitter, it’s time to upgrade to some new ammunition. First Blood doesn’t ask for permission, it invades your workout, takes no prisoners, and leaves weakness at the door. Mango Mayhem is here to dominate!\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45146240057520,"sku":"ML850057789904","price":59.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/1_447c91fe-2ccd-4f24-a3b1-61a49abd9d4a.png?v=1780775668"},{"product_id":"f-tyranny-sampler-pack","title":"'Merica Labz F-Tyranny Sampler Pack","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBig D Energy†\u003c\/li\u003e\n\u003cli\u003eFuel The Rebellion†\u003c\/li\u003e\n\u003cli\u003eExplosive Pumps†\u003c\/li\u003e\n\u003cli\u003ePatriotic Power†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eF Tyranny – Zero F#CK$ Given Pre-workout delivers a clinically charged blend of high-performance ingredients to help you conquer workouts with zero compromise. This pre-workout starts strong with L-Citrulline and Beta-Alanine, both powerful titans for endurance and performance. Citrulline can boost blood flow and ATP regeneration while flushing out fatigue-inducing ammonia, while beta-Alanine fuels carnosine synthesis, buffering lactic acid buildup in muscles to extend endurance and delay exhaustion—perfect for high-intensity, muscle-taxing sessions.\u003c\/p\u003e\n\u003cp\u003eTo sharpen your mental edge and amplify motivation, the tyranny fighting formula includes L-Tyrosine, Alpha-GPC, and Huperzine A, a synergistic trio for focus, neurotransmitter support, and memory enhancement. For relentless energy, Caffeine Anhydrous, Caffeine Citrate, and Dynamine™ team up for a fast-acting, sustained stimulant experience without the crash. Dynamine™ in particular adds a rapid mood and motivation boost with minimal cardiovascular strain.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnosis, treat, cure, or prevent any diseases.\u003c\/i\u003e\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":45146242187440,"sku":"ML850057789898","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/0001_2.png?v=1780775791"},{"product_id":"cant-cancel-patriotism-shaker","title":"'Merica Labz Can't Cancel Patriotism Shaker","description":"\u003cp\u003eNo snowflakes. No shortcuts. Just hard work baby!\u003c\/p\u003e\n\u003cp\u003eThe 'MERICA LABZ Standard 28oz. Shaker ain’t your average shaker cup — it’s a battle-tested bottle for the boys in the back who lift heavy, work harder, and live louder.\u003c\/p\u003e\n\u003cp\u003eWith its bold 'MERICA LABZ and CAN’T CANCEL PATRIOTISM logos, this shaker screams strength, grit, and freedom! Whether you're tossing back a pre-workout, crushing a mid-set sip, or slamming a post-lift recovery shake, this thing's built to handle it — no leaks, no BS.\u003c\/p\u003e\n\u003cp\u003eIt’s not just about gains — it’s about pride, power, and putting in the work.\u003c\/p\u003e\n\u003cp\u003eFuel your freedom — one scoop at a time. This is the 'MERICA LABZ Standard 28oz. 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