{"title":"ALL","description":"","products":[{"product_id":"5-at","title":"5-AT","description":"\u003cp style=\"color: #9c0c30;\"\u003e\u003cstrong\u003eIngredients in this product are not WADA approved. Do not take if you are tested by WADA standards. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e5-Etioallocholen-3b,7b,17b-triol: More commonly known as androstenetriol, 5-etioallocholen-3 beta-7 beta-17beta-triol is a metabolite of the ubiquitous endogenous steroid, dehydroepiandrosterone (DHEA). DHEA is one of the most abundant endogenous steroids in the human body, playing a critical role in a number of bodily functions. These functions include, though are not limited to, serving as an intermediate (a middle piece) in the synthesis of sex steroids such as testosterone and estrogen, up-regulating (increasing) immune response and countering the immunosuppressive actions of corticosteroids, and maybe the most impressive, directly and strongly suppressing the release of cortisol itself!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eThough DHEA’s properties have been well-established and understood for decades, derivatives and metabolites of DHEA have more recently been the subject of research in animals and humans – demonstrating effects that are, at times, many orders of magnitude more significant than the parent compound (up to 100x as potent!).\u003c\/p\u003e\n\u003cp\u003eLike DHEA, cortisol is one of the body’s most abundant and important endogenous steroids. While detailing in full the expansive list of cortisol’s functions is impossible, we can generally say that cortisol’s role in the human body is to break down bodily tissue and nutrients for the purpose of energy provision (to be catabolic), to act as an immunosuppressive, and to regulate blood sugar. Cortisol fulfills these functions by inducing gluconeogenesis (the breakdown of non-glucose intermediates, such as amino acids in muscle tissue, into glucose) and glycogenolysis (the breakdown of glycogen into glucose), inhibiting peripheral glucose utilization, and inhibiting cell lines critical to the body’s immune response.\u003c\/p\u003e\n\u003cp\u003eIn less complex terms, we can simply say that cortisol is responsible for inhibiting many of the processes that we as fitness enthusiasts want to start, and for starting many of the processes that we want to inhibit. Cortisol plays a role in:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePreventing our muscle cells from uptaking glucose (inducing insulin resistance).\u003c\/li\u003e\n\u003cli\u003ePreventing muscle protein synthesis.\u003c\/li\u003e\n\u003cli\u003eThe breakdown of glycogen (the compound responsible for that “full look”).\u003c\/li\u003e\n\u003cli\u003eSuppressing the immune processes involved in muscle growth.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhile these are necessary functions, their overexpression is precisely the opposite of what we want – in fact, certain trials in humans have shown that an increase in plasma cortisol within the physiologic range increases proteolysis (breakdown of proteins) and degrades whole body amino acid synthesis! That is bad, bad news.\u003c\/p\u003e\n\u003cp\u003eEnter DHEA and its metabolite, androstenetriol. In emerging animal literature, both androstenetriol and its metabolites have been shown to possess very potent anti-glucocorticoid activity – remembering that cortisol is the parent compound for this group – and anti-immunosuppressive actions in a number of different tissue types. In fact, androstenetriol is one of the most potent anti-glucocorticoids the body produces – exerting almost unbelievable effects in certain pro-inflammatory cell lines.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-5T.jpg?v=1597908865\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_5-AT_2020_6.25x2.25_FIN-OL.pdf?v=1644226124\"\u003e5-AT Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3426813542429,"sku":"SHOP672975315429","price":34.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/5AT_FRONT.png?v=1760395353"},{"product_id":"acetyl-l-carnitine","title":"Acetyl-L-Carnitine","description":"\u003cp\u003eAcetyl-L-carnitine has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromote fatty acid and carbohydrate metabolism\u003c\/li\u003e\n\u003cli\u003eBe involved in brain processes such as mood and memory\u003c\/li\u003e\n\u003cli\u003ePlay a key role in protein synthesis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eAcetyl-L-Carnitine (ALCAR) is a little bit like your 401K: you need it, you know you should pay attention to it, but it’s not exactly the sexiest topic. We know; we feel you! But we also know that ALCAR is one of the most fascinating, useful, and physiologically exciting workout supplements on the planet. You’re hard-pressed to find a single other ingredient that is involved in so many critical bodily processes: fatty acid and carbohydrate metabolism, neurotransmission, exercise performance and capacity, brain function – the list goes on! So, like your 401K contribution, don’t forget to pay into your ALCAR fund. \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eL-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions. \u003c\/p\u003e\n\u003cp\u003eUnfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-ALCAR.jpg?v=1597908997\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Alcar_2020_7.5x2.5_FIN-OL.pdf?v=1644226026\"\u003eAcetyl-L-Carnitine Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3426815016989,"sku":"SHOP672975315405","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/ACETYL_FRONT.png?v=1760395319"},{"product_id":"bcaas","title":"BCAAs","description":"\u003cp\u003eBranch Chain Amino Acids have been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease skeletal muscle protein synthesis.\u003c\/li\u003e\n\u003cli\u003eHelp to assist in muscle cell repair after exercise.\u003c\/li\u003e\n\u003cli\u003eHelp support immune system health after periods of physical stress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIf you’ve taken BCAAs before, then you have probably heard somebody drone on about how they are unnecessary, how all their protein comes from dietary sources, and probably, how they raise their own pigs in the backyard for pork chops. That’s all great, and while we agree that whole food sources are the best, we also know that supplemental BCAAs can play a huge role in attaining your fitness goals. During a workout, before, or after, our 2:1:1 BCAAs are perfect for crafting a workout cocktail that is specific to you and your needs.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eBranched-Chain Amino Acids (BCAAs) have been demonstrated to possess a wide range of physiological benefits, including cell signaling, regulation of protein synthesis and cell metabolism, hypertrophic growth and the mitigation or reduction of post-exercise muscle soreness. BCAAs themselves are considered essential amino acids, or EAAs, as the human body is not capable of synthesizing them. While leucine, isoleucine, and valine, have collectively been shown to regulate critical physiological processes in the body, leucine has been shown to have particularly direct effects on protein synthesis and tissue growth.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-BCAA.jpg?v=1597909130\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_BCAA_2020_10x4_FIN-OL.pdf?v=1644226366\"\u003eBCAAs Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3426819571741,"sku":"SHOP672975315368","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/BCAA_FRONT.png?v=1760395151"},{"product_id":"beta-alanine","title":"Beta Alanine","description":"\u003cp\u003eBeta-Alanine has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease muscle strength.\u003c\/li\u003e\n\u003cli\u003eIncrease overall muscle performance.\u003c\/li\u003e\n\u003cli\u003eIncrease aerobic and anaerobic endurance.\u003c\/li\u003e\n\u003cli\u003eDecrease muscular fatigue in response to high intensity exercise (weight training).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eYou know the tingling sensation you get after taking beta-alanine? Well, we are here to reveal the long held secret behind that feeling, guarded for years by bodybuilding elitists: it’s nothing less than the feeling of magic, and success. \u003c\/p\u003e\n\u003cp\u003eOf course, we are kidding. Who do we look like, every other supplement manufacturer? That sensation is actually a phenomenon known as paresthesia, induced when the nerves under the skin are bound to and activated. It is thought that beta-alanine binds to these same nerves, and thus produces the same sensation.\u003c\/p\u003e\n\u003cp\u003eWith that said, beta-alanine’s effectiveness and versatility have given it an almost magic-like status amongst fitness enthusiast. With evidence demonstrating reductions in fatigue in response to high intensity exercise, amongst other things, you might think it’s magic, too!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eBeta-alanine is the rate-limiting substrate in the production of intramuscular carnosine, and its supplementation is responsible for directly increasing levels of carnosine in skeletal muscle. As a dietary supplement, beta-alanine has a range of applications, including serving as a cellular buffer, and increasing the capacity of skeletal muscles for work. Trials in humans have demonstrated that beta-alanine supplementation is directly linked to an increase in muscular strength in acute challenges, increased muscular performance, and a decrease in muscular fatigue.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-BETA.jpg?v=1597909250\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Beta_Alanine_2020_10x2.375_FIN-OL.pdf?v=1644226494\"\u003eBeta Alanine Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3426822520861,"sku":"SHOP672975315382","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/BETAA_FRONT.png?v=1760395106"},{"product_id":"creatine-monohydrate","title":"Creatine Monohydrate","description":"\u003cp\u003eCreatine monohydrate has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease muscle mass\/size (when used in conjunction with a resistance training program).\u003c\/li\u003e\n\u003cli\u003eImprove strength, power, and performance in repetitive bouts of brief, high intensity physical activity (e.g. sprints, jumping).\u003c\/li\u003e\n\u003cli\u003eDecrease muscular fatigue in response to high intensity exercise (weight training).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eTHIS PRODUCT IS INFORMED SPORT CERTIFIED\u003c\/h3\u003e\n\u003cp\u003eThis certification ensures that Creatine Monohydrate, is tested for banned substances and meets the highest standards for quality, safety, and transparency. This certification can provide elite athletes and average gym goers with the confidence that every batch is free from contaminants and complies with WADA, as well as other sports league regulations.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eEvery write-up crafted about creatine, including ours, should simply say: it’s creatine, enough said. This is, after all, the most studied, the most anecdotally verified, and the most well known dietary supplement available to us – and with good reason. The evidence on creatine truly does, “speak for itself.”\u003c\/p\u003e\n\u003cp\u003eWith that said, much hoopla has arisen over the past few years regarding how to take creatine, when to take creatine, which form is the best, and so on. We have simplified that for you, and provided you the best, highest purity creatine monohydrate on the market at a competitive price – unbeatable, we’d say!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eCreatine is perhaps the most studied and verified of all dietary supplements, earning its moniker as the, “grandfather of supplements.” Through a number of enzymatic and cellular steps, creatine is first metabolized into a compound known as phosophocreatine, and eventually into a compound known as ATP (adenosine triphosphate) – the so-called, “energy currency” of the human body. As a dietary supplement, the use of creatine over extended periods of time has been linked to a wide-range of physiological benefits, including: cell volumization, increased delivery of plasma (blood) nutrients to the cell, an increase in skeletal muscle total mass and protein synthesis, decrease in muscular fatigue, and increased endurance.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-CREATINE.jpg?v=1597909681\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_Creatine_P65_FIN-OL.pdf?v=1644226888\"\u003eCreatine Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"400g","offer_id":45079062479024,"sku":"SHOP672975315344","price":24.99,"currency_code":"USD","in_stock":true},{"title":"100g","offer_id":45079062511792,"sku":"SHOP850080302828","price":9.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Creatine_UF_Front.png?v=1752584552"},{"product_id":"glutamine","title":"Glutamine","description":"\u003cp\u003eGlutamine has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eHelp maintain immune system function.\u003c\/li\u003e\n\u003cli\u003eFacilitate muscle glycogen recovery after intense physical activities (weight training).\u003c\/li\u003e\n\u003cli\u003eRestore glutamine levels required for healthy muscle growth after intense physical exercise (e.g. sprints, jumping).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eTo glutamine, or not to glutamine – that is the question. Well, it’s really not much of a question, considering the potential benefits of a high quality, high purity glutamine are far too numerous to ignore. \u003c\/p\u003e\n\u003cp\u003eDespite the widely held belief that the scientific jury on glutamine is out, a fair amount of evidence exists to suggest that glutamine is beneficial to the human body in a variety of applications. Most of the problem, however, arises in the paltry servings that most companies throw into their formulations – effectively relegating glutamine to the “window dressing” category. \u003c\/p\u003e\n\u003cp\u003eNot us. We are proud to feature glutamine, at effective servings, in our products. And we are even prouder to provide you a high quality source of pure glutamine that you can add to your already killer stack.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eGlutamine is one of the body’s most abundant amino acids, and is an amino acid known as, “conditionally essential.” This means that while the body is capable of producing it under normal physiological conditions, it may require additional dietary sources under certain conditions such as athletic training or stress. In these conditions, glutamine takes on a critical role in the metabolism of muscular protein, in the volumization of cells, and the reduction of cell catabolism (particularly in stressful or traumatic situations). Glutamine has additionally been demonstrated to be immunoprotective in stressful situations, meaning that supplementation with glutamine may help to maintain immune system function.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-GLUTAMINE.jpg?v=1597909789\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Glutamine_2020_10x4_FIN-OL.pdf?v=1644226985\"\u003eGlutamine Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3426826518557,"sku":"SHOP672975315351","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/GLUTAMINE_Front.png?v=1753129802"},{"product_id":"hmb","title":"HMB","description":"\u003cp\u003eHMB has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eAttenuate the rate of muscle protein breakdown.\u003c\/li\u003e\n\u003cli\u003eReduce muscle damage during periods of strenuous exercise.\u003c\/li\u003e\n\u003cli\u003eIncrease power output during explosive movements\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eHMB (otherwise known as β-Hydroxy β-Methylbutyrate) is like the pretty girl who used to sit across from you in biology: sexy, mysterious, but most of all, pretty complex and little understood. And like that girl, the more you actually understand about this fascinating compound, the more you will like it.\u003c\/p\u003e\n\u003cp\u003eHMB burst onto the bodybuilding market in the early 1990’s, and every supplement company and their brother marketed the compound so heavily it gained a reputation as snake oil. The reviews were so varied that HMB was almost relegated to the dustbin of supplement history.e\u003c\/p\u003e\n\u003cp\u003eTimes have changed, however, and people have once again begun to realize that, when used properly at an effective serving, HMB’s positive contributions to a muscle-sparing environment are impossible to overlook.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eHMB (β-Hydroxy β-Methylbutyrate) is an endogenous metabolite of leucine consumption, being derived from its parent amino acid through two steps of enzymatic conversion. In total, approximately 5% of leucine by weight of consumption is converted into HMB.\u003c\/p\u003e\n\u003cp\u003eOnce converted, HMB has been demonstrated to possess several interesting effects. In cellular assays, HMB was shown to increase the rate of skeletal protein synthesis through the same mechanism as its parent compound, leucine – the all-important mTOR-P13K pathway that regulates the majority of muscle protein synthesis in vivo. This mechanism has also translated into practical benefits to human muscle, as various trials have demonstrated HMB to slow the rate of skeletal muscle breakdown, increase power output over both acute (short) and chronic (long-term) trials, as well as mitigating muscle damage during high-intensity exercise.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-HMB.jpg?v=1597909864\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_HMB_2020_8x2_FIN-OL.pdf?v=1644227045\"\u003eHMB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3426829008925,"sku":"SHOP672975315399","price":34.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HMB_FRONT.png?v=1760394993"},{"product_id":"core-test","title":"Test","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCalcium D-Aspartic Acid\u003c\/strong\u003e - Supports Health Testosterone Levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Aids in Cortisol Reduction to Help with Body Composition\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBulbine Natalensis\u003c\/strong\u003e - Increase in Overall Vitality\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIf you don’t know your best yet, you’ll certainly know it when Core TEST helps you reach it.\u003c\/p\u003e\n\u003cp\u003eWe’ve scoured the literature and eventually created a formula packed with effective ingredients targeting multiple pathways of healthy testosterone support. This is the best, most comprehensive, multi-pathway testosterone support product on the market.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e1 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eHealthy testosterone support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eBeing at your best, your peak, isn’t a subjective state of mind or a feeling one has – it’s a physiological state, a confluence of metabolic factors that result in the best, most peak, most alpha version of you stepping out into the world and into the gym every day. Are you doing what’s necessary to be there?\u003c\/p\u003e\n\u003cp\u003eIf not, then Core has your back with the newest evolution in healthy testosterone and male support: Core TEST. By now, you already know the drill: we take the best ingredients, backed by clinical research, and include them in serving sizes actually reflected in the literature. Core TEST is no different.\u003c\/p\u003e\n\u003cp\u003eWe’ve scoured the literature, alpha and beta tested more formulas than you can count, and eventually created a formula packed with actually effective ingredients targeting multiple pathways of healthy testosterone support. Calcium DAA, one of the best known support supplements on the market, backed by clinical research in humans. KSM66, an ingredient with a long history of use in traditional medicine now backed by an unimpeachable record of cortisol reduction, healthy testosterone support, and hormone optimization. We could’ve given you KSM66 and left it at that – the ingredient is that good. But we didn’t. We included Bulbine natalensis, Tongkat Ali, and a potent estrogen modulator in Pine extract to cap off the savagery. This is the best, most comprehensive, multi-pathway testostone support product on the market.\u003c\/p\u003e\n\u003cp\u003eAll in all, we have created a formula that you’ll know is working. If you don’t know your best yet, you’ll certainly know it when Core TEST helps you reach it.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium D-Aspartic Acid\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eD-Aspartic Acid, the d isomer form of the amino acid aspartate, is an amino acid that is found naturally in several endocrine glands, including the testes and pituitary. While the correlation between DAA and testosterone production has been clinically documented, research indicates several possible mechanisms for these effects.\u003c\/p\u003e\n\u003cp\u003eIt’s likely that DAA acts as a neuromodulator influencing several pathways that govern the reproductive system, particularly testosterone production. Some studies indicate that DAA’s concentrated presence in the hypothalamus, pituitary, and testes identify this protein as an up-regulator of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), growth hormone (GH), and testosterone. Some studies have found that DAA also stimulates a protein called StAR. StAR is necessary for the cholesterol transport in the cell that is needed for testosterone production. Further, its role in modulating the sexual drive implicates DAA assists nootropic activity, supporting health levels of dopamine and serotonin. Balanced levels of dopamine and serotonin have a range of significant benefits.\u003c\/p\u003e\n\u003cp\u003eThe existing research in human males suggests these mechanisms of action have plausible, real world activity. A six-month trial in average men, for example, saw increases to circulating testosterone of 30-60%. The increase over baseline persisted for the entirety of the trial in certain subjects, suggesting that DAA does not lose its effects over time or with repeated administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal,\u003c\/em\u003e colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant for Core TEST is a study involving KSM66® and testosterone. 46 male patients were treated with KSM66® or placebo for 90 days, with measurements of serum hormone levels taken at the end of the 90 day treatment. The study established that 675mg of KSM66 over 90 days had a statistically significant impact on healthy testosterone production in males, as compared to placebo. The same study also found an increase in healthy production of LH (luteinizing hormone), suggesting that KSM66’s method of action is at the pituitary level.\u003c\/p\u003e\n\u003cp\u003eTo put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eBulbine natalensis\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e (stem) Extract (10:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBulbine natalensis is a herb endemic to Southern African that has historically been used as an aphrodisiac in traditional medicine preparations. Recent animal research has demonstrated that the herb has healthy testosterone supporting effects in rats and may also elicit positive effects on cognition.\u003c\/p\u003e\n\u003cp\u003eWhile Bulbine natalensis’ method of action is not certain, research conducted on rats suggests its testosterone-support functions stem from an increase in LH (luteinizing hormone). Luteinizing hormone is a hormone released by the pituitary gland to signal the Leydig cells in the testes to produce testosterone. The animal trial demonstrating an increase in LH also demonstrated an increase in rat testosterone levels at 14 days. The study revealed an increase in circulating testosterone of 40%.\u003c\/p\u003e\n\u003cp\u003eIn these same trials, an aqueous extract of the herb was found to dose-dependently lower estrogen levels in male rats. Research has not established whether the estrogen-lowering effects of Bulbine natalensis are a cause or consequence of its ability to support healthy testosterone levels.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eEurycoma longifolia\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e (root) Extract (100:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe name \u003cem\u003eEurycoma longifolia \u003c\/em\u003eis probably familiar to most within the bodybuilding and fitness community, as it has a long history of use as an aphrodisiac supplement. Also known as Tongkat Ali, Malaysian Ginsgeng, and Longjack, the herb is found in temperate regions of SouthEast Asia and has been used for centuries as an aphrodisiac in medicinal systems local to those regions.\u003c\/p\u003e\n\u003cp\u003eWestern research has begun to establish that \u003cem\u003eEurycoma longifolia’s \u003c\/em\u003edoes in fact have an effect on libido, at least in animal trials. Trials in rats have demonstrated Tongkat Ali increased measures of sexuality (mounting frequency, latency to ejaculation and partner selection), while \u003cem\u003ein vitro \u003c\/em\u003eassays have identified pro-erectile bioactive compounds.\u003c\/p\u003e\n\u003cp\u003eThough more research is required to establish Tongkat’s aphrodisiac and\/or pro-erectile effects in humans, the existing animal research is fairly consistent in suggesting the herb’s effects in these areas.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePine Extract (rosin) (97% abieta-8,11,13-trien-18-oic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAbieta-8,11,13-trien-18-oic acid, more commonly known as Dehydroabietc acid or DHAA, is a terprene compound isolated from several plants and trees, including certain species of Pine. Certain assays have also isolated DHAA from resin of \u003cem\u003eCommiphora myrrha.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eWhile limited in amount, the research that exists on DHAA is promising. Prior to discussing this research, it may be useful to explain the research term IC50. IC50 is a measurement in estrogenic assays that describes the amount of a given aromatase-inhibiting compound needed to reduce half (or 50%) of the aromatase enzyme. The aromatase enzyme, in turn, is the enzyme responsible for converting testosterone to estrogen. The prescription drug Formestane, for example, has an IC50 value of 0.6 mu – with a lower value indicating a more potent compound. (The less compound needed to reduce aromatase by 50%, the more powerful it is).\u003c\/p\u003e\n\u003cp\u003eDHAA’s IC50 value – according to the available research – is 0.3 mu, suggesting that it has potent activity against the aromatase enzyme. While the research exhibiting DHAA’s precise IC50 value is \u003cem\u003ein vitro\u003c\/em\u003e, animal research does exist to suggest a practical, real-world effect. Agricultural studies in fish examining DHAA as an environmental factor suggest that DHAA \u003cem\u003esignificantly \u003c\/em\u003eand level-dependently reduces circulating estrogen in certain fish species.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-TEST-2020.jpg?v=1597301883\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_TEST_2020_PRIMAL_PUNCH_FIN-OL.pdf?v=1639562855\"\u003ePrimal Punch Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_TEST_2020_PRIMAL_BLACK_LIGHTNING_FIN-OL_compressed_1.pdf?v=1639562730\"\u003eBlack Lightning Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-TEST-Product-References.pdf?12965010941871190252\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Primal Punch","offer_id":32075154587763,"sku":"SHOP672975315023","price":56.99,"currency_code":"USD","in_stock":true},{"title":"Black Lightning","offer_id":32075154620531,"sku":"SHOP672975315030","price":56.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TEST_BL_Front-1.png?v=1757596231"},{"product_id":"core-omega","title":"Omega","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eEPA\/DHA\u003c\/strong\u003e - May support normal brain function\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEPA\/DHA\u003c\/strong\u003e - Superior triglyceride form\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEPA\/DHA\u003c\/strong\u003e - Produced under nitrogen barrier\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHigh Purity Fish Oil\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis is not just another fish oil product – it is \u003cem\u003ethe\u003c\/em\u003e fish oil product.\u003c\/p\u003e\n\u003cp\u003eOMEGA contains high levels of the all-important DHA and EPA, with 480mg and 720mg respectively in each serving. Produced under a nitrogen barrier, this is the purest fish oil product possible.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e2 soft gels per serving.\u003c\/li\u003e\n\u003cli\u003e60 servings per container.\u003c\/li\u003e\n\u003cli\u003eHeart and brain health.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhen it comes to dietary supplement purchases, consumers are discerning and exact: the dose, form, extract, standardization and more must precisely conform to their standards. The brand matters, the compounds matter, and how those compounds are produced matters.\u003c\/p\u003e\n\u003cp\u003eBut when it comes to the basic supplements, the staples, most people have the attitude, “It’s all the same.” They travel to their local supplement store, browse quickly online, or grab whatever’s on the grocery store shelves and call it a day. Why? Shouldn’t the staples, something you are placing in your body everyday, be purchased with as much exactitude as the exotic stuff? And more importantly, shouldn’t the staples be produced with as much care and attention to specifics as the exotic stuff?\u003c\/p\u003e\n\u003cp\u003eAt Core, we think they should – and that’s why we’ve released OMEGA. OMEGA is a fish oil supplement, the Core way. What does that mean? Well, it means carefully selecting a fish oil manufacturer for our product that produces its fish oils under the all important nitrogen barrier – a manufacturing technique that greatly reduces the chance for oxidation, significantly expands the product’s effective shelf life, and all but eliminates any “fish” taste or smell from the oil. It also means ensuring that our fish oil product contains high levels of the all-important DHA and EPA, with 480mg and 720mg respectively in each serving. Lastly, it means using the purified triglyceride form, rather than the more common ethyl esters.\u003c\/p\u003e\n\u003cp\u003eIn total, this is not just another fish oil product – it is the fish oil product.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological properties and effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNitrogen Barrier Production \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOil derived from marine animals – commonly referred to as “fish oils” – are widely consumed for the high amounts of polyunsaturated fatty acids (such as DHA and EPA) that they contain and the potential health benefits that these fatty acids confer. Unfortunately, polyunsaturated fatty acids are notoriously unstable: they are composed of double-bonds between carbon atoms, a chemical structure that is notoriously susceptible to oxidation. (Oxidation is the process of producing oxygen species as a consequence of a compound’s exposure to oxygen.)\u003c\/p\u003e\n\u003cp\u003eFor fish oil, oxidation has a number of deleterious effects – principally, the production of hydroperoxides (the first step in oxidation) and secondary oxygen products not only produce the rancid, “fish” smell typically associated with lower quality fish oil products; but perhaps more importantly, in breaking the double bond structure of the fish oil, these oxygen species degrade the integrity of the product and thus reduce their potential health benefits. The oxidation degradation is unfortunately widespread. One study found that 50% of 171 fish oil supplements in Canada exceeded the limits for at least one measure of oxidation, and 39% exceeded the international voluntary safety recommendations for total oxidation (TOTOX value).” Another study found that approximately 29% of fish oil supplements in the United States similarly exceeded recommended values.\u003c\/p\u003e\n\u003cp\u003eLuckily, research has shown that reducing the exposure of fish oils to oxygen and environmental factors (humidity and temperature fluctuations) during the production process can significantly mitigate oxidation. One of the most effective ways to reduce oxygen exposure is to blanket the oil, as soon as its processed and produced, in an inert gas such as argon or nitrogen – thereby preventing the fish oil from coming into contact with oxygen at all. While exact values will vary by product, research has shown that both primary oxidation (the production of hydroperoxides, measured in peroxide value, PV) and secondary oxidation (measured in TOTOX (total oxidation value) and a-nsidine values) are vastly reduced through a nitrogen blanket or barrier. \u003c\/p\u003e\n\u003cp\u003eIn sum, producing fish oils under a nitrogen blanket or barrier not only reduces the rancid smell typically associated with fish oil products; but vastly extends their shelf life and integrity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eTriglycerides vs Ethyl Ester Forms\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe have established that \u003cem\u003ehow \u003c\/em\u003efish oils are produced may impact their viability as a dietary supplement. But the production process is not the only salient factor in fish oil efficacy and viability – the \u003cem\u003eform \u003c\/em\u003ethat a fish oil takes is paramount, as well. Specifically, the differences between triglycerides and ethyl esters may be formative in how fish oils are absorbed and confer their potential health benefits.\u003c\/p\u003e\n\u003cp\u003eFirst, a little primer on what triglycerides and ethyl esters are. Triglycerides are a molecular form common to almost all plant and animal species: a glycerol backbone with three fatty acids (in the case of fish oils, EPA and DHA) attached to them. For example, the “stuff” of human adipose (fat) tissue is triglycerides. Ethyl Esters, on the other hand, lack a glycerol backbone – they are a single fatty acid molecule attached to an ethanol molecule. Unlike triglycerides, ethyl esters are not a natural molecular form and formed solely through chemical synthesis.\u003c\/p\u003e\n\u003cp\u003eWhile the difference between triglycerides and ethyl esters as applied to fish oil may seem academic, it in fact has profound implications for the absorption and bioavailability of these oils. In very condensed form, the issue is twofold: how the fish oil is taken up into the bloodstream (absorption) and how it is made available to cells once that has occurred (bioavailability). In both contexts, there is evidence that triglycerides are superior to the ethyl ester form.\u003c\/p\u003e\n\u003cp\u003eFor bioavailability, the issue is how the small intestine breaks down each form of fish oil. As a natural product, our bodies are intrinsically capable of breaking down triglycerides via bile salts and pancreatic lipase. Once ingested, pancreatic lipase and bile salts are released, and in the small intestine, the triglyceride is broken down into so-called emulsion droplets – which can then easily be broken up, detaching the two fatty acid molecules from the glycerol backbone. Not so with ethyl esters. Not only is pancreatic lipase (by some estimates) 50% less effective in breaking down ethyl esters; but once digested, ethyl esters must be \u003cem\u003econverted \u003c\/em\u003einto triglycerides through the liberated fatty acids attaching to a glycerol molecule. Essentially, your body must reverse the entire metabolism of ethyl esters, then go through the normal triglyceride metabolism.\u003c\/p\u003e\n\u003cp\u003eThe biochemical differences between triglycerides and ethyl esters have been demonstrated in trials examining bioavailability and absorption efficiency. One study found that, when ingested in triglyceride form, EPA and DHA levels were 340% and 271%, respectively, as compared to the ethyl ester form. Additional research has found a 25% increase in plasma EPA and DHA levels over a six month period; that ethyl esters are “poorly absorbed” by man; and that triglyceride form fish oils suffer less oxidation (on shelf) than the ethyl ester form.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEPA and DHA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNow that we know why producing fish oils under nitrogen barrier protects the integrity of fish oil, and why triglycerides are superior to ethyl esters, we have only one major question left: \u003cem\u003ewhat benefits do fish oils (specifically, EPA and DHA) pose to humans\u003c\/em\u003e?\u003c\/p\u003e\n\u003cp\u003eEicosapentaenoic acid (EPA) and cocosahexaenoic acid (DHA) have myriad health benefits, but their best-studied (and approved by the FDA) use is to balance and maintain healthy triglyceride levels. Triglycerides, as we mentioned, are produced naturally by most animals. They are necessary for a wide range of physiological function, but their overabundance is implicated in a number of pathological conditions. As a consequence, ingesting external forms of triglycerides – such as fish oils – can help balance triglycerides and maintain healthy levels. In perhaps the most robust meta-analysis to date, researchers examined 11 randomized human trials, comprised of 485 total individuals with a mean age of 25 to 49. The meta-analysis found robust evidence that DHA, specifically, exerts a significant triglyceride lowering and balancing effect. A similar meta-analysis focused on EPA found that its effects were comparable to DHA.\u003c\/p\u003e\n\u003cp\u003eBoth of these polyunsaturated fatty acids are best known for their triglyceride-lowering function, each exerts other interesting effects as well. Significant evidence suggests that EPA and DHA may mitigate the production of pro-inflammatory cytokines, molecules responsible for inducing the inflammation cascade in the body. Others studies suggest high levels of brain DHA are associated with verbal fluency and memory in healthy, normal adults – with one study finding that 6 months of DHA supplementation in young, healthy adults increased working memory assessed by recall.\u003c\/p\u003e\n\u003cp\u003eOne of fish oil’s (specifically, EPA’s) effects that may be of interest to fitness and physique athletes is its ability to induce AMPk (adenonsine monophosphoate kinase). AMPk, otherwise known as the “master metabolic switch,” is a heterotrimeric enzyme responsible for energy catabolism in muscle and fat cells. When activated, AMPk increases lipolytic (the catabolism of fat tissue) signaling as a means of energy provision. Several studies demonstrate that high levels of EPA indirectly stimulate AMPk activation via decreasing PPARy.\u003c\/p\u003e\n\u003cp\u003eThough less well-studied or confirmed, emerging research suggests that DHA and EPA levels may be formative in maintaining healthy and normal moods, due to altering certain neurological proteins. These literature require follow-up and replication, but show promise in establishing a new purpose for DHA and EPA supplementation.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-OMEGA-2020.jpg?v=1586243286\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_OMEGA_8.5x3.25_FIN-OL.pdf?v=1639556455\"\u003eCore OMEGA Label \u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-OMEGA-Product-References.pdf?3889446998475729901\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":3427025551389,"sku":"SHOP672975009724","price":44.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/OMEGAFRONT_22d0fad9-790c-4bc3-8c6b-12cda715f7ff.png?v=1760376853"},{"product_id":"big-poppa-stack","title":"Big Poppa Stack","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eALPHA - Ultra Potent Natural Hormone Optimizer\u003c\/li\u003e\n\u003cli\u003eHARD - Advanced Recomposition \u0026amp; Hardening Agent\u003c\/li\u003e\n\u003cli\u003eTEST - Healthy Testosterone Support\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"TEST - Black Lightning","offer_id":18643521896563,"sku":"672975315030","price":132.99,"currency_code":"USD","in_stock":true},{"title":"TEST - Primal Punch","offer_id":43793270636720,"sku":"672975315023","price":132.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/BigPoppa.jpg?v=1721059129"},{"product_id":"core-alpha","title":"Alpha","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eN-methyl-D-aspartic acid (NMDA)\u003c\/strong\u003e - Supports healthy testosterone levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e3-desoxy, 7-keto-DHEA\u003c\/strong\u003e - Supports healthy estrogen levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eColeus forskohli root extract\u003c\/strong\u003e - Assists in healthy weight management\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"color: #9c0c30;\"\u003e\u003cstrong\u003eIngredients in this product are not WADA approved. Do not take if you are tested by WADA standards. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eUnleash your inner ALPHA male with the ultra-potent Core ALPHA!\u003c\/p\u003e\n\u003cp\u003eCore ALPHA is an all-natural, innovative product featuring ingredients backed by numerous clinical studies. Core ALPHA’s ingredients are all-natural and powerful, providing a safe and effective way to support healthy hormone function and balance.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e2 capsules per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eHormone balance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCore Nutritionals has been known to produce some of the best healthy hormone support supplements on the market. Our extensive in-house research and multiple blood analyses utilizing our own formulations have indicated significant improvements in all studied metrics over an 8-week trial period. Core Nutritionals natural hormone support arsenal includes products to help you manage and adapt to stresses, support healthy testosterone, as well as improve overall quality of life. To add to that arsenal, Core Nutritionals is proud to present to you Core ALPHA!\u003c\/p\u003e\n\u003cp\u003eCore ALPHA is an all-natural, innovative product featuring ingredients backed by numerous clinical studies. Core ALPHA’s ingredients are not only all-natural but powerful – providing a range of ingredients to support healthy hormone function and balance. As with all Core Nutritionals’ products, Core ALPHA’s ingredients are included in a non-proprietary blend featuring clinical servings, so you know exactly what you are supplementing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eUnleash your inner ALPHA male with the ultra-potent Core ALPHA!\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eScientific breakdown:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-methyl-D-aspartic acid (NMDA):\u003c\/strong\u003e D-aspartic acid (DAA) is an amino acid that is found naturally in several endocrine glands, including the testes and pituitary. While the correlation between DAA and testosterone production has been clinically documented, research indicates several possible mechanisms for these effects. It’s likely that DAA acts as a neuromodulator influencing several pathways that govern the reproductive system, particularly testosterone production. Some studies indicate that DAA’s concentrated presence in the hypothalamus, pituitary, and testes identify this protein as an up-regulator of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), growth hormone (GH), and testosterone. Some studies have found that DAA also stimulates a protein called StAR. StAR is necessary for the cholesterol transport in the cell that is needed for testosterone production. Further, its role in modulating the sexual drive implicates DAA assists nootropic activity, supporting healthy levels of dopamine and serotonin. Balanced levels of dopamine and serotonin have a range of significant benefits.\u003c\/p\u003e\n\u003cp\u003eTo improve on D-aspartic acid we have instead incorporated N-methyl-D-aspartate (NDMA) into the Core ALPHA formula. DAA is converted into NMDA, which is a potent stimulator of the N-methyl-D-aspartate receptor pathway. By directly stimulating this pathway, NMDA is needed only in small doses unlike DAA’s higher dose requirements. In fact, NMDA elicits its hormone releasing action at concentrations approximately 100-fold lower than DAA. Thus, at a 30 mg dose, NMDA, shows promise to support an optimal balance of hormones.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBrassaiopsis glomerulata leaf extract (10:1):\u003c\/strong\u003e Brassaiopsis glomerulata is a large shrub of the Araliaceae family that occurs in south and Southeast Asia. Throughout Asia, this plant is used to treat rheumatism and back pain, aid in digestion, and treat bone fractures in traditional medicinal systems (TMS). Despite its many medicinal uses, the most interesting aspect of the leaves of Brassaiopsis glomerulata is their ability to reduce the activity of aromatase. Studies show that multiple components of a Brassaiopsis glomerulata leaf extract are capable of aromatase inhibition. The addition of this 10:1 extract in Core ALPHA, along with the 3D7K, gives this product a one-two punch at supporting a healthy estrogen balance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMucuna pruriens seed extract (50% L-dopa):\u003c\/strong\u003e Mucuna pruriens is one of the popular medicinal plants of India and is known to contain various beneficial nutritional compounds. The main nutrient found in Mucuna pruriens is L-dopa, which acts as a natural source of dopamine. Prolactin is a hormone released by the pituitary gland, which is believed to exert anti-androgenic effects in men.. Mucuna pruriens’ ability to support healthy dopamine levels may significantly reduce the release of prolactin hormone by the pituitary glands offering powerful benefits. In addition, clinical evidence suggests that Mucuna pruriens not only supports healthy growth hormone levels but also contains naturally occurring serotonin precursors to support mood, memory, and overall well-being. Clinically shown to support optimal balance of growth hormone, prolactin, serotonin and other beneficial hormones, Mucuna pruriens may also assist healthy weight management and stress support.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (cholecalciferol):\u003c\/strong\u003e Vitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, , support for immune and blood pressure health, lean body mass, and weight management). Clinical trials have even linked Vitamin D3 with an increase in overall health and well-being. Although some foods contain vitamin D, the human body generates most of its vitamin D needs from the skin through regular exposure to sunlight. Severe vitamin D deficiency is a significant and widespread problem, especially in North America. In addition to its well-known properties for supporting bone density and strength and general inflammatory response, Cholecalciferol is included in Core ALPHA because studies have shown that higher levels of vitamin D in men are correlated with higher levels of circulating testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as zinc aspartate):\u003c\/strong\u003e Zinc deficiency is prevalent throughout the entire world, including the United States. Both severe and moderate zinc deficiencies are positively correlated with lower testosterone levels in men. And while zinc deficiency has been shown to lower your testosterone levels, zinc supplementation has been correlated with an increase in testosterone levels. Clinical research indicates that zinc deficiency reduces circulating luteinizing hormone and testosterone concentrations, may lower healthy levels of aromatase (increasing estrogen levels), and modifies sex steroid hormone receptor levels, thereby contributing to unhealthy hormone balance and male sexual function. Zinc supplementation with the aspartate form can support optimal zinc absorption and hormone balance.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-ALPHA-2020.jpg?v=1592389807\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ALPHA_2020_FIN-OL.pdf?v=1638797400\"\u003eCore ALPHA Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Core_ALPHA.pdf?v=1599729023\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":13148215378035,"sku":"SHOP672975315009","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/ALPHAFRONT_25eb7840-783d-451c-b319-c54be449725c.png?v=1760378847"},{"product_id":"core-multi","title":"Multi","description":"\u003ch2 class=\"slogan\"\u003e\u003cbr\u003e\u003c\/h2\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eFull daily serving (or more) for most key vitamins and minerals\u003c\/li\u003e\n\u003cli\u003eVeggie caps for enhanced absorption\u003c\/li\u003e\n\u003cli\u003eSpectra anti-oxidant blend\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFull Spectrum Multivitamin and Mineral\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eVegetable Caps\u003c\/li\u003e\n\u003cli\u003eEnhanced Absorption\u003c\/li\u003e\n\u003cli\u003eEfficacious Servings\u003c\/li\u003e\n\u003cli\u003eNo Proprietary Blends\u003c\/li\u003e\n\u003cli\u003eGluten Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNailing a completely balanced diet every day, one that contains the full spectrum of essential and non-essential vitamins and minerals alike, would be amazing. It would be even better if everyone did that. In that case, the often-quoted but little understood claim of many “gurus” that a vitamin supplement is unnecessary would be correct.\u003c\/p\u003e\n\u003cp\u003eBut that’s not the case, not at all. In fact, research shows that most people – yes, even you, the fit person reading this – do not eat a balanced diet. Many people lack critical nutrients from their diet, either by absence (not eating them at all) or by over- or under-consuming other trace minerals or vitamins necessary for the original vitamin’s homeostasis. The result, in either case, is a vitamin and mineral environment that could and can be optimized.\u003c\/p\u003e\n\u003cp\u003eFor that reason, we’ve formulated Core MULTI. Like the typical diet, when we looked around the industry at existing multi-vitamin offerings, we found critical defects: too much of this, too little of that, and so on. So, we set out to alter that arrangement and formulate a multi with ingredients included in specific proportions to maximize synergy and minimize redundancy.\u003c\/p\u003e\n\u003cp\u003eThe result is a formula not only with 100% (and often more) of almost all your essential vitamins and minerals, but also a broad-spectrum antioxidant blend antioxidant blend (Spectra™), berberine HCL, and numerous trademarked forms of vitamins and minerals. If you need a broad range of essential vitamins and minerals in sufficient amounts and in the most efficient forms, then Core MULTI is for you.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eB Vitamins (Thiamine, Riboflavin, Niacin, B6 [Pyridoxine], Folic Acid, B12, Biotin, and Pantothenic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Though both molecularly and physiologically distinct, they are also deeply interrelated in their effects, synthesis and metabolism. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) in order to maintain the cell functions to which B vitamins contribute.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin A (as Beta Carotene)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBeta carotene is itself not an essential vitamin but is rather the precursor to the fat-soluble and essential vitamin, vitamin A (Retinol). Like B vitamins, the term vitamin A refers to the compound class retinoids, comprised of retinol, retinal (also called retinaldehyde), retinoic acid, and provitamin A compounds such as beta carotene.\u003c\/p\u003e\n\u003cp\u003eAs their names suggest, retinoids are critical to the function of human eyes and therefore to the maintenance of circadian rhythms (our “biological clock”). Vitamin A combines with proteins in the eye to form light-sensing cells that both facilitate vision and regulate our sleep-wake cycles.\u003c\/p\u003e\n\u003cp\u003eBeyond its role in sight, vitamin A is also essential for cellular growth and differentiation and the immune system.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C (as Ascorbic Acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/p\u003e\n\u003cp\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (as Cholecalciferol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an import and biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin E (as Mixed Tocopherols) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin E is another technical misnomer, as the term refers to a group of compounds known as tocopherols with eight biologically-active constituents: alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol. Alpha-tocopherol is the principal bioactive in humans, though the presence of other tocopherols has been linked to beneficial effects.  \u003c\/p\u003e\n\u003cp\u003eAs a result of its robust antioxidant activity, vitamin E assists in the maintenance and support of several physiological processes, though most notably sight and the immune system. Emerging research also suggests that the alpha-tocopherol form of vitamin E inhibits an enzyme known as protein kinase C, and therefore contributes to the healthy regulation of smooth muscle cell growth and differentiation.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCritically, we have used the natural version of vitamin E (technically d-alpha tocopherol) and not the synthetic (dl-alpha tocopherol). The difference is a meaningful one: the single isomer of d-alpha tocopher\u003c\/span\u003e\u003cspan\u003eol is easier and more efficiently absorbed and used in the body as compared to the eight isomers in the dl analog.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium (as Calcium Carbonate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body – including mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, requires sufficient levels of vitamin D.\u003c\/p\u003e\n\u003cp\u003eWhen present in sufficient amounts, calcium is necessary for the adequate formation, function, and remodeling of both bone and teeth. Insufficient levels of calcium are associated with degenerative bone and joint disorders such as osteoporosis, wherein bone accretion slows or stops; thereby reducing bone mass and density and decreasing bone strength.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIodine (As Kelp (Ascophyllum nodosum))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced-diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for the proper cognitive development in the child.\u003c\/p\u003e\n\u003cp\u003eAs implied, however, the most important of iodine’s functions is assisting the body to produce and maintain healthy levels of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine\/epinephrine, largely determine the body’s metabolic rate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as Albion® Di-Magnesium Malate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.\u003c\/p\u003e\n\u003cp\u003eMagnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells.\u003c\/p\u003e\n\u003cp\u003eIn men, magnesium (along with zinc) is necessary for the maintenance of healthy levels of testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as Zinc Aspartate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs an essential mineral, like magnesium, zinc is also involved in a wide-range of essential biological functions in the human body – and a requirement in the catalytic activity of over 100 enzymes.\u003c\/p\u003e\n\u003cp\u003eMost notably, zinc is vital for immune function, protein synthesis, cellular division, and DNA synthesis. For immune function, zinc is required for the function of a group of immune cells known as neutrophils and macrophages, which eliminate pathological cells and their products from the body.\u003c\/p\u003e\n\u003cp\u003eWith magnesium, sufficient levels of zinc are also necessary for the production and maintenance of healthy levels of testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCopper (as TRAACS® Copper Bisglycinate Chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCopper is a trace element necessary for the production, function, and maintenance of a diverse range of compounds involved in physiological function.\u003c\/p\u003e\n\u003cp\u003eThe brain, the heart, bone, and connective tissue specifically require copper or the enzymes it catalyzes to properly grow and differentiate their various cell types. Like many of the ingredients in Core MULTI, copper is also required for the homeostasis of other minerals, specifically zinc.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eManganese (Manganese Citrate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eManganese is a required element for not only humans, but all living organisms. Manganese primarily acts as an antioxidant, specifically scavenging a radical oxygen species known as superoxide.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChromium (as Chromium Picolinate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChromium is an essential, though little understood, trace element found in certain foods and industrial compounds. Only one of chromium’s two forms, the form used in Core MULTI, chromium 3+, is biologically active.\u003c\/p\u003e\n\u003cp\u003eWhile not as well-defined as other trace elements, chromium’s physiological actions nevertheless seem pivotal to the production and transmission of healthy levels of insulin. Emerging research also seems to suggest that chromium is directly involved in the metabolism of carbohydrates.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolybdenum (as TRAACS® Molybdenum Glycinate Chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMolybdenum is an essential trace element, involved in at least four enzymatic reactions necessary for urea excretion and a number of other physiological functions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBerberine HCL\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThere is extensive literature demonstrating that berberine is a potent AMPk agonist in skeletal muscle. Based on the pharmacological similarities between berberine and the anti-diabetic medicine metformin (with respect to AMPk activation), it is possible that berberine may promote an anti-catabolic state through increased expression of AMPk. \u003c\/p\u003e\n\u003cp\u003eThe human data – in both healthy and disease state populations – demonstrating berberine’s other physiological effects are numerous. A 2012 meta-analysis examined 14 randomized trials, containing 1068 patients, and assessed berberine’s efficacy in numerous biometrics, including resting plasma glucose levels, plasma insulin levels, body weight, body mass index, and reduction in fat mass and serum triglycerides and total cholesterol content. The aggregate data suggests that berberine performs at least as well as oral hypoglycemic agents (such as metformin) in these key metrics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoron Citrate \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoron is a mineral present in multiple fruits, vegetables, tubers, and drinking water, though it is not widely accepted as either an essential mineral or essential vitamin. Boron affects a few physiological functions in the body, particularly modulating hormonal homeostasis.\u003c\/p\u003e\n\u003cp\u003eWhile still emerging, recent data suggest that boron may play a role in potentiating free testosterone levels in even healthy men. In one study, otherwise healthy men were provided an acute serving of boron and had their free and total levels of testosterone, alone with SHBG (sex hormone binding globulin) and DHT (dihydrotestosterone) levels measured. In that study, total testosterone was unaltered, but free testosterone was enhanced by 14%, while SHBG was significantly (9%) reduced.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCholine (as Choline Bitartrate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e Choline is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for a number of functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003c\/p\u003e\n\u003cp\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpectra™\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpectra™ is the first scientifically validated formula of fruits, vegetables, and herbs shown to inhibit free radical production, optimize cellular metabolic activity, and increase nitric oxide levels within our bodies\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 46.1255%; text-align: center;\"\u003e\u003cimg style=\"float: none;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/science_multi_1.jpg?v=1532337742\" alt=\"\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2915%; text-align: center;\"\u003e\u003cimg style=\"float: none;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/multi_science_2.jpg?v=1532337813\" alt=\"\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSpectra™ represents the latest evolution in the fight against potentially-damaging free radicals. For the first time anywhere, the biological effects of a natural supplement on the changes of oxidative and nitrosative stress markers, as well as cellular metabolic activity, have been clinically observed in the human body. Spectra™ has been reported to decrease ROS, increase cellular oxygen consumption in blood and mitochondria, decrease extracellular H2O2, and reduce TNFα-induced inflammatory response in humans.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-MULTI-2020.jpg?v=1585646276\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MULTI_8.5x3.25_FIN-OL.pdf?v=1639556211\"\u003eCore MULTI Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_MULTI_Product_Refferences.pdf?16007690605497637436\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":31493039718515,"sku":"SHOP672975009717","price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/MULTIFRONT_8333ca6f-18bc-4b4a-90e5-51ef91824b06.png?v=1760376807"},{"product_id":"core-intra","title":"Intra","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCyclic Dextrin\u003c\/strong\u003e - Support endurance\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull serving of EAA's\u003c\/strong\u003e - Support recovery and muscle protein synthesis\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlycerSize®\u003c\/strong\u003e - Increase blood flow during and after exercise\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eThe fitness and supplement industries are in a constant state of change. We are learning more each day about how the human body works – and in the process, learning that positive adaptations in response to exercise are facilitated by proper nutrition. As a result, more research than ever is being conducted on the value – and specific protocols involved in – peri- or intra-workout nutrition and supplementation. Research is revealing that adequate intra-workout nutrition and supplementation can delay fatigue and increase endurance, facilitate muscle-specific anabolic response to exercise, reduce delayed onset muscle soreness and increase a wide-range of athletic performance metrics.\u003c\/p\u003e\n\u003cp\u003eAt Core Nutritionals, we’ve taken this research seriously and have distilled its results into the most complete and robust intra-workout supplement on the market – Core INTRA. Core INTRA contains a mix of cutting-edge ingredients and longstanding pillars of supplementation to address most, if not all, major metabolic pathways associated with exercise. Core INTRA’s key ingredients have been demonstrated in scientific research to have a range of positive effects, including, but not limited to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eDelaying fatigue onset\u003c\/li\u003e\n\u003cli\u003eIncreasing maximal voluntary contractile force\u003c\/li\u003e\n\u003cli\u003eIncrease maximal oxygen uptake capacity\u003c\/li\u003e\n\u003cli\u003eReducing delayed onset muscle soreness\u003c\/li\u003e\n\u003cli\u003eIncreasing one rep maximums in bench press and squat\u003c\/li\u003e\n\u003cli\u003eIncreasing localized blood flow\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eEssentially, this product is the intra-workout solution. No more need for mixing and matching, or simply dismissing the valuable role that intra-workout nutrition and supplementation plays. Now, in a single scoop, you have a complete solution – and one that tastes amazing, too!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePerformance Carbohydrate Blend (Cyclic Dextrin and Dextrose):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOne of the main goals post workout is to restore muscle glycogen that has been depleted during the workout. The body will even break down muscle tissue for this purpose if an adequate influx of glucose – obtained from the consumption of carbohydrates – is not provided. For this reason, it is vital to include carbohydrates in and around one’s workout.\u003c\/p\u003e\n\u003cp\u003eThough \u003cem\u003eopinion\u003c\/em\u003e varies, the scientific literature is relatively clear that fast–digesting carbohydrates such as cyclic dextrin and dextrose create optimal conditions for the post-workout synthesis of both skeletal muscle protein and muscle glycogen. Not only have all three of Core INTRA’s carbohydrates sources demonstrated higher rates of post-exercise glycogenesis (glycogen resynthesis) as compared to other carbohydrate sources, they have also been shown to optimize insulin response and blunt cortisol release to a greater degree than other carbohydrate sources.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCyclic Dextrin\u003c\/strong\u003e is considered one of the most beneficial carbohydrate sources in a performance context, due to its low osmolality leading to expedient stomach clearing and low bloating. Research conducted on top swimmers, swimming in a flowing water pool, confirmed that cyclic dextrin’s fast gastric emptying contributed to increased endurance (longer swim times). Swimmers provided a sports drink containing cyclic dextrin had approximately 50% longer swim time than swimmers provided a mixture of water and glucose only.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDextrose\u003c\/strong\u003e functions at such a higher capacity because of molecular structure, given that it is otherwise known as pure glucose – your body’s preferred energy substrate and the necessary component for the synthesis and resynthesis of glycogen. Bypassing the lengthy and metabolically costly process of digestion and breakdown, dextrose can be absorbed directly through the gut into the bloodstream and can cause an insulin response faster than any other carb. Additionally, since dextrose is already in the form the body requires, it can be used immediately for glycogen replenishment.\u003c\/p\u003e\n\u003cp\u003eIn combination, the carbohydrates in Core INTRA, in their precise serving sizes, interact to form a comprehensive post-workout nutrition strategy:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eDextrose acts quickly to create an immediate supply of glucose and to stimulate post-workout insulin levels.\u003c\/li\u003e\n\u003cli\u003eCyclic dextrin balances that insulin response.\u003c\/li\u003e\n\u003cli\u003eTogether, they all rapidly, and in a sustained fashion, provide your body with a prime environment for the synthesis of both glycogen and ATP.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe rapid, but very beneficial, influx of glucose from oral carbohydrate supplementation quickly suppresses cortisol and the negative effect it has on the expression of metabolically critical proteins and growth factors – ensuring that myocytes (muscle cells) function in an ideal environment. In addition, these carbohydrates induce a beneficial insulin response, the effects of which include stimulating glycogen storage, the transport of glucose into muscle cell mitochondria, and an increase in amino acid utilization.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAmino Acids:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf one were to think of the body as a construction project, amino acids would be the most basic building materials: raw lumber, mortar, bricks, and so on. While the assembly of these building blocks is of course critically important to the function of the building – and one of the amino acids, leucine, controls its own assembly – the quality and availability of the materials themselves is arguably more important. Not enough concrete? The foundation cracks and the building falls.\u003c\/p\u003e\n\u003cp\u003eYour body is the exact same way. It is comprised of various amino acids, both essential and non-essential, that comprise the cellular basis of each cell in your body. When it comes down to skeletal muscle, the most important are the EAAs – or essential chained amino acids. Comprised of nine amino acids, these compounds effectively control the rate at which your muscle grows (hypertrophies), its contractile force, its endurance, and so on – to say they are massively important is an understatement. For this reason, they form the basis of any competently designed supplement protocol.\u003c\/p\u003e\n\u003cp\u003eCollectively, as stated above, the essential amino acids are famous for their role in skeletal muscle protein synthesis and metabolism. Of the nine, leucine is both the most physiologically important with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, by both insulin-mediated and non-insulin mediated mechanisms.\u003c\/p\u003e\n\u003cp\u003eLeucine’s insulin-mediated effects are largely the result of its activation of the classical insulin receptor substrate (IRS)\/phosphatidylinositol (PI) 3-kinase (PI3K)\/Akt\/mTOR signal transduction pathway. In this pathway, the bonding of a substrate (glucose) eventually activates a compound known as Akt. Once phosphorylated and activated, Akt signals the release of the famous mammalian target of rapamycin (mTOR). mTOR then increases the translation of muscle-cell ribosomal proteins that increase ribosome biogenesis, which is the literal production of proteins. Leucine has additionally been shown to positively regulate protein synthesis independent of insulin. In certain trials where rapamycin and leucine were co-administered, rapamycin showed only partial inhibition of leucine’s effects on muscle protein synthesis.\u003c\/p\u003e\n\u003cp\u003eIn more practical terms, there is a significant body of evidence demonstrating the positive effect of amino acids on athletic performance. Extensive studies in exercise-trained populations reveal that, collectively, amino acids may:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eReduce total muscle soreness after intense resistance training, and\/or further delay its onset.\u003c\/li\u003e\n\u003cli\u003eDecrease muscle recovery time between bouts of intense resistance exercise training.\u003c\/li\u003e\n\u003cli\u003eIncrease lean body mass when used daily, in conjunction with diet and exercise.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBeta-Alanine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCarnosine is a bit of an odd duck: we know that it is crucial for muscle function, and that dietary sources of carnosine are essential, but we don’t know precisely how its working. Moreover, for decades, we had no idea how to increase intramuscular concentrations, as exogenous carnosine sources degraded in the body so fast as to be effectively useless.\u003c\/p\u003e\n\u003cp\u003eEnter beta-alanine. Simply a different iteration of one of the amino acids that comprises carnosine itself (alanine), beta-alanine has proven to be the most effective means of significantly increasing intramuscular concentrations of carnosine – and therefore of promoting all of carnosine’s various beneficial effects on muscle performance. If that weren’t enough, beta-alanine has also demonstrated beneficial physiological effects independent of its parent compound. In order to understand why, though, we need to first understand some of the basic behind carnosine itself.\u003c\/p\u003e\n\u003cp\u003eCarnosine, a cytoplasmic dipeptide synthesized from the precursors L-histidine and l-alanine, is present in high concentrations in skeletal muscle and plays a pivotal role as a, “chemical buffer” in myocytes (muscle cells). It has long been known that carnosine concentrations are highest in glycolytic, rather than oxidative muscle fibers (roughly speaking, explosive vs., endurance muscle fibers, respectively), and thus long hypothesized that this amino acid is required for sustained performance during supramaximal exercise. Recent research demonstrates that carnosine exerts its physiological effects in long hypoxic (low oxygen) drives by functioning as a high-capacity pH buffer in skeletal muscle, preventing the pH ratio of plasma from dropping too low – and therefore preventing crucial pH-dependent processes such as protein synthesis from being inhibited by acidosis.\u003c\/p\u003e\n\u003cp\u003eDespite its critical role in skeletal muscle anaerobic performance, intramyocellular synthesis of carnosine is rate-limited by the availability of l-alanine. Unfortunately, the majority of literature demonstrates that attempting to increase intramuscular levels of carnosine via either direct carnosine or alanine supplementation is largely ineffective due to carnosine\/alanine pharmacokinetics. Enter beta-alanine. Research with beta-alanine demonstrates consistent and dose-dependent increases to intramuscular carnosine concentrations with beta-alanine supplementation, with certain studies showing an increase of 40-60% with chronic administration. These same literatures reveal a synergistic effect of exercise on beta-alanine supplementation, whereby the muscle adaptive changes associated with resistance training promote further intramuscular carnosine production in response to beta-alanine supplementation.\u003c\/p\u003e\n\u003cp\u003eIn simpler language, this essentially means that beta-alanine is a dietary supplement that promotes its own effects in combination with exercise. As you exercise, you simultaneously intensify beta-alanine’s physiological actions – both directly, as well as in the production of intramuscular carnosine. Once ingested, beta-alanine’s exercise-specific beneficial activity is well-established. Elevation of intramuscular carnosine content via beta-alanine supplementation has been show to improve performance in the following ways:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eBoth acute and chronic increases in total work capacity, measured by total volume during exercise sessions.\u003c\/li\u003e\n\u003cli\u003eHighly significant increases to TTE (total time to exhaustion), one of the most accurate and comprehensive measures of endurance. In various trials, beta-alanine supplementation has been shown to increase TTE by upwards of 20%.\u003c\/li\u003e\n\u003cli\u003eIncreases to total muscle power output in both acute and chronic trials, suggesting that beta-alanine’s most significant benefit is to those engaging in power-dependent resistance training.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn total, a significant body of research exists to suggest that beta-alanine may significantly increase muscle power output, strength, training volume and output, overall performance in hypoxic (oxygen-deprived) conditions and peak VO2 max (oxygen holding capacity).\u003c\/p\u003e\n\u003cp\u003eThese myriad benefits make beta-alanine both one of the most-studied, and most well-rounded dietary supplements. Beta-alanine not only has direct, actionable physiological effects, but also promotes critical muscle physiologic adaptations that promote its own effects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlycerSize® (65% glycerol):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlycerol is a fascinating and highly useful compound that has achieved a somewhat cult status in the fitness community – while both peer-reviewed research and anecdotal reports centered on the endurance functions of glycerol are plentiful, its bodybuilding applications are not as widely lauded. Those who do use glycerol, however, are persistent in their belief that it provides some of the most noticeable, and effective, engorging (“pump”) effects possible.\u003c\/p\u003e\n\u003cp\u003eGlycerol has been well-established as a so-called, “hyperhydrating agent” because of its ability to potently and positively affect plasma (blood) osmolality. As an incredibly powerful osmotic agent, and when combined with large quantities of water, glycerol induces the intracellular retention of fluid (not the extracellular kind, you do not want) that would otherwise be renally excreted. Various research has shown that glycerol’s capacity to positively affect osmolality and expand fluid volume (an increase in total body water) has beneficial effects on performance and physiologic function.\u003c\/p\u003e\n\u003cp\u003eStudies that administered glycerol before both moderate and high endurance fitness tests found that glycerol reduced increases to core temperature, caused athletes to exercise significantly longer before fatigue, reduced urinary elimination of water and increased total body water content, and, in several studies, significantly improved intramuscular water expansion. In less complex terms, this means glycerol has been demonstrated to keep your muscles hydrated, significantly increase the ever-desired, “pump effect” of muscle engorgement, and, maybe most importantly when it comes to a supplement formulation, deliver and keep more nutrients where they are needed (inside the muscle).\u003c\/p\u003e\n\u003cp\u003eUntil recently, however, most of these studies noted a significant drawback: the low glycerol concentration of market-available glycerol products forced researchers to test glycerol loads that were significantly higher than average use cases. Core INTRA uses GlycerSize® to overcome precisely this problem.\u003c\/p\u003e\n\u003cp\u003eGlycerSize® is a highly-concentrated (65%) form of glycerol that offers greater water stability, and therefore potency, as compared to standard GMS (glycerol monostearate). Of particular interest to bodybuilders, GlycerSize®’s greater potency translates to even greater levels of intramuscular water retention – keyword, intramuscular, and therefore no bloat – over GMS.\u003c\/p\u003e\n\u003cp\u003eOverall, supplementation with GlycerSize® has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eKeep athletes hyperhydrated for extended periods of time.\u003c\/li\u003e\n\u003cli\u003eReduce post-workout urine volume (more efficient fluid use).\u003c\/li\u003e\n\u003cli\u003eReduce post-workout urine volume (more efficient fluid use).\u003c\/li\u003e\n\u003cli\u003eLower heart rate and improve endurance time.\u003c\/li\u003e\n\u003cli\u003eEnhance plasma and intramuscular volume expansion.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eElevATP® (Ancient Peat and Apple Fruit Extract)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAdenosine triphosphate and other ATP metabolites are involved in a number of biological processes including cardiac function, blood flow, muscle contraction and neurotransmission. ATP is the primary molecule that acts as a carrier for energy within cells. It has also often been studied that increased levels of ATP have shown increases in health and performance. Supplementation with exogenous ATP has often shown its ability to increase ATP concentrations in blood. Oral supplementation with ancient peat and apple extracts have exhibited their ability to increase intracellular and intramuscular ATP levels. ElevATP® is a blend these specific polyphenols that works to increase endogenous ATP levels without a simultaneous increase in serum lactate. The significance of this is that usually with an increase in endogenous ATP there is an increase in intracellular free radicals. When these free radicals are not present, oxidative stress is mitigated and there is more potential for the beneficial increases in ATP to take center stage. These increases of ATP are essential as when available energy is increased it can have positive benefits in terms of increased power, strength, and overall exercise performance. One study in particular looked at dosing ElevATP® against placebo and showed that the group who received ElevATP® saw a blood ATP increase of 45% on average along with no increase in oxidative blood glucose. This type of result has been shown repeatedly in studies and has given ElevATP® the reputation to be a beneficial compound for the goals of improving endurance, strength, power, and other training specific adaptations.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-INTRA-2021.jpg?v=1614634551\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_INTRA_LEMON_LIME-FIN_compressed.pdf?v=1643985910\" target=\"_blank\"\u003eLemon Lime Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_INTRA_PINEAPPLE_PEACH-FIN.pdf?v=1643985805\" target=\"_blank\"\u003ePineapple Peach Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Core_Intra1.pdf?v=1614614521\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Lemon Lime","offer_id":40600293179568,"sku":"SHOP672975315696","price":59.99,"currency_code":"USD","in_stock":true},{"title":"Pineapple Peach","offer_id":40600293212336,"sku":"SHOP672975315702","price":59.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/INTRA_PP_FRONT.png?v=1767614755"},{"product_id":"core-pro-5lb","title":"Pro 5lb","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhey protein blend\u003c\/strong\u003e - Sustained release of recovery and growth agents\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive enzyme blend\u003c\/strong\u003e - Digestive enzyme blend supports healthy carbohydrate and fat breakdown\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVersatility\u003c\/strong\u003e - Designed to maximize your protein needs any time of the day\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.corenutritionals.com\/products\/core-pro-2lb\"\u003e \u003cbutton type=\"submit\" class=\"btn black-carbon-btn\" style=\"width: 100%; height: 50px; font-size: 20px;\"\u003eGet Core PRO 2LB\u003c\/button\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSustained Release Protein Blend\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYou want to recover. You don’t want to gag while doing it.\u003c\/p\u003e\n\u003cp\u003eWe chose the protein blend and taste for Core PRO with that in mind. Our mix of proteins have a robust and complete amino acid profile that has been shown in research to increase lean muscle impact – while our flavoring tastes like a cheat!\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e1 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e28 (2LB)\/70 (5LB) servings per container.\u003c\/li\u003e\n\u003cli\u003eProtein blend with gourmet taste.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhat do you look for in a protein supplement? More importantly, what should you look for? Let’s be honest: in 2020, taste is paramount to the experience. Amazing taste was our priority for the reformulation of Core PRO – and we succeeded beyond our wildest dreams, if we say so ourselves.\u003c\/p\u003e\n\u003cp\u003eBut this is Core Nutritionals, meaning that function must always match taste and form. Core PRO is no different. While the protein blend in Core PRO was always industry-leading, we have made it even better. Our blend of whey concentrate, whey isolate, and milk protein isolate delivers smooth texture, fast and slow-digesting proteins, and a complete amino acid profile that suits your needs. In other words, have perfected the marriage of TASTE AND PERFORMANCE, and the result is Core PRO.\u003c\/p\u003e\n\u003cp\u003eCore PRO is a clinical-strength, sustained release protein formula, specifically designed to keep you fueled with the right growth\/recovery agents over extended periods of time. This innovative blend provides the perfect arrangement of both fast-uptake and sustained-release proteins, from superior cold-processed whey proteins and micellar casein-rich milk protein sources. This strong synergistic blend helps promote optimal growth and recovery by providing the vital building blocks your body needs, exactly when you need them most. Our superior protein blend contains a generous array of BCAAs (branched-chain amino acids) in their naturally-occurring biological ratios, to delay fatigue and expedite your recovery.\u003c\/p\u003e\n\u003cp\u003eThe benefits don’t stop there. To make this the most effective recovery formula available, we’ve enhanced it with a powerful digestive enzyme blend, including protein-digesting proteases, to improve absorption and accelerate nutrient uptake. The beneficial fatty acids from MCTs (medium chain triglycerides) in Core PRO help preserve lean mass while unleashing your body’s natural metabolic potential. And unlike some formulas, you never have to worry about taking it at the wrong time. Staying fueled all day or overnight never tasted so good!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eScientific breakdown:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe said above that protein powders need to – or at least should – have a purpose: to improve recovery times, and ultimately, body composition. But how does that occur? Or more specifically, what needs to happen in the body in order to recover from a workout, and subsequently improve body composition. To sum it up with one phrase, net protein balance needs to be positive.\u003c\/p\u003e\n\u003cp\u003eWhen you vigorously train or exert yourself, a process called protein degradation (the breakdown of muscle protein) begins so that the body can fuel itself, and a process called muscle protein synthesis (the creation of muscle protein) slows down. Think of this like shutting off your engine (protein synthesis), in order to fuel your car (muscle protein breakdown). As this entire process plays out, the available pool of amino acids in skeletal muscle depletes, as they too are drawn in and broken down in the natural, catabolic process during exercise training.\u003c\/p\u003e\n\u003cp\u003eWhile this situation is quite adequate during a training session, it’s precisely the opposite of what we want afterwards. At that point, we want the available pool of amino acids to increase, protein degradation to slow or stop, and muscle protein synthesis to increase. Enter protein supplements. Protein powders are a quick, convenient way to rapidly increase the available pool of amino acids in skeletal muscle.\u003c\/p\u003e\n\u003cp\u003eHowever, not all proteins are created equal when assessed within the matrix of molecular triggers, enzymes, and amino acids that constitute skeletal muscle protein synthesis. Low quality blends, fillers, masking agents, and the like reduce the net protein content of many protein products, ultimately reducing lean muscle impact.\u003c\/p\u003e\n\u003cp\u003eA quality protein supplement not only contains a high amount of protein, but the protein sources from which it draws need to be themselves high quality – and the benefit a particular protein source has can be assessed by analyzing its amino acid profile. Human skeletal muscle makes the most use out of a few, particular amino acids (the BCAAs among them), and so a quality protein needs to have an amino acid profile that is optimal for this context.\u003c\/p\u003e\n\u003cp\u003eWe chose the protein blend for Core PRO with optimization in mind. Our mix of cold-processed undenatured whey protein concentrate, cross-flow microfiltered whey protein isolate, and milk protein isolate has a complete amino acid profile that has been shown in research to increase nitrogen retention, lean muscle impact, and satiating ability (the feeling of fullness). This blend has also been specifically configured to provide both rapid and sustained additions to your body’s amino acid profile – meaning your recovery is not only supported immediately after a session, when you most need it, but over time as well.\u003c\/p\u003e\n\u003cp\u003eBest of all, we have moved to a \u003cem\u003efully transparent\u003c\/em\u003e label for Core PRO. Meaning that not only do we disclose the protein sources themselves and their specific yields, but we have also disclosed the entire formula’s amino acid profile. You can see, for example, that each serving yields a full 2.6g of leucine – a leucine dose supported in the literature to maximally increase muscle protein synthesis.\u003c\/p\u003e\n\u003cp\u003eHere is a more complete breakdown of each protein source:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCold-processed undenatured whey protein concentrate:\u003c\/strong\u003e Whey protein concentrate is probably the most common form of whey protein you will find. However, how it is processed is where the benefit truly lies. This process of cold processed undenaturization preserves the molecular structure of the amino acid particles as well as the immune boosting benefits that it contains. This undenatured protein is also a rich source of amino acids, including those needed for the synthesis of glutathione, which is an important antioxidant that can be depleted by stress (exercise stress included). This makes it a great foundation for your post workout recovery nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCross-flow microfiltered whey protein isolate:\u003c\/strong\u003e whey protein isolate is an extremely “clean” form of whey protein. It yields a higher amount of amino acids, half of which are from the essential amino acids (cannot be made by the body). Microfiltration eliminates a large majority of the fat and lactose from the whey, which makes it easily digestible and quickly absorbed into the body. This cross-flow process uses a highly intricate method to isolate the protein. It is not subjected to chemicals and is thus left in its most natural state.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Protein Isolate:\u003c\/strong\u003e milk protein isolate is obtained through the partial removal of non-protein materials from skim milk (lactose and other minerals). What you are left with is a dry product that contains more than 90% protein by weight. This product contains both casein and whey proteins in their original proportions found in milk, without combining separately produced casein and whey proteins. It contains very little fat and lactose and also has a very high amino acid composition making it a perfect addition to this blend.\u003c\/p\u003e\n\u003cp\u003eThis blend has also been specifically configured to provide both rapid and sustained additions to your body’s amino acid profile – meaning your recovery is not only supported immediately after a session but will also carry you to your next meal. On top of that, our flavors are out of this world! We’ve also boosted this protein blend with digestive enzymes that will provide you with all of the confidence that those nutrients you just supplied your body with will do their part in your quest for the optimal result!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDigeSEB Digestive enzyme blend:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOne can easily make the argument that dietary enzymes – and in particular, digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc).\u003c\/p\u003e\n\u003cp\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products. For a whey product, in particular – a compound that requires significant digestion and breakdown – this is madness.\u003c\/p\u003e\n\u003cp\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In Core PRO, we have included a digestive enzyme blend called DigeSEB comprised by amylases, proteases, lactases, amylases, and cellulases, allowing for a full and complete breakdown of all PRO’s components. Research suggests that whey absorption through the blood is heavily impacted by its gastric digestibility. Using DigeSEB ensures that the protein – along with its milk and whey sugars and fats – are completely broken down.\u003c\/p\u003e\n\u003cp\u003eDigeSEB ensures that Core PRO not only provides gourmet taste and clinical ingredients within the protein itself, but that your protein also increases the effectiveness of your pre and post-workout nutrition in general.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoconut Oil Creamer (Medium Chain Triglycerides):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCoconut oil made of 100% Medium chain triglycerides has been shown to have the greatest health benefits. MCTs are made up of a chemical structure that allows them to quickly and effectively bypass gastric uptake for transport directly to the liver for oxidation and then used for energy. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-PRO-2020.jpg?v=1585897600\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core-PRO-5lb-2023-GAIN-FIN-OL.pdf?v=1693234512\"\u003eVanilla Toffee Gaintime 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_PRO_5lb_2023-BLUEBERRY-FIN-OL.pdf?v=1693234511\"\u003eBlueberry Muffin 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_5lb_PEANUT_BUTTER_CUP_FIN-OL_compressed.pdf?v=1643989839\"\u003eChocolate Peanut Butter 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_5lb_FRENCH_TOAST_FIN-OL_compressed.pdf?v=1643989680\"\u003eCinnamon French Toast 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_5lb_COOKIES_N_CREAM_FIN-OL_compressed.pdf?v=1643989621\"\u003eCookies 'n Cream 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_5lb_CHOCOLATE_FIN-OL_compressed.pdf?v=1643989474\"\u003eDeath by Chocolate 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_5lb_VANILLA_CUPCAKE_FIN-OL_compressed.pdf?v=1643989888\"\u003eFrosted Vanilla Cupcake 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_5lb_FRUITY_CEREAL_FIN-OL_compressed.pdf?v=1643989784\"\u003eFruity Cereal 5LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES_-_Core_PRO.pdf?v=1586182614\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Strawberries n' Cream","offer_id":44950007480496,"sku":"SHOP850080302309","price":109.99,"currency_code":"USD","in_stock":true},{"title":"Cookies 'n Cream","offer_id":31482036781171,"sku":"SHOP850057790511","price":109.99,"currency_code":"USD","in_stock":true},{"title":"Chocolate Peanut Butter Cup","offer_id":31482036715635,"sku":"SHOP850057790528","price":109.99,"currency_code":"USD","in_stock":true},{"title":"Death by Chocolate","offer_id":31482036846707,"sku":"SHOP850057790535","price":109.99,"currency_code":"USD","in_stock":true},{"title":"Frosted Vanilla Cupcake","offer_id":31482036912243,"sku":"SHOP850057790504","price":109.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PRO_SC_FRONT.png?v=1770324306"},{"product_id":"core-greens","title":"Greens","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eTruServ®\u003c\/strong\u003e - 100% Real, whole food nutrition. Equivalent to 14 kale leaves, 4 spinach leaves, and 1 broccoli floret\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpectra™\u003c\/strong\u003e - Clinically proven blend of free radical fighting antioxidants from fruits and vegetables\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e5 Billion CFU Probiotic\u003c\/strong\u003e - Optimal digestive health support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eFrom a very early age, we all learned about the importance of eating your fruits and vegetables. For some reason, whether it is a taste issue or lack of convenience, in this day and age many people are lacking these precious foods in their diets. With Core GREENS you no longer need to miss out.\u003c\/p\u003e\n\u003cp\u003eWith its comprehensive \"greens\" (and \"reds\") superfood formula, added probiotic and digestive enzyme blends, and delicious taste, Core GREENS is a convenient and systematic general health and wellness supplement. Providing critical micronutrients and antioxidants that your body needs in a single delicious scoop, Core GREENS was formulated for maximum health benefits.Key ingredients in Core GREENS have been shown to improve a wide range of crucial health measures.\u003c\/p\u003e\n\u003cp\u003eMaintaining optimal health has never been more difficult. Demanding work schedules leave little time for preparing a diet full of the micronutrient-dense foods our bodies require, leaving us scrambling for patchwork solutions. Though we can supplement our diet with a range of solutions, most are too narrow in focus, cause bloating and gas due to lacking digestive enzymes, or are cost prohibitive. Core GREENS attempts to break that mold, providing a whole-food solution to ensure that you can meet your recommended daily intake of not only valuable vitamins and minerals – but also optimize your diet with probiotics, digestive enzymes, and potent anti-oxidants.\u003c\/p\u003e\n\u003cp\u003eThe heart of our GREENS formula is our plant blend, constituted by: Psyllium husk, TruServ® (organc kale, broccoli, and spinach), barley grass, wheat grass, chlorella, spirulina and Spectra™. Our 11+ gram scoop provides the function equivalent of several pounds of these greens. Additionally, one scoop serving delivers you 100% of the daily value of 13 vitamins and a range of antioxidants and bioactives. To complement the greens themselves, we have added TruServ® and Spectra™ two industry-leading plant and vegetable\/fruit blends. And lastly, to ensure that GREENS does not cause the bloating and gas associated with many greens products, we have included not only probiotics, but a full-spectrum digestive enzyme blend. Were that not enough, the product tastes fantastic!\u003c\/p\u003e\n\u003cp\u003eNow more than ever, your optimal health is too important to leave to chance. Core GREENS is the most convenient and easiest way to deliver to your body the vitamins, minerals, bioactives and antioxidants it requires to function optimally.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTruServ®:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe TruServ® program is a customizable whole food powder solution by Core Nutritionals’ key partner, Futureceuticals. Core Nutritionals included Futureceuticals’ greens blend, which includes 14 kale leaves, four spinach leaves, and one broccoli floret in each 2g powder serving.\u003c\/p\u003e\n\u003cp\u003eThe benefit of the TruServ program is the verification process. The TruServ Verified® process is FutureCeuticals’ exclusive method of substantiation that connects their extensive production data and the USDA Nutritional database to only our fruit, vegetable and leafy green ingredients. The result is a greens blend verified and substantiated by the USDA itself – giving you additional piece of mind. Each TruServ® blend is organic, fully disclosed, and comes from a dependable and sustainable supply chain.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpectra™:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpectra™ is the first scientifically validated formula of fruits, vegetables, and herbs shown to inhibit free radical production, optimize cellular metabolic activity, and increase nitric oxide levels within our bodies\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Stimulate_antioxidant_activit_within_the_human_body.jpg?v=1587382537\"\u003e \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/support_efficient_cellular_oxygen_consumption.jpg?v=1587382537\"\u003e\u003c\/p\u003e\n\u003cp\u003eSpectra™ represents the latest evolution in the fight against potentially-damaging free radicals. For the first time anywhere, the biological effects of a natural supplement on the changes of oxidative and nitrosative stress markers, as well as cellular metabolic activity, have been clinically observed in the human body. Spectra™ has been reported to decrease ROS, increase cellular oxygen consumption in blood and mitochondria, decrease extracellular H2O2, and reduce TNFα-induced inflammatory response in humans.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePsyllium Husk 85% (husk):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMost of the literature on the beneficial health outcomes of fiber consumption comes from population-level epidemiological studies relying on self-reported fiber intake levels. Problematically, these epidemiological studies often fail to control for residual confounds, making the physiological benefits of fiber less clear.\u003c\/p\u003e\n\u003cp\u003eLuckily, recent evidence in well-controlled, long-term trials using natural fiber supplements such as psyllium husk are beginning to elucidate the benefits of fiber supplementation. Those trials demonstrate that the physical effects of fiber in the small intestine drive metabolic health effects (lowering cholesterol and improving glycemic control); while in the large intestine, fiber can provide a laxative effect. As to the effects in the small intestine, a small trial on cereals, in 345 subjects, showed that the cereals highest in viscosity – psyllium husk is extremely high viscosity – lowered LDL cholesterol by 45% on average.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChlorella and Spirulina Powder:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChlorella and spirulina are the organisms behind the most common forms of green and blue\/green algae, respectively. Chlorella has been variously classified as either a plant or a protist, while spirulina is a kind of cyanobacteria and thus classified as a bacteria. Regardless of the taxonomical differences between chlorella and spirulina, emerging evidence suggests that both have a range of benefits for human health.\u003c\/p\u003e\n\u003cp\u003eThe first benefit is that the macronutrient constituents in the plants themselves are favorable. Spirulina is a source of high-quality protein, γ-linolenic acid, and phycocyanin content. Chlorella, in turn, contains a variety of bioactives, including nucleic acids, amino acids, vitamins, minerals, polysaccharides, glycoproteins, and β-glucans.\u003c\/p\u003e\n\u003cp\u003eIn addition to their macronutrient content, both chlorella and spirulina contain bioactive compounds that emerging evidence suggests have potential health effects. Polypeptide chains isolated from chlorella, for example, were shown in in vitro and animal models to be potent ACE inhibitors. ACE (angiotensin converting enzyme) is an enzyme that catalyzes the conversion of inactive Angiotensin I (AG-I) to the active Angiotensin II (AG-II). In turn, AG-II binds to the Angiotensin II receptor in smooth muscle and elicits the production of aldosterone – creating a hypertensive effect through direct and indirect means. While still preliminary, evidence suggests that the isolated polypeptides in chlorella may be ACE inhibitors.\u003c\/p\u003e\n\u003cp\u003eSimilar trials on the reduction of HbA1C, for example, demonstrate that these microalgae and their constituent parts may indeed be superfoods.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDigestive enzyme blend:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOne can easily make the argument that dietary enzymes – and in particular, digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc).\u003c\/p\u003e\n\u003cp\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products.\u003c\/p\u003e\n\u003cp\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In Core GREENS, we have included a digestive enzyme blend comprised by amylases, proteases, lactases, amylases, and cellulases, allowing for a full and complete breakdown of all GREENS’ components.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProbiotic blend:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eUnder normal conditions, our gut microbiota – the constellation of intestinal flora that play innumerable physiological roles – are balanced between “good” and “bad” bacteria. The good bacteria confer immunity to us from pathogens, improve digestion of food, help regulate mood and more – while the “bad” bacteria cause a range of pathological conditions, invite pathogens, and generally wreak havoc on our bodies. The point of a well-designed probiotic is maintaining this intestinal balance in the “good” direction.\u003c\/p\u003e\n\u003cp\u003eUsing a probiotic supplement helps offset the microbiotic impact of stressors such as illness, medications (antibiotics), hormonal variations, and an incomplete diet. While the evidence is still emerging, the potential health benefits of probiotics have been seen in many conditions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin A (as Beta Carotene)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBeta carotene is itself not an essential vitamin but is rather the precursor to the fat-soluble and essential vitamin, vitamin A (Retinol). Like B vitamins, the term vitamin A refers to the compound class retinoids, comprised of retinol, retinal (also called retinaldehyde), retinoic acid, and provitamin A compounds such as beta carotene.\u003c\/p\u003e\n\u003cp\u003eAs their names suggest, retinoids are critical to the function of human eyes and therefore to the maintenance of circadian rhythms (our “biological clock”). Vitamin A combines with proteins in the eye to form light-sensing cells that both facilitate vision and regulate our sleep-wake cycles.\u003c\/p\u003e\n\u003cp\u003eBeyond its role in sight, vitamin A is also essential for cellular growth and differentiation and the immune system.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C (as Ascorbic Acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/p\u003e\n\u003cp\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (as Cholecalciferol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an import and biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin E (as Mixed Tocopherols)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin E is another technical misnomer, as the term refers to a group of compounds known as tocopherols with eight biologically-active constituents: alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol. Alpha-tocopherol is the principal bioactive in humans, though the presence of other tocopherols has been linked to beneficial effects.\u003c\/p\u003e\n\u003cp\u003eAs a result of its robust antioxidant activity, vitamin E assists in the maintenance and support of several physiological processes, though most notably sight and the immune system. Emerging research also suggests that the alpha-tocopherol form of vitamin E inhibits an enzyme known as protein kinase C, and therefore contributes to the healthy regulation of smooth muscle cell growth and differentiation.\u003c\/p\u003e\n\u003cp\u003eCritically, we have used the natural version of vitamin E (technically d-alpha tocopherol) and not the synthetic (dl-alpha tocopherol). The difference is a meaningful one: the single isomer of d-alpha tocopherol is easier and more efficiently absorbed and used in the body as compared to the eight isomers in the dl analog.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eB Vitamins (Thiamine, Riboflavin, Niacin, B6 [Pyridoxine], Folic Acid, B12, Biotin, and Pantothenic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Though both molecularly and physiologically distinct, they are also deeply interrelated in their effects, synthesis and metabolism. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) in order to maintain the cell functions to which B vitamins contribute.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-GREENS.jpg?v=1587155948\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_GREENS_11.25x5_CHOCOLATE_FIN.pdf?v=1638802747\"\u003eChocolate Decadence Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_GREENS_11.25x5_BERRY_FIN_compressed.pdf?v=1638802419\"\u003eBerry Bliss Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_GREENS_11.25x5_ARNOLD_PALMER_FIN.pdf?v=1638802025\" target=\"_blank\"\u003eArnold Palmer Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_GREENS_11.25x5_GRAPE_CANDY_FIN.pdf?v=1638803050\"\u003eGrape Candy Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Core-GREENS.pdf?v=1587383216\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Grape Candy","offer_id":37972914667696,"sku":"SHOP672975315498","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Chocolate Decadence","offer_id":31523574874227,"sku":"SHOP672975009885","price":49.99,"currency_code":"USD","in_stock":false},{"title":"Berry Bliss","offer_id":31523574906995,"sku":"SHOP672975009878","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Arnold Palmer","offer_id":37972910538928,"sku":"SHOP672975315481","price":49.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/GREENS_AP_Front_d46e91e9-d014-4950-95f4-821d5f07ec2c.png?v=1764881313"},{"product_id":"core-hard","title":"Hard","description":"\u003cp\u003eBenefits of Core HARD may include the following:  \u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Reduction in cortisol levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDIM\u003c\/strong\u003e - Regulate healthy estrogen production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eL-Theanine\u003c\/strong\u003e - Increased measures of well being\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eYour diet is impeccable and couldn’t be any more in check – macros, micros, you have it all down. Your workouts? Get out of here! You have slaved, grinded, and grunted your way through leg workouts so intense the gym staff cried – and those were on your worst days. And yet, something is missing.\u003c\/p\u003e\n\u003cp\u003eIt’s that “extra” level of shred, “that look.” You know exactly what we mean. That type of leanness and density that makes an arm look twice as big, a stomach look twice as lean, and a forearm look like a roadmap for the Italian countryside. It’s that kind of elusive hardness that’s so rare, most of us simply chalk it up to genetics, or luck, or steroids, or whatever excuse we have handy – and yet we all still want it.\u003c\/p\u003e\n\u003cp\u003eThe reality is that it isn’t all that unattainable. Getting “that” look, “that” hardness, is about hormonal balance, optimization and body recomposition. It’s a matter of adding in that final piece of the puzzle that makes the entire picture come out perfectly.\u003c\/p\u003e\n\u003cp\u003eTo be hard, you need to get HARD. It’s that simple.\u003c\/p\u003e\n\u003cp\u003eCore HARD is another product in the Core Nutritionals’ lineup to follow the basic, but indispensable principles that Core Nutritionals is slowly making an industry standard: create products with effective ingredients, in effective doses, in a non-proprietary formula. This time around, we have applied those principles to the problem of softness that we all despise and have developed the most advanced ultra-hardening and recomposition agent on the market.\u003c\/p\u003e\n\u003cp\u003eTaking advantage of both the old and the new, Core Nutritionals has employed both modern, cutting-edge compounds and traditional herbs to create a balanced approach to delivering hardness. Key ingredients in Core HARD affect some of the body’s critical physiological pathways, combining sexiness and science in a single, non-proprietary formula. We have included five powerful ingredients into a full month's worth of stimulant free, recomposition goodness. The result? Reduced cortisol levels, healthy estrogen and hormone regulation, weight loss and lean muscle growth, increased measures of well-being, improved athletic performance, stamina and power.\u003c\/p\u003e\n\u003cp\u003eCore HARD can be used alone, or in a stack with other Core Nutritionals’ products. The BURN HARD stack (Core HARD plus \u003ca title=\"Core BURN - Stimulant Thermogenic\" href=\"https:\/\/www.corenutritionals.com\/products\/core-burn-powder\" target=\"_blank\"\u003eCore BURN\u003c\/a\u003e) will be the ultimate fat blasting and hardening stack. Men can try the HARD A.B.s stack (Core HARD plus \u003ca title=\"Core ALPHA - All Ultra Potent Natural Hormone Optimizer\" href=\"https:\/\/www.corenutritionals.com\/products\/core-alpha\" target=\"_blank\"\u003eCore ALPHA\u003c\/a\u003e and \u003ca title=\"Core BURN - Stimulant Thermogenic\" href=\"https:\/\/www.corenutritionals.com\/products\/core-burn-powder\" target=\"_blank\"\u003eCore BURN\u003c\/a\u003e) to help create that chiseled look that all men want.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidylserine (50%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhosphatidylserine, colloquially known as PS, is a nearly ubiquitous phospholipid found in various membranous tissues throughout the body. PS’s ubiquity coincides with its necessity for crucial physiological functions, as the phospholipid is implicated in several components of cell communication, as well as the mediation of catecholamine synthesis and transmission in the brain (along with other neuroendocrine functions). In a fitness-related context, a nascent but growing body of methodologically-sound research suggests that PS may play a role in increasing exercise capacity.\u003c\/p\u003e\n\u003cp\u003eStudies administering the compound in both acute and chronic fashion suggest that PS has a measurable effect on exercise capacity. In a double-blind, placebo-controlled, randomized trial involving 16 trained athletes, phosphatidylserine was administered for 10 days prior to an acute exercise challenge. Exercise markers such as exercise time to exhaustion, sprint performance, and ratings of perceived exertion, were measured post-exercise. The authors found that exercise time to exhaustion was significantly altered. Related studies using similar serving sizes have found that chronic PS administration increased shot accuracy in golfers, increased exercise time to exhaustion by 28% in cyclists, and reduced subjective feelings of stress and soreness in others.\u003c\/p\u003e\n\u003cp\u003eOverall, phosphatidylserine appears to play a valuable role in the increase in exercise capacity. PS may therefore play a critical role in the continued exercise success of bodybuilders in a, “cutting” or recomposition stage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal\u003c\/em\u003e, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).\u003c\/p\u003e\n\u003cp\u003eTo put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eColeus forskohlii\u003c\/em\u003e (std. to 20% forskolin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003ci\u003eColeus forskohlii\u003c\/i\u003e standardized to 20% forskolin is included for its direct role in body recomposition—the ability to reduce body fat while preserving lean mass. Forskolin activates a compound called adenylate cyclase, which can increase intracellular cAMP, a key regulator of fat mobilization and metabolic activity. Several studies have shown its power when it comes to fat mass reduction while also maintaining lean mass. One 12-week randomized, placebo-controlled study showed that subjects supplementing with forskolin lost an average of \u003cstrong data-end=\"546\" data-start=\"515\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003e10 lb of fat mass\u003c\/span\u003e\u003c\/strong\u003e while\u003cb\u003e \u003c\/b\u003e\u003cstrong data-end=\"583\" data-start=\"553\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003emaintaining lean body mass\u003c\/span\u003e\u003c\/strong\u003e, whereas the placebo group lost only 2lb and experienced a decline in lean mass. Another human trial showed a \u003cstrong data-end=\"764\" data-start=\"708\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003esignificant reduction in body fat percentage (−1.2%)\u003c\/span\u003e\u003c\/strong\u003e and a \u003cstrong data-end=\"815\" data-start=\"771\"\u003e\u003cspan style=\"font-family: 'Aptos',sans-serif; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; font-weight: normal;\"\u003etrend toward increased free testosterone\u003c\/span\u003e\u003c\/strong\u003e, supporting muscle preservation during caloric deficit. By improving nutrient partitioning, shifting calories toward muscle recovery and performance rather than fat storage, \u003ci\u003eColeus forskohlii\u003c\/i\u003e can support a harder, leaner physique without stimulant reliance, making it a clinically supported tool for sustainable recomposition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3'-Diindolylmethane (DIM)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to (but probably cannot) identify \u003cem\u003ea specific\u003c\/em\u003e estrogen.\u003c\/p\u003e\n\u003cp\u003eThese \u003cem\u003especific estrogens\u003c\/em\u003e, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an \u003cem\u003eestrogen antagonist\u003c\/em\u003e. Yes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called “phytonutrients” have become the focus of clinical research, as these natural compounds have shown the ability to increase the ratio of good, estrogen decreasing estrogens (such as 2-OHE), to bad, estrogen increasing estrogens (such as 16-OHE1). One of these phytonutrients, a dietary indole known as indole-3-carbinol (I3C), is the bioactive phytochemical and a presumed modulator of reduced cancer risk in areas with high cruciferous vegetable consumption. Unfortunately, despite its potent antiestrogenic activity, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003eLuckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound with respect to antiestrogenic action – promoting the metabolism of beneficial estrogens that themselves reduce estrogenic activity.\u003c\/p\u003e\n\u003cp\u003eAside from its healthy-estrogen promoting abilities, DIM also exerts its own direct physiological effects, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromoting pathways of internal estrogen metabolism that favour the production of anti-estrogen estrogens.\u003c\/li\u003e\n\u003cli\u003eAdjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.\u003c\/li\u003e\n\u003cli\u003eLimit the cell division and growth of certain estrogens.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lie in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Theanine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThough the literature surrounding L-theanine is still emerging, the amino acid is slowly building a reputation as one of the most interesting and exciting compounds being targeted for therapeutic use. L-theanine is an amino acid found almost exclusively in tea, constituting approximately 1-2% of the dry weight of tea – resulting in a 25–60 mg theanine load per 200 ml serving of liquid tea.\u003c\/p\u003e\n\u003cp\u003eFirst identified in green tea and in the mushroom \u003cem\u003eXerocomus badius\u003c\/em\u003e, L-theanine readily crosses the blood-brain barrier in a dose-dependent manner, and it is thought to influence the central nervous system (CNS) through a variety of mechanisms, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncreasing the release and concentration of dopamine.\u003c\/li\u003e\n\u003cli\u003eInhibiting glutamate reuptake and blockade of glutamate receptors in the hippocampus.\u003c\/li\u003e\n\u003cli\u003eIncreasing gamma-aminobutyric acid (GABA – a neurotransmitter associated with the regulation of responses) concentrations.\u003c\/li\u003e\n\u003cli\u003eIncreasing levels of serotonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn addition to these more well-demonstrated effects, emerging electroencephalography trials on theanine suggest that the amino acid may exert a positive effect on alpha waves – a type of brain wave implicated in restful relaxation. Alpha activity has also been associated with increased creativity, increased performance under stress, and improved learning and concentration, as well as decreased anxiety.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_NEW.png?v=1753093928\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_LABEL_1.png?v=1753093978\"\u003eCore HARD Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_HARD_2025_References.docx?v=1753096766\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":31844500373619,"sku":"SHOP850757001641","price":44.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_FRONT_cbbbf7d3-ea1f-4330-b44a-babe58fbc1a2.png?v=1768407986"},{"product_id":"core-vegan","title":"Vegan 2lb","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eLactose, Soy, and Gluten Free\u003c\/li\u003e\n\u003cli\u003eGourmet Taste\u003c\/li\u003e\n\u003cli\u003eAdded Fermented Vegan BCAAs\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eFinding balance for a vegan protein is difficult. Often, you are sacrificing either taste or a quality amino acid profile to achieve the other.\u003c\/p\u003e\n\u003cp\u003eCore VEGAN solves this problem. To ensure you receive a complete protein with every serving of our pea and brown rice protein blend, we add fermented vegan BCAAs to every scoop. To ensure maximum digestibility, we also add the digestive blend DigeSEB™, an exact mixture of amylases, lactase, proteases, lipase, and cellulase\u003c\/p\u003e\n\u003cp\u003eFinally, the taste. We get it: vegan proteins do not typically taste great. Core VEGAN does. We worked relentlessly to nail down a flavor profile and creamy texture that rivals any animal-based protein. Our testers called it the best-tasting plant-based protein on the market. Yes, that good.\u003c\/p\u003e\n\u003cp\u003eIn our space, the word “vegan” was once considered pejorative. No longer. An emerging consensus demonstrates that it is possible to combine vegan and athletic lifestyles, with purpose-built solutions allowing vegans to consume the necessary range of macro-and micronutrients. Vegan protein rose quickly to the fore. As those who follow a vegan diet or lifestyle cannot consume dairy, the traditional protein source of whey is closed off to them–resulting in a range of plant-based proteins. There was a problem, however: they tasted disgusting and felt even worse drinking\u003c\/p\u003e\n\u003cp\u003eWith Core VEGAN it is easy to hit your protein goals without choking down some leafy sludge. Our optimized blend of pea and brown rice proteins has an optimal amino acid profile far superior to any other plant protein source. To supplement these protein sources, we add fermented, vegan-friendly BCAAs– abundant in animal protein sources but often lacking in a strictly vegan diet. BCAAs are the powerhouse behind repair and recovery from the everyday labors that your body endures.\u003c\/p\u003e\n\u003cp\u003eOn top of our protein blend and BCAAs, we added DigeSEB™ – a complex blend of digestive enzymes to ensure optimal gut digestibility and nutrient absorption. While other vegan proteins may leave you bloated and gassy, DigeSEB™ helps eliminate this discomfort so you can enjoy your protein and benefit entirely from it too!\u003c\/p\u003e\n\u003cp\u003eIn all, Core VEGAN represents the elusive perfect balance for a plant-based protein: a complete protein source with \u003cstrong\u003eAMAZING TASTE\u003c\/strong\u003e and mouth feel. Compromise is no longer the “name of the game” with plant-based proteins.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePlant-based Protein Blend\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePea protein, being a nutritional powerhouse with unique benefits, is the backbone of Core VEGAN. Not only is pea protein one of the most complete plant protein sources, it also confers some unique benefits. One of these benefits is that it is derived from a source that is hypoallergenic, meaning it is a preferred protein source for those who have dietary restrictions. Pea protein is also rich in essential and branch chained amino acids, making it great for muscle building and recovery. An 8-week study made up of 15 participants showed that when consumed along with resistance training, pea protein elicits just as much muscle protein synthesis as its whey counterpart. When it comes to digestibility, 95-98% of the proteins in peas are digestible, which makes its absorptive properties optimal. The minimal processing that is done also removes the fibers and starches that can prolong digestion and reduce its absorptive properties.\u003c\/p\u003e\n\u003cp\u003eMuch like peas, brown rice is derived from a source that is hypoallergenic making it a great alternative for those with dietary restrictions, especially lactose intolerance. In studies when compared to whey, participants who also engaged in physical exercise exhibited similar responses in metrics that were measured. These included decreased soreness, improvements in power, increases in muscle mass, as well as decreases in body fat.\u003c\/p\u003e\n\u003cp\u003eTo summarize the qualities of these two complimentary protein sources, their benefits include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eLow allergenic response and suitable for those with dietary restrictions.\u003c\/li\u003e\n\u003cli\u003eSimilar amino acid structure and muscle building response when consumed along with resitance training.\u003c\/li\u003e\n\u003cli\u003eHigh bioavailability and digestibility, reducing bloat and increasing protein delivery to tissues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eVegan Coconut Oil Creamer\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMedium chain triglycerides are a form of fat with 6-12 carbon fatty acid esters, a chemical structure that allows them to effectively bypass gastric uptake for transport directly to the liver for oxidation. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003eThis vegan coconut oil creamer also imparts a rich smoothness to this plant-based protein blend, giving it a pleasant mouthfeel unlike most vegan proteins on the market.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVegan BCAA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eProteins have been talked about as being one of the most beneficial nutrients for your body when it comes to growth, maintenance, and support. But when we dive deeper into proteins, we discover that they are made up of their own building blocks called amino acids. When it comes to skeletal muscle, the BCAAs (Leucine, Isoleucine, and Valine) are the most important. These three separate amino acids single handedly influence the actions of muscles, including the rate at which muscle grows, its power output, its endurance, etc. Like we said before, even those following an animal free diet deserve gains too! We have added vegan BCAA, in the research-backed 2:1:1 ratio, to our Core VEGAN protein to fill in the gaps and help support the BCAA’s already found in the protein sources included. This makes for an internal environment that will help delay muscle soreness, decrease recovery times, as well as positively impact your body composition goals. To sum up what a large body of evidence has already exhibited, BCAA can:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eDelay\/reduce the onset of muscle soreness after intense exercise.\u003c\/li\u003e\n\u003cli\u003eDecrease muscle recovery time between bouts of intense resistance exercise training.\u003c\/li\u003e\n\u003cli\u003ePositively impact body composition when combined with proper diet and exercise.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDigeSEB™\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe know that digestion and absorption is an extremely important, and often overlooked property of many diets. Digestive enzymes are then equally overlooked and forgotten when it comes to a supplementation regimen. These powerful little protein structures influence many complex processes that occur within our bodies. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breakdown of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc).\u003c\/p\u003e\n\u003cp\u003eAs you have probably seen by now, we here at Core Nutritionals do not cut corners. Like our whey blend counterpart Core PRO, we have added the comprehensive and clinically proven benefits of digestive enzymes into Core VEGAN. DigeSEB™ is comprised of amylases, proteases, lactases, amylases, and cellulases, allowing for a full and complete breakdown of every component.\u003c\/p\u003e\n\u003cp\u003eDigeSEB™ ensures that Core VEGAN not only tastes great but also increases the effectiveness of your pre- and post-workout nutrition in general.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-VEGAN-REV_ea443a0f-ecef-455d-8b0e-291176ea3c59.jpg?v=1603103280\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-BROWNIE-FIN-OL_compressed.pdf?v=1644225517\"\u003eChocolate Brownie Batter Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-PANCAKE-FIN-OL_compressed.pdf?v=1644225651\"\u003eMaple Pancake Batter Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-PB_PIE-FIN-OL_compressed.pdf?v=1644225714\"\u003ePeanut Butter Pie Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-VANILLACREME-FIN-OL_compressed.pdf?v=1644225795\"\u003eVanila Cream Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN_Frosted_Cinnamon_Bun_FIN-OL.pdf?v=1649831324\"\u003eFrosted Cinnamon Bun Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN_Strawberry_FIN-OL.pdf?v=1649831324\"\u003eStrawberry Cream Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES_-_VEGAN.pdf?v=1592810779\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Peanut Butter","offer_id":44793889095856,"sku":"SHOP672975315603","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Strawberry","offer_id":41576418115760,"sku":"SHOP658580070649","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Chocolate Brownie","offer_id":31844368220275,"sku":"SHOP672975009892","price":49.99,"currency_code":"USD","in_stock":true},{"title":"Vanilla Cream","offer_id":39729454121136,"sku":"SHOP672975315818","price":49.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/VEGAN3FRONT_888880d5-ee92-4bc3-b4f6-b06b40ed36f5.png?v=1767385845"},{"product_id":"core-hard-extreme","title":"Hard Extreme","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Reduction in cortisol levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDIM\u003c\/strong\u003e - Regulate healthy estrogen production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eL-Theanine\u003c\/strong\u003e - Increased measures of well being\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eTo be hard, you need to get HARD. It's that simple.\u003c\/p\u003e\n\u003cp\u003eCore HARD is the pinnacle in recomposition supplementation. The ingredients in HARD have been specifically chosen to balance your hormonal environment and maximize your lean mass.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e3 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eBody recomposition.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eYour diet is impeccable and couldn’t be any more in check – macros, micros, you have it all down. Your workouts? Get out of here! You have slaved, grinded, and grunted your way through leg workouts so intense the gym staff cried – and those were on your worst days. And yet, something is missing.\u003c\/p\u003e\n\u003cp\u003eIt’s that “extra” level of shred, “that look.” You know exactly what we mean. That type of leanness and density that makes an arm look twice as big, a stomach look twice as lean, and a forearm look like a roadmap for the Italian countryside. It’s that kind of elusive hardness that’s so rare, most of us simply chalk it up to genetics, or luck, or steroids, or whatever excuse we have handy – and yet we all still want it.\u003c\/p\u003e\n\u003cp\u003eThe reality? It isn’t all that unattainable. Getting “that” look, “that” hardness, is about balance and recomposition. It’s a matter of adding in that final piece of the puzzle that makes the entire picture come out perfectly.\u003c\/p\u003e\n\u003cp\u003eTo be hard, you need to get HARD. It’s that simple.\u003c\/p\u003e\n\u003cp\u003eCore HARD is another product in the Core Nutritionals’ lineup to follow the basic, but indispensable principles that Core Nutritionals is slowly making an industry standard: create products with effective ingredients, in effective doses, in a non-proprietary formula. This time around, we have applied those principles to the problem of softness that we all despise and have developed the most advanced ultra-hardening and recomposition agent on the market.\u003c\/p\u003e\n\u003cp\u003eTaking advantage of both the old and the new, Core Nutritionals has employed both modern, cutting-edge compounds and traditional herbs to create a balanced approach to delivering hardness. Key ingredients in Core HARD affect some of the body’s critical physiological pathways, combining sexiness and science in a single, non-proprietary formula. We have included seven powerful ingredients into a full month's worth of stimulant free, recomposition goodness.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-Spectrum Ashwagandha Extract (Withania somnifera) (root) (5% withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal\u003c\/em\u003e, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66\u003csup\u003e®\u003c\/sup\u003e to include in its HARD formula. KSM-66\u003csup\u003e®\u003c\/sup\u003e is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66\u003csup\u003e®\u003c\/sup\u003e not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO\u003csup\u003e2\u003c\/sup\u003e max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidylserine (50%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhosphatidylserine, colloquially known as PS, is a nearly ubiquitous phospholipid found in various membranous tissues throughout the body. PS’s ubiquity coincides with its necessity for crucial physiological functions, as the phospholipid is implicated in several components of cell communication, as well as the mediation of catecholamine synthesis and transmission in the brain (along with other neuroendocrine functions). In a fitness-related context, a nascent but growing body of methodologically-sound research suggests that PS may play a role in increasing exercise capacity.\u003c\/p\u003e\n\u003cp\u003eStudies administering the compound in both acute and chronic fashion suggest that PS has a measurable effect on exercise capacity. In a double-blind, placebo-controlled, randomized trial involving 16 trained athletes, phosphatidylserine was administered for 10 days prior to an acute exercise challenge. Exercise markers such as exercise time to exhaustion, sprint performance, and ratings of perceived exertion, were measured post-exercise. The authors found that exercise time to exhaustion was significantly altered. Related studies using similar serving sizes have found that chronic PS administration increased shot accuracy in golfers, increased exercise time to exhaustion by 28% in cyclists, and reduced subjective feelings of stress and soreness in others.\u003c\/p\u003e\n\u003cp\u003eOverall, phosphatidylserine appears to play a valuable role in the increase in exercise capacity. PS may therefore play a critical role in the continued exercise success of bodybuilders in a, “cutting” or recomposition stage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePomegranate Extract (Punica granatum) (hull) (ellagic acid 40%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePomegranate is a fruit-bearing deciduous shrub, endemic to and cultivated in wide swaths of both Europe and Asia. Pomegranate is also the predominant member of two species comprising the Punicaceae family\u003c\/p\u003e\n\u003cp\u003ePomegranate fruit has long been consumed as a dietary staple, and recent research has uncovered that the peel, in particular, harbors a broad range of physiologically active compounds known as polyphenols – most prominently ellagitannins. When consumed, these ellagitannins are hydrolyzed to ellagic acid in the gut, and released into the blood, allowing ellagic acid to be widely distributed to many target tissues and organs. \u003c\/p\u003e\n\u003cp\u003eWhile still preliminary, emerging animal and in vitro data on PME (pomegranate extract) suggests that both specific and whole plant extracts may exert interesting endocrine effects. In a study examining the effects of PME on cultured human cells, PME was shown to down-regulate estrogen-receptor gene expression, and inhibit binding – suggesting that PME may possess some anti-estrogenic effects, at least in vitro. In another study in rats, PME’s robust antioxidant profile was hypothesized to increase androgenic activity via reducing oxygen radicals in the testes.\u003c\/p\u003e\n\u003cp\u003eThough PME lacks robust human data, the available literature suggests that this compound may possess some highly useful physiological effects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhite Button Mushroom Extract (Agaricus blazei) (fruit) (30% polysaccharides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAgaricus blazei\u003c\/em\u003e, known commonly by a plethora of names – including button mushroom, white button mushroom, table mushroom, and champignon mushroom – is a small, edible mushroom endemic to North America and Europe. The most commonly consumed mushroom on the planet, commercial production and consumption of white button mushroom has existed since at least the early 18\u003csup\u003eth\u003c\/sup\u003e century, while indigenous oral records suggest the plant was consumed for centuries prior.\u003c\/p\u003e\n\u003cp\u003eRecent medical research has discovered that white button mushroom is a rich source of biologically-active compounds, including ergothioneine, an antioxidant with particularly potent free radical scavenging activity. Similar research has found that white button mushrooms – along with other varieties – possess unsaturated fatty acids such as linoleic acid, linolenic acid, and conjugated linoleic acid that may exert inhibitory activity on human aromatase, a cytochrome-P450 complex responsible for the conversion of testosterone into estrogen.\u003c\/p\u003e\n\u003cp\u003eIn two separate studies by similar researchers, both rats and human cell lines were fed and\/or incubated with various extract strengths and doses of white button mushroom extract. Both the animal experiments and “in-cell” aromatase assays demonstrated that WBME exerted powerful anti-aromatase effects, reducing total aromatase amounts and activity across all experimental conditions.\u003c\/p\u003e\n\u003cp\u003eThe most encouraging aspect of these studies is the servings of white button mushroom used in the experimental conditions: they are easily achievable through oral consumption, unlike many other plant-based, physiologically active compounds.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Theanine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThough the literature surrounding L-theanine is still emerging, the amino acid is slowly building a reputation as one of the most interesting and exciting compounds being targeted for therapeutic use. L-theanine is an amino acid found almost exclusively in tea, constituting approximately 1-2% of the dry weight of tea – resulting in a 25–60 mg theanine load per 200 ml serving of liquid tea.\u003c\/p\u003e\n\u003cp\u003eFirst identified in green tea and in the mushroom \u003cem\u003eXerocomus badius\u003c\/em\u003e, L-theanine readily crosses the blood-brain barrier in a dose-dependent manner, and it is thought to influence the central nervous system (CNS) through a variety of mechanisms, including:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eInhibiting glutamate reuptake and blockade of glutamate receptors in the hippocampus.\u003c\/li\u003e\n\u003cli\u003eIncreasing gamma-aminobutyric acid (GABA – a neurotransmitter associated with the regulation of responses) concentrations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn addition to these more well-demonstrated effects, emerging electroencephalography trials on theanine suggest that the amino acid may exert a positive effect on alpha waves – a type of brain wave implicated in restful relaxation. Alpha activity has also been associated with increased creativity, increased performance under stress, and improved learning and concentration, as well as decreased anxiety.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3'-Diindolylmethane (DIM)\u003cu\u003e\u003cbr\u003e\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E\u003csub\u003e2\u003c\/sub\u003e), estrone (E\u003csub\u003e1\u003c\/sub\u003e), and estriol (E\u003csub\u003e3\u003c\/sub\u003e), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to identify \u003cem\u003ea specific\u003c\/em\u003e estrogen.\u003c\/p\u003e\n\u003cp\u003eThese \u003cem\u003especific estrogens\u003c\/em\u003e, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an \u003cem\u003eestrogen antagonist. \u003c\/em\u003eYes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called phytonutrients have become the focus of clinical research, as these natural compounds have shown the ability to modulate the body’s estrogen ratio. One of these phytonutrients, is a dietary indole known as indole-3-carbinol (I3C). Unfortunately, despite its metabolic usefulness, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cu data-mce-fragment=\"1\"\u003eCocoabuterol®\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCocoabuterol®, made up of the bioactive compounds found in cocoa, has been shown through studies and application to have beneficial factors on fat loss, muscle building, and insulin sensitivity. This caffeine free ingredient exhibits a mechanism of action in the body to increase cAMP (cyclic adenosine monophosphate) levels, which acts as a second messenger and regulator of many movements exhibited by all three types of cells in the human body. In this context, fat (adipose) tissue epinephrine utilizes cAMP to increase to triglyceride hydrolysis and cardiac (heart) muscle epinephrine utilizes it to increase contraction rate. This action can have positive benefits on body composition and performance.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTheobromine, one of the main methylxanthine compounds found in cocoa is primarily effective in the increase of nitric oxide to in the blood stream, which is beneficial to produce the “pump” when ingested pre-workout. Another reaction that can be seen with theobromine is dilation of blood vessels. This can increase blood flow during vigorous exercise leading to increased time to exhaustion but also can pose benefits to individuals who suffer from high blood pressure. Theobromine also has a very high bioavailability and ability to stay in the body for extended periods of time (7-8 hours). Several studies have also looked at the effects of theobromine on human subjects and results have shown its ability to reduce oxidative stress on cells and regulation of gene expression.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCocoabuterol® has also been shown to have positive benefits on reducing oxidative stress in the body. Due to its rich antioxidant properties, it has the ability to fight off free radicals that can be detrimental. In addition to this, the polyphenols that Cocoabuterol® contains have been shown to reduce inflammatory signals within the body that can also be detrimental biomarkers. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eBy now you have read some of the amazing benefits of Cocoabuterol® and why we have included in this recomposition agent. When your goal is maintaining muscle mass, shedding body fat, reducing overall stress, and performing at your peak, we make sure you are equipped with the right ingredients, in the right dosages, and for the right purpose. In summary, Cocoabuterol® does all of these things by:\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cul data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eIncreasing power output due to elevated NO production via theobromine effects.\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eIncreasing adipose usage through cAMP action in the body.\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eImproving senses of well-being due to high levels of polyphenols and antioxidants reducing overall stress on the body from workouts and life events.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-HARDX-2020.jpg?v=1594626584\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_HARD_EXTREME_11.5x2.375_PINEAPPLE_STRAWBERRY-FIN.pdf?v=1639493578\"\u003ePineapple Strawberry Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_HARD_EXTREME_11.5x2.375_BLACK_LIGHTNING-FIN_compressed.pdf?v=1639493414\"\u003eBlack Lightning Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-HARD-Extreme-Refferences.pdf?3720008071589287876\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Pineapple Strawberry","offer_id":31907295527027,"sku":"SHOP672975315306","price":49.99,"currency_code":"USD","in_stock":false},{"title":"Black Lightning","offer_id":31907295559795,"sku":"SHOP672975315290","price":49.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/products\/hard-pinneapple-strawberry.png?v=1594626285"},{"product_id":"core-mrp","title":"MRP","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein blend\u003c\/strong\u003e - \u003cspan data-mce-fragment=\"1\"\u003eSustained release for all day amino acid support \u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCarb blend\u003c\/strong\u003e - Low glycemic and grain-sourced carbohydrates\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMicronutrients\u003c\/strong\u003e - Full spectrum of vitamins and minerals\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eDiet is the most critical aspect for training success.\u003c\/p\u003e\n\u003cp\u003eCore MRP is designed with optimal results in mind. Our high quality, grain-sourced carbohydrates, multiple (and rich) protein sources, premium flavors, and a plethora of extras all come in a gourmet-tasting, instantized powder.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e2 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e20 servings per container.\u003c\/li\u003e\n\u003cli\u003eComprehensive meal formula.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePop quiz: what’s the absolute, without question, most critical component to achieving those roadmap veins and granite abs you have always wanted? How hard and how frequently you work your abs? The intensity of your cardio training, maybe; or the HIIT training you’ve been doing? If you said any of the above, you’re wrong – while exercise is a critical component of achieving your body composition goals, the diet remains king.\u003c\/p\u003e\n\u003cp\u003eWhile it remains the most important component in a healthy lifestyle, a finely-tuned diet is often a difficult and impractical thing to implement. The most dedicated among us – and probably you, too – pack our fridge with Tupperware so high that chicken and plastic starts bursting through the freezer. We’ve all had the, “I eat this because...” conversation while at work, lugged our preferred food items to school, work, the park, and everywhere in between, and cursed the fact we went anywhere ill-prepared that day. There needs to be an easier – but equally effective – way, doesn’t there?\u003c\/p\u003e\n\u003cp\u003eWell, at Core Nutritionals, we think we have found that better way: Core MRP. Core MRP is not only designed with optimal nutrients (macro and micro) in mind, but perhaps more importantly, it’s designed to fit in your life, not run it. Our high quality, grain-sourced carbohydrates, multiple (and rich) protein sources, premium flavors, and a plethora of extras all come in a gourmet-tasting, instantized powder – giving you the freedom to plan your favorite activities, and your diet, together.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCarbohydrate Blend:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBefore we dive in to understand the complexity of Core MRP, lets back up and first understand exactly what’s occurring when we consume carbohydrates on a daily basis – and in particular, when we consume around our workouts (peri-workout nutrition).\u003c\/p\u003e\n\u003cp\u003eThe consumption of carbohydrates, by its nature, results in an increase in the concentration of plasma glucose (or blood sugar) – and, in turn, insulin is released from the pancreas as a result. Insulin then initiates a number of signal transduction pathways related to both protein and glucose metabolism, with the upshot being increased glycolysis (breakdown of glucose to ATP), glucose oxidation in response to greater glucose availability in the cell, and glycogen synthesis (the stuff that essentially makes muscles, “pop”). In other words, an entire host of both necessary and amazing things!\u003c\/p\u003e\n\u003cp\u003eWith that said, insulin does induce some negative effects, as well. This powerful hormone is responsible for a range of lipogenic (fat-creating) effects, including both adipocyte differentiation (turning what are known as pre-adipocytes into mature adipocytes, or fat cells), and proliferation (the expansion of cells). Insulin controls these processes by tightly regulating numerous signal transduction pathways, and is in fact one of the key hormones responsible for controlling how adipocytes function.\u003c\/p\u003e\n\u003cp\u003eSo, you have a hormone that, on the one hand, does a range of absolutely crucial things related to muscle and muscle cell metabolism, and on the other, does similarly crucial things related to fat and fat cell metabolism. How do we separate the good from the bad, then?\u003c\/p\u003e\n\u003cp\u003eThe easiest, most reliable way to ensure that these processes continue to work in favor of your body composition goals, is to very carefully and strategically select your carbohydrates sources. For us at Core, and specifically for Core MRP, this means choosing only low glycemic carbohydrates for inclusion in our everyday meal supplement.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhole Grain Oats:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLow-glycemic carbohydrates are ones that elicit a smaller, “glycemic” or glucose-releasing response in the body; meaning they also induce less of an insulinemic response, as well. The result is that low glycemic carbohydrates, as research indicates, not only cause enhanced fat oxidation (the literal burning of fat) when compared to high GI carbs, but also spare muscle glycogen. This result is the best of both worlds: your metabolic engine stays engaged, and the substance that gives your muscles their fullness, glycogen, is spared.\u003c\/p\u003e\n\u003cp\u003eIt is for the reasons above that high-quality, low-glycemic carbohydrates are such a crucial component to an excellent meal supplement. Unfortunately, that is simply not the industry trend: even a cursory glance at most, “meal replacements” reveals a litany of high-glycemic, insulin-inducing carbohydrates that, while they have their place, are completely inappropriate to include in an all-day, everyday meal replacement.\u003c\/p\u003e\n\u003cp\u003eCore MRP is not like the rest. We are setting a new standard with the product that started it all. We have chosen only high-quality whole grain oat flour to include as your carbohydrate source. Oats offer a wide variety of benefits aside from just providing carbohydrates for the body. Some of these include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eOats contain considerable amounts of valuable nutrients such as proteins, starch, unsaturated fatty acids and dietary fiber as soluble and insoluble fractions.\u003c\/li\u003e\n\u003cli\u003eOats contain high amounts of beta glucan, a fiber that has been studied extensively for its benefits on aiding digestion and supporting the gut microbiome.\u003c\/li\u003e\n\u003cli\u003eOats also have been shown to aid in the controlling of certain heart related conditions, such as high cholesterol.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWe at Core have put a lot of time and effort into the formulation of our products, and Core MRP is not different. This allows you to remain confident that consuming Core MRP is not only allowing you to cost-effectively and conveniently meet your caloric goals for the day, but more importantly, that our product is not compromising your hard work or lifestyle.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtein Blend:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf you have been following us for quite some time, we likely don’t need to explain just how and why adequate protein intake is fundamental to achieving your goals. With that said, there may be some confusion as to what specific kinds of protein are going to benefit your goals and why.\u003c\/p\u003e\n\u003cp\u003eLike we did with carbohydrates above, let’s look into the specifics a little bit rather than just supplying a generic answer. We are anything but generic after all! The word “protein,” without any qualification, is perhaps the broadest term you can possibly use when speaking about biology – to the point where asking, “How much protein should I consume, and which kind?” renders itself useless. Considering proteins are more or less complex compositions of amino acids, and considering that amino acids have different functions, what we want to ask is something more specific like, “Which kinds of protein have the amino acid composition best suited to my goals, and when should I consume them?” A mouthful, but you get the point!\u003c\/p\u003e\n\u003cp\u003eSo, what does a, “good” amino acid composition for a protein supplement look like? Well, while biologists would never use the term, “good”, they describe more robust proteins – one with amino acid profiles that can best facilitate tissue growth – as, “complete proteins.” These proteins contain high amounts of essential amino acids, are rapidly digestible, and support the available amino acid profile over a long period of time.\u003c\/p\u003e\n\u003cp\u003eSimply put, and if we use the definition above, Core MRP has one of the most complete amino acid profiles available in any supplement. We have a included a blend of the most bioavailable and high quality proteins to create a blend specifically catered to fuel your body’s need throughout an entire day, not to mention we have full transparency on our label too, so you know exactly how much of each protein you are getting.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCold-processed undenatured whey protein concentrate:\u003c\/strong\u003e Whey protein concentrate is probably the most common form of whey protein you will find. However, how it is processed is where the benefit truly lies. This process of cold processed undenaturization preserves the molecular structure of the amino acid particles as well as the immune boosting benefits that it contains. This undenatured protein is also a rich source of amino acids, including those needed for the synthesis of glutathione, which is an important antioxidant that can be depleted by stress (exercise stress included). This makes it a great foundation for your post workout recovery nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCross-flow microfiltered whey protein isolate:\u003c\/strong\u003e whey protein isolate is an extremely “clean” form of whey protein. It yields a higher amount of amino acids, half of which are from the essential amino acids (cannot be made by the body). Microfiltration eliminates a large majority of the fat and lactose from the whey, which makes it easily digestible and quickly absorbed into the body. This cross-flow process uses a highly intricate method to isolate the protein. It is not subjected to chemicals and is thus left in its most natural state.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Protein Isolate:\u003c\/strong\u003e milk protein isolate is obtained through the partial removal of non-protein materials from skim milk (lactose and other minerals). What you are left with is a dry product that contains more than 90% protein by weight. This product contains both casein and whey proteins in their original proportions found in milk, without combining separately produced casein and whey proteins. It contains very little fat and lactose and also has a very high amino acid composition making it a perfect addition to this blend.\u003c\/p\u003e\n\u003cp\u003eTo both immediately increase the amino acid pool, and fuel your bodily processes (like protein synthesis) throughout the day, we’ve strategically included such a robust, multi-purpose blend using multiple forms of synergistic proteins that truly complement each other to positively impact your health and fitness.\u003c\/p\u003e\n\u003cp\u003eThe point of an excellent meal supplement is to cover all your bases, so you don’t have to. Core MRP in MJ with the ball with 5 seconds on the clock and The Bulls down by 1. Our multi-stage protein blend is ready to give you everything you need to maximize recovery, increase protein synthesis, and improve your health when you need it most. If your body needs it, Core MRP has it.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhole Food Based Vitamins and Minerals:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThere are a lot of great things about Core MRP already, but what really makes it stand out from other meal supplements on the market is the complete and well-roundedness of this product. Our sources of carbohydrates are more superior, our blend of protein is unmatched, and last but not least, our completely whole food-based blend of micronutrients is second to none.\u003c\/p\u003e\n\u003cp\u003eListing each of our micronutrients in succession, along with all the benefits they pose to the human body, would require us to write a book – literally. We have included everything from A to Zinc in dosages needed that will truly make a difference. We have also added a specific and blend of key foods, like broccoli, kale, sweet potato, chlorella, and shiitake mushroom to name a few. This is the most complete meal supplement on the market.\u003c\/p\u003e\n\u003cp\u003eIn addition to our vitamin and mineral matrix, we have also included the digestive enzyme blend, DigeSEB™, comprised by five of the most clinically-researched, critical function enzymes available. We have chosen this blend for its powerful synergistic properties and abilities to help aid in the breakdown of milk proteins and sugars, support healthy carbohydrate and fat metabolism and breakdown, and assist in the metabolism of carbohydrates and starch.\u003c\/p\u003e\n\u003cp\u003eFor a more in-depth look, take a look at our supplement facts table below!\u003c\/p\u003e\n\u003cp\u003eFor a more in-depth look, take a look at our supplement facts table below!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-MRP2020.jpg?v=1595228900\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_MRP_2023_BANANA_NUT_BREAD-FIN_1.pdf?v=1695644681\"\u003eBanana Nut Bread Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-BLUEBERRY_CRUMB_FIN-OL.pdf?v=1639495234\"\u003eBlueberry Crumb Cake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-DOUBLE_CHOCOLATE_FIN-OL_compressed_1.pdf?v=1639495571\"\u003eDouble Chocolate Oatmeal Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-PB_OATMEAL_COOKIE_FIN-OL_compressed.pdf?v=1639496009\"\u003ePeanut Butter Oatmeal Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-VANILLA_POUNDCAKE_FIN-OL_compressed.pdf?v=1639496196\"\u003eVanilla Poundcake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020_CHOCOLATE_CARAMEL_CANDY_BAR-FIN_compressed.pdf?v=1639556587\"\u003eCaramel Candy Bar Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020_PUMPKIN_PIE-FIN_compressed_1.pdf?v=1639495111\"\u003ePumpkin Pie Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2021-CARROT_CAKE-FIN_compressed.pdf?v=1639496458\"\u003eCarrot Cake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2021-SMORES-FIN_compressed_1_ba0fbab8-9a60-46f6-a060-a82d73cdfe7f.pdf?v=1639497007\"\u003eS'mores Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MRP_2020-BROWN_SUGAR_FIN-OL.pdf?v=1658906456\"\u003eBrown Sugar \u0026amp; Cinnamon Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-MRP-REFFERENCES.pdf?v=1595229378\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Banana Nut Bread","offer_id":42833452695728,"sku":"SHOP850051031252","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Blueberry Muffin","offer_id":31915088674931,"sku":"SHOP850757001849","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Peanut Butter Oatmeal Cookie","offer_id":31915088740467,"sku":"SHOP8507570018070","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Cookies n' Cream","offer_id":44921434407088,"sku":"SHOP850057789379","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Death By Chocolate","offer_id":44921434439856,"sku":"SHOP850057789874","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Vanilla Poundcake","offer_id":31915088773235,"sku":"SHOP672975315818","price":54.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/MRP_PBOC_FRONT_6176821a-da83-48f5-8d0c-5636bd093980.png?v=1772111616"},{"product_id":"core-shred","title":"Shred","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eStimulant-free thermogenic\u003c\/li\u003e\n\u003cli\u003eSupport healthy weight management\u003c\/li\u003e\n\u003cli\u003eIncrease lipolysis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003eIt’s late evening and you need to crush your workout – worst of all, you're deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e1 scoop per serving.\u003c\/li\u003e\n\u003cli\u003e56 servings per container.\u003c\/li\u003e\n\u003cli\u003eHealthy thyroid support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIt’s late evening and you need to crush your workout – worst of all, your deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?\u003c\/p\u003e\n\u003cp\u003ePrior to now, you sucked it up and chugged your ultra-potent and effective stimulant-based thermogenic (such as BURN Powder!) and dealt with the consequences. But as of now, you take a scoop of the ultra-potent and equally effective, non-stimulant-based thermogenic Core SHRED.\u003c\/p\u003e\n\u003cp\u003eWe’ve taken our typical approach to product formulation – proven ingredients at clinically-effective and clinically-proven serving sizes – and applied it to creating a comprehensive, multiple-pathway non-stimulant thermogenic product. The result is a product covering major pathways of lipolysis in multiple, non-redundant, and synergistic ways, all without any neurological stimulation whatsoever.\u003c\/p\u003e\n\u003cp\u003eWhether you’re taking a break from stimulants, are stimulant sensitive, or simply want a non-stimulant thermogenic to stack with our excellent stimulant-based offerings, Core SHRED is the perfect solution. Use it anytime, night or day, to help crush your regular exercise program and consistent diet!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcetyl-l-Carnitine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions. Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOlive Extract (Oleaeuropaeai) (leaf) (20% oleuropein):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eOlea europaea\u003c\/em\u003e, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea. As the fruits, oils, and extracts of \u003cem\u003eOlea europaea L\u003c\/em\u003e. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.\u003c\/p\u003e\n\u003cp\u003eOleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research inanimals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eColeus forskohlii root extract (20% forskolin):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eColeus forskohlii\u003c\/em\u003e is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.\u003c\/p\u003e\n\u003cp\u003eA recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core SHRED!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCapsiAtra®:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways – most notably, those related to energy expenditure and lipid utilization.\u003c\/p\u003e\n\u003cp\u003eCapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways – most notably, those related to energy expenditure and lipid utilization.\u003c\/p\u003e\n\u003cp\u003eThe thermogenic and lipolytic effects of capsinoids, like capsaicin itself, are mediated by the Transient Receptor Potential Vanilloid 1 (TRPV1) receptors in the mouth and throughout the gastrointestinal tract. TRPV1 receptors in the gut are linked with the sympathetic nervous system (SNS). When activated, they increase SNS activity (the figure below). TRPV1 receptors present on the tongue and in the oral cavity are responsible for, among other things, detection of thermal heat. When capsaicin binds to oral TRPV1 sites, one feels the sensation of heat and pungency. Capsinoids also stimulate TRPV1 receptors, but their effect is primarily on receptors in the throat and gut, not the mouth. Owing to the structural differences from capsaicin, the capsinoids are unable to reach the TRPV1 receptors on the tongue, which are located slightly below the mucosal surface. As a result, capsinoids do not produce the oral sensation of heat or the pungent taste associated with chili peppers, but they do produce the capsaicin-like SNS response once they bind to TRPV1 receptors in the throat and gut.\u003c\/p\u003e\n\u003cp\u003eThe capsinoids have multiple biological functionalities. The sports nutrition properties are directly linked to their use in energy manipulation. The capsinoids have three principal mechanisms of action. First, they up-regulate UCP-3 (Mitcohondrial Uncoupling Protein-3) in muscle cells. This causes ATP production to be dissociated with the respiration occurring in the mitochondria. This energy is then released as heat: an effect that is mirrored in caloric restriction as a means to economize energy. Second, they up-regulate UCP-1 (Uncoupling Protein-1, aka Thermogenin). This protein is only expressed in brown adipose tissue and is used to generate non- shivering thermogenesis; a process that evolved to protect against hypothermia. The up-regulation of UCP-1 can positively affect fat utilization and improve insulin sensitivity of tissues. Third, the capsinoids stimulate lipolysis via hydrolysis of triglycerides into glycerol plus three fatty acids. The release of these free fatty acids into the circulation is key to the energy regulating properties of the compound. Allowing these to become readily available as energy sources during exercise means that oxidation of muscle glycogen can be delayed, resulting in significant improvements in endurance.\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core-sherd.png?v=1596464988\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGrains of Paradise Extract (12.5% 6-paradol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAframomum melegueta\u003c\/em\u003e, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger \u003cem\u003e(Zingiberaceae)\u003c\/em\u003e family. While complete compositional analysis have not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger – principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol.\u003c\/p\u003e\n\u003cp\u003eAlong with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose-dependently mediate the PI3K (phosphoinositide 3-kinase)\/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.\u003c\/p\u003e\n\u003cp\u003eIn the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePro-GBB™ (Gamma Butyrobetaine Ethyl Ester HCL):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCore SHRED is using the trademarked form of Gamma Butyrobetaine Ethyl Ester HCL, or GBB for short, Pro-GBB™. GBB is a naturally occurring molecule in the body that aids in the boosting of the non-essential amino acid L-carnitine. L-carnitine plays a key role in energy production by its ability to transport fatty acids into the cell’s mitochondria (‘energy producing powerhouse’) to be used for energy. Studies have shown that when GBB is present it can increase the bodies L-carnitine supply, thus providing enhanced benefits. So, in simplified terms, GBB increases usable L-carnitine in the body which increases the mitochondria’s ability to use fatty acids for energy. With the goal of reducing body fat or even improving performance, L-carnitine shows particular benefits in this field. A study conducted on mammals looked at the responses of L-carnitine supplementation on growth performance as well as circumference measurements. The results showed that weights of muscle tissue increased, whereas abdominal fat percentage decreased.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-SHRED-2020.jpg?v=1596180373\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_SHRED_11.5x2.375_PINEAPPLE_STRAWBERRY-FIN_1.pdf?v=1639561708\"\u003ePineapple Strawberry Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_SHRED_11.5x2.375_TROPIC_HEAT-FIN.pdf?v=1639561505\"\u003eTropic Heat Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-Shreed-REFFERENCES.pdf?v=1596465403\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Pineapple Strawberry","offer_id":31943985823859,"sku":"SHOP672975315092","price":44.99,"currency_code":"USD","in_stock":false},{"title":"Tropic Heat","offer_id":31943985856627,"sku":"SHOP672975315108","price":44.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/products\/shred-pinneapple-strawberry.png?v=1597066883"},{"product_id":"core-flex","title":"Flex","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCissus\u003c\/strong\u003e - Improved joint function and strength\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBoswellia\u003c\/strong\u003e - Promotes healthy tendons and strengthens cartilage\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChondroitin\u003c\/strong\u003e - Contains antioxidants to help boost recovery\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eDon’t leave your recovery to chance.\u003c\/p\u003e\n\u003cp\u003eCore FLEX is an ultra-potent combination of 11 clinical ingredients, crafted to ensure the maintenance of strong and healthy tendons and ligaments. Best of all, its all-in-one blend combines the efficacy of single ingredient products, with the synergy of an entire joint product lineup.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e8 tablets per serving.\u003c\/li\u003e\n\u003cli\u003e30 servings per container.\u003c\/li\u003e\n\u003cli\u003eSoft tissue support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWe’ve all been there. You have a bit of cashed saved up, and a hard choice to make: do you buy the new, shiny toy, or fix that sort of irritating sound your engine is making? I mean, sure, maybe the engine breaks down, but that’s only a possibility – you will most certainly enjoy that new toy! Am I right?\u003c\/p\u003e\n\u003cp\u003eWrong. Just like a vehicle, our bodies are exposed to the constant wear and tear of demanding daily use, a fact especially true of athletes. As we put more and more weight on the bar, run faster and further, and push our bodies to the limit, our joints, tendons, and ligaments require regular maintenance to keep them in optimal health. We need to fix that sort of irritating sound our engine is making, in other words.\u003c\/p\u003e\n\u003cp\u003eCore FLEX provides a superior way to do so. Core FLEX is an ultra-potent combination of 11 ingredients, verified by clinical research and included in clinical serving sizes, crafted to ensure the maintenance of strong and healthy tendons and ligaments. Best of all, Core FLEX’s all-in-one blend combines the efficacy of single ingredient products, with the synergy of an entire joint product lineup.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChondroitin and Glucosamine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChondroitin and Glucosamine are substances found naturally in the body, and in particular, in and around the cartilage and other connective tissues.Glucosamine falls within a class of compounds known as amino sugar, and is a precursor to a molecule called glycosaminoglycan. The human body produces and distributes both of these compounds as critical components in the production of cartilage and other connective tissue . It also aids in lubricating and providing thickness to the cartilage around damaged joints. Chondroitin sulfate is a type of glycosaminoglycan and complex carbohydrate rich in sulfur, and is a relative of glucosamine. Chondroitin is one of the major constituents of cartilage, not only providing structure and stability, but also water for the purpose of lubrication.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethylsulfonylmethane (MSM):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMSM is a naturally occurring, organosulfur molecule that can be synthesized both naturally and synthetically from DSMO. While the majority of MSM present in the human body is ingested – either deliberately or accidentally – the compound does have a natural presence in certain tissues and fluids in the body, including cerebrospinal fluid. MSM appears to assist healthy biochemical communication between cells that may assist joint flexibility and mobility. While still emerging, certain data on MSM appears to show a promising role for the compound in the maintenance of proper joint function. Several studies demonstrate joint function increases on the WOMAC scale ranging from 20-35%, while animal data suggests equally significant results. Though not every trial on MSM reveals such significant results, a meta-analysis conducted in 2011 found that the overwhelming majority of clinical MSM trials featured function improvements over placebo.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCissus quadrangularis:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCissus quadrangularis (CQ) is a plant with a long history of use in traditional and folk medicinal systems, including thousands of years of documented use in the Siddha and Ayurvedic traditions. While the specific use of Cissus in these systems varied, the most common traditional preparations related to analgesia, general tonics, and bone fracture healing. More recent research has developed physiological explanations for CQ’s traditional efficacy, including the reduction of pro-inflammatory cytokines, modulation of the glucocorticoid system (in animal trials), and the proliferation of osteoblast (bone-forming cell) DNA.\u003c\/p\u003e\n\u003cp\u003eSpecific to bone formation, there is strong data to suggest that CQ increases the accumulation of compounds known as mucopolysaccharides – long chain sugar molecules that precede mineralization in the process of bone formation. Think of these compounds sort of like the wet newspaper before it becomes paper mache. As stated, separate research also suggests that extracts of CQ stimulated osteoblastogenesis, the process of forming bone cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBlack cherry extract:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBlack cherry extract contains a number of beneficial compounds, including high levels of anthocyanin – an extremely potent anti-inflammatory compound which some animal evidence has shown plays a role in the maintenance of articular jointsIt is rich in antioxidants and catechins, chlorogenic acid, and flavonal glycoside, and has been used to support healthy uric acid levels typically associated with complete joint health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTurmeric (95% curcumin):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTumeric is a root endemic to certain regions of Southeast Asia and India, and has been a staple in the Siddha traditional medicinal system for thousands of years. Tumeric is noted in Siddha texts for various uses, including as an ancient equivalent of an anti-microbial agent.\u003c\/p\u003e\n\u003cp\u003eMore recently, numerous studies seem to suggest that its primary bioactive constituent, curcumin,  powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses.\u003c\/p\u003e\n\u003cp\u003eThough Tumeric contains approximately 5% curcumin by weight, we have used a highly standardized extract of 95% - recognizing that the wealth of research on curcumin demands that it be included in clinical serving sizes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoswellia (37.5% boswellic acids):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoswellia is a tree resin extract that is a traditional part of Indian medicine. In modern clinical trials the active agenct, boswellic acid, has been found to inhibit the production of pro-inflammatory leukotrienes. Similarly to curcumin, boswellic acids have demonstrated a significant attenuation of NF-kB production in various animal and \u003cem\u003ein vitro \u003c\/em\u003eassays.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBromelain (2400GDU\/g):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBromelain is a collection of protein-digesting enzymes found in pineapple juice and in the stem of pineapple plants. It has been shown to have a myriad of health benefits including speed of recovery, antioxidant properties, and assisting cardiovascular and circulatory health. The mechanism of the anti-inflammatory activity is not very well understood, but like curcumin and boswellia it appears to support inflammatory marker balance. Numerous studies have shown bromelain’s ability to assist and speed recovery time following various health related procedures.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is not only a powerful antioxidant, but also supports a healthy immune system, protects cells from oxidized particles and free radicals, and assists other physiological functions. A major study by the University of California at Berkeley found that supplementing with 500 milligrams of Vitamin C (the daily serving contained in Core FLEX) led to a 24% reduction in levels of C-reactive protein, a consistent marker of inflammation. In conjunction with the other ingredients, it is important component of strong joints and overall health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, , immune and cardiovascular health, muscle protein synthesis, and weight management. Although some foods contain Vitamin D3, the human body generates most of its Vitamin D3 needs from the skin through regular exposure to sunlight. Healthy and normal Vitamin D3 levels are essential to maintaining numerous bodily processes, including regulating the pro-inflammatory responses of joints and connective tissues to damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePiperine (95%)\u003c\/strong\u003e:\u003c\/p\u003e\n\u003cp\u003ePiperine a black pepper extract, is included because it dramatically increases the bioavailability of curcuminoids (see above). Without piperine, the serum concentration and absorption rates of the active agents in curcumin would be significantly reduced. Piperine facilities the full effects of the curcumin.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-FLEX-2020.jpg?v=1596180787\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_FLEX_8.5x3.25_FIN-OL.pdf?v=1638801046\" target=\"_blank\"\u003eCore FLEX Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-FLEX-Product-References.pdf?6302103401660858656\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":31946453549171,"sku":"SHOP672975009694","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/FLEX_FRONT.png?v=1760385682"},{"product_id":"core-post","title":"Post","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCyclic Dextrin®\u003c\/strong\u003e - Replenish muscle glycogen and shuttle needed amino acids to muscle cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVelositol®\u003c\/strong\u003e - Helps amplify effects of whey protein to increase muscle protein synthesis\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitacherry®\u003c\/strong\u003e - Maximize muscle recovery after weight training\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e It has been called the most important meal of the day, “the anabolic window”, and eating for anabolism. Whatever name you give it, the premise remains: post-workout nutrition is crucial to reaching your fitness and physique goals. Post-workout nutrition plays a number of critical anabolic (tissue building) functions, chief among them being the maximization of glycogen storage and protein synthesis, while simultaneously minimizing protein breakdown and the excessive release of catabolic (tissue destroying) hormones. Incomplete or insufficient post-workout nutrition isn’t a recipe that will likely yield a tasteful result.\u003c\/p\u003e\n\u003cp\u003eThis all raises the question: what is the ideal post workout nutrition? Is it common knowledge, or an industry secret? Maybe a certain ratio of carbohydrates to protein, or fat to protein; maybe the timing, frequency, and method of ingestion? Well, we are here to offer some clarifying insight. To be honest, the situation is vastly less complex, more well-known, and easier to implement than most would have you believe.\u003c\/p\u003e\n\u003cp\u003eHigh quality, fast-digesting carbohydrates and protein have been shown time and again to induce the most optimal conditions for growth in clinical studies – and that is precisely what Core has attempted to emulate with Core POST. Core POST takes the guesswork out of post workout recovery, containing the fast-acting proteins and carbs (whey isolate, dextrose, and Cluster Dextrin®), along with other anabolic agents (free-form L-Leucine, Velositol®, VitaCherry®, and Bioperine®) needed to increase absorption in order to maximize muscle recovery after weight training. This combination of ingredients can quickly replenish muscle glycogen and shuttle much needed amino acids to muscle cells. Whether you are bulking up or slimming down, all of these ingredients are crucial for proper recovery.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecovery Carb Blend (Dextrose and Cluster Dextrin®):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs mentioned above, one of the main goals post workout is to restore muscle glycogen that has been depleted during the workout. The body will even break down muscle tissue for this purpose if an adequate influx of glucose – obtained from the consumption of carbohydrates – is not provided. For this reason, it is vital to include carbohydrates in the post-workout drink.\u003c\/p\u003e\n\u003cp\u003eThough \u003cem\u003eopinion\u003c\/em\u003e varies, the scientific literature is relatively clear that fast–digesting carbohydrates such as dextrose and Cluster Dextrin® create optimal conditions for the post-workout synthesis of both skeletal muscle protein and muscle glycogen. Not only have both of Core POST’s carbohydrates sources demonstrated higher rates of post-exercise glycogenesis (glycogen resynthesis) as compared to other carbohydrate sources, they have also been shown to optimize insulin response and blunt cortisol release to a greater degree than other carbohydrate sources.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDextrose\u003c\/strong\u003e functions at such a higher capacity because of molecular structure, given that it is otherwise known as pure glucose – your body’s preferred energy substrate and the necessary component for the synthesis and resynthesis of glycogen. Bypassing the lengthy and metabolically costly process of digestion and breakdown, dextrose can be absorbed directly through the gut into the bloodstream and can cause an insulin response faster than any other carb. Additionally, since dextrose is already in the form the body requires, it can be used immediately for glycogen replenishment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCluster Dextrin®\u003c\/strong\u003e, the second carbohydrate source in Core POST, is derived from corn. This carb source is extremely efficient in its digestion and exhibits little to no abdominal bloating. Research conducted on top swimmers, swimming in a flowing water pool, confirmed that Cluster Dextrin’s fast gastric emptying contributed to increased endurance (longer swim times). Swimmers provided a sports drink containing Cluster Dextrin had approximately 50% longer swim time than swimmers provided a mixture of water and glucose only.\u003c\/p\u003e\n\u003cp\u003eIn combination, the carbohydrates in Core POST, in their precise serving sizes, interact to form a comprehensive post-workout nutrition strategy:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eDextrose acts quickly to create an immediate supply of glucose and to stimulate post-workout insulin levels.\u003c\/li\u003e\n\u003cli\u003eDue to their molecular structure, Cluster Dextrin® balance that insulin response.\u003c\/li\u003e\n\u003cli\u003eTogether, they all rapidly, and in a sustained fashion, provide your body with a prime environment for the synthesis of both glycogen and skeletal muscle\u003c\/li\u003e\n\u003cli\u003eAnd most importantly, they do so without the bloat!\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eClinical research is clear that carbohydrates of this type, in combination with whey protein isolate, rapidly reverse high levels of cortisol and low levels of insulin that are associated with high intensity exercise. The rapid, but very beneficial, influx of glucose from oral carbohydrate supplementation quickly suppresses cortisol and the negative effect it has on the expression of metabolically critical proteins and growth factors – ensuring that myocytes (muscle cells) function in an ideal environment. In addition, these carbohydrates induce a beneficial insulin response, the effects of which include stimulating glycogen storage, the transport of glucose into muscle cell mitochondria, and an increase in amino acid utilization.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCold-Processed Microfi¬ltered Non-GMO Whey Protein Isolate:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf the post-workout environment were a jungle, whey protein isolate would be the lion – its king. While it is difficult to overstate the critical role that post-exercise protein consumption plays in both a macro (body composition) and micro (small-scale, physiological changes) context, some ambiguity remains: what is the ideal form, frequency, timing, and amount of protein consumption post-exercise? Luckily for you, Core Nutritionals’ research hounds have crunched the numbers and read the studies for you, and the result is a very precise amount of whey protein isolate included in Core POST.\u003c\/p\u003e\n\u003cp\u003eIn a statement that should not surprise a single athlete or casual weightlifter, intense resistance training has a profound effect on the function and structure of skeletal muscle and muscle proteins. Immediately following an intense bout of resistance exercise, a process known as muscle protein breakdown – with its sidekick, leucine oxidation – begin to literally tear down your skeletal muscle from the inside. While resistance training simultaneously increases a process known as protein synthesis, the fractional synthesis rate (how quickly the protein is synthesized) is often far exceeded by the rate of muscle protein breakdown and leucine oxidation. The result is that, in that absence of mitigating factors such as post-workout nutrition, your body is in a state of negative protein balance – i.e., catabolism.\u003c\/p\u003e\n\u003cp\u003eIn order to counteract a negative intramuscular protein balance, a number of things need to occur – mostly, a rapid increase in the availability of amino acids, and the optimization of several metabolically critical hormones (such as insulin). The combination of protein and carbohydrates contained in Core POST achieves precisely this balance, and research on whey protein and dextrose in combination demonstrates that this combination maximizes the stimulation of muscle protein synthesis and results in even greater muscle anabolism than either alone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFree Form Vegan Leucine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe branch-chained amino acids leucine, isoleucine, and valine are famous for their role in skeletal muscle protein synthesis and metabolism, and additionally comprise approximately one-third of all skeletal muscle protein. Of the three, leucine is both the most physiologically important with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, by both insulin-mediated and non-insulin mediated mechanisms.\u003c\/p\u003e\n\u003cp\u003eLeucine’s insulin-mediated effects are largely the result of its activation of the classical insulin receptor substrate (IRS)\/phosphatidylinositol (PI) 3-kinase (PI3K)\/Akt\/mTOR signal transduction pathway. In this pathway, the bonding of a substrate (Insulin activates a compound known as PI3K, which in turn activates, Akt. Once phosphorylated and activated, Akt signals the release of the famous mammalian target of rapamycin (mTOR). mTOR then increases the translation of muscle-cell ribosomal proteins that increase ribosome biogenesis, which is the literal production of proteins. Leucine plays a critical role in all of this, creating the translation initiation factors that are the rate-limiting step in the production of the ribosomes spoken about above. Carbohydrates alone, other essential amino acids, and non-essential amino acids have not been shown to have the stimulatory effects on muscle protein synthesis – leucine alone has, highlighting is primacy as a muscle protein activator. Leucine has additionally been shown to positively regulate protein synthesis independent of insulin. In certain trials where rapamycin and leucine were co-administered, rapamycin showed only partial inhibition of leucine’s effects on muscle protein synthesis. Rapamycin is also a critical component to the PI3K\/Akt\/mTOR pathway, as the mTOR (mammalian target of rapamycin) suggests. One of rapamycin’s primary functions is to inhibit mTOR. So, if leucine-mediate protein synthesis is only partially blocked by rapamycin, but rapamycin fully inhibits mTOR, this suggests that leucine-mediate protein synthesis is only partially dependent on the PI3K pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVelositol®:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVelositol®, a patented complex of amylopectin\/chromium, is a fascinating compound – with emerging clinical data to suggest that it is effective in significantly enhancing skeletal muscle protein synthesis when combined with whey protein (vs whey alone).\u003c\/p\u003e\n\u003cp\u003eIn a double-blind crossover study, featuring 10 exercise-trained adults, researchers combined Velositol® with 6g of whey protein to measure what effects, if any, the compound would exert on skeletal muscle protein synthesis. (The control group consumed 6g of whey alone.) After collecting baseline muscle biopsies – to measure phenylalanine, a marker of muscle-building – the subjects performed eight reps of leg extensions. A final muscle biopsy was taken post-workout, to measure the changes in muscle protein synthesis between the study and control group.\u003c\/p\u003e\n\u003cp\u003eThe results were significant: the researchers found that muscle protein synthesis had nearly doubled in the Velositol® group, compared to the control. The researchers hypothesized that the mechanism of action of Velositol® is the stimulated uptake of leucine and other amino acids due to an influx of insulin (from the chromium).\u003c\/p\u003e\n\u003cp\u003eWhile further study is warranted, the existing data on Velositol® suggests it’s a must-have addition to any recovery matrix.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitacherry®:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitacherry®, comprised of Montmorency tart cherries, is a highly studied ingredient that has been shown to aid in muscle recovery as well as protect against post-exercise soreness and fatigue. Vitacherry® is filled with free radical fighting phytonutrients and compounds that work synergistically synergistically work together to reduce exercise induced inflammation. A 2016 study including 27 participants looked at the benefits of short-term supplementation with Montmorency tart cherries surrounding an endurance event showed positive results when it came to the benefits listed above. ItWhat was found was that supplementation in conjunction with a a vigorous exercise event had positive benefits towards:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eReduced immune and inflammatory response to stress\u003c\/li\u003e\n\u003cli\u003eIncreased performance\u003c\/li\u003e\n\u003cli\u003eReduced soreness perception\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBioPerine®:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). ItsIt’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by. When it comes to post exercise nutrition, efficiency and speed with which nutrients can enter the system and get to their target is of the upmost importance. The “window of opportunity” is much larger than what has been previously thought, but when your results weigh heavily on post-exercise nutrition, maximal absorption and use of nutrients is extremely important.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at BioPerine®’s impact on nutrient absorption have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core POST, when post workout nutrition is King!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-POST-2020.jpg?v=1597302549\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_POST_2020_FRUITY_CEREAL_FIN-OL_compressed.pdf?v=1639557092\"\u003eFruity Cereal Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_POST_2020_HOT_COCOA_FIN-OL_compressed.pdf?v=1639557271\"\u003eHot Cocoa Label\u003c\/a\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_POST_2020_PB_BRITTLE_FIN-OL_compressed.pdf?v=1639557411\"\u003e\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Refferences-Post.pdf?v=1597417034\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Vanilla Ice Cream","offer_id":44774771949744,"sku":"SHOP850057789300","price":59.99,"currency_code":"USD","in_stock":true},{"title":"Fruity Cereal","offer_id":31970943467635,"sku":"SHOP672975315337","price":59.99,"currency_code":"USD","in_stock":false},{"title":"Hot Cocoa","offer_id":31970943500403,"sku":"SHOP672975315313","price":59.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/POST_VANILLAICECREAM_FRONT_2b5a00ba-9f3c-42a2-9465-209f23fc515f.png?v=1760377601"},{"product_id":"vitamin-c","title":"Vitamin C","description":"\u003cp\u003eVitamin C, also known as ascorbic acid, is an essential vitamin for the human body possessing high antioxidant properties. Some of its primary benefits include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eImmunity and wound healing\u003c\/li\u003e\n\u003cli\u003eGrowth and development of all body tissues\u003c\/li\u003e\n\u003cli\u003eCollagen formation, including the maintenance of cartilage, bones, and teeth\u003c\/li\u003e\n\u003cli\u003eAbsorption of Iron\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eVitamin C is probably something most have heard of being an importance since an early age. Just as it benefits supporting normal growth and development during early life stages, it continues to benefit life expectancy and preservation as we age.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/p\u003e\n\u003cp\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-VITAMIN_C_772e2a5a-35df-424b-8049-cf4c7b223047.jpg?v=1603352125\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Vitamin_C_2020_8.5x3.25_FIN-OL_1.pdf?v=1726584664\"\u003eVitamin C Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e1.\u003c\/b\u003e “Ascorbic Acid”. \u003ci\u003eThe American Society of Health-System Pharmacists\u003c\/i\u003e. Archived from the original on December 30, 2016. Retrieved December 8, 2016.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.\u003c\/b\u003e “Fact Sheet for Health Professionals - Vitamin C”. \u003ci\u003eOffice of Dietary Supplements, US National Institutes of Health\u003c\/i\u003e. February 11, 2016. Archived from the original on July 30, 2017.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e3.\u003c\/b\u003e \u003ci\u003eWHO Model Formulary 2008\u003c\/i\u003e (PDF). World Health Organization. 2009. p. 496. ISBN 9789241547659. Archived (PDF) from the original on December 13, 2016. Retrieved December 8, 2016.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.\u003c\/b\u003e Hemilä H, Chalker E (January 2013). “Vitamin C for preventing and treating the common cold”. \u003ci\u003eThe Cochrane Database of Systematic Reviews\u003c\/i\u003e (1): CD000980. doi:10.1002\/14651858.CD000980.pub4. PMID 23440782.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5.\u003c\/b\u003e Ye Y, Li J, Yuan Z (2013). “Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials”. \u003ci\u003ePLOS One\u003c\/i\u003e. 8 (2): e56803. Bibcode:2013PLoSO...856803Y. doi:10.1371\/journal.pone.0056803. PMC 3577664 . PMID 23437244.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e6.\u003c\/b\u003e Duerbeck NB, Dowling DD, Duerbeck JM (March 2016). “Vitamin C: Promises Not Kept”. \u003ci\u003eObstetrical \u0026amp; Gynecological Survey\u003c\/i\u003e. 71 (3): 187–93. doi:10.1097\/OGX.0000000000000289. PMID 26987583.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e7.\u003c\/b\u003e “Ascorbic acid Use During Pregnancy | Drugs. com”. \u003ci\u003eDrugs.com\u003c\/i\u003e. Archived from the original on December 31, 2016. Retrieved December 30, 2016.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e8.\u003c\/b\u003e Institute of Medicine (2000). “Vitamin C”. \u003ci\u003eDietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids\u003c\/i\u003e. Washington, D.C.: The National Academies Press. pp. 95–185. ISBN 0-309-06935-1. Archived from the original on September 2, 2017. Retrieved September 1, 2017.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e9.\u003c\/b\u003e “Vitamin C”. \u003ci\u003eMicronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR\u003c\/i\u003e. January 14, 2014. Retrieved March 22, 2017.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":31971219767411,"sku":"SHOP672975315443","price":15.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/VITC_FRONT.png?v=1760395184"},{"product_id":"vitamin-d3","title":"Vitamin D3","description":"\u003cp\u003eVitamin D is a fat-soluble vitamin that can be obtained in a few different ways. It can be obtained from sun exposure, foods, and in supplement forms. It is traditionally found in two types, D2 and D3. D2 comes from plant sources, such as mushrooms and fortifies foods. D3 comes from animal sources like fish oil, liver, and egg yolks. It is also produced when the body is exposed to sunlight. Vitamin D is essential for the regulation of phosphorus and calcium and for ensuring the immune system is functioning optimally.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eVitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an important biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.\u003c\/p\u003e\n\u003cp\u003eVitamin D also works to promote adequate calcium absorption in the intestinal tract, which is needed to enable normal bone mineralization and to prevent involuntary muscle contractions that lead to cramps and spasms. Vitamin D is also needed for bone growth and bone remodeling performed by specific cells call osteoblasts and osteoclasts.\u003c\/p\u003e\n\u003cp\u003eOther roles that this fat-soluble vitamin play in the body include immune function, glucose metabolism, as well as modulation of cell processes, such as cell growth.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-VITAMIN_D3_edef42df-0611-4243-b914-659f792ce840.jpg?v=1603352125\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Vitamin_D3_2020_6.25x2.25_FIN-OL.pdf?v=1644227483\"\u003eVitamin D3 Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eHolick MF\u003c\/b\u003e (December 2004). \"Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.\" \u003ci\u003eThe American Journal of Clinical Nutrition\u003c\/i\u003e. 80 (6 Suppl): 1678S–88S. PMID 15585788.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eHolick MF\u003c\/b\u003e (March 2006). \"High prevalence of vitamin D inadequacy and implications for health.\" \u003ci\u003eMayo Clinic Proceedings\u003c\/i\u003e. 81 (3): 353–73. doi:10.4065\/81.3.353. PMID 16529140.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCalvo MS, Whiting SJ, Barton CN\u003c\/b\u003e (February 2005). \"Vitamin D intake: a global perspective of current status.\" \u003ci\u003eThe Journal of Nutrition\u003c\/i\u003e. 135 (2): 310–6. PMID 15671233.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNorman AW\u003c\/b\u003e (August 2008). \"From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health.\" \u003ci\u003eThe American Journal of Clinical Nutrition\u003c\/i\u003e. 88 (2): 491S–499S. PMID 18689389.\u003c\/li\u003e\n\u003cli\u003e\"\u003cb\u003eVitamin D\u003c\/b\u003e.\" \u003ci\u003eNIH Office of Dietary Supplements\u003c\/i\u003e. February 11, 2016. \"\u003cb\u003eVitamin D Tests\u003c\/b\u003e.\" \u003ci\u003eLab Tests Online (USA)\u003c\/i\u003e. American Association for Clinical Chemistry. Retrieved June 23, 2013.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eHollis BW\u003c\/b\u003e (January 1996). \"Assessment of vitamin D nutritional and hormonal status: what to measure and how to do it.\" \u003ci\u003eCalcified Tissue International\u003c\/i\u003e. 58 (1): 4–5. doi:10.1007\/BF02509538. PMID 8825231.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eHolick MF, Schnoes HK, DeLuca HF, Suda T, Cousins RJ\u003c\/b\u003e (July 1971). \"Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine.\" \u003ci\u003eBiochemistry\u003c\/i\u003e. 10 (14): 2799–804. doi:10.1021\/bi00790a023. PMID 4326883.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eWolf G\u003c\/b\u003e (June 2004). \"The discovery of vitamin D: the contribution of Adolf Windaus.\" \u003ci\u003eThe Journal of Nutrition\u003c\/i\u003e. 134 (6): 1299–302. PMID 15173387.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":31971250765939,"sku":"SHOP672975315450","price":14.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/D3_FRONT.png?v=1760395538"},{"product_id":"zinc","title":"Zinc","description":"\u003ch2 class=\"slogan\"\u003e\u003cb\u003e\u003cspan\u003eBOOST\/PREVENT\/AID\u003c\/span\u003e\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eZinc has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003esupport the function of cells related to immune response\u003c\/li\u003e\n\u003cli\u003eaid in metabolic function\u003c\/li\u003e\n\u003cli\u003esupports normal testosterone production\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIf there ever was a super hero amongst mineral, zinc would be it. This mineral is crucial and is essential for more than 200 different enzymatic reactions in the human body. In other words, it is essential to keep you living and performing at a high-level day in and day out. Your body gets put through the ringer day in and day out and you cant do it alone, consider zinc to be the director of the show supporting you internally.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFull Science:\u003c\/b\u003e Zinc is a beneficial mineral that has been often researched for its significant immune-supportive benefits. Zinc has a role in every single cell of our bodies and is an important co-factor in over 200 enzymatic reactions that induce functions such as:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eWhite blood cell production\u003c\/li\u003e\n\u003cli\u003eTestosterone production\u003c\/li\u003e\n\u003cli\u003eEye health\u003c\/li\u003e\n\u003cli\u003eSkin health\u003c\/li\u003e\n\u003cli\u003eNormal growth and development\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eZinc in the \u003ci\u003echelated\u003c\/i\u003e form (\u003ci\u003ebisglycinate\u003c\/i\u003e) has been studied and shown to offer a form that is superior in its absorptive properties and is very well tolerated by the human body. This form is absorbed intact and thus does not compete with other minerals for absorption in the digestive tract.\u003c\/p\u003e\n\u003cp\u003eOne comparative study consisting of 30 female participants given a random form of zinc or placebo showed that the participants given zinc \u003ci\u003ebisglycinate\u003c\/i\u003e had significant increases in serum blood levels of zinc compared to other forms.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-ZINC_743d65bb-d91c-4d65-a2ca-868fa3980109.jpg?v=1603352125\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Zinc_2020_6.25x2.25_FIN-OL.pdf?v=1644227551\"\u003eZinc Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences\u003c\/b\u003e:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGandia P, Bour D, Maurette J-M, et al. A bioavailability study comparing two oral formulations of zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers. \u003ci\u003eInt J Vitamin Nutr Res\u003c\/i\u003e 2007;77(4):243-248.\u003c\/li\u003e\n\u003cli\u003eDiSilvestro R, Koch E, Rakes L. Moderately high dose zinc gluconate or zinc bisglycinate: effects on plasma zinc and erythrocyte superoxide dismutase in young adult women. \u003ci\u003eBiol Trace Elem Res\u003c\/i\u003e 2015;168(1):11-14.\u003c\/li\u003e\n\u003cli\u003eDiSilvestro R, Swan M. Comparison of four commercially available zinc supplements for performance in a zinc tolerance test. \u003ci\u003eFASEB J\u003c\/i\u003e 2008;22:693.3.\u003c\/li\u003e\n\u003cli\u003eDiSilvestro R, Hart S, Marshall T, et al. Enhanced aerobic exercise performance in women by a combination of three mineral chelates plus two conditionally essential nutrients. \u003ci\u003eJ Int Soc Sports Nutr\u003c\/i\u003e 2017;14:42.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":31971259646067,"sku":"SHOP672975315467","price":15.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/ZINC_FRONT.png?v=1760395505"},{"product_id":"core-zzz","title":"Zzz","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003e5-HTP\u003c\/strong\u003e - Improves quality of sleep with no withdrawal effect\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMucuna pruriens\u003c\/strong\u003e - Improves GH release during sleep for better recovery\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan data-mce-fragment=\"1\"\u003eL-Glycine\u003c\/span\u003e\u003c\/strong\u003e - Aids in digestion and lowering blood sugar\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eYou know the feeling: the weights feel heavy, the treadmill feels painfully slow, and every minute you’re looking up at the clock wondering when the workout is going to be over. Why? It’s not your diet – your food journal is so detailed it makes engineers blush. It’s not your supplementation – you are using the entire Core lineup like every smart trainer does. Ah, that’s right. Last night was a brutal mashup of tossing and turning set to the tune of your spouse’s snoring and the neighbor’s dog barking.\u003c\/p\u003e\n\u003cp\u003eIf recovery is the key to success, then say “hello” to the locksmith. Core ZZZ is a perfectly-designed product with a single goal in mind: maximizing your recovery. We have included only the best and most effective recovery agents, at the proper serving sizes, to take the guesswork out of a good night’s rest. We have also specifically chosen these ingredients for the pathways they target, ensuring that every possible physiological pathway for recovery is covered.\u003c\/p\u003e\n\u003cp\u003eNo more tossing nights and no more wasted workouts – put recovery at the top of your list by putting Core ZZZ at the center of your supplement lineup.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMineral blend (Vitamin B-6 (as Pyridoxine HCL), Magnesium (as Magnesium aspartate), and Zinc (as Zinc monomethionine)):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSleep is important, but sleep is not important for its own sake. Rather, we sleep because of the collection of physiological processes that it enables: the repair of tissue, the biosynthesis and release of hormones, and so on. While each of the individual ingredients in our mineral blend is important in this regard, the formulation as a whole has previously been demonstrated to have tangible physiological effects.\u003c\/p\u003e\n\u003cp\u003eIn a randomized, double-blind, placebo-controlled study, 27 NCAA football players consumed a supplement containing Vitamin B-6, Magnesium, and Zinc, or placebo, for an 8-week period. Measurements for free testosterone, IGF-1, and muscle strength and power were taken at the conclusion of the study. The authors found statistically significant increases to all measured indices, with a particularly high spike in free testosterone as compared to placebo.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGamma-aminobutyric acid (GABA):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGABA, known technically as, γ-Aminobutyric acid, is a potent depressive and the chief inhibitory neurotransmitter in the human brain. As GABA plays a critical role in the sedative and depressive functions of the brain, GABA receptor subtypes – principally GABAA – have been positively associated with the regulation of the sleep-wake cycle.\u003c\/p\u003e\n\u003cp\u003eGiven its pivotal status in the regulation of sedation and sleep, both GABA itself as well as GABA agonists (GABAergics) have been researched for their capacity to modulate sleep and mood. A 1996 animal model study established that stimulation of the GABAA receptor-subtype through exogenous GABA intake led an increase in the length of slow-wave sleep. A further 2006 study found that increasing plasma levels of GABA through supplementation was associated with regulation of the posterior hypothalamus “sleep-wake switch,” a physiological mechanism used to control sleep in mammals.\u003c\/p\u003e\n\u003cp\u003eIn addition to GABA’s potential role in the regulation of sleep itself, additional research has uncovered that GABA may potentiate certain benefits of deep sleep – namely, the increase in plasma growth hormone. The first study to demonstrate GABA’s growth-hormone potentiating effect was a 1980 study in 19 healthy subjects. This placebo-controlled trial found that a 5 gram serving of GABA significantly increased plasma levels of growth hormone as compared to controls. A further study in 2008 demonstrated similar results, with 50% increases in plasma levels of certain growth hormone isoforms in response to GABA administration in healthy subjects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Glycine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-Glycine is a non-essential amino acid, so-called because the human body is capable of synthesizing glycine from sources internal to the body (serine). Like many other amino acids, glycine possesses physiological effects independent of its function as a ‘building block’ to protein. In glycine’s case, its physiological effects stem from its role as a neurotransmitter in the human brain.\u003c\/p\u003e\n\u003cp\u003eThree methodologically-sound studies have investigated glycine’s effect on sleep and sleep quality in humans – and each used the same serving size as that found in Core ZZZ, 3 grams. In studies conducted in 2006 and 2007, ingestion of 3 grams of glycine prior to sleep was found to have both subjective and objective positive effects on sleep. Subjectively, participants reported more satisfactory sleep, less daytime sleepiness, and improved cognitive function. Objectively, PSG measurements revealed less latency to sleep onset and deep sleep. These results were confirmed in a more recent 2012 study which focused principally on glycine-dependent improvements to daytime cognitive function in sleep-deprived volunteers.\u003c\/p\u003e\n\u003cp\u003eOverall, these human trials suggest a possible role for glycine in the regulation of beneficial sleep cycles at a serving size of 3 grams.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Tryptophan\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-Tryptophan is an essential amino acid, and one of the most critical in the human body. Tryptophan is critical because it is the biological precursor to both serotonin (one of the body’s principal neurotransmitters regulating mood, appetite, and sleep) and niacin (a vitamin and a crucial biological intermediate).\u003c\/p\u003e\n\u003cp\u003eAmong dietary supplements or ingredients purported to regulate the sleep-wake cycle, tryptophan is perhaps the most well-studied. The body of literature pertaining to tryptophan’s sedative effects is vast and varied, reaching back at least 40 years and featuring hundreds of articles. Despite the enormity of this body of literature, and therefore potential for disagreement or conflicting data, scientific consensus exists that tryptophan exerts positive effects on the regulation of the sleep wake cycle in humans – evinced by placebo-controlled trials in humans.\u003c\/p\u003e\n\u003cp\u003eOne such placebo-controlled, double-blind trial involved 10 healthy volunteers ingesting either 1.2 grams or 2.4 grams of tryptophan prior to sleep. Blood and urine measurements were taken at regular intervals, and sleep was measured both objectively (latency to sleep) and subjectively using the Stanford Sleepiness scale. Both serving sizes of tryptophan were highly correlated with a significant reduction in sleep latency and significant improvements to subjective sleep quality on the Stanford Sleepiness Scale.\u003c\/p\u003e\n\u003cp\u003eResults such as this have been reproduced in dozens of clinical trials involving healthy\/normal and sleep-disturbed subjects, men and women, younger and older participants, and featuring serving sizes as low as 500mg and high as 15 grams. These studies nearly universally reflect that exogenous tryptophan supplementation is positively correlated with an improvement in sleep quality and an objective reduction in sleep latency – with the best effect’s resultant from a 1 gram to 1.5 gram serving size.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Ornithine HCL:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-Ornithine is a non-protein amino acid, meaning that, unlike most other amino acids, it is not involved in the production of proteins and is not encoded by DNA. In humans, ornithine is most commonly associated with the urea cycle, though recent research has revealed a potential role for ornithine in the regulation of sleep and arousal.\u003c\/p\u003e\n\u003cp\u003eThough data on ornithine is not extensive, recent research has demonstrated that it may play a role in both objective and subjective assessments of sleep quality in humans. In a double-blind, placebo-controlled, randomized trial, 400mg or placebo was administered to 52 healthy adults experiencing mild fatigue. Ornithine was consumed consecutively for 8 weeks, with measurements for cortisol being collected – along with both subjective and objective measures of sleep quality.\u003c\/p\u003e\n\u003cp\u003eAt the conclusion of the trial, most participants experienced both subjective and objective improvements to the quality of their sleep. The researchers also noted that ornithine supplementation resulted in a small but statistically significant reduction to plasma concentrations of cortisol.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMucuna pruriens Extract (seed) (50% L-dopa):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eMucuna pruriens\u003c\/em\u003e is a hanging or climbing plant endemic to India and sub-Saharan Africa. The plant has been used extensively in the Indian traditional medicinal system known as Ayurveda for a number of purposes, including virility and gastrointestinal disorders.\u003c\/p\u003e\n\u003cp\u003eIn the context of recovery, data is limited but promising. In a 2012 study, 18 healthy men and women with impaired sleeping were given a supplement containing Velvet Bean (MP) for 28 days. At the conclusion of the study, the participants completed the well-regarded and industry-standard Pittsburgh Quality Sleep Index.\u003c\/p\u003e\n\u003cp\u003eThe authors note that supplementation with the Velvet bean-containing product improved the reported scores in every category of the PQSI. Many categories saw improvements of over 50%. Moreover, the authors noted both that Velvet Bean, not the other ingredient in the studied supplement, was the bioactive compound responsible for these effects, and that Velvet Bean has been demonstrated to improve GH release during sleep in other independent trials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Theanine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-Theanine is a non-protein amino acid found mostly in green tea. The structure of L-Theanine closely resembles L-glutamic acid and has a mechanism of action they may be mediated through glutamate receptors, a possibility supported by its partial co-agonistic effect on the N-methyl-D-aspartate receptor. Due to L-Theanine being a widely ingested phytochemical during normal every day life, it has the potential to be an ingredient in many nutraceutical applications due to its proposed benefits on cognitive function and neuroprotective properties. L-Theanine has been studied in several instances on its benefits in these areas. In humans, L-Theanine has been shown to play a beneficial role in tasks requiring heightened focus and attention as well as positive effects on mental state, including improved sleep quality. A four week, randomized, placebo controlled and double-blind study consisting of 30 individuals assessing L-Theanine’s influence on stress related symptoms and cognitive function resulted in positive outcomes. At 200mg per day results revealed positive benefits sleep quality, decreased sleep disturbance, and reduced need for sleep medication. For cognitive function, verbal fluency and execution during concentration required tasks was also increased. The benefits of L-Theanine have mostly been studied for its acute effects on the user. Long term effects can likely be seen by how the acute affects influence changes in lifestyle. However, studies like this are promising on the benefits of L-Theanine.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e5-HTP (5-hydroxytryptophan):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSerotonin has often been at the center of the discussion in the regulation of sleep. This “feel good” hormone has been shown to be essential in many physiological functions including circadian rhythm, thermoregulation, cognition, and nociception. When serotonin levels are low, it is critical to find ways to restore balance. Supplementation, to help with recovery and sleep, can be beneficial in reducing stress and restoring this balance. 5-HTP (5-hydroxytryptophan) is a natural chemical compound that has been shown to benefit certain aspects of health, including mental function and sleep quality as it is a natural precursor to serotonin in the brain. 5-HTP passes the blood brain barrier easily, making it very efficient in its action. 5-HTP, when combined with other nutrients such as GABA, may be effective at decreasing time required to fall asleep and improving sleep quality and duration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMelatonin:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIrregular sleep is a problem that is common amongst the population and most are often searching for remedies to improve sleep quality and circadian rhythms. Melatonin is a neurohormone that is secreted by the pineal gland known for its sleep regulation properties. Its secretion is often suppressed by light, which when this occurs can often disrupt normal sleep patterns. When sleep patterns are disrupted and irregular, it has the ability to increase risks of certain health issues and premature aging. Supplementation exerts most of it benefits through decreased sleep latency and increased onset of sleep. This can also be related to its ability to work with the biochemistry and decrease body temperature in users. Supplementation with melatonin is the most efficient way to increase melatonin levels prior to sleeping. However, diet and improvements in quality of life are also ways to improve normal melatonin secretion as well as normal circadian rhythm for better quality sleep.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-ZZZ-2020.jpg?v=1601031291\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ZZZ_11.375x3_PINEAPPLE_PEACH_FIN-OL.pdf?v=1644308281\"\u003eCore ZZZ Pineapple Peach Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ZZZ_11.375x3_BLUEBERRY_LEMONADE-FIN.pdf?v=1661239307\"\u003eCore ZZZ Blueberry Lemonade Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES_-_Core_ZZZ_9afb4e0f-abe1-454e-85ff-d9d522b7e9e2.pdf?v=1600944665\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Pineapple Peach","offer_id":41921296498864,"sku":"SHOP672975009748","price":39.99,"currency_code":"USD","in_stock":true},{"title":"Blueberry Lemonade","offer_id":41944115970224,"sku":"SHOP658580071202","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/ZZZ_BL_Front_1.png?v=1757531845"},{"product_id":"core-collagen","title":"Collagen","description":"\u003ch2 class=\"slogan\"\u003e\u003cstrong\u003eJOINTS\/HAIR, SKIN, NAILS\/BONES\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eMedium Chain Triglycerides\u003c\/p\u003e\n\u003cp\u003eCoconut oil made of 100% Medium chain triglycerides has been shown to have the greatest health benefits. MCTs are made up of a chemical structure that allows them to quickly and effectively bypass gastric uptake for transport directly to the liver for oxidation and then used for energy. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003eThey also allow for a rich and smooth mouthfeel, which in the context of a collagen creamer, this will add a velvety addition to your favorite beverage.\u003c\/p\u003e\n\u003cp\u003eCollagen is by far the most plentiful protein found in the human body. It makes up the body’s skeletal framework, as well as provides integrity to ligaments, tendons, and other connective tissues found inside the body. It is also a primary component of healthy hair, skin, nails, as well as other important structures of the body. Collagen supplements have become increasingly popular as of late, but most people do not know that the type of collagen matters just as much as the quality of the source. Core has combined Collagen Types I and III from high quality bovine hide that works to provide strength for structures such as skin, tendons, bones, connective tissues, teeth, muscles, organs, and arteries.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eCollagen and its many types are by far the most plentiful protein found in the human body. It makes up the body’s skeletal framework as well as provides integrity to ligaments, tendons, and other connective tissues found inside the body. It is also a primary component of healthy hair, skin, nails, as well as other important structures of the body. Collagen supplementation has become increasingly popular, especially for its cosmetic benefits. When it comes to your skin, as the largest organ in the body, it relies very heavily on the presence of collagen (skin is roughly 70% collagen protein). As we age, natural collagen production begins to slow, and we have to rely on dietary sources to keep collagen levels up. Foods like chicken, bone broth, fish, citrus fruits, berries, garlic, and leafy greens contain nutrients that can stimulate natural collagen formation, but supplementing with collagen protein (and its specific types) can also be crucially beneficial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eType I\u003c\/strong\u003e specifically benefits your skin health. One randomized, placebo-controlled clinical trial confirmed that skin aging can be addressed using nutrients, such as collagen, that are able to promote skin health. Results showed that after three months of oral intake, skin hydration, elasticity, roughness, and density all showed significant improvements. Also, since the nutrients were taken orally, a deeper dermatological activation was achieved, which can equate to a longer lasting regeneration of skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eType III\u003c\/strong\u003e collagen on the other hand is found in the walls of arteries and organs such as the esophagus, spleen, pancreas, and gallbladder. It can also be found in some muscle fibers. As with the skin, as we age, the structural integrity of tissues can begin to degenerate. Supplementation can provide an extra backbone of support when adequate nutrients are not being taken in to aid in supporting an optimally functioning digestive system.\u003c\/p\u003e\n\u003cp\u003eCollagen protein can also be a great protein type for those who do not digest other protein powders very well. It is well tolerated by most consumers and offers another high-quality source of protein that can ultimately increase the function of digestive organs that work to break down and absorb other whole food sources and proteins. As a result, collagen protein can arguably be seen as one of the most beneficial types of protein one can consume.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"supplement-facts\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-COLLAGEN.jpg?v=1597909459\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Collagen_2020_FIN-OL.pdf?v=1644226773\"\u003eUnflavored Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Collagen_STRAWBERRY-LEMONADE-FIN.pdf?v=1652106500\"\u003eStrawberry Lemonade Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Collagen_PEACH-MANGO-FIN.pdf?v=1652106500\"\u003ePeach Mango Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Collagen_CHOCOLATE-FIN.pdf?v=1654069447\"\u003eChocolate Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Chocolate","offer_id":41698267201712,"sku":"SHOP658580070786","price":44.99,"currency_code":"USD","in_stock":true},{"title":"Unflavored","offer_id":41634478063792,"sku":"SHOP672975315474","price":44.99,"currency_code":"USD","in_stock":true},{"title":"Strawberry Lemonade","offer_id":41634478096560,"sku":"SHOP658580070809","price":44.99,"currency_code":"USD","in_stock":true},{"title":"Peach Mango","offer_id":41634478129328,"sku":"SHOP658580070793","price":44.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/COLL_CH_FRONT_e6c2d822-0c28-497e-8d30-f67813b06eb9.png?v=1764874853"},{"product_id":"2020-crush-it-r-premium-embroidered-zip-up-hoodie","title":"CRUSH IT® Premium Embroidered Zip Hoodie","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eCRUSH IT!® Premium Embroidered Hoodie (light grey with black embroidery).\u003c\/li\u003e\n\u003cli\u003eFeaturing the new 2020 Core Nutritionals logo on the front chest and back, and CRUSH IT logo on the right sleeve.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Small","offer_id":37350624198832,"sku":"","price":69.99,"currency_code":"USD","in_stock":false},{"title":"Medium","offer_id":37350624231600,"sku":"","price":69.99,"currency_code":"USD","in_stock":true},{"title":"Large","offer_id":37350624264368,"sku":"","price":69.99,"currency_code":"USD","in_stock":true},{"title":"X-Large","offer_id":37350624297136,"sku":"","price":69.99,"currency_code":"USD","in_stock":false},{"title":"XX-Large","offer_id":37350624329904,"sku":"","price":69.99,"currency_code":"USD","in_stock":false},{"title":"XXX-Large","offer_id":37350624362672,"sku":"","price":69.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/products\/grey-hoodie6.png?v=1604003343"},{"product_id":"training-journal","title":"Crush It Training Journal","description":"\u003cp\u003eBuilt for structure and consistency, this training journal helps you plan sessions, track performance, and stay focused on steady progress. A simple, effective tool for athletes committed to improving every workout and reaching long-term goals.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":37800420180144,"sku":"COR-TrainingJournal","price":15.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Frame4_a2f416fb-b0bc-4a4e-848b-1b4d543bc6b6.jpg?v=1777655635"},{"product_id":"core-sear","title":"Sear","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSinetrol®\u003c\/strong\u003e - Blend of polyphenols aiding in weight management\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitoBurn™\u003c\/strong\u003e - Initiates the \"browning\" of adipose tissue\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eParadoxine®\u003c\/strong\u003e - Non-stimulant thermogenesis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eWhy do we call it “burning fat”? It is a strange turn of phrase, as the body does not “burn” the adipose tissue (the technical name for “fat”). Of course, heat is involved in the base process of fat metabolism, hydrolysis, but the average person of course does not have this in mind. What the common phrasing captures is that the adipose tissue is now being used for fuel – burned up, as gasoline is burned up in a combustion engine as fuel for the vehicle. In this sense, the phrase “burning fat” captures something essential about the mechanisms of adipose metabolism. One mechanism of increasing this process overall is increasing the conversion of WAT (white adipose tissue) to BAT (brown adipose tissue) – known as the “browning” of fat.\u003c\/p\u003e\n\u003cp\u003eIt is precisely this mechanism that Core SEAR affects. There are many pathways to enhance lipolysis, the process by which stored triglycerides – the “stuff” of fat tissue – are broken down to release their potential energy into actual energy. One of the most effective is modulating the enzymes that interconvert WAT (white adipose tissue, which stores energy) to BAT (brown adipose tissue, which releases energy) and the chemical and enzymatic cascades that induce lipolysis. SEAR addresses both. Sinetrol XPur®, a blend of citrus fruit extracts, and MitoBurn™, a metabolite of L-valine, have been demonstrated to increase white-to-brown adipose tissue conversion and therefore the resultant energy expenditure increase. Meanwhile, Coleus forskholli and Paradoxine® have been shown to heavily influence cellular communication and enzymatic pathways involved in lipolysis, specifically the cAMP and AMPk pathways.\u003c\/p\u003e\n\u003cp\u003eTogether, this simple but incredibly powerful formula earns its name: searing white into brown adipose tissue and increasing your body’s energy expenditure due to fat metabolism.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSinetrol® XPur [blend of Grapefruit (\u003cem\u003eCitrus paradise L.\u003c\/em\u003e) (fruit), Guarana (\u003cem\u003ePaullinia cupara Kunth\u003c\/em\u003e) (seed), Sweet Orange and Blood Orange (\u003cem\u003eCitrus sinesis L. Osbeck\u003c\/em\u003e) (fruit Extracts)]:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMetabolism involves the chemical reactions that break down the foods we eat into separate compounds. Sugars, fats, and amino acids provide our body with energy to function on a daily basis. These compounds can help our body carry out many functions but when overconsumed they get stored as energy in specific adipose (fat) cells. These cells make up our fatty tissue and can further be classified as white adipose tissue (WAT) and brown adipose tissue (BAT). The color of brown fat is due to a larger number of mitochondria being present in those tissues. Mitochondria are the energy producing structures of the cells. Most of our body’s fat is WAT, which stores energy, and when to much WAT builds up the outcome is obesity. This can also be characterized as an enlargement in adipocyte size that results from increased triglyceride storage. Brown adipose tissue, or BAT, on the other hand breaks down blood sugar (glucose) and fat molecules into usable forms of energy, mainly to create heat and maintain body temperature (homeostasis). The ratio between these two adipose tissue types determines the level of energy expenditure, which is unbalanced in those who have more body fat. Research has been centered around finding optimal ways to tap into BAT’s ability to improve obesity, and other metabolic issues.\u003c\/p\u003e\n\u003cp\u003eSinetrol® is a unique blend of citrus polyphenols that are specifically meant to target body fat mass and improve long term body composition. These citrus polyphenols have been shown to enhance the physiological energetic pathways that influence lipolysis, destoring fat that has been accumulated within white adipose cells. This process occurs at the adipocyte level, helping to reach a balance between energy storage and usage, through a process of browning of adipocytes. Sinetrol® enhances the bodies physiological lipolysis process through phosphodiesterase (PDE) inhibition. This inhibition causes the rate of cyclic adenosine monophosphate (cAMP) to be maintained at sufficient levels, which is needed to enhance the baseline lipolysis yield. This process does two things. First, it can increase lipase activity, which is essential for breaking off fatty acids from triglycerides. Second, it can stimulate an increase in the number of mitochondria in your adipose tissue (mitochondrial myogenesis), thus giving your adipose tissue a brown color in appearance. In addition to this browning process, a protein called UPC-1 (uncoupling protein) is also increased. Studies have shown that it is through these primary mechanisms of action that Sinetrol® exhibits the benefit of enhancing lipolytic rate and browning of adipocytes, leading to increased thermogenesis and utilization of fatty acids and sugars as usable forms of energy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMitoBurn™ (L- β-Aminoisobutyric Acid):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn recent studies, MitoBurn™ (L-BAIBA), a metabolite of L-valine, has the ability to stimulate certain “exercise factors” that are released from skeletal muscle in response to muscular stress, in particular muscle contraction. L-BAIBA, a powerful myokine, plays a role in the benefits of regular exercise and begins a positive sequence of events, some of which include increased fatty acid oxidation, improved glucose uptake, and reduced fat mass. Although L-BAIBA primarily works to initiate the “browning” of adipose tissue, it also has been shown to decrease the “beiging” of adipose tissue. This beiging process is when the body reverses the preferred adipose tissue color of brown (high energy usage) back to white (high energy storage). Although most studies have been completed in rats, some results that have been obtained in cell culture models and human cohorts and shown a novel function to support L-BAIBA’s involvement in regulation of carbohydrate and lipid metabolism. These studies also support that L-BAIBA primarily exhibits its benefits in conjunction with physical activity. This is shown from skeletal muscle myokines (peptides) that play an important role is the processes listed above. These myokines are produced, expressed, and released by muscle fibers when under forceable contractions and exert both local and pleiotropic effects. Myokines also help to configure the immune-metabolic factor interactions and health promoting effects of physical exercise that stimulate the communication between skeletal muscle and adipose tissue. Adipose tissue itself will release proinflammatory cytokines in response to inactivity and can be a leading reason for the development of metabolic diseases.\u003c\/p\u003e\n\u003cp\u003eThis supported research of MitoBurn™ (L-BAIBA) and its benefits show that through its myokine activity and communication through physical activity as well as its ability to aid in the browning of adipose tissue, lead it to be a proposed beneficial intervention for the purposes of body composition improvements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eColeus forskohlii\u003c\/em\u003e Extract (root) (20% forskolin):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eColeus forskohlii\u003c\/em\u003e is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, \u003cem\u003eColeus forskholii\u003c\/em\u003e preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however,\u003cem\u003e Coleus forksholii\u003c\/em\u003e and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.\u003c\/p\u003e\n\u003cp\u003eA recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of \u003cem\u003eColeus forskholii\u003c\/em\u003e, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. \u003cem\u003eColeus forskholii\u003c\/em\u003e – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core SEAR!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eParadoxine® Grains of Paradise (std. to 12.5% 6-Paradol):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAframomum melegueta\u003c\/em\u003e, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger (\u003cem\u003eZingiberaceae\u003c\/em\u003e) family. While complete compositional analysis has not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger – principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol. 6-paradol acts as a lock and key mechanism to work along side the mechanisms of action of the other ingredients found in Core Sear.\u003c\/p\u003e\n\u003cp\u003eParadoxine® specifically is an ethanol extract of Grains of Paradise. Studies have shown that this extract can increase energy expenditure through its browning of fat tissue (similar to Sinetrol® and Mitoburn™).\u003c\/p\u003e\n\u003cp\u003eAlso, along with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose-dependently mediate the PI3K (phosphoinositide 3-kinase)\/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.\u003c\/p\u003e\n\u003cp\u003eIn the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/812a9102306e35017d3717fdad9aab08.png?v=1758304117\" class=\"img-responsive\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/SEAR_References.pdf?v=1609846574\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":37925256495280,"sku":"SHOP672975315597","price":44.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/SEAR.png?v=1758303725"},{"product_id":"core-poise","title":"Poise","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMagnesium and Iodine:\u003c\/strong\u003e Provides optimal thyroid hormone balance. Aids in menstrual symptom relief.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChaste Tree Extract \u003c\/strong\u003e- Can provide menstrual symptom relief.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSetria® Glutathione\u003c\/strong\u003e - Antioxidant rich. Neutralizes free radicals.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBioPerine®\u003c\/strong\u003e - Increased bioavailability of key nutrients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eNot every supplement is about “the gains.” While the sports nutrition and performance space, as the name implies, justifiably focuses on supplements that maximize athletic performance, too often the space neglects imperatives outside the gym. That is, the space ignores that we all exist outside the gym, at home and in the workplace, and have supplemental needs in these spaces too – to help us respond to and optimize our daily lives. This is especially true for women, who are too often marketed only “weight loss” supplements, ignoring that women have extensive physiological needs.\u003c\/p\u003e\n\u003cp\u003eAnd let’s face it: modern life only exacerbates these needs. Environmental stressors, work, inconsistent diet, and poor sleep habits all contribute to a lifestyle deleterious to the homeostasis of key bodily systems. Chief among them, the complex endocrine pathway that regulates the synthesis, distribution, and uptake of hormones. It is becoming increasingly hard to maintain the healthy and normal hormonal homeostasis that allows us to perform optimally in the gym and workplace. This is especially true for women.\u003c\/p\u003e\n\u003cp\u003eCore POISE is a unique and specifically formulated solution to this problem. Our tailored ingredient profile addresses the mechanisms associated with the body’s stress response. Key ingredients such as magnesium, DIM, Chaste berry, and pregnenolone, are all heavily involved in sex hormone biosynthesis and estrogen balance, and some have been demonstrated to mitigate some of the discomfort associated with PMS. Other ingredients, such as iodine, turmeric extract and Olea europaea help optimize your body’s response to stress, providing and supporting thyroid health. Stress impact on the thyroid can lead to a suppressed metabolism, which can lead to unwanted weight gain. So, while POISE will not make your life easier, it certainly makes responding to it easier.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as Magnesium Bisglycinate Chelate (TRAACS™):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.\u003c\/p\u003e\n\u003cp\u003eIn addition to these benefits, magnesium (especially Magnesium Bisglycinate Chelate) has been studied for its benefits in reducing dysmenorrhea (menstrual cramps) through its ability to relax the smooth muscle of the uterus and reduce the prostaglandins that cause painful cramps. Magnesium levels also tend to fluctuate during a menstrual cycle. During the second half of a cycle when estrogen and progesterone are higher, magnesium levels tend to drop even more. Supplementation with a high-quality magnesium can assist in maintaining an optimal level.\u003c\/p\u003e\n\u003cp\u003eMagnesium’s influence on the thyroid is also of importance. Magnesium is responsible not only for making the inactive T4 (thyroxine) in the thyroid gland but also for converting T4 into the active form of T3 (triiodothyronine). This is important because the metabolism of your body’s cells is enhanced by T3 specifically. These two hormones have a large influence on metabolic rate, heart and digestive function, muscle control, brain development and bone maintenance. Studies have shown that severely low serum magnesium can be associated with an increased risk of anti-thyroglobulin antibodies, which can be a sign of thyroid gland damage caused by the immune system. It has also shown an increased risk of Hashimoto thyroiditis and hypothyroidism, two common autoimmune disorders.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIodine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced-diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for proper cognitive development in the child.\u003c\/p\u003e\n\u003cp\u003eAs implied, however, the most important of iodine’s functions is assisting the body’s production and maintenance of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine\/epinephrine, largely determine the body’s metabolic rate.\u003c\/p\u003e\n\u003cp\u003eIn addition to these benefits for the thyroid, iodine can also be a critical element for women’s health. About 70% of the body’s iodine is concentrated in the tissues of the brain, immune system, ovaries, uterus, breasts, and prostate gland (in men). Being this close to the female reproductive system, iodine also has a large effect on ovulation and estrogen. Iodine is believed to reduce ovulation pain, prevent ovarian cysts, and boost progesterone levels when there is too much estrogen present, which can cause heavy menstruation, breast pain, fibroids, and premenstrual irritability. Iodine can also help reduce estrogen related side effects in two ways: by promoting healthy detoxification of estrogen and by making cells less sensitive to estrogen.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Tyrosine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTyrosine is amongst a class of amino acids known as ‘non-essential’ amino acids, so called because the body can produce them endogenously, and it is therefore not essential through dietary means. That being said, tyrosine is also what is known as a conditionally-essential amino acid; conditionally-essential because, along with glucose and ammonia, the synthesis of tyrosine additionally requires adequate levels of phenylalanine. Once synthesized, tyrosine is one of the most critical amino acids, given its prominent role as a substrate in the synthesis of the catecholamines dopamine, norepinephrine, and epinephrine, in addition to both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones.\u003c\/p\u003e\n\u003cp\u003eThyroid hormones are in fact derivatives of tyrosine that are bound covalently to iodine, meaning that tyrosine (as well as iodine) needs to be present in order for thyroid hormones to be produced. This supplementation can boost thyroid hormones levels in those who may have suppressed thyroid hormones levels. (It is important to note, however, that individuals who are already being prescribed thyroid medications or have an overactive thyroid should be cautious when supplementing with tyrosine and should seek the guidance of a healthcare professional prior to supplementing).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTurmeric Extract (Curcuma longa) (root) (95% curcuminoids):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCurcumin, the primary curcuminoid found in turmeric (a root known for its spice), has been the basis of many clinical studies for its therapeutic properties and ability to modulate multiple cells signaling pathways in certain inflammatory diseases known to humans.\u003c\/p\u003e\n\u003cp\u003eNumerous studies seem to suggest that curcumin powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses. In relation to autoimmune conditions, Hashimoto’s thyroiditis is one in particular that is considered the leading cause of hypothyroidism. The overabundance of chronic inflammation found in the thyroid during these conditions can lead to less production of thyroid hormone all together, thus leading to a generalized slowing of a person’s metabolism.\u003c\/p\u003e\n\u003cp\u003eTurmeric can also have a positive impact on PMS related symptoms. This is seen primarily through the increased neurotransmitter release and inflammatory response associated with pre-menstrual occurrences. Many of the mood and behavior changes associated with PMS can be traced to neurotransmitter changes such as decreased norepinephrine, dopamine, and serotonin. These changes can be subject to the decline in estrogen and progesterone during this period. Turmeric has been shown in studies to increase these neurotransmitters, thus impacting these symptoms in a positive way. The increased inflammatory response due to the PMS period as well can be mitigated in the presence of turmeric due to its high anti-inflammatory benefits.\u003c\/p\u003e\n\u003cp\u003eStudies have shown that low quality curcumin has low bioavailability and benefit, which is why we have used a high standard curcumin with 95% curcuminoids and have also included the trademarked Bioperine® in this formula. These two ingredients have a largely cohesive impact that can drastically improve the health benefit. Studies have shown that Bioperine® significantly improved curcumin uptake by upwards of 2000% at doses that proved to be clinically beneficial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOlive Extract (Olea europaea) (leaf) (20% Oleuropein):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eUsing products derived from the olive tree for the basis of benefitting human health dates back several centuries. There has been a good body of research done lately on the benefits of olives and its derivatives. The polyphenols found in olives (and unrefined virgin olive oil) contain highly potent antioxidant and free radical fighting properties, making them highly sought out for their anti-inflammatory and immune boosting benefits. As we have discussed in subsequent ingredients and their benefits, these anti-inflammatory and immune boosting benefits include the positive impacts made towards thyroid health and PMS. Oleuropein is the most potent polyphenol found in olives (our source of olives contains 20%) and exhibits a very high antioxidant effect on the body through different mechanisms, resulting in an enhanced antioxidant response. This potential is mainly related to its ability to improve radical stability through the formation of intramolecular hydrogen bonds. Oleuropein may also be able to counteract oxidative stress and has shown in vitro to have a protective effect on lipid oxidation. As mentioned above, olive-derived phenolic compounds, including oleuropein, can have a beneficial anti-inflammatory effect. These compounds can decrease concentrations of pro-inflammatory agents that stimulate more inflammation in several different pathologies. It has been studied that oleuropein is able to elicit protective effects on modulating parameters of inflammation and other oxidative stressors.\u003c\/p\u003e\n\u003cp\u003eOleuropein has also been seen is studies to have positive impacts on thyroid conditions, in particular hypothyroidism (underactive thyroid), where the thyroid underproduces thyroxine and and overproduces Thyroid Stimulating Hormone (TSH). This high level of TSH can be expressed from the pituitary gland secreting excess amounts of TSH to stimulate the thyroid gland to produce more thyroid hormone in an attempt to balance secretions. Olive leaf supplementation has been shown to positively impact the thyroid this by promoting a lowering of TSH levels and increasing T3 (triiodothyronine) levels in an attempt to normalize thyroid function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChaste Tree Extract (Vitex agnus-castus) (fruit) (1.5% Agnusides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChaste Tree Berry, also known as Vitex agnus castus (VAC), is a shrub that is native to both Mediterranean Europe and Central Asia. Clinical reviews have supported the use of VAC as a remedy for many female conditions, including menstrual disorders (amenorrhea, dysmenorrhea), premenstrual syndrome (PMS), corpus luteum insufficiency, hyperprolactinemia, infertility, acne, menopause, and disrupted lactation. Chaste Berry exhibits a mechanism of action that increases dopamine activity in the brain, which results in a reduction of prolactin release in the body. When there is an increase in prolactin it can cause disturbances in a women’s menstrual cycle as well as deficiency in their levels of estrogen and progesterone. A prospective, multicenter trial in the efficacy of VAC on PMS was investigated in 50 patients. The Moos’ menstrual distress questionnaire (MMDQ) was the primary parameter and self-assessment was the second parameter. The inclusion of VAC showed that PMS-related symptoms were reduced but then gradually returned after cessation of the trial period. Studies such as this one show that using VAC as a remedy for the symptoms associated with PMS can show clear improvements but should mainly be used for symptomatic relief rather than relief for the duration of the syndrome.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSetria® L-Glutathione:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePMS is often a high stress event for an individual. The overabundance of estrogen compared to progesterone can increase overall stress. When cortisol is not controlled, it can further lower progesterone, further dividing the needed balance between these two complimentary hormones. Glutathione is an amino acid containing molecule of L-glutamic acid, L-cysteine, and Glycine. It is vital to many different properties and is best known for being a powerful antioxidant. The ‘glutathione system’ comprises the enzymes that synthesize glutathione within a cell as dedicated enzymes that use glutathione for its antioxidant effects. Glutathione supplementation is thought to support this pool of glutathione present in cells and thus maintain the efficacy of the entire system. Free radicals can be a byproduct of many different things such as exercising, eating, and breathing to name a few. When these molecules overcome the body at the cellular level, this constant barrage can have negative impacts on health and overall wellness. This barrage can also include the stresses that one’s body might endure during pre-menstruation. Setria® L-Glutathione provides a potent supply of antioxidants that bind these free radicals, which can help keep them from causing lasting damage. Glutathione not only has the ability to neutralize free radicals, but it also can reactivate other antioxidants, such as Vitamin C and Vitamin E. Once these vitamins and their antioxidants do their job of neutralizing free radicals, they become unstable radicals themselves. Glutathione can help recycle these unstable molecules back to their antioxidant rich properties.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3'-Diindolylmethane (DIM):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to (but probably cannot) identify a \u003cem\u003especific\u003c\/em\u003e estrogen.\u003c\/p\u003e\n\u003cp\u003eThese \u003cem\u003especific\u003c\/em\u003e estrogens, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an estrogen antagonist. Yes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called “phytonutrients” have become the focus of clinical research, as these natural compounds have shown the ability to increase the ratio of good, estrogen decreasing estrogens (such as 2-OHE), to bad, estrogen increasing estrogens (such as 16-OHE1). One of these phytonutrients, a dietary indole known as indole-3-carbinol (I3C), is the bioactive phytochemical and a presumed modulator of reduced cancer risk in areas with high cruciferous vegetable consumption. Unfortunately, despite its potent antiestrogenic activity, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003eLuckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound with respect to antiestrogenic action – promoting the metabolism of beneficial estrogens that themselves reduce estrogenic activity.\u003c\/p\u003e\n\u003cp\u003eAside from its healthy-estrogen promoting abilities, DIM also exerts its own direct physiological effects, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromoting pathways of internal estrogen metabolism that favor the production of anti-estrogen estrogens.\u003c\/li\u003e\n\u003cli\u003eAdjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.\u003c\/li\u003e\n\u003cli\u003eLimit the cell division and growth of certain estrogens.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lie in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePregnenolone: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePregnenolone, or pregn-5-en-3β-ol-20-one, is known as the grandmother hormone due to its precursor role in the endogenous biosynthesis of most steroid hormones as well as others, including progesterone and estrogen. Pregnenolone also has a high relationship in the balancing of beta-estradiol and progesterone, which can have a positive impact on the distressing of symptoms associated with PMS, including menopausal depression. When pregnenolone levels are low, whether it be due to high amounts of oxidative stress, increased cortisol, etc. it can have a negative impact on other bodily functions that are governed by hormones. When women in particular have low progesterone during their monthly cycle, it can lead to heavy menstruation and increased levels of estrogen, which can decrease sex drive and increase weight gain. Pregnenolone needs to be present in order for the balance of progesterone and estrogen to occur. This balance of hormones can thus lead to more balance during the menstruation period and lower the severity of PMS symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioperine® (95% Black Pepper Extract):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by. In this specific product for Core POISE, it is included because it dramatically increases the bioavailability of curcuminoids (see above). Without Bioperine, the serum concentration and absorption rates of the active agents in curcumin would be significantly reduced.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at the impact of BioPerine® on nutrient absorption have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core POISE.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg class=\"img-responsive\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-POISE-2020.jpg?v=1607511548\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_POISE-PR_7.125x2.625_FIN-OL.pdf?v=1639556575\"\u003eCore POISE Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Poise_Refferences.pdf?v=1607340646\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":38173893296304,"sku":"SHOP672975009328","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/POISEFRONT_68b3523c-feba-477f-a239-994630040e98.png?v=1760379098"},{"product_id":"core-iso-2lb","title":"Iso 2lb","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhey protein isolate\u003c\/strong\u003e - 100% micro filtered, cold processed, whey protein isolate\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity\u003c\/strong\u003e - Zero artificial fillers\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTaste\u003c\/strong\u003e - No sugar added\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eYour workout is the jungle. Whey isolate is the lion – its King.\u003c\/p\u003e\n\u003cp\u003eCore ISO is, simply put, the pinnacle. Our protein’s quality, level of purity, and most importantly, gourmet taste, make drinking a shake your favorite and most effective part of your training day!\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e1 scoop per serving.\u003c\/li\u003e\n\u003cli\u003e32 servings per container.\u003c\/li\u003e\n\u003cli\u003ePurest protein available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIf the post-workout environment were a jungle, whey protein isolate (WPI) would be the lion – its king. Newer proteins enter into the market, receive fanfare and applause, and then inevitably fall out of favor. WPI, however, is the U.S. Dollar, Greenwich Mean Time, or Michael Jordan’s dunking prowess: it is the reference standard against which everything else is measured. The success or efficacy of all other proteins is gauged relative to what the one true king, WPI, has previously done.\u003c\/p\u003e\n\u003cp\u003eSo, given WPI’s long-standing Elvis status, there is simply no way it could be improved on. Right? Wrong. Amino-filled and\/or spiked, low quality, low purity WPI formulas still run rampant on the market – robbing consumers of what they should be receiving, and exchanging the king for a jester.\u003c\/p\u003e\n\u003cp\u003eThat has never been Core’s approach, and it never will be. With Core ISO, we have developed the purest, highest-quality, least-adulterated WPI product on the market. We have taken the highest purity, non-instantiated, non-soy, non-GMO whey protein isolate available, and essentially added nothing to it: we have added no sugars, making it the perfect versatile protein; and we have added no artificial colors, meaning you can feel good about drinking it.\u003c\/p\u003e\n\u003cp\u003eDid we mention we use natural flavoring? And Oh. My. Goodness, what flavoring it is! While the bitterness of WPI overcomes most brand’s offering, and results in a dull, palette-killing powder you need to choke down, Core ISO tastes like a gourmet pastry chef set up shop, on your tongue, and started making soufflés like nobody’s business.\u003c\/p\u003e\n\u003cp\u003eCore ISO is, simply put, the pinnacle. Our protein’s quality and level of purity transcends it to the level of being a necessity; a part of your supplement and training setup that is simply assumed to be there, because it must be there. So, if you are already taking or planning to use protein, why not use the version of the standard that rises above the rest?\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhey Protein Isolate (WPI):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhey protein isolate (WPI) was said above to be the king of proteins, but what does that mean? Why are proteins in general necessary, and more importantly, what are their functions as a workout supplement?\u003c\/p\u003e\n\u003cp\u003eWhen you vigorously train or exert yourself, a process called protein degradation (the breakdown of muscle protein) begins so that the body can fuel itself. Think of this like shutting off your engine, in order to fuel your car (muscle protein breakdown). As this entire process plays out, the available pool of amino acids in skeletal muscle depletes, as they too, are drawn in and broken down in the natural, catabolic process during exercise training.\u003c\/p\u003e\n\u003cp\u003eWhile this situation is quite adequate during a training session, it’s precisely the opposite of what we want afterwards. At that point, we want the available pool of amino acids to increase, protein degradation to slow or stop, and muscle protein synthesis to increase. The famous, “anabolic window” is occurring during this time period, so a protein powder that is rapidly digested, and that rapidly increases the available pool of amino acids, is needed to ensure that the switch between protein degradation to synthesis is as beneficial as possible. After this anabolic window passes, or before it even begins, we also want to ensure that the available pool of amino acids is high enough for your body’s constant growth cycle.\u003c\/p\u003e\n\u003cp\u003eAt this period, protein quality is also vital. Human skeletal muscle makes the most use out of a few, particular amino acids, and so a quality protein needs to have an amino acid profile that is optimal for this context. An, “optimal amino acid profile” contains a high amount of BCAAs, and in particular leucine, to counteract the rate of leucine oxidation that occurs as the fractional rate of protein synthesis decreases, and the rate of muscle protein degradation increases.\u003c\/p\u003e\n\u003cp\u003eWe chose whey protein isolate as the only protein in Core ISO for precisely these reasons. An excess amount in the available pool of amino acids (especially leucine) is called hyperaminoacidaemia, or specifically to leucine, leucinaemia. After a period of intense exercise training, we want this condition to arise immediately, peak after approximately one hour, and then be sustained until another protein source can be ingested. The evidence is quite clear that whey protein isolate not only achieves this, but also may achieve it at a greater potency as compared to other protein sources.\u003c\/p\u003e\n\u003cp\u003eIn a non-double blind study, two groups of healthy men received either micellar casein, or whey protein isolate, after a sustained bout of exercise training. Post-training, muscle protein synthesis, essential amino acid, and leucine levels were tested and compared. The study authors conclude that, “the ingestion of isolated whey protein supports greater rates of MPS than micellar casein both at rest and after resistance exercise in healthy elderly men. This result is probably related to a greater hyperaminoacidaemia or leucinaemia with whey ingestion.”\u003c\/p\u003e\n\u003cp\u003eAs we said above, it is critical for a protein’s effectiveness that it contain a robust amino acid profile, one that is particular high in leucine. This is because leucine is both the most physiologically important amino acid, with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, as in the above study, by both insulin-mediated and non-insulin mediated mechanisms.\u003c\/p\u003e\n\u003cp\u003eIn order to counteract a negative intramuscular protein balance, a number of things need to occur – mostly, a rapid increase in the availability of amino acids. There is strong evidence to suggest that, amongst protein supplement, WPI best achieves this feat.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-ISO2020.jpg?v=1590048878\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_CHOCOLATE_FIN-OL_compressed.pdf?v=1643986567\"\u003eChocolate Decadence 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_PEANUT_BUTTER_CUP_FIN-OL_compressed.pdf?v=1643986567\"\u003eChocolate Peanut ButterCup 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_TOFFEE_FIN-OL_compressed.pdf?v=1643986567\"\u003ePeanut Butter Toffee 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_RED_VELVET_CAKE_FIN-OL_compressed.pdf?v=1643986567\"\u003eRed Velvet Cake 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_STRAWBERRY_SHORTCAKE_FIN-OL_compressed.pdf?v=1643986567\"\u003eStrawberry Shortcake 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_VANILLA_CAKE_FIN-OL_compressed.pdf?v=1643986567\"\u003eVanilla Cake 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_MINT_COOKIE_FIN-OL_compressed.pdf?v=1643986567\"\u003eChocolate Mint Cookie 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_CINNAMON_BUN_FIN-OL_compressed.pdf?v=1643986567\"\u003eFrosted Cinnamon Bun 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_LEMON_POUNDCAKE_FIN.pdf?v=1658387675\"\u003eLemon Pound Cake 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ISO_2lb_CAPPUCCINO_FIN.pdf?v=1660736508\"\u003eCappuccino 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-ISO-Product-References.pdf?16897565604338014006\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Chocolate Peanut Butter Cup","offer_id":39517214212272,"sku":"SHOP672975315122","price":59.99,"currency_code":"USD","in_stock":false},{"title":"Chocolate Mint Cookie","offer_id":39517214539952,"sku":"SHOP672975315719","price":59.99,"currency_code":"USD","in_stock":true},{"title":"Frosted Cinnamon Bun","offer_id":39517214572720,"sku":"SHOP672975315726","price":59.99,"currency_code":"USD","in_stock":false},{"title":"Vanilla Cake","offer_id":39517214474416,"sku":"SHOP672975315160","price":59.99,"currency_code":"USD","in_stock":false},{"title":"Chocolate Decadence","offer_id":39517214146736,"sku":"SHOP672975315115","price":59.99,"currency_code":"USD","in_stock":true},{"title":"Strawberry Shortcake","offer_id":39517214343344,"sku":"SHOP672975315153","price":59.99,"currency_code":"USD","in_stock":false},{"title":"Cappuccino","offer_id":41919199346864,"sku":"SHOP850016858382","price":59.99,"currency_code":"USD","in_stock":false},{"title":"Lemon Pound Cake","offer_id":41825270464688,"sku":"SHOP658580070946","price":59.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/ISO_CPBC_FRONT.png?v=1760611786"},{"product_id":"core-pro-2lb","title":"Pro 2lb","description":"\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhey protein blend\u003c\/strong\u003e - Sustained release of recovery and growth agents\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eDigestive enzyme blend\u003c\/strong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e - Digestive enzyme blend supports healthy carbohydrate and fat breakdown\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eVersatility\u003c\/strong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e - Designed to maximize your protein needs any time of the day\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003ca href=\"https:\/\/www.corenutritionals.com\/products\/core-pro-5lb\"\u003e \u003cbutton style=\"width: 100%; height: 50px; font-size: 20px;\" class=\"btn black-carbon-btn\" type=\"submit\"\u003eGet Core PRO 5LB\u003c\/button\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSustained Release Protein Blend\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYou want to recover. You don’t want to gag while doing it.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThat’s why we built Core PRO: a protein powder that tastes incredible and works even better. Our carefully chosen protein blend offers a robust amino acid profile shown to support lean muscle growth—while our flavors make it feel like a cheat.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003e1 scoop per serving\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003e28 (2LB) \/ 70 (5LB) servings per container\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eProtein blend with gourmet taste\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhy Core PRO?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn today’s world, taste is everything—and Core PRO delivers. But this is Core Nutritionals, meaning function always matches flavor. Our mix of whey concentrate, whey isolate, and milk protein isolate creates a smooth texture, complete amino acid profile, and both fast- and slow-digesting proteins. The result is a marriage of taste and performance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCore PRO is a clinical-strength, sustained release formula designed to fuel growth and recovery over extended periods. By combining fast-uptake whey with casein-rich milk protein, this blend supports immediate recovery and long-term muscle repair. It is loaded with naturally occurring BCAAs, helping delay fatigue and speed up recovery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWe’ve gone further by adding digestive enzymes for absorption and MCTs (medium chain triglycerides) to help preserve lean mass while boosting metabolism. Core PRO works any time—day or night—keeping you fueled whenever you need it.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003esplit\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eScientific Breakdown\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eRecovery depends on positive net protein balance: slowing muscle protein breakdown while increasing synthesis. After training, protein supplements provide the amino acids your body needs to tip this balance in your favor.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBut not all proteins are equal. Many products are filled with low-quality blends and fillers. Core PRO is different. Our cold-processed whey concentrate, cross-flow micro filtered whey isolate, and milk protein isolate deliver:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eA complete amino acid profile\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eSuperior nitrogen retention\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eIncreased lean muscle impact\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eStrong satiety (feeling of fullness)\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAnd unlike most brands, we’re fully transparent. Our label discloses exact yields and the full amino acid profile. Each serving provides 2.6g of leucine, the proven dose to maximize muscle protein synthesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eThe Core PRO Protein Sources\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCold-Processed Whey Concentrate: Preserves amino acid structure and immune-boosting benefits while supplying antioxidants like glutathione. A strong base for recovery nutrition.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCross-Flow Whey Isolate: Extremely clean, with minimal fat and lactose, making it highly digestible and rapidly absorbed without harsh chemicals.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMilk Protein Isolate: Over 90% protein by weight, containing both casein and whey in their natural ratios. Low fat, low lactose, and high in amino acids for sustained recovery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis combination provides immediate recovery support and long-lasting amino acid delivery until your next meal.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eAdded Support Ingredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDigeSEB Digestive Enzyme Blend: Many brands overlook enzymes, but they are crucial for breaking down carbs, fats, and proteins. Core PRO includes amylases, proteases, lactases, and cellulases to ensure complete digestion and absorption. This makes your protein more effective both pre- and post-workout.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCoconut Oil Creamer (MCTs): MCTs bypass gastric uptake, go directly to the liver, and are rapidly used for energy. Research shows they increase resting energy expenditure by up to 65 percent while reducing fat storage, supporting both performance and body composition.\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cb\u003e\u003c\/b\u003e\u003cb id=\"docs-internal-guid-595b37a9-7fff-3ef7-e163-14316b189977\"\u003e\u003c\/b\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-PRO-2020.jpg?v=1585897600\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PRO-PeachCobbler-FINAL_Outlined.jpg?v=1738576863\"\u003ePeach Cobbler 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_PRO_2lb_CHOCOLATE_CARAMEL_BAR-FIN_compressed_1.pdf?v=1710751204\"\u003eChocolate Caramel Candy Bar 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_PEANUT_BUTTER_CUP_FIN-OL_compressed.pdf?v=1643989028\"\u003eChocolate Peanut Butter 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_FRENCH_TOAST_FIN-OL_compressed.pdf?v=1643988825\"\u003eCinnamon French Toast 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_COOKIES_N_CREAM_FIN-OL_compressed.pdf?v=1643988771\"\u003eCookies 'n Cream 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_CHOCOLATE_FIN-OL_compressed.pdf?v=1643988523\"\u003eDeath by Chocolate 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_VANILLA_CUPCAKE_FIN-OL_compressed.pdf?v=1643989086\"\u003eFrosted Vanilla Cupcake 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_FRUITY_CEREAL_FIN-OL_compressed.pdf?v=1643988885\"\u003eFruity Cereal 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_CHOCOLATE_MOCHA-FIN-OL_compressed.pdf?v=1643988590\"\u003eChocolate Mocha 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_BLUBERRY_MUFFIN_FIN-OL_compressed.pdf?v=1643988446\"\u003eBlueberry Muffin 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_GAINTIME_FIN-OL_compressed.pdf?v=1643988930\"\u003eVanilla Toffee Gaintime 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_COCONUT_CREAM_PIE_FIN-OL_compressed.pdf?v=1643988640\"\u003eCoconut Cream Pie 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_PRO_2lb_PISTACHIO_ICE_CREAM-FIN.pdf?v=1656589730\"\u003ePistachio Ice Cream 2LB Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES_-_Core_PRO.pdf?v=1586182614\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Airplane Cookies \u0026 Cream","offer_id":45113118064816,"sku":"SHOP850080302286","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Peanut Butter","offer_id":45031036813488,"sku":"SHOP850057789850","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Shamripped Shake","offer_id":45003451924656,"sku":"SHOP850080302293","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Frosted Vanilla Cupcake","offer_id":39799461314736,"sku":"SHOP850080302163","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Strawberries n' Cream","offer_id":44949988081840,"sku":"SHOP850057789867","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Cinnamon French Toast","offer_id":44915285328048,"sku":"SHOP850080302132","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Cookies n' Cream","offer_id":44915285360816,"sku":"SHOP850080302149","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Blueberry Muffin","offer_id":39799460987056,"sku":"SHOP850080302118","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Chocolate Peanut Butter Cup","offer_id":44878107148464,"sku":"SHOP850080302125","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Death by Chocolate","offer_id":39799461249200,"sku":"SHOP850080302156","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Holiday Sugar Cookie","offer_id":44848261267632,"sku":"SHOP850057790009","price":54.99,"currency_code":"USD","in_stock":false},{"title":"Chocolate Caramel Candy Bar","offer_id":43271681966256,"sku":"SHOP850051031801","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Milk Chocolate Cookies 'n Cream","offer_id":44931010855088,"sku":"SHOP850057789645","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Mixed Berry Cheesecake","offer_id":44931010887856,"sku":"SHOP850057789447","price":54.99,"currency_code":"USD","in_stock":true},{"title":"PB Cookies 'N Cream","offer_id":44931010920624,"sku":"SHOP850057789461","price":54.99,"currency_code":"USD","in_stock":true},{"title":"Vanilla Honey Graham","offer_id":44931010953392,"sku":"SHOP850057789454","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PRO_ACC_FRONT.png?v=1778791049"},{"product_id":"b-complex","title":"B-Complex","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eAid in energy metabolism.\u003c\/li\u003e\n\u003cli\u003eSupport optimal function of key structures, including the adrenal glands, musculoskeletal system, and digestive system.\u003c\/li\u003e\n\u003cli\u003eSupport cognition, mood, and overall well-being.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) in order to maintain the cell functions to which B vitamins contribute. Along with choline and inositol added, collectively this group of nutrients are essential for maintaining normal energy levels, cognition, mood, bodily function, and well-being.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eB Vitamins (Thiamine, Riboflavin, Niacin, B6 [Pyridoxine], Folic Acid, B12, Biotin, and Pantothenic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Though both molecularly and physiologically distinct, they are also deeply interrelated in their effects, synthesis and metabolism. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) in order to maintain the cell functions to which B vitamins contribute. Collectively this group of vitamins are essential for maintaining normal cognition, mood, bodily function, and well-being.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCholine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCholine is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for a number of functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003c\/p\u003e\n\u003cp\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInositol\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe nutrient inositol, also known as myo-inositol, was once called “vitamin B8”, however, it was later found to be produced by humans, and thus is not technically a vitamin. Inositol heightens the activity of serotonin in the brain, and thus has a vital role in mood and emotional balance. Inositol is also a type of sugar that influences the insulin response and several hormones associated with mood and cognition. It has antioxidant properties that fight the damaging effects of free radicals in the brain, circulatory system, and other body tissues.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-BCOMPLEX.jpg?v=1629733123\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/B-Complex_7.5x2.5-FIN-P65_17f66aba-94b0-40d1-b5c6-524ed0bc02e7.pdf?v=1644226214\"\u003eB Complex Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/B-Complex-REFFERENCES.pdf?v=1629727783\"\u003eDownload Refferences\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40403096830128,"sku":"SHOP672975315795","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/products\/B-Complex_RENDERING.png?v=1629703123"},{"product_id":"calcium-magnesium","title":"Calcium Magnesium","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eSupport the growth and function of bones, muscles, nerves, and heart.\u003c\/li\u003e\n\u003cli\u003eAct as a catalyst for over 300 ezymatic reactions in the body.\u003c\/li\u003e\n\u003cli\u003eWork synergistally to support normal bodily function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eCalcium is likely one of the first nutrients ever consumed by an individual. From the time you were born, calcium was likely introduced for its benefits of bone growth, muscle and nerve function, as well as heart function. As we age, the importance of calcium is also important as the need shifts from growth to maintenance of optimal function. If optimal calcium levels are not met, whether it be in childhood or adulthood the risk of deficiency can lead to less than optimal function and quality of life later on.\u003c\/p\u003e\n\u003cp\u003eMagnesium also plays a role in similar functions of muscle and nerve function, protein synthesis, and bone integrity, as well as being a catalyst for over 300 enzymatic reactions that regulate certain physiological functions in the human body. While magnesium is an essential nutrient, our bodies must receive it from either foods or supplementation. Supplementation can help ensure optimal levels are being met to maintain optimal bodily function. These can include bone and muscle integrity as well as digestion and ability for relaxation and recovery to take place.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThese two nutrients are essential on their own but they also work well together. It is important to note that their ratio between each other is important so there is not a competition between them. Core's Calcium\/Magnesium Citrate Commoditiy supplies the perfect ratio of calcium to magnesium for the body to maintain optimal functioning.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body – including mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, requires sufficient levels of vitamin D, which can also be found in Core Nutritionals Commodity line of products.\u003c\/p\u003e\n\u003cp\u003eWhen present in sufficient amounts, calcium is necessary for the adequate formation, function, and remodeling of both bone and teeth. Insufficient levels of calcium are associated with degenerative bone and joint disorders such as osteoporosis, wherein osteoblast (growth) slows or stops; thereby reducing bone mass and density and decreasing bone strength.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium Citrate\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, bone integrity, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.\u003c\/p\u003e\n\u003cp\u003eMagnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells.\u003c\/p\u003e\n\u003cp\u003eMagnesium itself is an essential nutrient. However, our bodies cannot produce magnesium on their own, so it must be obtained from food or in supplemental means. Magnesium citrate has a role of aiding in the maintenance of healthy magnesium levels, so with most of the body’s magnesium found within bones, muscles, and in non-muscular soft tissue, maintaining normal levels is vital to these structures’ integrity. In addition to these benefits, magnesium citrate can also benefit gastrointestinal distress through its ability to relieve constipation, gas, and bloating, thus establishing normal digestive processes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium and Magnesium in Combination\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe have talked about Calcium and Magnesium for their separate benefits towards optimal health but why are they essential to be taken together?\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium,\u003c\/strong\u003e as we discussed is the most abundant mineral found in the body and most of it is found in our skeletal system and is essential for the structural maintenance of the entire skeletal system. Adequate amounts of calcium in your diet can help reduce bone loss by 30 - 50 percent.\u003c\/p\u003e\n\u003cp\u003eThere are many forms of calcium that can be made available in a supplemental form. However, in order to be effective, calcium must be properly absorbed by the body. Chelated forms of calcium (calcium citrate, which is in this product) are going to be more effective due to its increased bioavailability for the body. For maximum absorption, calcium is best taken with a meal.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium,\u003c\/strong\u003e as we also discussed is a mineral that plays an important role in maintaining healthy bones, muscle function, and nerve function. It contributes to increased bone density and helps prevent the onset of osteoporosis.\u003c\/p\u003e\n\u003cp\u003eSince magnesium works closely with calcium, it is important to have an appropriate ratio of both minerals in order for them to be effective. A good rule of thumb is a 2:1 calcium-to-magnesium ratio. For example, if you take 1000mg of calcium, you should also take 500mg of magnesium (which is what is used in this product). If this ratio is off, there can be an internal competition for intestinal absorption between these two minerals, and their effects can be diminished. This has been seen in studies especially when calcium intake is much higher than magnesium. This can be important information, as the typical diet of most people often shows calcium consumption to be much higher than magnesium. Understanding this importance of balance between these two minerals can be necessary for maintaining optimal physiological function.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-CALCIUM.jpg?v=1629733128\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Calcium_Magnesium_2020_8.5x3.25-FIN-P65_4fde88b8-7913-4d66-8ac7-b888a4fee049.pdf?v=1644226614\"\u003eCalcium Magnesium Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Calcium-Magnesium-Citrate-REFFERENCES.pdf?v=1629728662\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40403194413232,"sku":"SHOP672975315788","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/CALCIUM_FRONT.png?v=1760395281"},{"product_id":"gut","title":"Gut","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCore Probiotic Blend™\u003c\/strong\u003e - Custom formulated blend of live organisms to provide the gut with beneficial bacterial support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCore Biome® Tributryin\u003c\/strong\u003e - Postbiotic that aids in the body's inflammatory response and stimulating growth of new cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSunFiber®\u003c\/strong\u003e - Prebiotic fiber that can help increase the absorption of important macronutrients and vital minerals\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\n\u003cp\u003eThe gut, or gastrointestinal (GI) tract is one of the largest systems responsible for keeping our body in working order. Food and a wide variety of nutrients pass through the separate parts, being broken down and absorbed only to be shuttled to their final destination to begin to do their job. In addition to this food, countless numbers of microorganisms from the environment pass through the gut – some of which may be detrimental to health and alter the integrity of the GI tract. Core GUT was formulated to provide all around GI tract support with beneficial bacteria in a custom probiotic blend, a useable form of food for these microorganisms in a prebiotic, beneficial by-products in a post biotic, and digestive enzymes to aid in the breakdown of crucial nutrients. This combination of ingredients has been shown to support the growth of healthy gut bacteria*, enhance immune function*, provide support for gut lining integrity*, and display protective effects on gut environment*.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium 8.5 billion CFU\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBifidobacterium are labeled as probiotics and normally live in the intestines and stomach. They are essential for helping your body perform essential functions such as digestion and fighting off harmful bacteria. There are a wide range of Bifidobacterium as well so we will outline each individually below.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium breve (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eOne of the most helpful probiotic bacteria in the human body. Widely used probiotic strain for pediatrics. Is widely present in the gut of breast-fed infants and is known to protect against human pathogens. Some other functions of B. breve are to ferment sugars, and to product lactic acid and acetic acid. Healthy amounts of this strain can improve gut related issues such as diarrhea, gas, allergies, and irritable bowel syndrome (IBS)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium infantis (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThis specific probiotic strain that is often used to alleviate irritable bowel syndrome as well as general abdominal discomfort and bloating.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium bifidum (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eBifidobacterium bifidum has shown promise in improving irritable bowel syndrome (IBS) constipation, lung infections, ulcerative colitis, diarrhea, and certain intestinal infections. One human study in 2011 on the benefits towards IBS showed that significant relief was reported with the administration of B. bifidum when placed against placebo. You can find this specific bacterium in foods like yogurt with added cultures, kefir, buttermilk, cured meats, sourdough bread, and sauerkraut.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium longum (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eBifidobacterium longum is classified as a multifunctional probiotic strain that has been shown to be highly effective in alleviating GI distress, immunological and infectious diseases. These benefits have been shown to be attributed to its ability to stabilize the gut microbiota and improve the overall intestinal environment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium lactis (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eLactic acid bacteria are among the most populated microflora that live within the human large intestine. They are believed to be play an integral role in the homeostasis of the gut microbiome as well as are highly beneficial for overall health. This specific Bifidobacterium can be found in many yogurts, cheeses, and other fermented dairy products and can possess benefits ranging from improved digestion, increased uptake of dietary minerals, reduction in cholesterol, as well as improvements in natural immunity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus 16.5 billion CFU\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs arguably the most common probiotic group, Lactobacillus can aid the body in the breakdown of foods, absorption of key nutrients, and defend against destructive organisms that can cause distress and other diseases.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus acidophilus (4 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eOne of the most common probiotic types that can be most commonly found in many fermented foods, and added to yogurts, and cheeses. This type of bacteria is found in the intestines and plays a vital role in boosting human health. This bacterium helps produce lactic acid. It goes through a process of producing an enzyme called lactase, which helps break down lactose into lactic acid. This bacterium has been extensively studied for its benefits of alleviating symptoms pertaining to IBS, diarrhea, bloating, and other GI distress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus plantarum (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. plantarum has a significant importance on boosting antioxidant activity as well as helping maintain intestinal permeability. It can work to suppress the growth of bacteria that produce gases in the intestines as well as benefit some who suffer from IBS.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus bulgaricus (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. bulgaricus has been used mostly as a probiotic to help aid in the improvements of digestion, prevent diarrhea, and to relieve symptoms associated with IBS. Alongside L. acidophilus it has the potential to work by helping the body maintain normal consistency of the bacteria living in the stomach and intestines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus casei (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eNaturally found in the gut as well as some fermented foods, L. casei has been shown to positively regulate our digestive system by contributing to the reduction of diarrhea. It can also positively impact constipation, Crohn’s disease, inflammatory bowel disease (IBD), IBS, lactose intolerance, and ulcerative colitis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus rhamnosus (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. rhamnosus is able to promote immune-responsiveness by reducing the expression of several activation and inflammation markers on monocytes and by increasing the production of interleukin in macrophages. It produces a biofilm that can protect the mucosa and also produces soluble fibers that are beneficial to the gut.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus brevis (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. brevis is a type of lactic acid bacteria found in milk-based products, fermented products, and in some plants as they decompose. Its benefits include alleviating diarrhea related symptoms in children and supporting natural killer (NK) cell activity in older individuals. These NK cells are a type of pathogen-killing cell that can fight off infections and stop the growth of cancerous cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus gasseri (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. gasseri is a unique strain of bacteria commonly found in the genital, urinary, and digestive systems of the body. It possesses many benefits but it has shown particular promise in aiding positive changes in weight and improvements in body composition. It has also shown promise in reducing blood and liver cholesterol, and reducing oxidative stress in the body. These benefits are most likely attributed from reduced inflammatory status present in adipose tissue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus fermentum (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. fermentum has been reported to enhance immunologic response as well as prevent community-acquired GI and upper respiratory infections. This specific strain of Lactobacillus also produces potent antimicrobial peptides, which can then be used as a food preservative or as alternatives in antibiotics. It has been studied to provide the benefit of decreasing cholesterol levels in the blood stream and to potentially prevent alcoholic liver disease and colorectal cancer in humans.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus reuteri (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThis well studied strain of Lactobacillus can colonize a large number of mammals and provide essential benefits. Found in the GI tract, urinary tract, skin, and breast milk, the benefits of this strain include the production of antimicrobial molecules that can inhibit the colonization of pathogenic microbes and strengthen the microbiota composition of its host. Other benefits include enhancing the immune system through the production of pro-inflammatory cytokines while promoting regulatory T-cell development and function, as well as strengthening the intestinal barrier. These T-cells help maintain intestinal homeostasis by controlling inflammation and inducing tolerance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus paracasei (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eAs a potent strain with immune modulation properties, several studies have shown that L. paracasei can provide relief from inflammatory bowel disease as well as alleviate inflammatory symptoms associated with colitis and other colon related issues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus salivarius (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThis probiotic species is widely found in the GI tract of mammals and has been shown to possess benefits that include relief from IBS related symptoms, pancreatic necrosis, and atopic dermatitis. Many of these benefits come from the species ability to suppress pro-inflammatory cytokines and bacterial overgrowth in the small intestine, which leads to reduced bacterial translocation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSaccharomyces 5 billion CFU\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSaccharomyces boulardii (5 billion CFU)\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eS. boulardii is a specific type of probiotic yeast that has been shown to possess benefits for human gastrointestinal health. The probiotic benefits of this organism include fighting against toxins and other harmful bacteria, increasing the function of the gut biome, providing inflammation relief for the gut lining to improve efficiency, boosting immune function, and helping to restore optimal nutrient levels, like short chain fatty acid production, for the gut. Some of the conditions that S. boulardii protects against are IBS, Crohn’s disease, Ulcerative colitis, and C. diff infections.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eTributyrin (as Core Biome™ 30% yielding 300mg)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe gut microbiome is responsible for contributions that maintain intestinal balance. Disturbances in this homeostasis can cause alterations in the metabolic and fermentation byproducts that occur in the gut. With the gut being so closely tied to many bodily processes involving many of the body’s vital systems, optimal gut health is of importance. The microbiota of the gut ferment undigested sugars to product short-chain fatty acids such as, acetate, propionate, and butyrate. Butyrate is especially essential as it has mechanisms of action that include effects of suppressing inflammation and immunoprotection, serving as the primary nutrient that provides energy to colonocytes, and regulating functions of gene expression, gut tissue development, oxidative stress reduction, and diarrhea control. When butyrate is depleted or scarce, GI distress and other injury can occur.\u003c\/p\u003e\n\u003cp\u003eSeveral studies have looked at the effectiveness of supplemental tributyrin on the benefits of gut health and have shown promising results. One animal study combining tributyrin with essential oils concluded that this combination improved the intestinal morphological structure and positively altered the intestinal microbiota and metabolites that benefit gut health. Another animal study analyzing parameters for growth as it pertains to performance of the gut microbiota concluded that, with the addition of tributyrin, there was an enhanced potential for energy metabolism and indicated that tributyrin can promote changes in the gut microbial communities. These positive changes seen can contribute to improving animal performance after weaning from an infant diet to an adult diet.\u003c\/p\u003e\n\u003cp\u003eSeveral human studies have also looked at tributyrin’s positive role on the body. Most of these studies have involved tumors of some sort, but this does provide promise to the potential benefits it can have when tumors are not present as increases in immunoprotection can beneficial for everyone. One human study showed that tributyrin was able to be cytostatic to cancer cells and induce differentiation and apoptosis (cell death) to colon cancer cells through the stimulation of interleukin-2 and -12 (2 cytokine signaling molecules in the immune system).\u003c\/p\u003e\n\u003cp\u003eWhile more studies can be beneficial for solidifying tributyrin’s benefits on gut health, these current studies do show its ability to provide immunoprotection and boost the overall function of the vital gut microbiome. CoreBiome® has been clinically proven to be a highly bioavailable source of this vital nutrient.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSunfiber® Guar Fiber\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSunfiber®, a fermented, dietary fiber, is a proven prebiotic fiber that increases both Bifidobacteria and Lactobacillus levels with the aim of providing digestive support. These beneficial bacteria promote a healthy gut microbiota and aim to enhance the overall function of the gut, thus leading to increased function of the other vital systems of the human body. Fermentation of Sunfiber® by the gut microbiome results in production of short-chain fatty acids such as butyrate, which as we discussed above, provides valuable energy for the digestive tract. The other benefits of this prebiotic include increasing the absorption of important macronutrients and vital minerals, increasing satiety and appetite control, regulating blood glucose levels, improving IBS related symptoms, and providing stool regularity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDigestive Enzyme Blend (Protease, Lactase, Amylase, Lipase)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOne can easily make the argument that dietary enzymes – and in particular, digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc).\u003c\/p\u003e\n\u003cp\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products.\u003c\/p\u003e\n\u003cp\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In Core Life Line’s Gut product, we have included a digestive enzyme blend comprised by:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eProteases- breaks down proteins and other peptides\u003c\/li\u003e\n\u003cli\u003eLactases- breaks down lactose\u003c\/li\u003e\n\u003cli\u003eAmylases- breaks down starches into useable sugars, such as glucose and maltose\u003c\/li\u003e\n\u003cli\u003eLipases- breaks down fats\/lipids which allow for a full and complete breakdown of all of your daily dietary components.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-GUT.jpg?v=1633098262\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_GUT_8.5x3.25-FIN.pdf?v=1632991200\"\u003eGUT Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-GUT.pdf?v=1632991495\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40809405677744,"sku":"SHOP658580070557","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/GUTFRONT_1aa7ea51-ca4f-407b-bde5-8c3a0b9f8f05.png?v=1760376615"},{"product_id":"core-prostate","title":"Prostate","description":"\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSaw Palmetto Extract\u003c\/strong\u003e - aims to maintain healthy prostate size.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStinging Nettle Extract\u003c\/strong\u003e - normal and healthy urinary flow and frequency.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLycopene\u003c\/strong\u003e - contributes to normal prostate function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-contrast=\"none\"\u003eFrom an early age, men are taught to associate their virility, potency, and vigor with their sense of masculinity. Yet, as we age, the vital systems and metabolic pathways that help us maintain that virility slowly begin to decline. For some, this is an unavoidable part of aging that should be handled with grace and acceptance. For others, such as those living the Crush It lifestyle, this akin to meekly accepting defeat when other options are available. You see, it is critical to maintain a healthy, normal prostate function. While aging makes maintaining this function increasingly difficult, there are robust supplement regimens that can assist in promoting proper prostate health and function. \u003c\/span\u003e\u003cspan data-ccp-props='{\"201341983\":0,\"335559739\":160,\"335559740\":259}'\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-contrast=\"none\"\u003eWhile many supplements singularly focus on an individual ingredient, this oversimplified single ingredient approach ignores the complexity of this multi-faceted issue – an issue that undoubtedly requires a multi-faceted solution. So, in line with the product development philosophy we’ve maintained at Core Nutritionals since our inception, we’ve elevated a product category and delivered a comprehensive prostate health formula suitable to such a complex and significant issue. By scouring the available clinical research, we’ve found a veritable constellation of ingredients that address every major pathway involved in the promotion of a healthy prostate. And, with that, we give you the premier solution for maintaining an optimal functioning prostate: Core PROSTATE! \u003c\/span\u003e\u003cspan data-ccp-props='{\"201341983\":0,\"335559739\":160,\"335559740\":259}'\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePumpkin Seed Oil Powder (Cucurbita pepo)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePumpkin seed has been used in the medical treatment realm for decades, especially for its noted benefits towards prostate health improvement. The fatty acids contained in pumpkin seeds, especially delta-7-sterols, tocopherols, and other micronutrients have shown specific promise in optimizing normal prostate function. A 2014 randomized, double-blind, placebo-controlled study looked at the effects of different administrations on subjects. Subjects were split and received either sweet potato starch, pumpkin seed oil, saw palmetto oil, and pumpkin seed oil with saw palmetto oil. What the results showed was that the group given pumpkin seed oil noticed improvements in quality of life and improvements in maximal urinary flow. These same improvements were also shown in the combined pumpkin seed oil and saw palmetto oil group making them both reputable complimentary products that can benefit the health of the prostate.\u003c\/p\u003e\n\u003cp\u003eOne of the primary mechanisms of action for pumpkin seeds is to block the conversion of testosterone to dihydrotestosterone, inhibiting the enzyme 5-α-reductase. Dihydrotestosterone is classified as a powerful metabolite of testosterone with critical functions as an androgen. While androgens can be beneficial for men, when they get too high, they can negatively affect certain parts of the human body, including the prostate, leading to issues such as less than optimal prostate function. Maintaining normal levels of dihydrotestosterone in the prostate is therefore a paramount property to maintaining the normal function of the prostate.\u003c\/p\u003e\n\u003cp\u003eZinc is also critical to normal prostate function. In fact, a normal functioning prostate has the highest levels of zinc in the body. A 2011 human study found an increase in urinary zinc excretion. Pumpkin seeds are naturally high in zinc, leading to their consumption could be beneficial to extract their prostate health improving properties.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSaw Palmetto Extract (Serenoa repens) (fruit) (85% Total Fatty Acids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSaw Palmetto is a traditional herb that grows in the Southern coastal regions of the United States that has been often used to maintain normal, healthy prostate function. Growth of the prostate is believed to happen through the action of 5α-reductase, which catalyzes the conversion of testosterone to dihydrotestosterone. Dihydrotestosterone binds to nuclear androgen receptors and activates the transcription of androgen-regulated genes that are mitogenic to both epithelial and stromal cells. Due to the fact that the development and growth of the prostate gland depend on androgen stimulation, the mechanisms of action of saw palmetto include several antiandrogenic effects, such as inhibition of 5α-reductase I and II and inhibition of binding of dihydrotestosterone (DHT) to the cytosolic androgen receptors, anti-proliferative effects and anti-inflammatory effects. Several studies have shown that saw palmetto, and the mechanisms of action listed above may positively influence the prostate by helping to maintain its optimal size and function, which then equates to a healthy urinary flow and frequency.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStinging Nettle Extract (Urtica dioica) (root) (20:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStinging nettle has been widely used is traditional medicine for its benefits as a diuretic and to treat things like joint pain, eczema, arthritis, gout, and anemia. More recently, stinging nettle has been utilized for the purpose of maintaining normal urinary flow and contributing to a healthy, optimal functioning prostate. Stinging nettle has also showed effectiveness when used in combination with other herbs, like saw palmetto (above). Human studies have shown this effectiveness in these areas, like urinary flow maintenance, through their specific mechanisms of action, which were discussed in the paragraph above. The mechanism of action for stinging nettle is still somewhat unclear but it seems likely that sex hormone binding globulin (SHBG), aromatase (the key enzyme in estrogen biosynthesis), epidermal growth factor and prostate steroid membrane receptors are involved in the anti-prostatic effect. While the mechanism of action may be unclear at the present moment, the success of stinging nettle in human studies makes it a promising application for maintaining normal prostate health and function.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cp\u003eInduce G1\/S arrest of the cell cycle\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003eInduce apoptosis\u003c\/li\u003e\n\u003cli\u003eInhibit angiogenesis Regulate sex hormones and\u003c\/li\u003e\n\u003cli\u003eIncrease antioxidant activity\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePygeum Bark Extract (Pygeum africanum) (3% Phytosterols)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe bark of Pygeum africanum, also known as the African prune tree native to tropical Africa, is a compound that has often been utilized for its benefits in maintaining prostate health. The mechanism of action for pygeum remains somewhat unclear. Studies utilizing pygeum bark have also shown promise in their benefits in support the maintenance of prostate health both in vitro and in vivo. In one in vitro study in particular, results showed that pygeum bark extract was able to inhibit the growth of PC-3 and LNCaP cells, as well as induce apoptosis and altered cell kinetics, and downregulated ERalpha and PKC-alpha protein. In vivo, utilizing TRAMP mice, the application of pygeum bark extract showed a significant reduction (35%) in prostate cancer incidence compared to mice fed another substance. Another analysis looking at 18 randomized controlled trials looked at the how pygeum africanum benefitted men and prostate health. Pygeum was shown to provide a large improvement in urinary function and flow measures when compared to other men in the study not administered pygeum. Men using pygeum africanum also noticed nocturia was reduced by 19%, residual volume of urine reduced by 24%, and peak urine flow increased by 23%. These results leave pygeum administration as a potentially beneficial application for those looking to maintain normal prostate function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBeta-Sitosterol (40%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eβ-sitosterol is the most abundant plant sterol in the human diet and is also the major component of several traditional medicines, including saw palmetto and devil’s claw. It is believed to help maintain prostate function by aiding in the and ease of urinary flow. A few studies have been conducted on BS effectiveness on urinary system function and flow with promising results. One randomized placebo-controlled study on men showed promising results on these issues. Results revealed that men administered β-sitosterol noticed a more efficient flow measure and increased prostate function. While β-sitosterol can benefit from more studies, the current studies show promise and ability to work in synergy with the other components of Core’s comprehensive prostate funtion formula.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLycopene (Lycopersicon esculentum) (fruit)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLycopene, a carotenoid found largely in tomato, pink grapefruit, and watermelon, is a natural and effective nutrient that has been able to show ability in supporting optimal prostate function. Several studies have been conducted showing lycopene’s effectiveness in maintaining this prostate function in both in-vivo and in-vitro conditions. Results of these studies showed that lycopene was able to inhibit prostatic IGF-I signaling, IL-6 expression, and androgen signaling. Lycopene was also able to show improvements in gap-junctional communication and oxidative defense genes, which can be essential for maintaining prostate function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoron (as Albion® Boroganic Glycine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoron is a mineral present in multiple fruits, vegetables, tubers, and drinking water, though it is not widely accepted as either an essential mineral or essential vitamin. Boron affects a few physiological functions in the body, particularly modulating hormonal homeostasis.\u003c\/p\u003e\n\u003cp\u003eWhile still emerging, recent data suggest that boron may play a role in potentiating free testosterone levels in healthy men. In one study, otherwise healthy men were provided an acute serving of boron and had their free and total levels of testosterone, alone with SHBG (sex hormone binding globulin) and DHT (dihydrotestosterone) levels measured. In that study, total testosterone was unaltered, but free testosterone was enhanced by 14%, while SHBG was significantly (9%) reduced. Boron has also shown substantial evidence in playing a role in supporting normal prostate function, specifically through lowering PSA (prostate specific antigen), which can be a marker for prostate abnormality advancement. Other studies have shown the effectiveness of adequate boron levels on optimizing prostate health. One human study concluded that men who ingested the greatest amount of boron in their diet were 54% less likely to be at risk of prostate related issues when compared to the lowest intake.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-PROSTATE.jpg?v=1633679693\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_PROSTATE_8.5x3.25-FIN.pdf?v=1633427276\"\u003eProstate Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Prostate.pdf?v=1633428194\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40772922179760,"sku":"SHOP658580070571","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PROSTATEFRONT_19e2f4ab-9820-4e9e-ae3d-9f34afe2b481.png?v=1760376906"},{"product_id":"core-soothe","title":"Soothe","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCissus quadrangularis\u003c\/strong\u003e - improved joint integrity and function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBoswellia\u003c\/strong\u003e - promotes healthy tendon and cartilage strength..\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCurcumin\u003c\/strong\u003e - suppresses pro-inflammatory compounds\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eInflammation, aches and pains are an inescapable reality for anyone seriously engaged in bodybuilding or fitness. After all, building muscle literally involves tearing your own muscle fibers apart, forcing the body to respond with inflammation and pain. Yet the body doesn't always provide a proportional response and occasionally allows inflammation and pain to kick into overdrive. For some, the best approach to this is to be patient, let the body heal on its own time while dealing with the nagging injuries, aches and pain. For others, well, let's just say that some of us are unwilling to let anything stand in the way of our fitness goals. For those noble few, it's about pushing through the soreness as one more challenge to overcome, lest they miss out on further gains or fall behind the rest of the pack.\u003c\/p\u003e\n\u003cp\u003eIt goes without saying that rest is essential for growth and repair, however, you can’t stop living your life - especially if your goal is to CRUSH IT on the daily basis. To help ensure you lead that lifestyle day in and day out, you need to provide your body with certain nutrients capable of providing an additional layer of protection against the rigors of pain and inflammation.\u003c\/p\u003e\n\u003cp\u003eThis is exactly what Core SOOTHE offers - an additional layer of relief and protection. Formulated with clinically researched ingredients that have proven time and time again to support tissue repair, like those seen from Cissus quadragularis, antioxidant support, from Phyto-C™; and inflammatory suppression, from Boswellia, Curcumin and Ginger Extract. The synergistic nature of these ingredients is unmatched by any product that we have ever seen, as far as suppressing harmful free radical advancement, and aiding in strengthening vital supporting structures is concerned. That's what led us to developing this blend, and that's why you need Core SOOTHE.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCissus Quadrangularis Extract (stem) (5% ketosterones)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCissus quadrangularis (CQ) is a plant with a long history of use in traditional and folk medicinal systems, including thousands of years of documented use in the Siddha and Ayurvedic traditions. While the specific use of Cissus in these systems varied, the most common traditional preparations related to analgesia, general tonics, and bone fracture healing. More recent research has developed physiological explanations for CQ’s traditional efficacy, including the reduction of pro-inflammatory cytokines, modulation of the glucocorticoid system (in animal trials), and the proliferation of osteoblast (bone-forming cell) DNA.\u003c\/p\u003e\n\u003cp\u003eSpecific to bone formation, there is strong data to suggest that CQ increases the accumulation of compounds known as mucopolysaccharides – long chain sugar molecules that precede mineralization in the process of bone formation. Think of these compounds sort of like the wet newspaper before it becomes paper mache. As stated, separate research also suggests that extracts of CQ stimulated osteoblastogenesis, the process of forming bone cells.\u003c\/p\u003e\n\u003cp\u003eIn relation to its positive effects toward certain inflammatory markers, which are key factors that contribute to osteoarthritis and bone damage, CQ (along with Withania somnifera) showed promise as a remedy in some animal studies. When the model was placed under an overabundance of oxidative stress and toxicity and cell death was high, the administration of CQ inhibited the gene expression of cytokines and matrix metalloproteinases, which are known to cause bone damage and cartilage aggravation. Additionally, CQ and the combination of W. somnifera, was shown to enhance cartilage tissue formation and positively impact osteoarthritis markers. These results provide positive validation to Cissus quadrangularis effectiveness in suppressing damaging inflammatory markers and being a potential therapeutic remedy for rheumatic and other joint disorders and conditions.\u003c\/p\u003e\n\u003cp\u003eThere have also been several human studies performed to validate CQ effectiveness. One study conducted on exercise trained men with joint pain showed that the administration of CQ was able to suppress inflammatory responses as well as improve markers of osteoarthritis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoswellia Extract (Boswellia serrate) (Gum resin) (65% boswellic acids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoswellia is a tree resin extract that is a traditional part of Indian medicine. In modern clinical trials the active agent, boswellic acid, and the gum resin it contains possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids, and four pentacyclic triterpenic acids, which are responsible for the inhibition of pro-inflammatory enzymes. Out of the four pentracyclic triterpenic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. In human study’s, Boswellia has shown effectiveness in the managements of osteoarthritis and other joint related conditions. Several studies proved that Boswellia extract was effective at reducing pain and stiffness, increasing pain threshold, as well as improving overall joint function when compared to placebo. Similarly, to curcumin, boswellic acids have demonstrated a significant attenuation of NF-kB production in various animal and in vitro assays. Curcumin and Boswellia in combination as a treatment method for osteoarthritis has also showed beneficial results. One clinical human trial showed that this combination was able to increase the efficacy of osteoarthritis treatments due to its synergistic effects on oxidative stress reduction.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCurcumin (Curcuma longa) (95% Curcuminoids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCurcumin, the primary polyphenol found in turmeric (a root known for its spice), has been the basis of many clinical studies for its therapeutic properties and ability to modulate multiple cells signaling pathways in certain inflammatory diseases known to humans.\u003c\/p\u003e\n\u003cp\u003eNumerous studies seem to suggest that curcumin powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses. Conditions where curcumin can provide benefit is in the management of certain metabolic diseases, anxiety, arthritis, and exercise induced inflammation that contributes to muscle damage and soreness. Most of curcumins benefits stem from its inflammation suppressing qualities along with potent antioxidant activity.\u003c\/p\u003e\n\u003cp\u003eStudies have shown that low quality curcumin has low bioavailability and benefit, which is why we have used a high standard curcumin with 95% curcuminoids and have also included the trademarked Bioperine® in this formula. These two ingredients have a largely cohesive impact that can drastically improve the health benefit. Studies have shown that Bioperine® significantly improved curcumin uptake by upwards of 2000% at doses that proved to be clinically beneficial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGingever® (Zingiber officinale) (root) (Ginger Extract 10%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGinger is a flowering plant from the Zingiberaceae family with a lengthy history of culinary and medicinal use largely attributed to the therapeutic value of its antioxidant and anti-inflammatory properties.\u003c\/p\u003e\n\u003cp\u003eModern clinical trials have attributed the therapeutic benefits of ginger to its unique phytochemical substances (the biologically active organic compounds created by the plant) and its overall chemical composition. Ginger derives its anti-inflammatory effects from the non-volatile components found within the plant, specifically gingerols, shogaols, paradols, and zingerone. Studies have shown that these non-volatile compounds have anti-inflammatory properties with the potential to provide therapeutic relief for degenerative disorders such as arthritis and joint disorders, digestive distress, cardiovascular disorders, and other ailments. Likewise, the potent antioxidative properties of the non-volatile compounds found within ginger help alleviate age-related oxidative stress markers and have been shown to protect against ethanol-induced hepatotoxicity through suppression of oxidative stresses.\u003c\/p\u003e\n\u003cp\u003eResearch has also shown that ginger serves an effective inflammatory mediator able to decrease swelling, pain, and other inflammatory markers, especially with through the actions of [6]-gingerol. Here, data suggests that the anti-inflammatory action of ginger occurs through the inhibition of macrophage and neutrophil activation, as well as negatively affecting monocyte and leukocyte migration. According to the results of a study conducted on rats, there was a marked decrease in inflammatory cells infiltration and swelling, as well as an increase in antioxidant capacity, after the administration of ginger and its bioactive components. Core Nutritionals has chosen to use the patented Gingever® as its source of Ginger for Life Line’s Soothe as it is a highly potent extract consisting of 10% of these beneficial gingerols\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhyto-C™ (Acerola extract, blueberry, strawberry, maqui berry, acai, tart cherry, kale, broccoli, green tea extract, green coffee bean extract, turmeric extract)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhyto-C™ is a trademarked complex blend of antioxidant rich superfoods clinically formulated to deliver a host of immune system supporting benefits. Combining ingredients such as blueberries, acai, tart cherry, kale, broccoli, green tea, turmeric, and others, you are ensuring that your body is being provided clinically proven and laboratory tested superfoods that will protect against free radicals and other cell destroying compounds. This neutralization of free radicals can protect vital cells, prevent illnesses, and reduce overall inflammation. Inflammation can disrupt normal cell processes thus leading to cell damage and disease. Inflammatory cells produce mediators such as cytokines, arachidonic acid, and other factors, which can precipitate a cascading negative reaction within the body. If this inflammation is not addressed in a reasonable manner, potentially permanent cell damage can occur. The key is to reach a point of equilibrium between free radical formation and antioxidant defense mechanisms. As a potent antioxidant source, Phyto-C™ can provide beneficial antioxidants for the body that can aid in this equilibrium and work to boost the immune system and overall health of the human body\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioperine® (Black Pepper Extract) (Piper nigrum) (fruit) (std. to 95% Piperine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of neighboring nutrients. When suppressing inflammation, overall efficiency and rapid delivery to the targeted cells have a multiplicative impact that enhances the overall therapeutic value of the administered compounds and nutrients. BioPerine® helps to increases the bioavailability and absorption of the aforementioned ingredients within Core Soothe.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients. Several studies looking at BioPerine® and its impact on nutrient absorption have been conducted with promising results. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks onBioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core Life Line’s inflammation suppressing product, Core Soothe.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-SOOTHE.jpg?v=1633679718\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_SOOTHE_8.5x3.25-FIN.pdf?v=1633430248\"\u003eSoothe Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Soothe_Product_References_1.docx?v=1633596179\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40773322604720,"sku":"SHOP658580070588","price":54.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/SOOTHEFRONT_d49b35b5-6b13-4639-b164-22ce77a7d584.png?v=1760382499"},{"product_id":"core-heart","title":"Heart","description":"\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHawthorne Berry Extract\u003c\/strong\u003e - blood vessel antioxidant support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBergamot\u003c\/strong\u003e - healthy cholesterol support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResveratrol\u003c\/strong\u003e - enhanced overall cardiovascular function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eEvery set, rep and mile, every breath, even your thoughts - ultimately every single one is driven by your heart. As the body’s engine and delivery system, no one escapes the undeniable need for a healthy cardiovascular system. For the driven athlete - such as those living the Crush It lifestyle - the aggregation of marginal gains provided by improving your cardiovascular health promises to elevate performance throughout your fitness regimen.\u003c\/p\u003e\n\u003cp\u003eAnd yet, few list improving cardiovascular function as a key priority within their fitness goals. You see, while the heart occupies the kind of rarified air reserved for central components of only the most vital bodily systems, its function is involuntary, its improvements invisible. You don’t have to think about beating your heart, it is done for you. What’s more, a well-maintained, highly trained heart muscle won’t get you noticed at the beach.\u003c\/p\u003e\n\u003cp\u003eThat said, however, our heart is one of the most important organs in the body and communicates, assists or supports literally every other major organ system. Without an efficient blood supply, your lungs will provide less oxygen to the muscles and access to key nutrients is reduced throughout the body, resulting in less effective workouts and suboptimal recovery. So, due to our passion for fitness, as well as our desire to help our customers improve and actualize their fitness goals, we've developed a clinically backed formulation for our new premier cardiovascular health supplement: Core HEART.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as Zinc Bisglycinate Chelate TRAACS®)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eZinc is an essential micronutrient and mineral that has been shown to affect the heart by modulation of cardiomyocyte oxidative stress and maintenance of myocardial structure. When cross sectional studies have been conducted, zinc deficiency has frequently been found to be a common link in those who have suffered heart related traumas. Myocardial tissue requires zinc in small quantities to maintain the extracellular structure formed by matrix metalloproteinases and to serve as a cofactor in free radical oxidation reactions catalyzed by superoxide dismutase (an enzyme that helps break down potentially harmful oxygen molecules in cells. When chronic inflammation is present, plasma zinc deficiency may lead to a relative deficiency in antioxidant enzymes, ultimately contributing to apoptosis and myocardial necrosis. As the lack of cardio function and zinc levels tend to decline with age, ensuring zinc optimal zinc levels can be of an importance in maintaining cardiac optimal cardiovascular function as one ages\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin K2 (as MenaQ7®, Menaquinone-7)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAdequate intake of vitamin K2 has been shown to significantly benefit cardiovascular function. Lifestyles and eating habits in the traditional western diet can often contribute to an accelerated calcium deposit in blood vessel walls and soft tissues, which can lead to dysfunctional cardiovascular health. Calcium does serve many vital roles in the human body, such as muscle contraction, nerve signaling, blood clotting properties, and blood vessel contraction and expansion. It is also recommended in a supplemental form for those individuals who are suffering from bone related declines for support. So yes, calcium is beneficial for heart health and a wide variety of bodily functions. Where calcium can become less beneficial is when it is overconsumed and renders normal calcium concentrations in the blood ineffective. So, there is evidence to show that serum levels of calcium in the upper normal range increase risk of cardiovascular function declines due to elevated blood clotting and calcium deposition in blood levels.\u003c\/p\u003e\n\u003cp\u003eEnter, vitamin K2, which specifically has been shown to inhibit this arterial calcification and arterial stiffening through its ability to activate matrix GLA protein, which inhibits calcium from forming deposits on the vessel walls. Vitamin K2 also is essential for maintaining blood homeostasis, as well as optimal bone and heart health through its role in inducing calcium use by proteins. With vitamin K2 being almost non-existent in typical diets on the western part of the world (partly due to our traditional eating habits), supplementation can be crucial to lowering risk of cardiovascular function decline. One study conducted using supplemental Vitamin K2 showed that consistent use of small doses (specifically Mena Q7) were enough to improve bone mineral density, bone strength, and cardiovascular health through the mechanisms of action listed above. The increase of calcium usage for purposes of osteoblast usage, increasing arterial elasticity, and reduction in age related arterial stiffening make vitamin K2 an essential mineral for optimal cardiovascular function and health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (as Cholecalciferol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an import and biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHawthorne Berry Extract (Crataegus oxyacantha) (fruit) (4:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHawthorne has been utilized for many centuries for its wide range of health benefits. One of these primary benefits is how it positively affects the cardiovascular system. The berries, or fruit, of the plant contain high amounts of bioflavonoids and proanthocyanidins, substances shown to contain most of the health promoting qualities. These antioxidants have several mechanisms of action on the cardiovascular system. Hypotensive (lowering blood pressure) improvements can be seen through vasorelaxation through the stimulation of nitric oxide production. Several studies have investigated this benefit on blood pressure as well. One human study conducted on individuals with high blood pressure showed that the administration of 1200mg of Hawthorn Berry (slightly more than what we use in this product), noticed substantial improvements in blood pressure when compared to placebo.\u003c\/p\u003e\n\u003cp\u003eHawthorne Berry can also play a role in preventing atherosclerosis, or a buildup of plaque in the blood vessels that occurs due to an imbalance in blood fat levels (typically high triglycerides and low HDL cholesterol). If this plaque continues to accumulate, it can lead to blockages in the blood vessels carrying blood to vital organs, ultimately resulting to heart attack or stroke. Anti-atherosclerotic improvements can be seen through the downregulation of capsase-3 gene expression. The capsase-3 gene is known for being a proapoptotic (cell killing) gene that has been reported in heart failure and myocardial infarction (heart attack). The regulation of lipoprotein lipase (regulates the delivery of fats to body tissues) expression and raised excretion of bile acids can also benefit the arteries. Several animal studies have examined the positive impact of Hawthorne Berries on cholesterol. One study on mice showed that mice given the extract resulted in a lower total and LDL cholesterol, as well as between 30-45% lower liver triglyceride levels compared to mice that were not administered the extract.\u003c\/p\u003e\n\u003cp\u003eOn cardiac cells, these antioxidants downregulate capsase-3 gene expression and inhibit 3’,5’-cyclic adenosine monophosphate phosphodiesterase, which can result in an increase in coronary flow, increase in relaxation velocity, and cause a positive inotropic effect (increase the strength of heart muscle contraction).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOlive Extract (Olea europaea) (leaf) 20% Oleuropein)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOlea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea. As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.\u003c\/p\u003e\n\u003cp\u003eOleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Research shows that olive leaf extract can benefit the heart by helping to prevent LDL cholesterol from building up in the arteries. This process can increase blood flow and lower blood pressure, which can thus reduce the risk of heart disease.\u003c\/p\u003e\n\u003cp\u003eRed Yeast Rice (Monascus purpureus)\u003c\/p\u003e\n\u003cp\u003eRed yeast rice is traditional Asian preparation of the rice grain with an extensive history dating back to 300 BC. The rice is fermented in a culture of yeast called Monascus purpureus, which transfers in bright red coloration to the white rice grains. In part due to its centuries of use in traditional Chinese medicine, red yeast rice is widely recommended in regimens intended to help establish normal cardiac function and lipid profiles.\u003c\/p\u003e\n\u003cp\u003eMore recent studies suggest the fungal metabolites found within red yeast rice demonstrate a positive impact on cholesterol and cardiac function. Specifically, a fungal secondary metabolite found within red yeast rice, known as monacolin K, has been shown to of particular interest. The primary mechanism of action of monacolin K is inhibition of the key enzyme, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, involved in cholesterol synthesis. Upon further evaluation of the lipid lowering properties of red yeast rice, recent research revealed them to be multifactorial, including the ability to downregulate the rate limiting step of hepatic cholesterol biosynthesis in a dose-dependent manner, indirectly cause an upregulation or availability of LDL-receptors in the liver, and possibly increase the hepatic excretion of bile acids, thereby creating an increased need for the availability of intrahepatic cholesterol for use in the synthesis of additional bile. The reduced intrahepatic cholesterol concentrations result in the upregulation or availability of LDL-receptors in the liver. The purpose of these additional LDL-receptors is to pull cholesterol out of circulation and bring it into the liver as a replacement for the reduced production inside the liver. When this happens, the plasma cholesterol levels will decrease through a reduction in the hepatic synthesis of cholesterol and through an increase in the removal of circulating cholesterol from blood plasma into the liver for use. These actions can help restore cholesterol levels to where they benefit cardiac and other bodily function.\u003cstrong\u003e Note: If you are taking other statins or other cholesterol lowering medication, please consult with your physician prior to supplementing with Core HEART.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBergamot Fruit Extract (Citrus aurantium bergamia) (30% Polyphenols)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBergamot, a citrus fruit native to southern Italy, has often been used to improve immunity and cardiovascular function. These benefits have been traced back to the phytochemicals and flavonoids that are contained within bergamot. Multiple studies have been conducted to show the efficacy of orally administered bergamot on reductions in total cholesterol and LDL cholesterol 1, where the end goal is the restoration of overall cardiovascular function and vessel health. The primary mechanism of action for the therapeutic phytochemicals found within bergamot is the inhibition of oxidation of low-density lipoprotein particles. When oxidation occurs to LDL particles, it produces a harmful form of cholesterol because of the damage caused by free radicals. This oxidative damage has been specifically linked to altered cardiovascular blood flow and cardiovascular vessel diseases. Phytochemicals such as naringin, neoeriocitrin, and rutin have been shown in vitro to possess antioxidant properties and ability to lower the oxidation of LDL particles.\u003c\/p\u003e\n\u003cp\u003eIn addition to the animal studies, several human trials have been conducted analyzing the benefits of bergamots. One 2011 randomized, double blind, placebo controlled clinical trial looked at the impact of bergamot administration for 90 days on total cholesterol, LDL levels, and HDL levels in patients. The results showed that 500mg of bergamot reduced total cholesterol (20%) and LDL (23%), while increasing HDL levels (26%). This is just one example but results of other studies show promise in bergamot’s cholesterol improving benefits as well as optimizing overall cardiovascular function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCurcumin (Curcuma longa) (root) (95% Curcuminoids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTurmeric is a root endemic to certain regions of Southeast Asia and India, and has been a staple in the Siddha traditional medicinal system for thousands of years. Turmeric is noted in Siddha texts for various uses, including as an ancient equivalent of an anti-microbial agent.\u003c\/p\u003e\n\u003cp\u003eMore recently, numerous studies seem to suggest that its primary bioactive constituent, curcumin, powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses.\u003c\/p\u003e\n\u003cp\u003eThough turmeric contains approximately 5% curcumin by weight, we have used a highly standardized extract of 95% - recognizing that the wealth of research on curcumin demands that it be included in clinical serving sizes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePolygonum cuspidatum Extract (root) (50% trans-Resveratrol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eResveratrol is a polyphenolic stilbene produced by various plants. Trace amounts of resveratrol can be obtained from certain foods but the clinical doses used for studies involving cardiovascular function are at much higher concentrations than can be likely received through dietary means. While the half life of resveratrol is relatively low (4-8 hours) after oral administration, a large number of animal studies have shown beneficial effects for cardiovascular function. The specific mechanisms of action for resveratrol are somewhat unclear, but studies have shown many positive benefits tracing back to decreases in oxidative stress response, increases in endothelial function, leading to more efficient diastolic function, cardiac remodeling, myocardial energetics, and vascular function. The proposed mechanism for the inflammation mediating effects can be brought back to an increased activation of the silent information regulator factor 2 related enzyme 1 (SIRT1). SIRT1 has been shown to protect against cardiac decline related inflammation. When studied, cells from mice with a SIRT1 knockout have shown increased pro-inflammatory cytokine levels. With resveratrol being a known activator of SIRT1 in animals, it is led to believe that the same mechanism can be beneficial in humans. This mechanism, along with other benefits on blood pressure (increased NO production), make resveratrol a valuable compound in establishing normal cardiac function and baselines of cardiac health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoenzyme Q10 (Ubidecarenone)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCoenzyme Q10, which is synthesized in the mitochondrial inner membrane, is an essential compound that plays many vital roles in the human body. Of these many roles, it is a key component in the electron transport chain in mitochondria necessary for ATP production. CoQ10 can also act as an intercellular antioxidant, protecting the plasmatic membrane against peroxidation. CoQ10 deficiency has been associated with less-than-optimal health status in organisms and has contributed to certain degenerative states involving blood sugar, the cardiovascular system, and musculoskeletal system. In relation to the cardiovascular system, oxidative stress is one of the main causes of cardiac decline. The antioxidant properties of CoQ10 are of particular importance in establishing normal function. It has been shown that individuals suffering from cardiac related abnormalities have significantly lower levels of CoQ10 as opposed to those with higher levels. With antioxidant effect and free radical neutralization being the primary mechanism of action, CoQ10 exhibits a secondary mechanism of action of well in playing a large role in the heart’s energetic needs. The process of cardiac contraction requires the release of Ca2+ from the SR and the following activation of the contractile proteins requires energy. It is believed that when there is myocardial failure, it is caused by a reduction in the production of energy from the mitochondria. This goes back to CoQ10s property of being a main component in the transport of electrons that are needed for ATP production. These two mechanisms of action have a particular importance for one’s quality of life as well as in maintaining proper cardiovascular function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioperine® (Black Pepper Extract) (std. to 95% Piperine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by. In this specific product for Core HEART, it is included because it dramatically increases the bioavailability of curcuminoids (see above). Without Bioperine, the serum concentration and absorption rates of the active agents in curcumin would be significantly reduced.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at the impact of BioPerine® on nutrient absorption have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core HEART.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-HEART.jpg?v=1634282355\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_HEART_8.5x3.25_FIN-OL.pdf?v=1634206628\"\u003eHEART Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Heart_Product_References_1.pdf?v=1634282698\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40813444366512,"sku":"SHOP658580070502","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HEARTFRONT_ec9289e7-3c06-4b10-b27e-869d089bb4e1.png?v=1760376692"},{"product_id":"core-liver","title":"Liver","description":"\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMilk Thistle Extract\u003c\/strong\u003e - hepatic stress suppression\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKatuki Extract\u003c\/strong\u003e - enhances bile production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTUDCA\u003c\/strong\u003e - enhance liver protection\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eFor many athletes, the liver isn’t the first thing that comes to mind when they think about optimizing their gains and recovery. Yet the liver has an undeniable impact on your overall health and fitness. Its actions aid in the filtering of harmful substances from the blood, production of proteins that carry hormones, drugs and fatty acids throughout the body, creates bile to breakdown fats, and stores glycogen, vitamins and other minerals for use in everyday processes. Conversely, the consistently elevated levels of muscle damage, excessive protein intake and stimulant use typical for your average weightlifter places additional stresses on the liver, leading to increased oxidative stress, liver damage and elevated markers of liver function.\u003c\/p\u003e\n\u003cp\u003eThis dynamic opposition, where liver function is essential for overall fitness and growth while the very processes involved in body recomposition can cause damage and reduce function, requires an effective remedy to aid with short term fitness goals, as well as long term liver health and function. Enter Core LIVER - our comprehensive liver support and detoxification supplement.\u003c\/p\u003e\n\u003cp\u003eWith overall liver health and function in mind, we scoured the available clinical research studies to formulate a liver supplement provides remedial support and protection through multiple metabolic pathways and mechanisms. Overall, this formula helps to provide protection against free radicals and liver damage, enhances liver function, and aids in detoxification. Don’t neglect your liver health or Core LIVER and keep living the Crush It lifestyle.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Thistle Extract (Silybum marianum) (seed) (80% silymarin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSilybum marianum, also known as milk thistle, is a medicinal thistle from the aster or daisy family that has been used in traditional medicines for many centuries for treatment of many different diseases. Many of these treatments have been to protect the liver and associated organs from damage\/further damage. There is evidence to support that milk thistle, and specifically the silymarin compound that is found within it, exhibits a mechanism of action for hepatoprotection from free radicals through antioxidant activity, enhanced protein synthesis, and possible anti-inflammatory or immunomodulating effects. These free radicals are generated through the damage to cellular membranes called lipoperoxidation. Additionally, silymarin also enhances liver glutathione production through the inhibition of hepatocyte glutathione reduction. This can further contribute to the antioxidant support and defense for the liver. Several studies have shown improvements in liver function in individuals with certain liver diseases leading to these proposed benefits. In one in vitro human study in particular, silymarin was shown to inhibit T-cell proliferation and proinflammatory cytokine secretion in a dose-dependent manner. Higher doses of silymarin were shown to specifically control hepatic inflammation responses in chronic liver diseases. It is important to note that in relation to liver diseases, milk thistle has been studied as a complimentary treatment method to traditional treatments and that it is important to live a healthy lifestyle to prevent these diseases as much as possible.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKatuki Extract (Picrorhiza kurroa) (rhizome and root)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKatuki, known by its botanical name Picorrhiza kurroa, comes from the Scrophulariaceae family. Picorrhiza, coming from the Greek word ‘Picroz’, means ‘bitter’ and ‘rhiza’ meaning ‘root’. This bitter quality is what katuki has been touted for its therapeutic benefits and is said to be cooling, cleansing, and possess anti-bacterial properties. Katuki has been shown to possess potent hepatoprotective and hepatostimulative properties to offer support to the overall function of the vital liver organ. Katuki offers support by stimulating the secretion of bile, which assists the liver enzymes in coming back to homeostasis. Additionally, katuki contains a compound called picroliv, or kutkin. This compound is mainly a glucoside (derived from glucose and most commonly found in plants) and is normally isolated from the roots and rhizomes of Picorrhiza kurroa for the uses to treat certain liver ailments. In rodents, picroliv has shown efficacy that can be similar to silymarin in models that have shown hepatic damage. As mentioned above, silymarin is a highly effective compound used in the controlling of hepatic inflammation which can lead to hepatic trauma. When chronic oxidative stress, toxins, and free radicals that can wreak havoc on the liver can be controlled, the function of the liver can be enhanced, thus creating a cascading sequence of related optimally functioning actions. Some of these actions include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ethe filtering process of the bodies blood from any poisonous substances like alcohol and other drugs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ethe production of a blood protein called albumin that is helpful in carrying hormones, drugs, and fatty acids throughout the body as well as aiding in the bodies blood clotting abilities following injury.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ethe production of bile, which is essential for the breakdown and digestion of fats and transport of other waste.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThe storage of glycogen, vitamins, and other minerals that can be used for normal everyday processes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSetria® Glutathione\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlutathione is an amino acid containing molecule of L-glutamic acid, L-cysteine, and Glycine that is particularly concentrated in the liver. The liver has a unique ability to synthesize cysteine, a glutathione precursor, from endogenous sources through the trans-sulphuration pathway or through protein breakdown and food. It is vital to many different properties and is best known for being a powerful antioxidant. It also plays a key role in the detoxification reactions in the liver and in regulation of the thiol-disulfide status of hepatocytes. The ‘glutathione system’ comprises the enzymes that synthesize glutathione within a cell as dedicated enzymes that use glutathione for its antioxidant effects. Glutathione supplementation is thought to support this pool of glutathione present in cells and thus maintain the efficacy of the entire system. This supplementation can be even more important if chronic disease is seen as “drying up” this pool of antioxidant rich compounds. Free radicals and toxins can be a byproduct of many different things such as exercising or poor physical health, eating, and daily unhealthy lifestyle activities to name a few. When these molecules overcome the body at the cellular level, this constant barrage can have negative impacts on health and overall wellness. This overabundance of oxidative stress can contribute to pathogenesis of many liver diseases, as well as exacerbate preexisting conditions. Setria® L-Glutathione provides a potent supply of antioxidants that bind these free radicals, which can help keep them from causing lasting damage. There have been some conflicting reports on whether oral glutathione supplementation was a viable way of increasing serum glutathione levels as opposed to intravenous methods. One long-term, randomized, placebo-controlled study on the effects of oral glutathione supplementation showed that dosages as low as 250mg of Setria® Glutathione were able to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease whole blood levels of glutathione by 17%\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease levels of glutathione in erythrocytes (white blood cells) by 29%\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis study, as well as others, shows that supplementation of glutathione and precursors to glutathione can be a reliable compliment to traditional therapies for many hepatic and hepatic related conditions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTUDCA (Tauroursodeoxycholic Acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTUDCA gets its acronym as being the taurine conjugate of ursodeoxycholic acid (UDCA), a secondary bile acid that is produced only by intestinal bacteria. UDCA was originally FDA approved for the treatment of certain cholestatic liver diseases based on its ability to protect hepatocytes (liver cells) from hydrophobic bile acids. Cholestasis occurs when bile acids get backed up in the liver and there is room for metabolism. These bile salts can be damaging to the cell membranes of nearby tissues, in particular liver tissues, and can begin to signal for cell death (apoptosis). TUDCA works through a mechanism of action that shows its ability to inhibit liver cell apoptosis by interfering with the mitochondrial pathway of cell death, inhibit oxygen-radical production, and reduce endoplasmic reticulum stress. The endoplasmic reticulum acts as a highway between the nucleus of a cell and the cytoplasm and is heavily involved in protein and lipid synthesis. Through this reduction in ER stress, TUDCA has garnered a reputation as being a beneficial remedy for a wide range or metabolic diseases, and for being a neurological protection agent. Although TUDCA has been shown to possess wide ranges of benefits, its most common and practical use has continually been seen in the ability to provide protection and overall health for the liver.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioperine® (Black Pepper Extract) (Piper nigrum) (fruit) (std. 95% piperine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have continually shown improvements in bioavailability of nutrients it is surrounded by. When it comes to post exercise nutrition, efficiency and speed with which nutrients can enter the system and get to their target is of the upmost importance. The “window of opportunity” is much larger than what has been previously thought, but when your results weigh heavily on post-exercise nutrition, maximal absorption and use of nutrients is extremely important.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at BioPerine®’s impact on oxidative stress have been performed. One study conducted on rats in 2013 looked at the influence of piperine on rats with developed disorders such as hypertension, increased inflammatory markers, and increased plasma liver enzymes after being fed a high carbohydrate and high fat diet. The results showed that after 16 weeks of supplementation with piperine these rats experienced normalized blood pressure, improved glucose tolerance, reduced markers of oxidative stress and inflammation, and improved liver function.\u003c\/p\u003e\n\u003cp\u003eWith more promising research being done on the effects of BioPerine® in the context of nutrient absorption, bioavailability, and its influence on certain health markers, it is only fitting that we include it in Core Life Line’s Liver support product.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-LIVER.jpg?v=1634282355\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_LIVER_8.5x3.25-FIN.pdf?v=1634206553\"\u003eLiver Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Liver_Product_References.pdf?v=1634282554\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":40813449248944,"sku":"SHOP658580070564","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/LIVERFRONT_0b2981cf-fdad-4666-b228-2e24d3c96047.png?v=1760376747"},{"product_id":"crush-it-coliseum-hoodies","title":"Crush It Coliseum Hoodies","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e50\/50 Cotton\/Poly 8oz Fleece\u003c\/li\u003e\n\u003cli\u003eFeatures convenient pouch pocket, matching drawstrings, and unrivaled durability\u003c\/li\u003e\n\u003cli\u003ePremium soft heavyweight hoodie\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Small","offer_id":41317130666160,"sku":"","price":44.99,"currency_code":"USD","in_stock":true},{"title":"Medium","offer_id":41317130698928,"sku":"","price":44.99,"currency_code":"USD","in_stock":true},{"title":"Large","offer_id":41317130731696,"sku":"","price":44.99,"currency_code":"USD","in_stock":false},{"title":"X-Large","offer_id":41317130764464,"sku":"","price":44.99,"currency_code":"USD","in_stock":false},{"title":"XX-Large","offer_id":41317130797232,"sku":"","price":44.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Coliseum-Hoodie3.png?v=1756752908"},{"product_id":"core-puddn","title":"Pudd'n","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCasein Protein Blend:\u003c\/strong\u003e Slow absorbing protein with a velvety texture.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Enzyme Blend:\u003c\/strong\u003e Supports healthy protein, carbohydrate, and fat breakdown.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConfectionary Inclusions:\u003c\/strong\u003e Added burst of flavor and texture in every bite.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eRaise your hand if you enjoyed single serving cups of PUDDN as a kid. Now… raise your hand if you want to enjoy PUDDN as an adult. Well, your wait is over. Introducing Core PUDDN!\u003c\/p\u003e\n\u003cp\u003eWith Core PUDDN, we chose the protein blend and flavors with your inner child in mind. Our mix of casein protein, whey concentrate, and milk protein isolate creates a robust and complete amino acid profile that has been shown in research to increase lean muscle growth. This specific protein blend along with added coconut oil creamer creates an amazingly smooth and velvety texture. Then we added decadent confectionary inclusions that will explode with flavor in every bite. You’ll easily be thinking your cheating on your diet with this PUDDN.\u003c\/p\u003e\n\u003cp\u003eWe challenge you to find another night time protein blend that checks off all of these boxes. Texture, flavor, added inclusions… the last thing you want to do is have to choke down some rough tasting protein powder with a chalky texture just to ensure your body is nourished while you sleep. Well, now you can enjoy a decadent dessert like treat while you get ready to go dream about making gains! Grab yourself some Core PUDDN!!!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicellar Casein\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCasein protein is the protein primarily found in the curds of milk and is roughly 75-80% of all milk proteins. Casein provides all essential amino acids, except cysteine, and has a high digestibility and bioavailability, making it a high-quality protein source to ingest. While whey protein contains a higher proportion of leucine, isoleucine, and valine, casein contains a higher proportion of other non-essential amino acids making them great compliments when they are combined in consumption (which will be discussed below).\u003c\/p\u003e\n\u003cp\u003eCasein exhibits a slow absorption and release of amino acids in to the body. This slow release contrasts the relatively efficient release of your standard whey protein concentrate. Due to this, casein has often been touted as the perfect “bedtime protein” so that the slow, yet steady release of amino acids can occur when the body is not in an active state for a lengthy period of time. The benefits of this allow for the body to remain satiated with amino acids through the night as well as increase muscle protein synthesis to maximize muscle recovery. Consumption of casein and whey protein before bed also has positive influence on the next morning resting metabolic rate. Several studies have demonstrated the positive benefits of consuming casein and post-exercise recovery. Although one can make the argument that any protein intake post exercise will increase recovery. The most important thing to remember is that any protein intake prior to sleep will be beneficial but the benefit of a slow releasing protein through the night can keep muscle satiated through the night when nutrients are needed for recovery.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCold Processed Undenatured Whey Protein Concentrate\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhey protein concentrate is probably the most common form of whey protein you will find. However, how it is processed is where the benefit truly lies. This process of cold processed undenaturization preserves the molecular structure of the amino acid particles as well as the immune boosting benefits that it contains. This undenatured protein is also a rich source of amino acids, including those needed for the synthesis of glutathione, which is an important antioxidant that can be depleted by stress (exercise stress included). This makes it a great foundation for your post workout recovery nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoconut Oil Creamer\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCoconut oil made of 100% Medium chain triglycerides has been shown to have the greatest health benefits. MCTs are made up of a chemical structure that allows them to quickly and effectively bypass gastric uptake for transport directly to the liver for oxidation and then used for energy. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Protein Isolate\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003emilk protein isolate is obtained through the partial removal of non-protein materials from skim milk (lactose and other minerals). What you are left with is a dry product that contains more than 90% protein by weight. This product contains both casein and whey proteins in their original proportions found in milk, without combining separately produced casein and whey proteins. It contains very little fat and lactose and also has a very high amino acid composition making it a perfect addition to this blend.\u003c\/p\u003e\n\u003cp\u003eThis blend has also been specifically configured to provide both rapid and sustained additions to your body’s amino acid profile – meaning your recovery is not only supported immediately after a session but will also carry you to your next meal. On top of that, our flavors are out of this world! We’ve also boosted this protein blend with digestive enzymes that will provide you with all of the confidence that those nutrients you just supplied your body with will do their part in your quest for the optimal result!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDigeSEB™ (Digestive Enzyme Blend: Amylases, Lactase, Proteases, Lipase, Cellulase)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOne can easily make the argument that dietary enzymes – and in particular, digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc.).\u003c\/p\u003e\n\u003cp\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products. For a whey product, in particular – a compound that requires significant digestion and breakdown – this is madness.\u003c\/p\u003e\n\u003cp\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In Core PUDDN, we have included a digestive enzyme blend called DigeSEB™ comprised by amylases, proteases, lactases, amylases, and cellulases, allowing for a full and complete breakdown of all PRO’s components. Research suggests that whey absorption through the blood is heavily impacted by its gastric digestibility. Using DigeSEB™ ensures that the protein – along with its milk and whey sugars and fats – are completely broken down.\u003c\/p\u003e\n\u003cp\u003eDigeSEB™ ensures that Core PUDDN not only provides gourmet taste and clinical ingredients within the protein itself, but that your protein also increases the effectiveness of your pre and post-workout nutrition in general.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-PUDD_N.jpg?v=1646123201\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Puddn-MT-CookieDough-Final-_2_92887d57-a80e-466e-abff-cf9c34991db3.jpg?v=1720450190\" target=\"_blank\"\u003eCookie Dough Moose Tracks Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_PUDDN_2lb_ROCKYROAD-FIN.pdf?v=1646037480\" target=\"_blank\"\u003eRocky Road Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_PUDDN_2lb_MOOSE-CHOCOLATE-FIN_compressed.pdf?v=1677055556\" target=\"_blank\"\u003eChocolate Moose Tracks Lebel \u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_PUDDN_2lb_MOOSE-ORIGINAL-FIN_compressed_1.pdf?v=1677055736\" target=\"_blank\"\u003eOriginal Moose Tracks Lebel\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PUDDN-REFFERENCES.pdf?v=1646037601\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Cookie Dough Moose Tracks","offer_id":43768826265776,"sku":"SHOP850057789119","price":35.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/PuddinCookieDough.png?v=1756686803"},{"product_id":"crush-it-kids-multi™","title":"Crush It Kids' MULTI™","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eFull daily serving (or more) for most key vitamins and minerals kids need.\u003c\/li\u003e\n\u003cli\u003eSupports proper nutrient balance in children\u003c\/li\u003e\n\u003cli\u003eNaturally flavored and delicious gummies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eDoes your child have unaddressed gaps in their essential nutritional needs?\u003c\/p\u003e\n\u003cp\u003eWouldn’t you do everything you can to ensure your children are able to put in the same effort and intensity to CRUSH IT on the daily as you do?\u003c\/p\u003e\n\u003cp\u003eIf you said yes to the questions above, your search is over! We’ve taken the passionate and data driven approach we use for all our other products to create a comprehensive, high quality nutritional option for the next generation of the Crush It Crew! We developed this formula to provide the essential vitamins and minerals necessary for the development of their bodies as they age so they grow into confident, powerful and healthy adults.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eThese delicious naturally flavored gummies were formulated to give our growing children 13 essential nutrients required for optimal growth and development.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamins A, C, D, E, \u0026amp; Zinc-\u003c\/strong\u003e Optimal immune system function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamin D-\u003c\/strong\u003e Strong teeth, joint, and bone formation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamins A, C, D, E, Biotin, \u0026amp; Zinc-\u003c\/strong\u003e Healthy vision and strong hair, skin, and nails.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIodine-\u003c\/strong\u003e Optimal thyroid function essential for growth, development, and metabolism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamins B6, B12, Biotin, Folate, Pantothenic Acid, and Inositol-\u003c\/strong\u003e Efficient break down of other nutrients for use as energy to function and to build strong tissues and to support muscles, and organs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamin B-6, B-12, E, Choline, Inositol, and Folate-\u003c\/strong\u003e Optimal brain development and cognitive function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWith these amazing flavors and a candy-like delivery system, your kids will never realize they’re contributing to their healthy growth and development!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-KIDSMULTI.jpg?v=1646986094\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_kids_MULTI_250cc-FIN.pdf?v=1646900857\"\u003eCrush It Kids' MULTI™ Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eReferences\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":41451595727024,"sku":"SHOP658580070670","price":24.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/products\/multi-kids.png?v=1646901743"},{"product_id":"lifeline-hair-skin-nails","title":"Hair, Skin, \u0026 Nails","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eBIOTIN \u003c\/strong\u003e- Can increase keratin production and rejuvenate hair follicles\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeratin Peptides \u003c\/strong\u003e- Main protein found in hair, skin, and nails\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAstrion™\u003c\/strong\u003e- Can increase the synthesis of collagen and hyaluronic acid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCeramosides™ \u003c\/strong\u003e- Can increase skin lubrication leading to more health, vibrant looking skin\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eMost bodybuilders and fitness enthusiasts completely overlook their skin when considering dietary and fitness supplementation, despite it being the largest organs in the human body. Likewise, both hair and nails also fail to receive much attention in this area. While many may point to hair, skin and nails as an aesthetic issue that has nothing to do with your overall health, this is not the case. All three are major indicators of internal homeostasis and overall health, while providing key protection to sensitive areas of your body.\u003c\/p\u003e\n\u003cp\u003eWithout additional nutritional supplementation, our hair, skin and nails inevitably suffer from the natural aging process and environmental damage. As we age, our body gradually loses its ability to produce or absorb key vitamins and nutrients as well as efficiently produce collagen, reducing the firmness of our skin and leading to wrinkles. Meanwhile, we also subject our bodies to a variety of environmental toxins and damaging UV radiation, all of which causes serious damage.\u003c\/p\u003e\n\u003cp\u003eHAIR, SKIN and NAILS addresses these often overlooked but important bodily components with a wide array of ingredients formulated to boost collagen synthesis, improve skin hydration, reduce wrinkles and fine lines, strengthen hair, reduce oxidative stress and support cellular and tissue health. Look your best on the outside while feeling your best on the inside with Core Lifeline HAIR, SKIN and NAILS!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C (as Ascorbic Acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is not only a powerful antioxidant, but also supports a healthy immune system, protects cells from oxidized particles and free radicals, and assists other physiological functions. It also has a key function is stimulating collagen formation, which is a major component of most of our body’s tissues, including hair, skin, and nails.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiotin (as d-Biotin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin B7, also known as biotin, is a crucial nutrient for achieving this goal. While many people can get enough B7 through diet alone, there are cases where people may want to try a supplemental form to achieve improved hair and nail health. The main mechanism of action for biotin and its hair health promoting benefits comes from its proposed ability to help in preventing hair loss by rejuvenating both the hair follicles and scalp. Biotin additionally plays a role in breaking down the dietary proteins into different amino acids required for the formation of keratin (specific protein of hair, skin, and nail cells). Increasing keratin production in the body promotes the production of healthy hair follicles. While biotin is highly prevalent in our bodies all the time, having additional biotin can further strengthen these specific cells to further prolong their health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMSM (Methylsulfonylmethane)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMSM is a naturally occurring, organosulfur molecule that can be synthesized both naturally and synthetically from DSMO. While the majority of MSM present in the human body is ingested – either deliberately or accidentally – the compound does have a natural presence in certain tissues and fluids in the body, including cerebrospinal fluid. While generally used for its benefits towards arthritis and pain relief, MSM also helps to form keratin, which as discussed above in the main protein found in hair, skin, and nails. It possesses the ability to form bonds that are vital to the strengthening of hair cells and influencing hair growth. With the primary mechanism of action being to act as a scavenger of free radicals, to provide a strong antioxidant effect to reduce oxidative stress, and to increase glutathione levels, MSM’s action on hair, skin, and nails has been shown to be its ability to act as a sulfur donor to keratin thus increasing the strength of this protein. It has also been shown in human studies to reduce signs of aging, such as facial wrinkles and skin roughness as well as improve skin firmness, elasticity, and hydration status, leading to healthier and more vibrant looking complexion. The antioxidant and keratin strengthening benefits of MSM on the health of hair, skin, and nails has been seen in numerous human studies, which leads it to be one of the most important components in Core’s Hair, Skin, and Nail health matrix.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHydrolyzed Keratin Peptides\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eConditioner is a common application most individuals include in their hair health regimen, but most people don’t know the real importance of incorporating protein specifically into the same regimen. This is where keratin comes into play, which as explained above is the main protein found in hair, skin, and nails. Hydrolyzed keratin has been shown to increase cysteine content, which increases tensile strength and minimizes damage. It also increases volume, strengthens your hair, and restores luster. Several studies have shown its efficacy towards hair, skin, and nail health. In relation to hair health, one human study concluded that participants who ingested keratin (along with other vitamins and minerals) experienced and large improvement in hair fallout compared to placebo, increased hair strength, and improvement in appearance over the course of 90 days.\u003c\/p\u003e\n\u003cp\u003eIn nail health, this same double-blind placebo-controlled study found that keratin supplemented at 500mg showed statistically significant improvements in nail health over the course of five key measures, breakage, strength, resistance, smoothness, and color.\u003c\/p\u003e\n\u003cp\u003eDuring this same study, keratins skin benefits were also exhibited in participants. When participants supplemented with 500mg of oral keratin skin measurements of moisture content, elasticity, wrinkles, protein content, and appearance all showed significant improvements. During this time frame, skin moisture increased by 11%, skin elasticity increased 7.2%, wrinkles decreased by 12%, and appearance improved by 58% with keratin supplementation.\u003c\/p\u003e\n\u003cp\u003eWith keratin being a major component of these vital structures, its supplementation can be beneficial if an individual is suffering from less-than-optimal hair, skin, and nail health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAstrion™ (Astragalus membranaceus \u0026amp; Centella asiatica) Root Extracts\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHerbs and plants have long been touted for their benefits towards health improvements and cosmetic application. Astrion™ is a comprehensive and clinically backed combination of \u003cem\u003eAstragalus membranaceous\u003c\/em\u003e and \u003cem\u003eCentella asiatica\u003c\/em\u003e root extracts aimed at providing pin point cosmeceutical improvements.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cem\u003eAstragalus membranaceus\u003c\/em\u003e, also known as Milkvetch, is considered to be one of the most important traditional Chinese medicines and has been used with various different natural remedies and herbal blends. This plant may reduce the physical and metabolic effects of ageing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eCentella asiatica\u003c\/em\u003e, also known as Indian Pennywort, is a traditional medicine that is mostly used and renowned in Ayurveda but has some usage in traditional Chinese medicine. This plant may inhibit a group of enzymes that break down collagen while simultaneously increasing the rate that collagen is synthesized.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhy is this collagen synthesis important? Collagen is a major component of the human body and its overall structure. This includes hair, skin, and nails, but also our bones, ligaments, muscles, organs, etc. In the cosmetic context, as our age increases our levels of collagen in our body reduce, which can lead to physical signs of aging, such as wrinkles, and brittle hair and nails. Astrion™ was formulated for the goal of supporting the body in maintaining its existing collagen and to also facilitate the stimulation of further collagen production.\u003c\/p\u003e\n\u003cp\u003eAstrion™ works through a process of triggering the body’s internal regeneration mechanisms to increase collagen and hyaluronic acid synthesis, as well as an increased absorption of proline (building block of collagen) and glucosamine (building block of hyaluronic acid) in skin cells. Clinical studies have shown that Astrion™ was able to increase collagen synthesis in the dermal layers of the skin by upwards of 80% and in epidermal layers by 60%. In the same study, synthesis of hyaluronic acid (the molecule that helps to keep skin looking and feeling soft and hydrated) was increased by up to 20%. Astrion™ has proven to be vital in its ability to enhance the body’s natural ability to create more of these vital nutrients and to improve the quality of the skin. These improvements that Astrion™ exhibits on the skin can also show reductions in the number and appearance of fine lines and wrinkles, as well as firming, hydrating and improving overall skin health resulting in a more radiant glow and complexion.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSetria® L-Glutathione\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlutathione is an amino acid containing molecule of L-glutamic acid, L-cysteine, and Glycine. It is vital to many different properties and is best known for being a powerful antioxidant. The ‘glutathione system’ comprises the enzymes that synthesize glutathione within a cell as dedicated enzymes that use glutathione for its antioxidant effects. Glutathione supplementation is thought to support this pool of glutathione present in cells and thus maintain the efficacy of the entire system. Free radicals can be a byproduct of many different things such as exercising, eating, and breathing to name a few. When these molecules overcome the body at the cellular level, this constant barrage can have negative impacts on health and overall wellness. In relation to hair, skin and nails this oxidative damage can lead to wrinkles, acne, and other skin related issues. Setria® L-Glutathione provides a potent supply of antioxidants that bind these free radicals, which can help keep them from causing lasting damage. It has the ability to protect against skin damage and preserve cellular integrity to rejuvenate skin and other cells to keep them at optimal health. Glutathione not only has the ability to neutralize free radicals, but it also can reactivate other antioxidants, such as Vitamin C and Vitamin E. Once these vitamins and their antioxidants do their job of neutralizing free radicals, they become unstable radicals themselves. Glutathione can help recycle these unstable molecules back to their antioxidant rich properties to allow them to work positively on the body.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHyaluronic Acid (Sodium Hyaluronate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSkin aging is as a result of several biologically independent processes. The first being an intrinsic, or unpreventable, process that affects the skin similar to how it affects our internal organs. The second is an extrinsic process, which is as a result of environmental factors such as ultraviolet (UV) exposure. While these intrinsic and extrinsic factors contribute to less than optimal looking and feeling skin, a loss of skin moisture is also a cause of this particular skin aging. The key molecule involved in maintenance of skin moisture is hyaluronic acid. Hyaluronic acid (HA), also known as hyaluronan, is a clear, gooey substance that is naturally produced by your body. The largest amounts of HA are found in your skin, connective tissue and eyes, but is found in many other tissues, with its main function being to help retain water for the purposes of keeping your tissues well lubricated and moist. The synthesis of HA increases during injury to tissues and wound healing as well as regulates several aspects of tissue repair, which can include activation of inflammatory cells to enhance immune response. Cosmetically these injuries can mean a cut or abrasion as well as sunburn, but can also mean internal injuries as well.\u003c\/p\u003e\n\u003cp\u003eAs we age it is experienced that the epidermal layer (top) of skin begins to lose HA over time, contributing to immediate changes in skin texture, tone, and moisture levels. The reasons for the change in HA balance with increased age is not entirely known. The overall loss of skin integrity parallels with the age-related declines in collagen extractability to keep joint and bone integrity in tact as well as muscle atrophy. In other words, this is deemed a normal part of aging. What supplemental HA can provide is a means to potentially slow this skin aging process and provide additional HA support to keep the skins (and other structures) cells hydrated and able to perform at their best.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDermaval® (Pomegranate Extract, Asparagus, Okra, CoffeeBerry® Extract, Quercetin, Acerola, Camu Camu, Acai, Mangosteen)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDermaval® is a blend of nine phytochemical-rich plant-based superfoods combined for their ability to coherently work to support the human body’s natural collagen levels as well as deliver nutrients to assist in natural collagen production. Pro-inflammatory enzymes, elastase and gelatinase, are known to wreak havoc on collagen and breakdown the vital tissue that is naturally produced by the body. Studies have shown that these pro-inflammatory enzymes may be stimulated by extrinsic factors (like UV light) or even our nutrition (food allergies\/sensitivities). So how can we prevent these enzymes from breaking down these vital tissues? Dermaval® and the plant-based ingredients it I comprised of have been studied immensely for their role in collagen production. This collagen production is something not entirely achieved from ingested animal collagen sources which are broken down in the digestive tract and renew collagen in the body, but don’t stimulate production. One human clinical study showed that this blend of superfoods was able to inhibit these pro-inflammatory enzymes, elastase and gelatinase, by roughly 98% and 33% respectfully in the first 120 min of consumption. Being able to regenerate collagen as well as naturally stimulate new collagen formation internally, you have the ability to provide extra support for the skin to withstand the rigors of everyday life as well as enhance the look, feel, and health of your skin that novel cosmetics may not be able to.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCeramosides™ Wheat Extract \u003cem\u003e(Triticum sativum)\u003c\/em\u003e (Seed) (std. to ≥ 50% glycosphingolipids, \u0026amp; ≥ 40% digalactosyldiacylglycerol (DGDG))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs we have covered in several sections, it is by now understood that the hair, skin, and nails can take a beating from the external and internal factors that they can be exposed to. These can be from the sun, the weather, stress, age, and even nutritional factors. Age in particular is not preventable as it is a natural occurrence and with that comes natural processes to happen. One of these is skin dehydration. Youthful and younger skin relies heavily on vital lipids (oils) to help moisturize the layers of the skin and to aid in the skins ability to act as the first line of protection for the body. These lipids, called ceramides, are rich in omega-3, 6, and 9 fatty acids and are the major constituent of lamellar sheets present in the intercellular spaces of the stratum corneum (outermost layer of skin). As we age, the loss of these ceramides often results in dry, itchy skin and can contribute to wrinkles, lower skin integrity. Supplementing with oral ceramides has been shown to naturally restore these lipid levels and aid in the hydration status and health of the skin and associated structures. Ceramosides™ is a clinically studies sources of these ceramides, which are carried via the bloodstream to help restore the water barrier to provide adequate hydration as well as lubricating the skin providing a healthy glow. These lipids can also be vital for someone who experiences dry skin as a result of weather, which can result in painful cracks and weak skin layers. Acting as a moisturizer, these lipids can help fill these cracks and provide support for the skin to better withstand these factors. A few key human studies have shown exceptional results with the addition of Ceramosides™ in the regimen. One human study showed that after two months of use, skin moisturization was able to increase by 21%, wrinkles were able to decrease by 18% and skin elasticity was able to increase 26%. With these kinds of results after a short period of time, it can be led to believe that even greater improvements can be seen with longer use.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-HAIRSKINNAILS.jpg?v=1652080715\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_HAIR_SKIN_NAILS_8.5x3.25-FIN.pdf?v=1651737337\"\u003eDownload Lifeline Hair, Skin, and Nails Label and Warnings\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Lifeline_Hair_Skin_Nails-refferences.pdf?v=1651737614\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":41622162866352,"sku":"SHOP658580070663","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HSNFRONT_b00ff68a-8192-430e-bfa0-4a16aa90e75e.png?v=1760382541"},{"product_id":"core-hydrate","title":"FUN SWEETS® HYDRATE","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Blend of Electrolytes\u003c\/strong\u003e- Can replace key electrolytes lost during intense training.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElevATP\u003c\/strong\u003e®- Can increase levels of endogenous ATP.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSenActiv\u003c\/strong\u003e®- Can promote muscle energy and regeneration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eHydration is one of the most important factors in athletic performance. Yet, many of the mass marketed “sports drinks” widely available today fail to properly address the issues posed by sustained periods of intense exercise. A broad base of research demonstrates that proper hydration and electrolyte levels can delay fatigue, increase endurance, reduce delayed onset muscle soreness, and increase a wide range of athletic performance metrics.\u003c\/p\u003e\n\u003cp\u003eAt Core Nutritionals®, we’ve reimagined the hydration process with our comprehensive electrolyte and hydration blend: HYDRATE. Core HYDRATE was developed with a comprehensive blend of cutting-edge ingredients and traditional electrolytes to address most, if not all, major important metabolic pathways associated with rehydration during intense physical activity. Core HYDRATE’s key ingredients have been demonstrated in scientific literature to have a range of positive effects, including, but not limited to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eAvoiding premature fatigue and muscle failures\u003c\/li\u003e\n\u003cli\u003eReenergizing and rejuvenating cells\u003c\/li\u003e\n\u003cli\u003eProtecting against free radical damage\u003c\/li\u003e\n\u003cli\u003eIncreasing endogenous ATP production\u003c\/li\u003e\n\u003cli\u003eEnhancing power output, strength, and overall athletic performance\u003c\/li\u003e\n\u003cli\u003eImproving stamina and recovery time\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eContained in single serve and portable packaging, Core HYDRATE can help you maintain your standards of athletic performance as a comprehensive source of hydration and electrolytes no matter where you are. With 4 amazing flavor options, you’ll be well equipped with everything you need to take your workouts to the next level!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C (as ascorbic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/p\u003e\n\u003cp\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium (as calcium carbonate, calcium citrate, dicalcium malate (DimaCal®))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body. As a key electrolyte it is responsible for mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, also requires sufficient levels of vitamin D. In the context of muscular contraction and relaxation, if calcium is required for strong contractions, magnesium is required for efficient relaxation of those muscle fibers.\u003c\/p\u003e\n\u003cp\u003eDimaCal® is a trademarked form of dicalcium malate, which is calcium bonded with malic acid. It has been shown in studies to be a much better absorbed form of calcium and has the ability to maintain serum calcium levels for a much longer period of time. This can lead to a better maintained electrolyte level and greater performance where calcium is required.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as magnesium carbonate, magnesium bisglycinate chelate (TRAACS®), magnesium citrate, magnesium glycinate glutamine chelate (TRAACS®))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMagnesium, an often-overlooked electrolyte, is the second most abundant intracellular cation (after potassium). It is a cofactor to over 300 enzymatic reactions in the body and is required for cellular energy metabolism, functioning of the sodium\/potassium adenosine triphosphatase pump, nerve conduction, and ion transport. Magnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells. Working alongside calcium, magnesium plays a crucial role in the body by regulating muscular contractions as well as cramp prevention. In the context of muscle health and rehydration, the longer and more intense a bout of physical activity is, the more magnesium is lost primarily through sweat and urine. This loss of electrolyte balance requires its replenishment so that physical performance can remain at its peak throughout the duration of the activity reducing the risk of injury or bodily harm. Regardless of the type of sport or exercise, muscular contractions and energy production could not occur consistently without the presence of magnesium.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as zinc bisglycinate chelate (Albion®))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs an essential mineral, like magnesium, zinc is also involved in a wide-range of essential biological functions in the human body – and a requirement in the catalytic activity of over 100 enzymes.\u003c\/p\u003e\n\u003cp\u003eMost notably, zinc is vital for immune function, protein synthesis, cellular division, and DNA synthesis. For immune function, zinc is required for the function of a group of immune cells known as neutrophils and macrophages, which eliminate pathological cells and their products from the body.\u003c\/p\u003e\n\u003cp\u003eWith magnesium, sufficient levels of zinc are also necessary for the production and maintenance of healthy levels of testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChloride (as potassium chloride)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChloride is one of the most important electrolytes in the human body. Similar to sodium and potassium, which will be discussed below, chloride creates specific channels in cell membranes which help to carry out different vital tasks. It is responsible for balancing the fluids on the inside of the cells with the fluids on the outside of the cells, as well as maintaining proper blood volume, blood pressure, and fluid pH. Chloride is also important for muscle and heart contraction as well as to aid in the carrying of nerve impulses between our nerve cells and our brain and the rest of the body. Additionally, chloride is needed to help red blood cells exchange oxygen and carbon dioxide in the lungs as well as plays a role in the digestion of foods by supporting hydrochloric acid production in the stomach. We often lose chloride through sweat and perspiration, which comes in the form of water and salt. Replenishment of chloride can come from utilizing salt (often found as sodium-chloride, or table salt), cheese, canned fish, and some processed meats. Overconsumption of some of these foods may not be beneficial for some individuals, so supplementation may be the best way for these individuals to replenish chloride in their bodies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSodium (as sodium citrate, sodium bicarbonate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSodium, like chloride above, is one of the most essential electrolytes for our body to utilize. Sodium helps to keep the water (mainly amount of fluid outside of the body’s cells) and electrolyte balance of the body, while also aiding in the contraction and relaxation of muscles as well as conducting nerve impulses. While only 500mg of sodium is needed per day for these functions to occur, we as active individuals need far more sodium in order to maintain these functions. We mostly lose sodium through sweat and urine, so the more active we are\/the more we sweat and the more we urinate, the more sodium is lost. Acquiring enough sodium through food and drink is crucial to establishing equilibrium again in order to maintain proper functioning and electrolyte balance within the body. The standard American diet is often overloaded with sodium and coupled with inactivity, which can lead to poor health and dysfunction. It is important to engage in physical activity of some kind most days and to eat a diet that is balanced in nutrients in order to maintain proper health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePotassium (as potassium citrate, coconut water concentrate, potassium glycinate chelate (TRAACS®))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePotassium, as sodium’s counterpart, acts as a critical electrolyte primarily by helping to maintain normal levels of fluids inside of our cells. Additionally, it helps muscles to contract and relax, aid in strong nerve function, as well as support normal blood pressure. It works very closely with sodium to create the membrane potential needed for the electrical currents that generate these functions to pass from one cell to the next. While the potassium levels in our body are regulated carefully, a diet lacking sufficient amounts of potassium (especially when combined with excess sodium) or one that contains too much potassium can eventually lead to certain types of dysfunctions and poor health status. When potassium levels in the body increase, the adrenal glands release the hormone aldosterone, which causes the kidneys to excrete excess potassium through the urine. When potassium levels are too low, aldosterone levels are suppressed, which can lead to conservation of potassium thus interfering with balance and negatively affecting transport channels that affect vital bodily functions. Potassium can be gotten from the diet in the form of fresh fruits and vegetables, such as sweet potatoes, beans, tomatoes, spinach and broccoli but supplementing can be an essential application as well to support an active lifestyle where excretion is higher than can be replenished through diet.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Taurine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThrough traditionally referred to as an amino acid due to its chemical structure, taurine is not an amino acid in the sense that leucine, alanine, or glutamine are. Its chemical status aside, taurine is considered one of the body’s most essential chemical compounds, as cardiovascular function, muscle development and function, along with optical and nervous systems in the body depend on its abundance. While data on taurine typically occurs with taurine in supplement combinations (with caffeine and other amino acids), these data nevertheless suggest that dietary supplementation with taurine may have beneficial effects on mental focus and alertness and may assist during times of increased physical exertion.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoconut Water Concentrate (Cocos nucifera)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCoconut water, like the name implies, is the liquid that is found within the coconut itself. Often having a slightly sweet, nutty flavor, it also contains an adequate amount of vitamins, minerals, and electrolytes like potassium, sodium, and magnesium. All of these electrolytes, like discussed in sections above, can help to boost hydration status and replenish nutrients lost through exercise or rigorous everyday activities. Potassium is the highest concentration in coconut water at roughly 600mg per cup (16% DV), which as discussed about it has a vital role in optimally functioning kidneys and strong muscle contractions. Potassium can also work to keep fluid levels and other electrolytes balanced during exercise. The high concentration of potassium in coconut water specifically can balance our sodium’s effects on blood pressure, and even lower blood pressure slightly, which can have its own benefits towards training and overall health and circulatory health. In addition to the added electrolytes that coconut water can provide, it also can provide a potent number of antioxidants that can aid in the neutralization of free radicals that can rapidly take over during intense training. By eliminating these free radicals, muscles will be able to perform longer and more efficiently, as well as be able to recover adequately. While general water consumption can be adequate as well, the added electrolytes coconut water can supply provides an added benefit that can improve performance and overall recovery.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eElevATP® (Ancient Peat and Apple Extract)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAdenosine triphosphate and other ATP metabolites are involved in a number of biological processes including cardiac function, blood flow, muscle contraction and neurotransmission. ATP is the primary molecule that acts as a carrier for energy within cells. It has also often been studied those increased levels of ATP have shown increases in health and performance. Supplementation with exogenous ATP has often shown its ability to increase ATP concentrations in blood. Oral supplementation with ancient peat and apple extracts have exhibited their ability to increase intracellular and intramuscular ATP levels. ElevATP® is a blend these specific polyphenols that can work to increase endogenous ATP levels without a simultaneous increase in serum lactate. The significance of this is that usually with an increase in endogenous ATP there is an increase in intracellular free radicals. When these free radicals are not present, oxidative stress is mitigated and there is more potential for the beneficial increases in ATP to take center stage. These increases of ATP are essential as when available energy is increased it can have positive benefits in terms of increased power, strength, and overall exercise performance. One study in particular looked at dosing ElevATP® against placebo and showed that the group who received ElevATP® saw a blood ATP increase of 45% on average along with no increase in oxidative blood glucose. This type of result has been shown repeatedly in studies and has given ElevATP® the reputation to be a beneficial compound for the goals of improving endurance, strength, power, and other training specific adaptations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eConcenTrace® AC (Trace Mineral Complex)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOur bodies are high functioning machines and require a lot of support to continue to perform at a high-level day in and day out. A lot of these needs are difficult to be acquired by diet alone, so supplementation is critical. Minerals are included in these daily needs and are vital to the bodies many processes. ConcenTrace® AC is a high-quality trace mineral complex providing a comprehensive blend of nutrients that are often hard to acquire from diet alone. Its manufacturing process makes it up to 26x more concentrated than other colloidal trace minerals, adding to its benefits. These minerals contained in the product are catalysts for all of the vitamins and other nutrients our body requires to function at an optimal level and maintain health. Some of these functions include electrolyte replacement, maintaining pH balance in the body, nourishing hair and skin, strengthening bones and joints, regulating the digestive system, and improving athletic performance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSenactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) Extracts\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSenactiv®, derived from extracts of Panax notoginseng and Rosa roxburghii, has been shown to act in a few pathways to reenergize and rejuvenate cells within the body that take a beating on a daily basis. Ultimately this product falls within a category known as senolytics, or compounds that primarily work to induce cell death. This may not sound ideal as we need our cells to function, but the key is to ensure that these compounds are working on the right kinds of cells.\u003c\/p\u003e\n\u003cp\u003eThe human body does contain many senescent cells, which are old cells and can be deteriorating. How these senolytics work to promote health is by speeding up the breakdown of these older cells as well as encouraging the grow of new, vibrant cells. The other benefit of Senactiv® and its ingredients is its ability to protect against muscle damage. Ginseng in particular has been shown to help reduce the proinflammatory state that is associated with rigorous training. Where this is going to benefit is to reduce inflammation and jumpstart the recovery process of torn down muscle fibers so these cells can begin to scar and grow stronger. The other benefit that ginseng has been able to show is it has been shown to improve VO2 mas by about 20% when compared to a control group in studies. This improvement can significantly improve oxygen uptake to increase delivery to muscle cells for the ability to push harder and longer.\u003c\/p\u003e\n\u003cp\u003eOn another angle of recovery, Senactiv® has been shown to improve the rate of glycogen storage after exercise. When glycogen can be stored efficiently post exercise it has the ability to attenuate the structural damage associated with training by allowing those carbohydrates and sugars going towards recovery.\u003c\/p\u003e\n\u003cp\u003eSenactiv® is a unique blend of ingredients but with sound research and application behind but with its benefits towards improved cell regeneration, VO2 max, and recovery, it is a great addition to this hydration product.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-HYDRATE.jpg?v=1663593862\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HYDRATE_5inch-Orange-Cream-FIN-v2_1.pdf?v=1723799415\" target=\"_blank\"\u003eFun Sweets® Orange Cream Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/hydrate-labels-CHERRYBERRY_compressed.pdf?v=1704879613\" target=\"_blank\"\u003eFun Sweets® Cherry Berry Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/hydrate-labels-BLUERAZ.pdf?v=1704879616\" target=\"_blank\"\u003eFun Sweets® Blue Raspberry Label\u003c\/a\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/hydrate-labels-BLUEICE_compressed.pdf?v=1704879613\" target=\"_blank\"\u003e\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES_Hydrate.pdf?v=1663144093\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Fun Sweets® Cherry Berry","offer_id":42875558985904,"sku":"SHOP850051031412","price":29.99,"currency_code":"USD","in_stock":true},{"title":"Fun Sweets® Mystery Flavor","offer_id":44809694871728,"sku":"SHOP850057789232","price":29.99,"currency_code":"USD","in_stock":true},{"title":"Fun Sweets® Blue Raspberry","offer_id":42875559018672,"sku":"SHOP850051031436","price":29.99,"currency_code":"USD","in_stock":true},{"title":"Fun Sweets® Orange Cream","offer_id":43859220070576,"sku":"SHOP850057789270","price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HYDRATE_BR_RIGHT-1_5aced96f-dd52-4b66-9030-3b647fd5ddfc.png?v=1761671583"},{"product_id":"coliseum-gym-towel","title":"Coliseum Gym Towel","description":"\u003cp\u003e29\"x14\", High quality, microfiber towel featuring the Crush It Coliseum logo\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":41998624194736,"sku":"promo \/ clothing","price":9.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/products\/coliseum-towel.jpg?v=1671467436"},{"product_id":"hoodie","title":"Crush It Coliseum Full Zip Hoodie","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePremium Hoodie featuring the Crush It Coliseum Gladiator Mask logo patch on front chest and the iconic CRUSH IT (R) up the back\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Small","offer_id":42422273409200,"sku":"","price":44.99,"currency_code":"USD","in_stock":false},{"title":"Medium","offer_id":42422458941616,"sku":"","price":44.99,"currency_code":"USD","in_stock":true},{"title":"Large","offer_id":42422458974384,"sku":"","price":44.99,"currency_code":"USD","in_stock":false},{"title":"X-Large","offer_id":42422461071536,"sku":"","price":44.99,"currency_code":"USD","in_stock":false},{"title":"XX-Large","offer_id":42422465036464,"sku":"","price":44.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core-productshoodies.png?v=1756752596"},{"product_id":"men-s-arm-tank","title":"Men’s Crush It Tank","description":"\u003cp\u003eThe Arm Tank features a neckline and shoulder straps that sit comfortably on the shoulders, while leaving the arms free to move and breathe and boasts a unique design that combines the freedom of a sleeveless shirt with the coverage and support of a traditional tank top. Made with a breathable fabric, this tank top will keep you cool during your workout and the soft, stretchy material conforms to your body for a supportive fit, while still allowing for a full range of motion.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Black \/ Small","offer_id":42649738805424,"sku":"","price":29.99,"currency_code":"USD","in_stock":true},{"title":"Black \/ Medium","offer_id":42649738838192,"sku":"","price":29.99,"currency_code":"USD","in_stock":true},{"title":"Black \/ Large","offer_id":42649738870960,"sku":"","price":29.99,"currency_code":"USD","in_stock":false},{"title":"Black \/ X-Large","offer_id":42649738903728,"sku":"","price":29.99,"currency_code":"USD","in_stock":false},{"title":"Black \/ XX-Large","offer_id":42649738936496,"sku":"","price":29.99,"currency_code":"USD","in_stock":false},{"title":"Green \/ Small","offer_id":42652560097456,"sku":"CLO100000000036_S","price":29.99,"currency_code":"USD","in_stock":true},{"title":"Green \/ Medium","offer_id":42652560130224,"sku":"CLO100000000036_M","price":29.99,"currency_code":"USD","in_stock":true},{"title":"Green \/ Large","offer_id":42652560162992,"sku":"","price":29.99,"currency_code":"USD","in_stock":false},{"title":"Green \/ X-Large","offer_id":42652560195760,"sku":"","price":29.99,"currency_code":"USD","in_stock":false},{"title":"Green \/ XX-Large","offer_id":42652560228528,"sku":"CLO100000000036_2XL","price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/blackperformancetank1.jpg?v=1683533882"},{"product_id":"fun-sweets-shaker","title":"Fun Sweets® Shaker","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e25oz. Core Nutritionals CRUSH IT Shakers with Thunder Ball\u003c\/li\u003e\n\u003cli\u003eFeaturing the iconic Fun Sweets\u003cspan data-mce-fragment=\"1\"\u003e®\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":42773149515952,"sku":"7360406683824","price":12.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core-products-shaker1.png?v=1756752370"},{"product_id":"core-bolic™-v2","title":"Bolic v2","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eCan Increase Muscle Protein Synthesis\u003c\/li\u003e\n\u003cli\u003eMay Increase Lean Body Mass\u003c\/li\u003e\n\u003cli\u003eCan Improve Athletic Performance\u003c\/li\u003e\n\u003cli\u003eCan Boost Recovery \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIntroducing Core BOLIC V2: Unleash Your Full Potential with Nature's Power\u003c\/p\u003e\n\u003cp\u003eIn the pursuit of peak physical performance, rapid recovery, and overall well-being, we present to you Core BOLIC V2—an innovative fusion of heavily studied ingredients meticulously crafted to elevate your capabilities. At its core are three remarkable components: PeptiStrong™, Maral Root Extract, and Camellia sinensis Extract, (fortified by the bioenhancing prowess of BioPerine®. Together, these elements unlock a world of possibilities that extend beyond the ordinary.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePeptiStrong™, hailing from fava beans (Vicia faba), takes center stage as a game-changing ingredient. It harbors a treasure trove of bioactive peptides, potent natural compounds also found in collagen, insulin, and glutathione. Patented and extensively researched, these peptides have displayed remarkable effects muscle protein synthesis, recovery, and overall muscle hypertrophy.\u003c\/li\u003e\n\u003cli\u003eMaral Root Extract, sourced from Rhaponticum carthamoides, is a revered natural ingredient renowned for its adaptogenic properties and myriad health benefits. Maral Root Extract is a game-changer for endurance, as it elevates adenosine triphosphate (ATP) production, extending exercise durations and delaying fatigue. Its ability to stimulate muscle protein synthesis, enhance muscle recovery, and improve muscular strength empowers you to achieve more during your workouts.\u003c\/li\u003e\n\u003cli\u003eCamellia sinensis Extract (Bean), standardized to an impressive 90% Epicatechin, adds another layer of excellence to Core BOLIC V2. Epicatechin shines in promoting muscle growth, strength, nitric oxide production, and overall heart and brain health. Furthermore, its nitric oxide-boosting capabilities translate to better blood flow, facilitating nutrient absorption and delivering an impressive pump during workouts.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioPerine®, a patented extract from Piper nigrum (black pepper) enhances bioavailability as well as elevates the effectiveness of Core BOLIC V2’s ingredients by inhibiting intestinal motility and dilating blood vessels in the gut—where nutrient absorption thrives.\u003c\/p\u003e\n\u003cp\u003eSo, as you can see, Core BOLIC V2 not only increases exercise performance, but makes the underlying anabolic response (muscle growth and protein synthesis) to exercise more efficient – ensuring that your hard work is paying off!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFava Bean (Vicia faba) Hydrolysate (as PeptiStrong™)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePeptiStrong™ is an ingredient derived from fava beans that contains extremely beneficial natural compounds called bioactive peptides. Other sources of naturally occurring bioactive peptides are collagen, insulin, and glutathione, all of which have crucially beneficial properties. These peptides have undergone patent protection and extensive research, including both pre-clinical and clinical studies. The studies have shown positive effects on gene expression and the secretion of tumor necrosis factor alpha (TNF-a). In vitro experiments using murine skeletal muscle cells and human macrophages have validated the ability of the peptides within PeptiStrong™ to increase muscle protein synthesis and reduce TNF-a secretion. The study also assessed the bioavailability and stability of the peptides, which proved to be resistant to digestion, displayed good intestinal barrier transport, and remained stable in plasma.\u003c\/p\u003e\n\u003cp\u003eIn an in vivo study using a murine model of muscle atrophy, PeptiStrong™ treatment for 18 days resulted in a significant attenuation of muscle loss and increased expression of muscle fibers. The treatment also upregulated protein-synthesis-related genes in muscle tissue. Other protein hydrolysates of fava bean and food-derived hydrolysates did not exhibit the same level of efficacy in vitro. Thus, PeptiStrong™ demonstrated efficacy in attenuating muscle atrophy through various mechanisms, including inflammation reduction and muscle protein synthesis.\u003c\/p\u003e\n\u003cp\u003eA clinical study compared the effects of PeptiStrong™ and milk protein supplementation on muscle mass and strength loss during limb immobilization. The study involved 30 young men subjected to one-legged knee immobilization followed by recovery. PeptiStrong™ supplementation performed similarly to milk protein in modulating muscle size loss during immobilization and regain during remobilization. Notably, higher muscle protein synthesis rates were observed during remobilization in the PeptiStrong™ group.\u003c\/p\u003e\n\u003cp\u003eAnother study with 30 healthy male subjects investigated the effects of PeptiStrong™ supplementation on strength recovery and fatigue. The subjects were divided into groups receiving either a placebo or 2.4 grams of PeptiStrong™ daily. Delayed onset muscle soreness (DOMS) was induced using resistance exercise, and the subjects' strength recovery and fatigue were measured over three days. PeptiStrong™ supplementation significantly improved strength recovery, reduced fatigue, and positively influenced markers associated with muscle homeostasis. Myostatin expression was also found to be significantly reduced, indicating an anabolic response following intense exercise.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaral Root Extract (Rhaponticum carthamoides) (10:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMaral Root Extract, derived from the plant Rhaponticum carthamoides, is a natural ingredient highly regarded for its adaptogenic properties and numerous health benefits. This herb has a rich history in traditional medicine and is known for its ability to enhance physical and mental performance, support stress resilience, boost energy levels, promote vitality, improve athletic performance, and aid in post-exercise recovery. One crucial aspect of athletic performance is the ability to maintain a high capacity throughout the event and be able to then recover efficiently. Maral Root Extract has shown potential in addressing both of these aspects. Let's first examine how this herb can enhance measures of athletic performance.\u003c\/p\u003e\n\u003cp\u003eWhen it comes to increasing endurance, two key factors play a significant role: oxygen and adenosine triphosphate (ATP). Oxygen is essential in breaking down carbohydrates, fats, and proteins and converting them into ATP, the primary energy source for the body. Maral Root Extract has been found to increase ATP production, which can allow individuals to exercise for longer periods and delay the onset of fatigue.\u003c\/p\u003e\n\u003cp\u003eFurthermore, studies suggest that Maral Root Extract supplementation may promote greater muscle protein synthesis. While the exact mechanisms of 20-hydroxyecdysone (a plant ecdysteroid) on muscle protein synthesis are not fully elucidated, it appears to involve a rapid increase in calcium in the cell (cytosol) causing activation of Akt\/PI3K signaling. This signaling promotes the metabolism, proliferation, cell survival, growth, and angiogenesis of cells. Along with these increases in muscle protein synthesis, Maral Root Extract has also been shown to aid in muscle recovery and improve muscular strength, enabling individuals to generate more power during workouts.\u003c\/p\u003e\n\u003cp\u003eMoreover, the active compounds present in Maral Root Extract, such as ecdysteroids and additional flavonoids, exhibit potential anti-inflammatory and antioxidant effects through their adaptogenic properties. These properties can help the body adapt to physical and mental stressors and can further contribute to improved muscle recovery, reduced exercise-induced muscle damage, and faster bounce back after intense training sessions.\u003c\/p\u003e\n\u003cp\u003eAdditionally, Maral Root Extract has been found to influence hormone levels, particularly testosterone and cortisol. It can help maintain a healthy testosterone-cortisol ratio, which is beneficial for muscle growth and recovery. Achieving hormonal balance can contribute to better exercise performance and body composition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCamellia sinensis Extract (Bean) (std. to 90% Epicatechin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eEpicatechin is a plant-based phytochemical, or flavanol, that is found in trace amounts in foods and liquids such as dark chocolate and green tea. Its physiological benefits have been studied for years and have resulted in promising results in relation to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnhanced muscle growth and strength\u003c\/li\u003e\n\u003cli\u003eIncreased nitric oxide production (better pumps)\u003c\/li\u003e\n\u003cli\u003eLowered cholesterol levels due to antioxidant content\u003c\/li\u003e\n\u003cli\u003eImprovements in brain and heart health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThese proposed benefits listed above and the compelling research surrounding them has led epicatechin to be involved in innovations where muscle growth and improved performance are the goal.\u003c\/p\u003e\n\u003cp\u003eHow does epicatechin work? Glad you asked. The proposed mechanism of action of epicatechin is through the inhibition of myostatin, which is a type of protein called a myokine that in essence acts as a regulating molecule released by muscles. Increased levels of myostatin have been linked to limiting the level of muscle growth. To combat an increased concentration of myostatin, epicatechin can work to increase another protein called follistatin which the body can then use to control metabolism, promote muscle growth, and boost fertility. Increased myostatin has been linked to the clinically obese and inactive as well as individuals who have some degree of insulin resistance. Studies have shown that aerobic activities, strength training, and some modifications to diet can, to a degree, decrease myostatin levels in muscle. When it comes to epicatechins ability to increase follistatin levels and further inhibit myostatin concentrations as few studies have been conducted for its efficacy.\u003c\/p\u003e\n\u003cp\u003eOne study conducted on males showed that just 170mg of epicatechin per day was able to increase follistatin by about 50% and decrease myostatin by about 17%, which also coincided with an increase in strength of about 7%.\u003c\/p\u003e\n\u003cp\u003eLooking at epicatechins nitric oxide boosting benefits, one animal study showed that nitric oxide and endurance was able to be increased even in the absence of exercise. This can aid in nutrient absorption and improved heart and muscle health outside of the gym but in the gym, it can also result in greater blood flow to muscles and stimulate a better pump in response to training.\u003c\/p\u003e\n\u003cp\u003eThe literature that has been presented on epicatechin in in vivo studies on muscle growth potential and improved overall health is promising and when combined with the other ingredients in this product, the body can be set up for the most beneficial environment for muscle growth, strength increases, and increases in performance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Bioperine® (Piper nigrum) (Fruit) (std. to 95% Piperine):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at the impact of BioPerine® on nutrient absorption and several plant compounds have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core BOLIC V2.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-BOLIC-2023.jpg?v=1696576317\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_BOLIC_2023_8.5x3.25-FIN.pdf?v=1696493534\"\u003eCore BOLIC Version V2 Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_BOLIC_V2_Product_References.docx?v=1696493236\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":42846303289520,"sku":"SHOP850051031214","price":59.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/BOLIC_FRONT_68a59313-6451-4850-a735-b219841df624.png?v=1760385628"}],"url":"https:\/\/www.corenutritionals.com\/collections\/all.oembed?page=10","provider":"Core Nutritionals","version":"1.0","type":"link"}