{"title":"National Testosterone Day Promo","description":"","products":[{"product_id":"5-at","title":"5-AT","description":"\u003cp style=\"color: #9c0c30;\"\u003e\u003cstrong\u003eIngredients in this product are not WADA approved. Do not take if you are tested by WADA standards. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e5-Etioallocholen-3b,7b,17b-triol: More commonly known as androstenetriol, 5-etioallocholen-3 beta-7 beta-17beta-triol is a metabolite of the ubiquitous endogenous steroid, dehydroepiandrosterone (DHEA). DHEA is one of the most abundant endogenous steroids in the human body, playing a critical role in a number of bodily functions. These functions include, though are not limited to, serving as an intermediate (a middle piece) in the synthesis of sex steroids such as testosterone and estrogen, up-regulating (increasing) immune response and countering the immunosuppressive actions of corticosteroids, and maybe the most impressive, directly and strongly suppressing the release of cortisol itself!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eThough DHEA’s properties have been well-established and understood for decades, derivatives and metabolites of DHEA have more recently been the subject of research in animals and humans – demonstrating effects that are, at times, many orders of magnitude more significant than the parent compound (up to 100x as potent!).\u003c\/p\u003e\n\u003cp\u003eLike DHEA, cortisol is one of the body’s most abundant and important endogenous steroids. While detailing in full the expansive list of cortisol’s functions is impossible, we can generally say that cortisol’s role in the human body is to break down bodily tissue and nutrients for the purpose of energy provision (to be catabolic), to act as an immunosuppressive, and to regulate blood sugar. Cortisol fulfills these functions by inducing gluconeogenesis (the breakdown of non-glucose intermediates, such as amino acids in muscle tissue, into glucose) and glycogenolysis (the breakdown of glycogen into glucose), inhibiting peripheral glucose utilization, and inhibiting cell lines critical to the body’s immune response.\u003c\/p\u003e\n\u003cp\u003eIn less complex terms, we can simply say that cortisol is responsible for inhibiting many of the processes that we as fitness enthusiasts want to start, and for starting many of the processes that we want to inhibit. Cortisol plays a role in:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePreventing our muscle cells from uptaking glucose (inducing insulin resistance).\u003c\/li\u003e\n\u003cli\u003ePreventing muscle protein synthesis.\u003c\/li\u003e\n\u003cli\u003eThe breakdown of glycogen (the compound responsible for that “full look”).\u003c\/li\u003e\n\u003cli\u003eSuppressing the immune processes involved in muscle growth.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhile these are necessary functions, their overexpression is precisely the opposite of what we want – in fact, certain trials in humans have shown that an increase in plasma cortisol within the physiologic range increases proteolysis (breakdown of proteins) and degrades whole body amino acid synthesis! That is bad, bad news.\u003c\/p\u003e\n\u003cp\u003eEnter DHEA and its metabolite, androstenetriol. In emerging animal literature, both androstenetriol and its metabolites have been shown to possess very potent anti-glucocorticoid activity – remembering that cortisol is the parent compound for this group – and anti-immunosuppressive actions in a number of different tissue types. In fact, androstenetriol is one of the most potent anti-glucocorticoids the body produces – exerting almost unbelievable effects in certain pro-inflammatory cell lines.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-5T.jpg?v=1597908865\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_5-AT_2020_6.25x2.25_FIN-OL.pdf?v=1644226124\"\u003e5-AT Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3426813542429,"sku":"SHOP672975315429","price":34.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/5AT_FRONT.png?v=1760395353"},{"product_id":"core-test","title":"Test","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCalcium D-Aspartic Acid\u003c\/strong\u003e - Supports Health Testosterone Levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Aids in Cortisol Reduction to Help with Body Composition\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBulbine Natalensis\u003c\/strong\u003e - Increase in Overall Vitality\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIf you don’t know your best yet, you’ll certainly know it when Core TEST helps you reach it.\u003c\/p\u003e\n\u003cp\u003eWe’ve scoured the literature and eventually created a formula packed with effective ingredients targeting multiple pathways of healthy testosterone support. This is the best, most comprehensive, multi-pathway testosterone support product on the market.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e1 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eHealthy testosterone support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eBeing at your best, your peak, isn’t a subjective state of mind or a feeling one has – it’s a physiological state, a confluence of metabolic factors that result in the best, most peak, most alpha version of you stepping out into the world and into the gym every day. Are you doing what’s necessary to be there?\u003c\/p\u003e\n\u003cp\u003eIf not, then Core has your back with the newest evolution in healthy testosterone and male support: Core TEST. By now, you already know the drill: we take the best ingredients, backed by clinical research, and include them in serving sizes actually reflected in the literature. Core TEST is no different.\u003c\/p\u003e\n\u003cp\u003eWe’ve scoured the literature, alpha and beta tested more formulas than you can count, and eventually created a formula packed with actually effective ingredients targeting multiple pathways of healthy testosterone support. Calcium DAA, one of the best known support supplements on the market, backed by clinical research in humans. KSM66, an ingredient with a long history of use in traditional medicine now backed by an unimpeachable record of cortisol reduction, healthy testosterone support, and hormone optimization. We could’ve given you KSM66 and left it at that – the ingredient is that good. But we didn’t. We included Bulbine natalensis, Tongkat Ali, and a potent estrogen modulator in Pine extract to cap off the savagery. This is the best, most comprehensive, multi-pathway testostone support product on the market.\u003c\/p\u003e\n\u003cp\u003eAll in all, we have created a formula that you’ll know is working. If you don’t know your best yet, you’ll certainly know it when Core TEST helps you reach it.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium D-Aspartic Acid\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eD-Aspartic Acid, the d isomer form of the amino acid aspartate, is an amino acid that is found naturally in several endocrine glands, including the testes and pituitary. While the correlation between DAA and testosterone production has been clinically documented, research indicates several possible mechanisms for these effects.\u003c\/p\u003e\n\u003cp\u003eIt’s likely that DAA acts as a neuromodulator influencing several pathways that govern the reproductive system, particularly testosterone production. Some studies indicate that DAA’s concentrated presence in the hypothalamus, pituitary, and testes identify this protein as an up-regulator of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), growth hormone (GH), and testosterone. Some studies have found that DAA also stimulates a protein called StAR. StAR is necessary for the cholesterol transport in the cell that is needed for testosterone production. Further, its role in modulating the sexual drive implicates DAA assists nootropic activity, supporting health levels of dopamine and serotonin. Balanced levels of dopamine and serotonin have a range of significant benefits.\u003c\/p\u003e\n\u003cp\u003eThe existing research in human males suggests these mechanisms of action have plausible, real world activity. A six-month trial in average men, for example, saw increases to circulating testosterone of 30-60%. The increase over baseline persisted for the entirety of the trial in certain subjects, suggesting that DAA does not lose its effects over time or with repeated administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal,\u003c\/em\u003e colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant for Core TEST is a study involving KSM66® and testosterone. 46 male patients were treated with KSM66® or placebo for 90 days, with measurements of serum hormone levels taken at the end of the 90 day treatment. The study established that 675mg of KSM66 over 90 days had a statistically significant impact on healthy testosterone production in males, as compared to placebo. The same study also found an increase in healthy production of LH (luteinizing hormone), suggesting that KSM66’s method of action is at the pituitary level.\u003c\/p\u003e\n\u003cp\u003eTo put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eBulbine natalensis\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e (stem) Extract (10:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBulbine natalensis is a herb endemic to Southern African that has historically been used as an aphrodisiac in traditional medicine preparations. Recent animal research has demonstrated that the herb has healthy testosterone supporting effects in rats and may also elicit positive effects on cognition.\u003c\/p\u003e\n\u003cp\u003eWhile Bulbine natalensis’ method of action is not certain, research conducted on rats suggests its testosterone-support functions stem from an increase in LH (luteinizing hormone). Luteinizing hormone is a hormone released by the pituitary gland to signal the Leydig cells in the testes to produce testosterone. The animal trial demonstrating an increase in LH also demonstrated an increase in rat testosterone levels at 14 days. The study revealed an increase in circulating testosterone of 40%.\u003c\/p\u003e\n\u003cp\u003eIn these same trials, an aqueous extract of the herb was found to dose-dependently lower estrogen levels in male rats. Research has not established whether the estrogen-lowering effects of Bulbine natalensis are a cause or consequence of its ability to support healthy testosterone levels.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eEurycoma longifolia\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e (root) Extract (100:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe name \u003cem\u003eEurycoma longifolia \u003c\/em\u003eis probably familiar to most within the bodybuilding and fitness community, as it has a long history of use as an aphrodisiac supplement. Also known as Tongkat Ali, Malaysian Ginsgeng, and Longjack, the herb is found in temperate regions of SouthEast Asia and has been used for centuries as an aphrodisiac in medicinal systems local to those regions.\u003c\/p\u003e\n\u003cp\u003eWestern research has begun to establish that \u003cem\u003eEurycoma longifolia’s \u003c\/em\u003edoes in fact have an effect on libido, at least in animal trials. Trials in rats have demonstrated Tongkat Ali increased measures of sexuality (mounting frequency, latency to ejaculation and partner selection), while \u003cem\u003ein vitro \u003c\/em\u003eassays have identified pro-erectile bioactive compounds.\u003c\/p\u003e\n\u003cp\u003eThough more research is required to establish Tongkat’s aphrodisiac and\/or pro-erectile effects in humans, the existing animal research is fairly consistent in suggesting the herb’s effects in these areas.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePine Extract (rosin) (97% abieta-8,11,13-trien-18-oic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAbieta-8,11,13-trien-18-oic acid, more commonly known as Dehydroabietc acid or DHAA, is a terprene compound isolated from several plants and trees, including certain species of Pine. Certain assays have also isolated DHAA from resin of \u003cem\u003eCommiphora myrrha.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eWhile limited in amount, the research that exists on DHAA is promising. Prior to discussing this research, it may be useful to explain the research term IC50. IC50 is a measurement in estrogenic assays that describes the amount of a given aromatase-inhibiting compound needed to reduce half (or 50%) of the aromatase enzyme. The aromatase enzyme, in turn, is the enzyme responsible for converting testosterone to estrogen. The prescription drug Formestane, for example, has an IC50 value of 0.6 mu – with a lower value indicating a more potent compound. (The less compound needed to reduce aromatase by 50%, the more powerful it is).\u003c\/p\u003e\n\u003cp\u003eDHAA’s IC50 value – according to the available research – is 0.3 mu, suggesting that it has potent activity against the aromatase enzyme. While the research exhibiting DHAA’s precise IC50 value is \u003cem\u003ein vitro\u003c\/em\u003e, animal research does exist to suggest a practical, real-world effect. Agricultural studies in fish examining DHAA as an environmental factor suggest that DHAA \u003cem\u003esignificantly \u003c\/em\u003eand level-dependently reduces circulating estrogen in certain fish species.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-TEST-2020.jpg?v=1597301883\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_TEST_2020_PRIMAL_PUNCH_FIN-OL.pdf?v=1639562855\"\u003ePrimal Punch Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_TEST_2020_PRIMAL_BLACK_LIGHTNING_FIN-OL_compressed_1.pdf?v=1639562730\"\u003eBlack Lightning Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-TEST-Product-References.pdf?12965010941871190252\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Primal Punch","offer_id":32075154587763,"sku":"SHOP672975315023","price":56.99,"currency_code":"USD","in_stock":true},{"title":"Black Lightning","offer_id":32075154620531,"sku":"SHOP672975315030","price":56.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TEST_BL_Front-1.png?v=1757596231"},{"product_id":"core-alpha","title":"Alpha","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eN-methyl-D-aspartic acid (NMDA)\u003c\/strong\u003e - Supports healthy testosterone levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e3-desoxy, 7-keto-DHEA\u003c\/strong\u003e - Supports healthy estrogen levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eColeus forskohli root extract\u003c\/strong\u003e - Assists in healthy weight management\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"color: #9c0c30;\"\u003e\u003cstrong\u003eIngredients in this product are not WADA approved. Do not take if you are tested by WADA standards. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eUnleash your inner ALPHA male with the ultra-potent Core ALPHA!\u003c\/p\u003e\n\u003cp\u003eCore ALPHA is an all-natural, innovative product featuring ingredients backed by numerous clinical studies. Core ALPHA’s ingredients are all-natural and powerful, providing a safe and effective way to support healthy hormone function and balance.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e2 capsules per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eHormone balance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCore Nutritionals has been known to produce some of the best healthy hormone support supplements on the market. Our extensive in-house research and multiple blood analyses utilizing our own formulations have indicated significant improvements in all studied metrics over an 8-week trial period. Core Nutritionals natural hormone support arsenal includes products to help you manage and adapt to stresses, support healthy testosterone, as well as improve overall quality of life. To add to that arsenal, Core Nutritionals is proud to present to you Core ALPHA!\u003c\/p\u003e\n\u003cp\u003eCore ALPHA is an all-natural, innovative product featuring ingredients backed by numerous clinical studies. Core ALPHA’s ingredients are not only all-natural but powerful – providing a range of ingredients to support healthy hormone function and balance. As with all Core Nutritionals’ products, Core ALPHA’s ingredients are included in a non-proprietary blend featuring clinical servings, so you know exactly what you are supplementing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eUnleash your inner ALPHA male with the ultra-potent Core ALPHA!\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eScientific breakdown:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-methyl-D-aspartic acid (NMDA):\u003c\/strong\u003e D-aspartic acid (DAA) is an amino acid that is found naturally in several endocrine glands, including the testes and pituitary. While the correlation between DAA and testosterone production has been clinically documented, research indicates several possible mechanisms for these effects. It’s likely that DAA acts as a neuromodulator influencing several pathways that govern the reproductive system, particularly testosterone production. Some studies indicate that DAA’s concentrated presence in the hypothalamus, pituitary, and testes identify this protein as an up-regulator of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), growth hormone (GH), and testosterone. Some studies have found that DAA also stimulates a protein called StAR. StAR is necessary for the cholesterol transport in the cell that is needed for testosterone production. Further, its role in modulating the sexual drive implicates DAA assists nootropic activity, supporting healthy levels of dopamine and serotonin. Balanced levels of dopamine and serotonin have a range of significant benefits.\u003c\/p\u003e\n\u003cp\u003eTo improve on D-aspartic acid we have instead incorporated N-methyl-D-aspartate (NDMA) into the Core ALPHA formula. DAA is converted into NMDA, which is a potent stimulator of the N-methyl-D-aspartate receptor pathway. By directly stimulating this pathway, NMDA is needed only in small doses unlike DAA’s higher dose requirements. In fact, NMDA elicits its hormone releasing action at concentrations approximately 100-fold lower than DAA. Thus, at a 30 mg dose, NMDA, shows promise to support an optimal balance of hormones.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBrassaiopsis glomerulata leaf extract (10:1):\u003c\/strong\u003e Brassaiopsis glomerulata is a large shrub of the Araliaceae family that occurs in south and Southeast Asia. Throughout Asia, this plant is used to treat rheumatism and back pain, aid in digestion, and treat bone fractures in traditional medicinal systems (TMS). Despite its many medicinal uses, the most interesting aspect of the leaves of Brassaiopsis glomerulata is their ability to reduce the activity of aromatase. Studies show that multiple components of a Brassaiopsis glomerulata leaf extract are capable of aromatase inhibition. The addition of this 10:1 extract in Core ALPHA, along with the 3D7K, gives this product a one-two punch at supporting a healthy estrogen balance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMucuna pruriens seed extract (50% L-dopa):\u003c\/strong\u003e Mucuna pruriens is one of the popular medicinal plants of India and is known to contain various beneficial nutritional compounds. The main nutrient found in Mucuna pruriens is L-dopa, which acts as a natural source of dopamine. Prolactin is a hormone released by the pituitary gland, which is believed to exert anti-androgenic effects in men.. Mucuna pruriens’ ability to support healthy dopamine levels may significantly reduce the release of prolactin hormone by the pituitary glands offering powerful benefits. In addition, clinical evidence suggests that Mucuna pruriens not only supports healthy growth hormone levels but also contains naturally occurring serotonin precursors to support mood, memory, and overall well-being. Clinically shown to support optimal balance of growth hormone, prolactin, serotonin and other beneficial hormones, Mucuna pruriens may also assist healthy weight management and stress support.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (cholecalciferol):\u003c\/strong\u003e Vitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, , support for immune and blood pressure health, lean body mass, and weight management). Clinical trials have even linked Vitamin D3 with an increase in overall health and well-being. Although some foods contain vitamin D, the human body generates most of its vitamin D needs from the skin through regular exposure to sunlight. Severe vitamin D deficiency is a significant and widespread problem, especially in North America. In addition to its well-known properties for supporting bone density and strength and general inflammatory response, Cholecalciferol is included in Core ALPHA because studies have shown that higher levels of vitamin D in men are correlated with higher levels of circulating testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as zinc aspartate):\u003c\/strong\u003e Zinc deficiency is prevalent throughout the entire world, including the United States. Both severe and moderate zinc deficiencies are positively correlated with lower testosterone levels in men. And while zinc deficiency has been shown to lower your testosterone levels, zinc supplementation has been correlated with an increase in testosterone levels. Clinical research indicates that zinc deficiency reduces circulating luteinizing hormone and testosterone concentrations, may lower healthy levels of aromatase (increasing estrogen levels), and modifies sex steroid hormone receptor levels, thereby contributing to unhealthy hormone balance and male sexual function. Zinc supplementation with the aspartate form can support optimal zinc absorption and hormone balance.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-ALPHA-2020.jpg?v=1592389807\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ALPHA_2020_FIN-OL.pdf?v=1638797400\"\u003eCore ALPHA Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Core_ALPHA.pdf?v=1599729023\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":13148215378035,"sku":"SHOP672975315009","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/ALPHAFRONT_25eb7840-783d-451c-b319-c54be449725c.png?v=1760378847"},{"product_id":"core-hard","title":"Hard","description":"\u003cp\u003eBenefits of Core HARD may include the following:  \u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Reduction in cortisol levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDIM\u003c\/strong\u003e - Regulate healthy estrogen production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eL-Theanine\u003c\/strong\u003e - Increased measures of well being\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eYour diet is impeccable and couldn’t be any more in check – macros, micros, you have it all down. Your workouts? Get out of here! You have slaved, grinded, and grunted your way through leg workouts so intense the gym staff cried – and those were on your worst days. And yet, something is missing.\u003c\/p\u003e\n\u003cp\u003eIt’s that “extra” level of shred, “that look.” You know exactly what we mean. That type of leanness and density that makes an arm look twice as big, a stomach look twice as lean, and a forearm look like a roadmap for the Italian countryside. It’s that kind of elusive hardness that’s so rare, most of us simply chalk it up to genetics, or luck, or steroids, or whatever excuse we have handy – and yet we all still want it.\u003c\/p\u003e\n\u003cp\u003eThe reality is that it isn’t all that unattainable. Getting “that” look, “that” hardness, is about hormonal balance, optimization and body recomposition. It’s a matter of adding in that final piece of the puzzle that makes the entire picture come out perfectly.\u003c\/p\u003e\n\u003cp\u003eTo be hard, you need to get HARD. It’s that simple.\u003c\/p\u003e\n\u003cp\u003eCore HARD is another product in the Core Nutritionals’ lineup to follow the basic, but indispensable principles that Core Nutritionals is slowly making an industry standard: create products with effective ingredients, in effective doses, in a non-proprietary formula. This time around, we have applied those principles to the problem of softness that we all despise and have developed the most advanced ultra-hardening and recomposition agent on the market.\u003c\/p\u003e\n\u003cp\u003eTaking advantage of both the old and the new, Core Nutritionals has employed both modern, cutting-edge compounds and traditional herbs to create a balanced approach to delivering hardness. Key ingredients in Core HARD affect some of the body’s critical physiological pathways, combining sexiness and science in a single, non-proprietary formula. We have included five powerful ingredients into a full month's worth of stimulant free, recomposition goodness. The result? Reduced cortisol levels, healthy estrogen and hormone regulation, weight loss and lean muscle growth, increased measures of well-being, improved athletic performance, stamina and power.\u003c\/p\u003e\n\u003cp\u003eCore HARD can be used alone, or in a stack with other Core Nutritionals’ products. The BURN HARD stack (Core HARD plus \u003ca title=\"Core BURN - Stimulant Thermogenic\" href=\"https:\/\/www.corenutritionals.com\/products\/core-burn-powder\" target=\"_blank\"\u003eCore BURN\u003c\/a\u003e) will be the ultimate fat blasting and hardening stack. Men can try the HARD A.B.s stack (Core HARD plus \u003ca title=\"Core ALPHA - All Ultra Potent Natural Hormone Optimizer\" href=\"https:\/\/www.corenutritionals.com\/products\/core-alpha\" target=\"_blank\"\u003eCore ALPHA\u003c\/a\u003e and \u003ca title=\"Core BURN - Stimulant Thermogenic\" href=\"https:\/\/www.corenutritionals.com\/products\/core-burn-powder\" target=\"_blank\"\u003eCore BURN\u003c\/a\u003e) to help create that chiseled look that all men want.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidylserine (50%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhosphatidylserine, colloquially known as PS, is a nearly ubiquitous phospholipid found in various membranous tissues throughout the body. PS’s ubiquity coincides with its necessity for crucial physiological functions, as the phospholipid is implicated in several components of cell communication, as well as the mediation of catecholamine synthesis and transmission in the brain (along with other neuroendocrine functions). In a fitness-related context, a nascent but growing body of methodologically-sound research suggests that PS may play a role in increasing exercise capacity.\u003c\/p\u003e\n\u003cp\u003eStudies administering the compound in both acute and chronic fashion suggest that PS has a measurable effect on exercise capacity. In a double-blind, placebo-controlled, randomized trial involving 16 trained athletes, phosphatidylserine was administered for 10 days prior to an acute exercise challenge. Exercise markers such as exercise time to exhaustion, sprint performance, and ratings of perceived exertion, were measured post-exercise. The authors found that exercise time to exhaustion was significantly altered. Related studies using similar serving sizes have found that chronic PS administration increased shot accuracy in golfers, increased exercise time to exhaustion by 28% in cyclists, and reduced subjective feelings of stress and soreness in others.\u003c\/p\u003e\n\u003cp\u003eOverall, phosphatidylserine appears to play a valuable role in the increase in exercise capacity. PS may therefore play a critical role in the continued exercise success of bodybuilders in a, “cutting” or recomposition stage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal\u003c\/em\u003e, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).\u003c\/p\u003e\n\u003cp\u003eTo put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eColeus forskohlii\u003c\/em\u003e (std. to 20% forskolin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003ci\u003eColeus forskohlii\u003c\/i\u003e standardized to 20% forskolin is included for its direct role in body recomposition—the ability to reduce body fat while preserving lean mass. Forskolin activates a compound called adenylate cyclase, which can increase intracellular cAMP, a key regulator of fat mobilization and metabolic activity. Several studies have shown its power when it comes to fat mass reduction while also maintaining lean mass. One 12-week randomized, placebo-controlled study showed that subjects supplementing with forskolin lost an average of \u003cstrong data-end=\"546\" data-start=\"515\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003e10 lb of fat mass\u003c\/span\u003e\u003c\/strong\u003e while\u003cb\u003e \u003c\/b\u003e\u003cstrong data-end=\"583\" data-start=\"553\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003emaintaining lean body mass\u003c\/span\u003e\u003c\/strong\u003e, whereas the placebo group lost only 2lb and experienced a decline in lean mass. Another human trial showed a \u003cstrong data-end=\"764\" data-start=\"708\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003esignificant reduction in body fat percentage (−1.2%)\u003c\/span\u003e\u003c\/strong\u003e and a \u003cstrong data-end=\"815\" data-start=\"771\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003etrend toward increased free testosterone\u003c\/span\u003e\u003c\/strong\u003e, supporting muscle preservation during caloric deficit. By improving nutrient partitioning, shifting calories toward muscle recovery and performance rather than fat storage, \u003ci\u003eColeus forskohlii\u003c\/i\u003e can support a harder, leaner physique without stimulant reliance, making it a clinically supported tool for sustainable recomposition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3'-Diindolylmethane (DIM)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to (but probably cannot) identify \u003cem\u003ea specific\u003c\/em\u003e estrogen.\u003c\/p\u003e\n\u003cp\u003eThese \u003cem\u003especific estrogens\u003c\/em\u003e, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an \u003cem\u003eestrogen antagonist\u003c\/em\u003e. Yes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called “phytonutrients” have become the focus of clinical research, as these natural compounds have shown the ability to increase the ratio of good, estrogen decreasing estrogens (such as 2-OHE), to bad, estrogen increasing estrogens (such as 16-OHE1). One of these phytonutrients, a dietary indole known as indole-3-carbinol (I3C), is the bioactive phytochemical and a presumed modulator of reduced cancer risk in areas with high cruciferous vegetable consumption. Unfortunately, despite its potent antiestrogenic activity, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003eLuckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound with respect to antiestrogenic action – promoting the metabolism of beneficial estrogens that themselves reduce estrogenic activity.\u003c\/p\u003e\n\u003cp\u003eAside from its healthy-estrogen promoting abilities, DIM also exerts its own direct physiological effects, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromoting pathways of internal estrogen metabolism that favour the production of anti-estrogen estrogens.\u003c\/li\u003e\n\u003cli\u003eAdjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.\u003c\/li\u003e\n\u003cli\u003eLimit the cell division and growth of certain estrogens.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lie in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Theanine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThough the literature surrounding L-theanine is still emerging, the amino acid is slowly building a reputation as one of the most interesting and exciting compounds being targeted for therapeutic use. L-theanine is an amino acid found almost exclusively in tea, constituting approximately 1-2% of the dry weight of tea – resulting in a 25–60 mg theanine load per 200 ml serving of liquid tea.\u003c\/p\u003e\n\u003cp\u003eFirst identified in green tea and in the mushroom \u003cem\u003eXerocomus badius\u003c\/em\u003e, L-theanine readily crosses the blood-brain barrier in a dose-dependent manner, and it is thought to influence the central nervous system (CNS) through a variety of mechanisms, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncreasing the release and concentration of dopamine.\u003c\/li\u003e\n\u003cli\u003eInhibiting glutamate reuptake and blockade of glutamate receptors in the hippocampus.\u003c\/li\u003e\n\u003cli\u003eIncreasing gamma-aminobutyric acid (GABA – a neurotransmitter associated with the regulation of responses) concentrations.\u003c\/li\u003e\n\u003cli\u003eIncreasing levels of serotonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn addition to these more well-demonstrated effects, emerging electroencephalography trials on theanine suggest that the amino acid may exert a positive effect on alpha waves – a type of brain wave implicated in restful relaxation. Alpha activity has also been associated with increased creativity, increased performance under stress, and improved learning and concentration, as well as decreased anxiety.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_NEW.png?v=1753093928\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_LABEL_1.png?v=1753093978\"\u003eCore HARD Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_HARD_2025_References.docx?v=1753096766\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":31844500373619,"sku":"SHOP850757001641","price":44.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_FRONT_cbbbf7d3-ea1f-4330-b44a-babe58fbc1a2.png?v=1768407986"},{"product_id":"core-hard-extreme","title":"Hard Extreme","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Reduction in cortisol levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDIM\u003c\/strong\u003e - Regulate healthy estrogen production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eL-Theanine\u003c\/strong\u003e - Increased measures of well being\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eTo be hard, you need to get HARD. It's that simple.\u003c\/p\u003e\n\u003cp\u003eCore HARD is the pinnacle in recomposition supplementation. The ingredients in HARD have been specifically chosen to balance your hormonal environment and maximize your lean mass.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e3 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eBody recomposition.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eYour diet is impeccable and couldn’t be any more in check – macros, micros, you have it all down. Your workouts? Get out of here! You have slaved, grinded, and grunted your way through leg workouts so intense the gym staff cried – and those were on your worst days. And yet, something is missing.\u003c\/p\u003e\n\u003cp\u003eIt’s that “extra” level of shred, “that look.” You know exactly what we mean. That type of leanness and density that makes an arm look twice as big, a stomach look twice as lean, and a forearm look like a roadmap for the Italian countryside. It’s that kind of elusive hardness that’s so rare, most of us simply chalk it up to genetics, or luck, or steroids, or whatever excuse we have handy – and yet we all still want it.\u003c\/p\u003e\n\u003cp\u003eThe reality? It isn’t all that unattainable. Getting “that” look, “that” hardness, is about balance and recomposition. It’s a matter of adding in that final piece of the puzzle that makes the entire picture come out perfectly.\u003c\/p\u003e\n\u003cp\u003eTo be hard, you need to get HARD. It’s that simple.\u003c\/p\u003e\n\u003cp\u003eCore HARD is another product in the Core Nutritionals’ lineup to follow the basic, but indispensable principles that Core Nutritionals is slowly making an industry standard: create products with effective ingredients, in effective doses, in a non-proprietary formula. This time around, we have applied those principles to the problem of softness that we all despise and have developed the most advanced ultra-hardening and recomposition agent on the market.\u003c\/p\u003e\n\u003cp\u003eTaking advantage of both the old and the new, Core Nutritionals has employed both modern, cutting-edge compounds and traditional herbs to create a balanced approach to delivering hardness. Key ingredients in Core HARD affect some of the body’s critical physiological pathways, combining sexiness and science in a single, non-proprietary formula. We have included seven powerful ingredients into a full month's worth of stimulant free, recomposition goodness.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-Spectrum Ashwagandha Extract (Withania somnifera) (root) (5% withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal\u003c\/em\u003e, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66\u003csup\u003e®\u003c\/sup\u003e to include in its HARD formula. KSM-66\u003csup\u003e®\u003c\/sup\u003e is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66\u003csup\u003e®\u003c\/sup\u003e not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO\u003csup\u003e2\u003c\/sup\u003e max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidylserine (50%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhosphatidylserine, colloquially known as PS, is a nearly ubiquitous phospholipid found in various membranous tissues throughout the body. PS’s ubiquity coincides with its necessity for crucial physiological functions, as the phospholipid is implicated in several components of cell communication, as well as the mediation of catecholamine synthesis and transmission in the brain (along with other neuroendocrine functions). In a fitness-related context, a nascent but growing body of methodologically-sound research suggests that PS may play a role in increasing exercise capacity.\u003c\/p\u003e\n\u003cp\u003eStudies administering the compound in both acute and chronic fashion suggest that PS has a measurable effect on exercise capacity. In a double-blind, placebo-controlled, randomized trial involving 16 trained athletes, phosphatidylserine was administered for 10 days prior to an acute exercise challenge. Exercise markers such as exercise time to exhaustion, sprint performance, and ratings of perceived exertion, were measured post-exercise. The authors found that exercise time to exhaustion was significantly altered. Related studies using similar serving sizes have found that chronic PS administration increased shot accuracy in golfers, increased exercise time to exhaustion by 28% in cyclists, and reduced subjective feelings of stress and soreness in others.\u003c\/p\u003e\n\u003cp\u003eOverall, phosphatidylserine appears to play a valuable role in the increase in exercise capacity. PS may therefore play a critical role in the continued exercise success of bodybuilders in a, “cutting” or recomposition stage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePomegranate Extract (Punica granatum) (hull) (ellagic acid 40%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePomegranate is a fruit-bearing deciduous shrub, endemic to and cultivated in wide swaths of both Europe and Asia. Pomegranate is also the predominant member of two species comprising the Punicaceae family\u003c\/p\u003e\n\u003cp\u003ePomegranate fruit has long been consumed as a dietary staple, and recent research has uncovered that the peel, in particular, harbors a broad range of physiologically active compounds known as polyphenols – most prominently ellagitannins. When consumed, these ellagitannins are hydrolyzed to ellagic acid in the gut, and released into the blood, allowing ellagic acid to be widely distributed to many target tissues and organs. \u003c\/p\u003e\n\u003cp\u003eWhile still preliminary, emerging animal and in vitro data on PME (pomegranate extract) suggests that both specific and whole plant extracts may exert interesting endocrine effects. In a study examining the effects of PME on cultured human cells, PME was shown to down-regulate estrogen-receptor gene expression, and inhibit binding – suggesting that PME may possess some anti-estrogenic effects, at least in vitro. In another study in rats, PME’s robust antioxidant profile was hypothesized to increase androgenic activity via reducing oxygen radicals in the testes.\u003c\/p\u003e\n\u003cp\u003eThough PME lacks robust human data, the available literature suggests that this compound may possess some highly useful physiological effects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhite Button Mushroom Extract (Agaricus blazei) (fruit) (30% polysaccharides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAgaricus blazei\u003c\/em\u003e, known commonly by a plethora of names – including button mushroom, white button mushroom, table mushroom, and champignon mushroom – is a small, edible mushroom endemic to North America and Europe. The most commonly consumed mushroom on the planet, commercial production and consumption of white button mushroom has existed since at least the early 18\u003csup\u003eth\u003c\/sup\u003e century, while indigenous oral records suggest the plant was consumed for centuries prior.\u003c\/p\u003e\n\u003cp\u003eRecent medical research has discovered that white button mushroom is a rich source of biologically-active compounds, including ergothioneine, an antioxidant with particularly potent free radical scavenging activity. Similar research has found that white button mushrooms – along with other varieties – possess unsaturated fatty acids such as linoleic acid, linolenic acid, and conjugated linoleic acid that may exert inhibitory activity on human aromatase, a cytochrome-P450 complex responsible for the conversion of testosterone into estrogen.\u003c\/p\u003e\n\u003cp\u003eIn two separate studies by similar researchers, both rats and human cell lines were fed and\/or incubated with various extract strengths and doses of white button mushroom extract. Both the animal experiments and “in-cell” aromatase assays demonstrated that WBME exerted powerful anti-aromatase effects, reducing total aromatase amounts and activity across all experimental conditions.\u003c\/p\u003e\n\u003cp\u003eThe most encouraging aspect of these studies is the servings of white button mushroom used in the experimental conditions: they are easily achievable through oral consumption, unlike many other plant-based, physiologically active compounds.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Theanine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThough the literature surrounding L-theanine is still emerging, the amino acid is slowly building a reputation as one of the most interesting and exciting compounds being targeted for therapeutic use. L-theanine is an amino acid found almost exclusively in tea, constituting approximately 1-2% of the dry weight of tea – resulting in a 25–60 mg theanine load per 200 ml serving of liquid tea.\u003c\/p\u003e\n\u003cp\u003eFirst identified in green tea and in the mushroom \u003cem\u003eXerocomus badius\u003c\/em\u003e, L-theanine readily crosses the blood-brain barrier in a dose-dependent manner, and it is thought to influence the central nervous system (CNS) through a variety of mechanisms, including:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eInhibiting glutamate reuptake and blockade of glutamate receptors in the hippocampus.\u003c\/li\u003e\n\u003cli\u003eIncreasing gamma-aminobutyric acid (GABA – a neurotransmitter associated with the regulation of responses) concentrations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn addition to these more well-demonstrated effects, emerging electroencephalography trials on theanine suggest that the amino acid may exert a positive effect on alpha waves – a type of brain wave implicated in restful relaxation. Alpha activity has also been associated with increased creativity, increased performance under stress, and improved learning and concentration, as well as decreased anxiety.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3'-Diindolylmethane (DIM)\u003cu\u003e\u003cbr\u003e\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E\u003csub\u003e2\u003c\/sub\u003e), estrone (E\u003csub\u003e1\u003c\/sub\u003e), and estriol (E\u003csub\u003e3\u003c\/sub\u003e), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to identify \u003cem\u003ea specific\u003c\/em\u003e estrogen.\u003c\/p\u003e\n\u003cp\u003eThese \u003cem\u003especific estrogens\u003c\/em\u003e, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an \u003cem\u003eestrogen antagonist. \u003c\/em\u003eYes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called phytonutrients have become the focus of clinical research, as these natural compounds have shown the ability to modulate the body’s estrogen ratio. One of these phytonutrients, is a dietary indole known as indole-3-carbinol (I3C). Unfortunately, despite its metabolic usefulness, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cu data-mce-fragment=\"1\"\u003eCocoabuterol®\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCocoabuterol®, made up of the bioactive compounds found in cocoa, has been shown through studies and application to have beneficial factors on fat loss, muscle building, and insulin sensitivity. This caffeine free ingredient exhibits a mechanism of action in the body to increase cAMP (cyclic adenosine monophosphate) levels, which acts as a second messenger and regulator of many movements exhibited by all three types of cells in the human body. In this context, fat (adipose) tissue epinephrine utilizes cAMP to increase to triglyceride hydrolysis and cardiac (heart) muscle epinephrine utilizes it to increase contraction rate. This action can have positive benefits on body composition and performance.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTheobromine, one of the main methylxanthine compounds found in cocoa is primarily effective in the increase of nitric oxide to in the blood stream, which is beneficial to produce the “pump” when ingested pre-workout. Another reaction that can be seen with theobromine is dilation of blood vessels. This can increase blood flow during vigorous exercise leading to increased time to exhaustion but also can pose benefits to individuals who suffer from high blood pressure. Theobromine also has a very high bioavailability and ability to stay in the body for extended periods of time (7-8 hours). Several studies have also looked at the effects of theobromine on human subjects and results have shown its ability to reduce oxidative stress on cells and regulation of gene expression.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCocoabuterol® has also been shown to have positive benefits on reducing oxidative stress in the body. Due to its rich antioxidant properties, it has the ability to fight off free radicals that can be detrimental. In addition to this, the polyphenols that Cocoabuterol® contains have been shown to reduce inflammatory signals within the body that can also be detrimental biomarkers. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eBy now you have read some of the amazing benefits of Cocoabuterol® and why we have included in this recomposition agent. When your goal is maintaining muscle mass, shedding body fat, reducing overall stress, and performing at your peak, we make sure you are equipped with the right ingredients, in the right dosages, and for the right purpose. In summary, Cocoabuterol® does all of these things by:\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cul data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eIncreasing power output due to elevated NO production via theobromine effects.\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eIncreasing adipose usage through cAMP action in the body.\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eImproving senses of well-being due to high levels of polyphenols and antioxidants reducing overall stress on the body from workouts and life events.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-HARDX-2020.jpg?v=1594626584\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_HARD_EXTREME_11.5x2.375_PINEAPPLE_STRAWBERRY-FIN.pdf?v=1639493578\"\u003ePineapple Strawberry Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_HARD_EXTREME_11.5x2.375_BLACK_LIGHTNING-FIN_compressed.pdf?v=1639493414\"\u003eBlack Lightning Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-HARD-Extreme-Refferences.pdf?3720008071589287876\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Pineapple Strawberry","offer_id":31907295527027,"sku":"SHOP672975315306","price":49.99,"currency_code":"USD","in_stock":false},{"title":"Black Lightning","offer_id":31907295559795,"sku":"SHOP672975315290","price":49.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/products\/hard-pinneapple-strawberry.png?v=1594626285"},{"product_id":"core-prostate","title":"Prostate","description":"\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSaw Palmetto Extract\u003c\/strong\u003e - aims to maintain healthy prostate size.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStinging Nettle Extract\u003c\/strong\u003e - normal and healthy urinary flow and frequency.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLycopene\u003c\/strong\u003e - contributes to normal prostate function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-contrast=\"none\"\u003eFrom an early age, men are taught to associate their virility, potency, and vigor with their sense of masculinity. Yet, as we age, the vital systems and metabolic pathways that help us maintain that virility slowly begin to decline. For some, this is an unavoidable part of aging that should be handled with grace and acceptance. For others, such as those living the Crush It lifestyle, this akin to meekly accepting defeat when other options are available. You see, it is critical to maintain a healthy, normal prostate function. While aging makes maintaining this function increasingly difficult, there are robust supplement regimens that can assist in promoting proper prostate health and function. \u003c\/span\u003e\u003cspan data-ccp-props='{\"201341983\":0,\"335559739\":160,\"335559740\":259}'\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-contrast=\"none\"\u003eWhile many supplements singularly focus on an individual ingredient, this oversimplified single ingredient approach ignores the complexity of this multi-faceted issue – an issue that undoubtedly requires a multi-faceted solution. So, in line with the product development philosophy we’ve maintained at Core Nutritionals since our inception, we’ve elevated a product category and delivered a comprehensive prostate health formula suitable to such a complex and significant issue. By scouring the available clinical research, we’ve found a veritable constellation of ingredients that address every major pathway involved in the promotion of a healthy prostate. And, with that, we give you the premier solution for maintaining an optimal functioning prostate: Core PROSTATE! \u003c\/span\u003e\u003cspan data-ccp-props='{\"201341983\":0,\"335559739\":160,\"335559740\":259}'\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePumpkin Seed Oil Powder (Cucurbita pepo)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePumpkin seed has been used in the medical treatment realm for decades, especially for its noted benefits towards prostate health improvement. The fatty acids contained in pumpkin seeds, especially delta-7-sterols, tocopherols, and other micronutrients have shown specific promise in optimizing normal prostate function. A 2014 randomized, double-blind, placebo-controlled study looked at the effects of different administrations on subjects. Subjects were split and received either sweet potato starch, pumpkin seed oil, saw palmetto oil, and pumpkin seed oil with saw palmetto oil. What the results showed was that the group given pumpkin seed oil noticed improvements in quality of life and improvements in maximal urinary flow. These same improvements were also shown in the combined pumpkin seed oil and saw palmetto oil group making them both reputable complimentary products that can benefit the health of the prostate.\u003c\/p\u003e\n\u003cp\u003eOne of the primary mechanisms of action for pumpkin seeds is to block the conversion of testosterone to dihydrotestosterone, inhibiting the enzyme 5-α-reductase. Dihydrotestosterone is classified as a powerful metabolite of testosterone with critical functions as an androgen. While androgens can be beneficial for men, when they get too high, they can negatively affect certain parts of the human body, including the prostate, leading to issues such as less than optimal prostate function. Maintaining normal levels of dihydrotestosterone in the prostate is therefore a paramount property to maintaining the normal function of the prostate.\u003c\/p\u003e\n\u003cp\u003eZinc is also critical to normal prostate function. In fact, a normal functioning prostate has the highest levels of zinc in the body. A 2011 human study found an increase in urinary zinc excretion. Pumpkin seeds are naturally high in zinc, leading to their consumption could be beneficial to extract their prostate health improving properties.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSaw Palmetto Extract (Serenoa repens) (fruit) (85% Total Fatty Acids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSaw Palmetto is a traditional herb that grows in the Southern coastal regions of the United States that has been often used to maintain normal, healthy prostate function. Growth of the prostate is believed to happen through the action of 5α-reductase, which catalyzes the conversion of testosterone to dihydrotestosterone. Dihydrotestosterone binds to nuclear androgen receptors and activates the transcription of androgen-regulated genes that are mitogenic to both epithelial and stromal cells. Due to the fact that the development and growth of the prostate gland depend on androgen stimulation, the mechanisms of action of saw palmetto include several antiandrogenic effects, such as inhibition of 5α-reductase I and II and inhibition of binding of dihydrotestosterone (DHT) to the cytosolic androgen receptors, anti-proliferative effects and anti-inflammatory effects. Several studies have shown that saw palmetto, and the mechanisms of action listed above may positively influence the prostate by helping to maintain its optimal size and function, which then equates to a healthy urinary flow and frequency.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStinging Nettle Extract (Urtica dioica) (root) (20:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStinging nettle has been widely used is traditional medicine for its benefits as a diuretic and to treat things like joint pain, eczema, arthritis, gout, and anemia. More recently, stinging nettle has been utilized for the purpose of maintaining normal urinary flow and contributing to a healthy, optimal functioning prostate. Stinging nettle has also showed effectiveness when used in combination with other herbs, like saw palmetto (above). Human studies have shown this effectiveness in these areas, like urinary flow maintenance, through their specific mechanisms of action, which were discussed in the paragraph above. The mechanism of action for stinging nettle is still somewhat unclear but it seems likely that sex hormone binding globulin (SHBG), aromatase (the key enzyme in estrogen biosynthesis), epidermal growth factor and prostate steroid membrane receptors are involved in the anti-prostatic effect. While the mechanism of action may be unclear at the present moment, the success of stinging nettle in human studies makes it a promising application for maintaining normal prostate health and function.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cp\u003eInduce G1\/S arrest of the cell cycle\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003eInduce apoptosis\u003c\/li\u003e\n\u003cli\u003eInhibit angiogenesis Regulate sex hormones and\u003c\/li\u003e\n\u003cli\u003eIncrease antioxidant activity\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePygeum Bark Extract (Pygeum africanum) (3% Phytosterols)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe bark of Pygeum africanum, also known as the African prune tree native to tropical Africa, is a compound that has often been utilized for its benefits in maintaining prostate health. The mechanism of action for pygeum remains somewhat unclear. Studies utilizing pygeum bark have also shown promise in their benefits in support the maintenance of prostate health both in vitro and in vivo. In one in vitro study in particular, results showed that pygeum bark extract was able to inhibit the growth of PC-3 and LNCaP cells, as well as induce apoptosis and altered cell kinetics, and downregulated ERalpha and PKC-alpha protein. In vivo, utilizing TRAMP mice, the application of pygeum bark extract showed a significant reduction (35%) in prostate cancer incidence compared to mice fed another substance. Another analysis looking at 18 randomized controlled trials looked at the how pygeum africanum benefitted men and prostate health. Pygeum was shown to provide a large improvement in urinary function and flow measures when compared to other men in the study not administered pygeum. Men using pygeum africanum also noticed nocturia was reduced by 19%, residual volume of urine reduced by 24%, and peak urine flow increased by 23%. These results leave pygeum administration as a potentially beneficial application for those looking to maintain normal prostate function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBeta-Sitosterol (40%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eβ-sitosterol is the most abundant plant sterol in the human diet and is also the major component of several traditional medicines, including saw palmetto and devil’s claw. It is believed to help maintain prostate function by aiding in the and ease of urinary flow. A few studies have been conducted on BS effectiveness on urinary system function and flow with promising results. One randomized placebo-controlled study on men showed promising results on these issues. Results revealed that men administered β-sitosterol noticed a more efficient flow measure and increased prostate function. While β-sitosterol can benefit from more studies, the current studies show promise and ability to work in synergy with the other components of Core’s comprehensive prostate funtion formula.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLycopene (Lycopersicon esculentum) (fruit)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLycopene, a carotenoid found largely in tomato, pink grapefruit, and watermelon, is a natural and effective nutrient that has been able to show ability in supporting optimal prostate function. Several studies have been conducted showing lycopene’s effectiveness in maintaining this prostate function in both in-vivo and in-vitro conditions. Results of these studies showed that lycopene was able to inhibit prostatic IGF-I signaling, IL-6 expression, and androgen signaling. Lycopene was also able to show improvements in gap-junctional communication and oxidative defense genes, which can be essential for maintaining prostate function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoron (as Albion® Boroganic Glycine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoron is a mineral present in multiple fruits, vegetables, tubers, and drinking water, though it is not widely accepted as either an essential mineral or essential vitamin. Boron affects a few physiological functions in the body, particularly modulating hormonal homeostasis.\u003c\/p\u003e\n\u003cp\u003eWhile still emerging, recent data suggest that boron may play a role in potentiating free testosterone levels in healthy men. In one study, otherwise healthy men were provided an acute serving of boron and had their free and total levels of testosterone, alone with SHBG (sex hormone binding globulin) and DHT (dihydrotestosterone) levels measured. In that study, total testosterone was unaltered, but free testosterone was enhanced by 14%, while SHBG was significantly (9%) reduced. Boron has also shown substantial evidence in playing a role in supporting normal prostate function, specifically through lowering PSA (prostate specific antigen), which can be a marker for prostate abnormality advancement. Other studies have shown the effectiveness of adequate boron levels on optimizing prostate health. One human study concluded that men who ingested the greatest amount of boron in their diet were 54% less likely to be at risk of prostate related issues when compared to the lowest intake.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-PROSTATE.jpg?v=1633679693\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_PROSTATE_8.5x3.25-FIN.pdf?v=1633427276\"\u003eProstate Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Prostate.pdf?v=1633428194\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40772922179760,"sku":"SHOP658580070571","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PROSTATEFRONT_19e2f4ab-9820-4e9e-ae3d-9f34afe2b481.png?v=1760376906"},{"product_id":"core-bolic™-v2","title":"Bolic v2","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eCan Increase Muscle Protein Synthesis\u003c\/li\u003e\n\u003cli\u003eMay Increase Lean Body Mass\u003c\/li\u003e\n\u003cli\u003eCan Improve Athletic Performance\u003c\/li\u003e\n\u003cli\u003eCan Boost Recovery \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIntroducing Core BOLIC V2: Unleash Your Full Potential with Nature's Power\u003c\/p\u003e\n\u003cp\u003eIn the pursuit of peak physical performance, rapid recovery, and overall well-being, we present to you Core BOLIC V2—an innovative fusion of heavily studied ingredients meticulously crafted to elevate your capabilities. At its core are three remarkable components: PeptiStrong™, Maral Root Extract, and Camellia sinensis Extract, (fortified by the bioenhancing prowess of BioPerine®. Together, these elements unlock a world of possibilities that extend beyond the ordinary.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePeptiStrong™, hailing from fava beans (Vicia faba), takes center stage as a game-changing ingredient. It harbors a treasure trove of bioactive peptides, potent natural compounds also found in collagen, insulin, and glutathione. Patented and extensively researched, these peptides have displayed remarkable effects muscle protein synthesis, recovery, and overall muscle hypertrophy.\u003c\/li\u003e\n\u003cli\u003eMaral Root Extract, sourced from Rhaponticum carthamoides, is a revered natural ingredient renowned for its adaptogenic properties and myriad health benefits. Maral Root Extract is a game-changer for endurance, as it elevates adenosine triphosphate (ATP) production, extending exercise durations and delaying fatigue. Its ability to stimulate muscle protein synthesis, enhance muscle recovery, and improve muscular strength empowers you to achieve more during your workouts.\u003c\/li\u003e\n\u003cli\u003eCamellia sinensis Extract (Bean), standardized to an impressive 90% Epicatechin, adds another layer of excellence to Core BOLIC V2. Epicatechin shines in promoting muscle growth, strength, nitric oxide production, and overall heart and brain health. Furthermore, its nitric oxide-boosting capabilities translate to better blood flow, facilitating nutrient absorption and delivering an impressive pump during workouts.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioPerine®, a patented extract from Piper nigrum (black pepper) enhances bioavailability as well as elevates the effectiveness of Core BOLIC V2’s ingredients by inhibiting intestinal motility and dilating blood vessels in the gut—where nutrient absorption thrives.\u003c\/p\u003e\n\u003cp\u003eSo, as you can see, Core BOLIC V2 not only increases exercise performance, but makes the underlying anabolic response (muscle growth and protein synthesis) to exercise more efficient – ensuring that your hard work is paying off!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFava Bean (Vicia faba) Hydrolysate (as PeptiStrong™)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePeptiStrong™ is an ingredient derived from fava beans that contains extremely beneficial natural compounds called bioactive peptides. Other sources of naturally occurring bioactive peptides are collagen, insulin, and glutathione, all of which have crucially beneficial properties. These peptides have undergone patent protection and extensive research, including both pre-clinical and clinical studies. The studies have shown positive effects on gene expression and the secretion of tumor necrosis factor alpha (TNF-a). In vitro experiments using murine skeletal muscle cells and human macrophages have validated the ability of the peptides within PeptiStrong™ to increase muscle protein synthesis and reduce TNF-a secretion. The study also assessed the bioavailability and stability of the peptides, which proved to be resistant to digestion, displayed good intestinal barrier transport, and remained stable in plasma.\u003c\/p\u003e\n\u003cp\u003eIn an in vivo study using a murine model of muscle atrophy, PeptiStrong™ treatment for 18 days resulted in a significant attenuation of muscle loss and increased expression of muscle fibers. The treatment also upregulated protein-synthesis-related genes in muscle tissue. Other protein hydrolysates of fava bean and food-derived hydrolysates did not exhibit the same level of efficacy in vitro. Thus, PeptiStrong™ demonstrated efficacy in attenuating muscle atrophy through various mechanisms, including inflammation reduction and muscle protein synthesis.\u003c\/p\u003e\n\u003cp\u003eA clinical study compared the effects of PeptiStrong™ and milk protein supplementation on muscle mass and strength loss during limb immobilization. The study involved 30 young men subjected to one-legged knee immobilization followed by recovery. PeptiStrong™ supplementation performed similarly to milk protein in modulating muscle size loss during immobilization and regain during remobilization. Notably, higher muscle protein synthesis rates were observed during remobilization in the PeptiStrong™ group.\u003c\/p\u003e\n\u003cp\u003eAnother study with 30 healthy male subjects investigated the effects of PeptiStrong™ supplementation on strength recovery and fatigue. The subjects were divided into groups receiving either a placebo or 2.4 grams of PeptiStrong™ daily. Delayed onset muscle soreness (DOMS) was induced using resistance exercise, and the subjects' strength recovery and fatigue were measured over three days. PeptiStrong™ supplementation significantly improved strength recovery, reduced fatigue, and positively influenced markers associated with muscle homeostasis. Myostatin expression was also found to be significantly reduced, indicating an anabolic response following intense exercise.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaral Root Extract (Rhaponticum carthamoides) (10:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMaral Root Extract, derived from the plant Rhaponticum carthamoides, is a natural ingredient highly regarded for its adaptogenic properties and numerous health benefits. This herb has a rich history in traditional medicine and is known for its ability to enhance physical and mental performance, support stress resilience, boost energy levels, promote vitality, improve athletic performance, and aid in post-exercise recovery. One crucial aspect of athletic performance is the ability to maintain a high capacity throughout the event and be able to then recover efficiently. Maral Root Extract has shown potential in addressing both of these aspects. Let's first examine how this herb can enhance measures of athletic performance.\u003c\/p\u003e\n\u003cp\u003eWhen it comes to increasing endurance, two key factors play a significant role: oxygen and adenosine triphosphate (ATP). Oxygen is essential in breaking down carbohydrates, fats, and proteins and converting them into ATP, the primary energy source for the body. Maral Root Extract has been found to increase ATP production, which can allow individuals to exercise for longer periods and delay the onset of fatigue.\u003c\/p\u003e\n\u003cp\u003eFurthermore, studies suggest that Maral Root Extract supplementation may promote greater muscle protein synthesis. While the exact mechanisms of 20-hydroxyecdysone (a plant ecdysteroid) on muscle protein synthesis are not fully elucidated, it appears to involve a rapid increase in calcium in the cell (cytosol) causing activation of Akt\/PI3K signaling. This signaling promotes the metabolism, proliferation, cell survival, growth, and angiogenesis of cells. Along with these increases in muscle protein synthesis, Maral Root Extract has also been shown to aid in muscle recovery and improve muscular strength, enabling individuals to generate more power during workouts.\u003c\/p\u003e\n\u003cp\u003eMoreover, the active compounds present in Maral Root Extract, such as ecdysteroids and additional flavonoids, exhibit potential anti-inflammatory and antioxidant effects through their adaptogenic properties. These properties can help the body adapt to physical and mental stressors and can further contribute to improved muscle recovery, reduced exercise-induced muscle damage, and faster bounce back after intense training sessions.\u003c\/p\u003e\n\u003cp\u003eAdditionally, Maral Root Extract has been found to influence hormone levels, particularly testosterone and cortisol. It can help maintain a healthy testosterone-cortisol ratio, which is beneficial for muscle growth and recovery. Achieving hormonal balance can contribute to better exercise performance and body composition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCamellia sinensis Extract (Bean) (std. to 90% Epicatechin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eEpicatechin is a plant-based phytochemical, or flavanol, that is found in trace amounts in foods and liquids such as dark chocolate and green tea. Its physiological benefits have been studied for years and have resulted in promising results in relation to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnhanced muscle growth and strength\u003c\/li\u003e\n\u003cli\u003eIncreased nitric oxide production (better pumps)\u003c\/li\u003e\n\u003cli\u003eLowered cholesterol levels due to antioxidant content\u003c\/li\u003e\n\u003cli\u003eImprovements in brain and heart health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThese proposed benefits listed above and the compelling research surrounding them has led epicatechin to be involved in innovations where muscle growth and improved performance are the goal.\u003c\/p\u003e\n\u003cp\u003eHow does epicatechin work? Glad you asked. The proposed mechanism of action of epicatechin is through the inhibition of myostatin, which is a type of protein called a myokine that in essence acts as a regulating molecule released by muscles. Increased levels of myostatin have been linked to limiting the level of muscle growth. To combat an increased concentration of myostatin, epicatechin can work to increase another protein called follistatin which the body can then use to control metabolism, promote muscle growth, and boost fertility. Increased myostatin has been linked to the clinically obese and inactive as well as individuals who have some degree of insulin resistance. Studies have shown that aerobic activities, strength training, and some modifications to diet can, to a degree, decrease myostatin levels in muscle. When it comes to epicatechins ability to increase follistatin levels and further inhibit myostatin concentrations as few studies have been conducted for its efficacy.\u003c\/p\u003e\n\u003cp\u003eOne study conducted on males showed that just 170mg of epicatechin per day was able to increase follistatin by about 50% and decrease myostatin by about 17%, which also coincided with an increase in strength of about 7%.\u003c\/p\u003e\n\u003cp\u003eLooking at epicatechins nitric oxide boosting benefits, one animal study showed that nitric oxide and endurance was able to be increased even in the absence of exercise. This can aid in nutrient absorption and improved heart and muscle health outside of the gym but in the gym, it can also result in greater blood flow to muscles and stimulate a better pump in response to training.\u003c\/p\u003e\n\u003cp\u003eThe literature that has been presented on epicatechin in in vivo studies on muscle growth potential and improved overall health is promising and when combined with the other ingredients in this product, the body can be set up for the most beneficial environment for muscle growth, strength increases, and increases in performance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Bioperine® (Piper nigrum) (Fruit) (std. to 95% Piperine):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at the impact of BioPerine® on nutrient absorption and several plant compounds have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core BOLIC V2.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-BOLIC-2023.jpg?v=1696576317\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_BOLIC_2023_8.5x3.25-FIN.pdf?v=1696493534\"\u003eCore BOLIC Version V2 Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_BOLIC_V2_Product_References.docx?v=1696493236\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":42846303289520,"sku":"SHOP850051031214","price":59.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/BOLIC_FRONT_68a59313-6451-4850-a735-b219841df624.png?v=1760385628"},{"product_id":"vital-t-testosterone-booster","title":"Vital-T","description":"\u003cp\u003e\u003cstrong\u003eTHE ULTIMATE TESTOSTERONE SUPPORT\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eENHANCE LIBIDO\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eBALANCE ESTROGEN\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eCONTROL CORTISOL\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003eUnlock your true vitality with VITAL-T — a next-generation natural testosterone booster designed to help you reclaim strength, energy, and performance. Powered by a synergistic blend of cutting-edge ingredients like Fadogia agrestis, Fenugreek seed extract and pregnenolone, and trademarked clinically backed ingredients like Tesnor®, Shoden® Ashwagandha, and Puremidine® Spermidine, VITAL-T has been meticulously designed to target every angle of hormone optimization. From supporting natural testosterone production and balancing estrogen, to enhancing vitality at the smallest cellular level, VITAL-T delivers a comprehensive formula for modern men who demand more from their bodies — as well as their supplements.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFadogia agrestis Extract 10:1 (SteM)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFadogia agrestis, a shrub native to West Africa, has been used in traditional medicine for centuries to support male vitality and performance. Today, science is beginning to validate what has been long believed—that Fadogia may play a role in supporting healthy testosterone levels. Standardized in a potent 10:1 extract, the concentration of bioactive compounds in Fadogia agrestis is significantly enhanced, making it more effective at delivering results in an efficient dose\u003c\/p\u003e\n\u003cp\u003eOne of the most exciting aspects of Fadogia agrestis is its potential to stimulate natural testosterone production. Preclinical studies suggest that it may act on the hypothalamic–pituitary–gonadal (HPG) axis, encouraging the release of luteinizing hormone (LH), a key signal for the testes to produce more testosterone. This makes Fadogia unique in that it doesn't just supply precursors—it may help your body generate more of its own testosterone through endocrine stimulation.\u003c\/p\u003e\n\u003cp\u003eHigher testosterone levels can translate into benefits such as improved energy, muscle strength, recovery, and libido. Athletes and other active individuals often look towards Fadogia as a natural, non-hormonal way to support elevated performance, drive, and optimal hormonal balance. When paired with other natural testosterone-supporting compounds like Tongkat Ali, or Boron, Fadogia agrestis extract can be a powerful addition to a well-rounded hormone health stack.\u003c\/p\u003e\n\u003cp\u003eWhile more human research is needed the results shown thus far are promising and have made Fadogia a standout in the world of natural testosterone support.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFenugreek Seed Extract (Trigonella foenum-graecum) (Seed) (Std. to 50% Saponins)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFenugreek seed extract, derived from Trigonella foenum-graecum, is a time-tested botanical with a rich history in both traditional medicine and modern sports nutrition. When standardized to 50% saponins—the primary active compounds responsible for many of its benefits—fenugreek is widely used to support healthy testosterone levels, enhance physical performance, and aid in muscle recovery and body composition improvements.\u003c\/p\u003e\n\u003cp\u003eOne of fenugreek’s most notable features is its potential to support free testosterone levels. While total testosterone is important, free testosterone is the biologically active form that directly influences strength, libido, muscle growth, and mood. Studies have shown that fenugreek extract may inhibit enzymes such as aromatase and 5-alpha-reductase, which can convert testosterone into estrogen and DHT respectively. By minimizing this hormonal conversion, fenugreek may help maintain a healthier balance of testosterone in the bodY.\u003c\/p\u003e\n\u003cp\u003eClinical research studies also support fenugreek’s ability to enhance strength and body composition. In several studies involving resistance-trained men, supplementation with fenugreek extract led to improvements in strength, lean muscle mass, and reductions in body fat—without causing significant hormonal imbalances or side effects. Additionally, its high saponin content may contribute to enhanced glycogen resynthesis, helping athletes recover faster after intense training.\u003c\/p\u003e\n\u003cp\u003eBeyond its performance benefits, fenugreek is also widely valued for supporting metabolic health. It has been studied for its potential role in promoting healthy blood sugar levels and improving insulin sensitivity—factors that are increasingly recognized as crucial to hormonal health and longevity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTesnor® (Pomegranate Extract (Peel) and Cocoa Extract (Bean))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTesnor®, a clinically studied proprietary blend of Punica granatum (pomegranate) peel and Theobroma cacao (cocoa) seed extracts, was specifically formulated to support healthy testosterone levels, muscle strength, and overall male vitality, especially in aging males. Tesnor® sets itself apart with is its dual-action mechanism—supporting both free and total testosterone levels—while also promoting muscle protein synthesis and reducing markers of oxidative stress.\u003c\/p\u003e\n\u003cp\u003eIn a randomized, double-blind, placebo-controlled clinical study, Tesnor® supplementation led to a significant increase in total testosterone by 22% and free testosterone by 19% in healthy men over an 8-week period. This is believed to be due to Tesnor’s ability to modulate the activity of enzymes such as 5-alpha-reductase and aromatase, which are responsible for the conversion of testosterone to dihydrotestosterone (DHT) and estrogen, respectively. By supporting a favorable testosterone-to-estrogen balance, Tesnor® can help maintain anabolic hormone levels while reducing the risk of estrogen dominance or excessive DHT conversion.\u003c\/p\u003e\n\u003cp\u003eAdditionally, Tesnor® has shown promise in improving muscle strength and performance metrics. In supporting clinical trials, participants experienced statistically significant improvements in handgrip strength and leg press performance—suggesting Tesnor’s application as a promising performance enhancer alongside traditional training and supplementation protocols. It can also support nitric oxide production and enhance overall blood flow, further contributing to athletic performance and sexual health.\u003c\/p\u003e\n\u003cp\u003eDiving deeper, the polyphenols in pomegranate and cocoa can offer potent antioxidant and anti-inflammatory properties, which may help reduce oxidative damage to Leydig cells—the cells in the testes responsible for testosterone production. This protective effect could support longer-term hormonal health, especially in aging males facing age-related testosterone decline.\u003c\/p\u003e\n\u003cp\u003eTesnor® represents a natural, evidence-backed ingredient for boosting testosterone, improving physical performance, and promoting overall male wellness. With its combination of clinically validated ingredients and multiple mechanisms of action, it serves as a great compliment to the other clinically backed ingredients found in this VITAL-T formulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStinging Nettle Extract (Urtica dioica) (Root) (20:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStinging nettle (Urtica dioica), an herb that has been traditionally used for centuries in medicine, has been subject to recent scientific interest for its potential benefits for hormonal health—particularly its role in supporting testosterone levels in men. While stinging nettle doesn't directly increase testosterone production, it exerts several key effects that can help maintain optimal levels of free (bioavailable) testosterone.\u003c\/p\u003e\n\u003cp\u003eOne of the most well-documented mechanisms of action by which stinging nettle supports testosterone is through its inhibition of sex hormone-binding globulin (SHBG). SHBG binds to testosterone in the bloodstream, leaving it inactive. Specific compounds in stinging nettle—particularly lignans found in the root—have been shown in vitro to bind to SHBG, potentially displacing testosterone and allowing for a greater proportion of it to remain free and active. This increase in free testosterone can translate to improved strength, vitality, libido, and mood in men.\u003c\/p\u003e\n\u003cp\u003eAdditionally, stinging nettle has been studied for its anti-inflammatory and anti-aromatase effects. Aromatase is the enzyme responsible for converting testosterone into estrogen. By inhibiting this enzyme it may help preserve testosterone levels, particularly in aging men who are more susceptible to this conversion. In one study published in Planta Medica, nettle root extract exhibited mild aromatase-inhibiting activity, supporting its potential role in hormone balance.\u003c\/p\u003e\n\u003cp\u003eFinally, stinging nettle may also support prostate health, another important consideration for aging men and those concerned with long-term hormonal optimization. Several clinical studies have shown that nettle root extract, when used alone or in combination with saw palmetto, can help alleviate lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH), without adversely affecting testosterone levels.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3-Diindolylmethane (DIM)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to (but probably cannot) identify a specific estrogen.\u003c\/p\u003e\n\u003cp\u003eThese specific estrogens, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an estrogen antagonist. Yes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called “phytonutrients” have become the focus of clinical research, as these natural compounds have shown the ability to increase the ratio of good, estrogen decreasing estrogens (such as 2-OHE), to bad, estrogen increasing estrogens (such as 16-OHE1). One of these phytonutrients, a dietary indole known as indole-3-carbinol (I3C), is the bioactive phytochemical and a presumed modulator of reduced cancer risk in areas with high cruciferous vegetable consumption. Unfortunately, despite its potent antiestrogenic activity, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003eLuckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound with respect to antiestrogenic action – promoting the metabolism of beneficial estrogens that themselves reduce estrogenic activity.\u003c\/p\u003e\n\u003cp\u003eAside from its healthy estrogen promoting abilities, DIM also exerts its own direct physiological effects, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromoting pathways of internal estrogen metabolism that favor the production of anti-estrogen estrogens.\u003c\/li\u003e\n\u003cli\u003eAdjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.\u003c\/li\u003e\n\u003cli\u003eLimit the cell division and growth of certain estrogens.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lies in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLongjack Root Extract (Eurycoma longifolia) (Root) (std. 35% Glycosaponins, 20% Eurypeptides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe name Eurycoma longifolia is probably familiar to most within the bodybuilding and fitness community, as it has a long history of use as an aphrodisiac supplement. Also known as Tongkat Ali, Malaysian Ginsgeng, and Longjack, the herb is found in temperate regions of Southeast Asia and has been used for centuries as an aphrodisiac in medicinal systems local to those regions.\u003c\/p\u003e\n\u003cp\u003eWestern research has begun to establish that Eurycoma longifolia’s does in fact have an effect on libido, in both animal and human trials. Over the past several decades, numerous in vivo animal and human studies have been conducted to further explore Eurycoma longifolia’s effect on the management of sexual disorders, infertility, low libido, and low testosterone levels. A large majority of these studies have gathered enough evidence to conclude that Eurycoma longifolia use in the support of improving these outcomes is an acceptable rationale. While the exact mechanism of action is somewhat unclear, it is suggested that it helps to restore normal testosterone levels through increasing the release of free testosterone from its binding hormone, sex hormone-binding globulin.\u003c\/p\u003e\n\u003cp\u003eBenefits from an increase in testosterone levels can include higher physical vigor and strength as well as increased vitality and cortisol management.\u003c\/p\u003e\n\u003cp\u003eThough more research is required to establish Tongkat’s aphrodisiac and\/or pro-erectile effects in humans, the existing animal research is fairly consistent in suggesting the herb’s effects in these areas.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eShoden® Ashwagandha (Withania somnifera) (Root and Leaf) (std. to 35% withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWithania somnifera Dunal, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, Withania somnifera is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwagandha has been the subject of numerous animals, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immunomodulating compound. Ashwagandha’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwagandha, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eCore Nutritionals selected the potent Shoden® Ashwagandha Extract due to these potential physiological benefits of withanolides to include in its Stabilize for Men formula. Shoden® is a full-spectrum Ashwagandha extract, standardized with 35% withanolides. Shoden® offers a very high bioavailability and demonstrated optimal activity even at low doses.\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within Shoden® has resulted in encouraging results in a number of human, clinical trials looking at the benefits on aerobic and anaerobic physical activity. In several randomized, double blinded, placebo-controlled studies, Shoden® Ashwagandha showed positive impacts on reduction of stress induced cortisol, power output, rate of perceived exertion, capillary lactate levels, and oxygen intake (VO2 max). Shoden® has also shown increases in DHEA-S and testosterone in men when supplemented.\u003c\/p\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant is reduction in cortisol. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePregnenolone\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePregnenolone is a naturally occurring steroid hormone and a critical precursor in the biosynthesis of other hormones, including testosterone, DHEA, progesterone, and cortisol. Often referred to as the \"mother hormone,\" pregnenolone plays a foundational role in maintaining an optimally functioning endocrine system. By replenishing or supporting pregnenolone levels, it's possible to positively influence the hormonal cascade that ultimately supports healthy testosterone production, especially in individuals experiencing age-related hormonal decline or chronic stress.\u003c\/p\u003e\n\u003cp\u003ePregnenolones mechanism of action for supporting testosterone lies in its role as an upstream precursor in the steroidogenic pathway. Synthesized primarily in the mitochondria of the adrenal glands and to some extent in the gonads and brain, pregnenolone is derived from cholesterol. From there, it can be converted into DHEA (dehydroepiandrosterone), which then serves as a direct precursor to both androstenedione and testosterone. This pathway suggests that supplementing with pregnenolone may help provide the raw materials necessary for endogenous testosterone synthesis, especially when the body is under stress or lacking in critical hormonal substrates.\u003c\/p\u003e\n\u003cp\u003eBeyond its role in testosterone synthesis, pregnenolone is also known for its neurosteroidal effects. It has been shown to influence memory, mood, and overall cognitive performance by modulating GABA and NMDA receptors in the brain. This is particularly relevant because chronic psychological stress and poor sleep — both of which pregnenolone may help regulate — are known to suppress testosterone levels. Therefore, pregnenolone may indirectly support testosterone production by helping the body better manage stress and maintain a favorable neuroendocrine environment.\u003c\/p\u003e\n\u003cp\u003ePregnenolone can offer a foundational approach to testosterone support by supporting the hormonal structure needed for healthy androgen production, making it a potentially valuable addition to a comprehensive hormone optimization protocol, especially for those focused on longevity, stress resilience, and endocrine balance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoron (as Boron Citrate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoron is a mineral present in multiple fruits, vegetables, tubers, and drinking water, though it is not widely accepted as either an essential mineral or essential vitamin. Boron affects a few physiological functions in the body, particularly modulating hormonal homeostasis.\u003c\/p\u003e\n\u003cp\u003eWhile still emerging, recent data suggest that boron may play a role in potentiating free testosterone levels in healthy men. In one study, otherwise healthy men were provided an acute serving of boron and had their free and total levels of testosterone, alone with SHBG (sex hormone binding globulin) and DHT (dihydrotestosterone) levels measured. In that study, total testosterone was unaltered, but free testosterone was enhanced by 14%, while SHBG was significantly (9%) reduced. Boron has also shown substantial evidence in playing a role in supporting normal prostate function, specifically through lowering PSA (prostate specific antigen), which can be a marker for prostate abnormality advancement. Other studies have shown the effectiveness of adequate boron levels on optimizing prostate health. One human study concluded that men who ingested the greatest amount of boron in their diet were 54% less likely to be at risk of prostate related issues when compared to the lowest intake.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePuremidine® (Spermidine Trihydrochloride 98%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpermidine, a naturally occurring polyamine found in foods like wheat germ, soybeans, and aged cheese, has gained popularity for its powerful cellular health and longevity-promoting properties. Puremidine® is a high-purity, clinically researched form of spermidine designed to deliver consistent, bioavailable doses. While spermidine is not a traditional testosterone booster, emerging evidence suggests it may support testosterone production indirectly by optimizing key cellular processes, particularly autophagy, mitochondrial function, and inflammation regulation.\u003c\/p\u003e\n\u003cp\u003eThe primary mechanism of action for spermidine is its ability to stimulate autophagy—the body’s process of cleaning out damaged cells and regenerating newer, healthier ones. This cellular renewal process is crucial for optimal function of testosterone-producing cells, especially the Leydig cells in the testes. Autophagy supports mitochondrial efficiency and reduces oxidative stress, both of which are essential for maintaining the energy-demanding process of steroidogenesis (testosterone synthesis). In essence, spermidine helps maintain the health and functionality of the very cells responsible for producing testosterone.\u003c\/p\u003e\n\u003cp\u003eAdditionally, spermidine has been shown to reduce systemic inflammation and support metabolic health, both of which are closely linked to hormonal balance. Chronic inflammation and metabolic dysfunction (e.g., insulin resistance) can impair the hypothalamic-pituitary-gonadal (HPG) axis and suppress testosterone production. By improving mitochondrial integrity and reducing pro-inflammatory cytokines, spermidine may help restore hormonal homeostasis and enhance the body’s responsiveness to luteinizing hormone (LH), the signal that stimulates testosterone synthesis.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/VITAL_T_SUPP_FACS.png?v=1747151411\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Vital-T-8.5x3.25-FINAL.pdf?v=1747151101\"\u003eVital-T Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":44409541460144,"sku":"SHOP850057789362","price":64.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/VITAL_T_FRONT.png?v=1753129937"}],"url":"https:\/\/www.corenutritionals.com\/collections\/national-testosterone-day-promo.oembed","provider":"Core Nutritionals","version":"1.0","type":"link"}